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11. 发明授权

US08293191B2 Method for transferring droplet 有权
标题翻译：液滴转移方法
公开(公告)号：US08293191B2
公开(公告)日：2012-10-23
申请号：US11675749
申请日：2007-02-16
申请人： Yoshinobu Kohara , Masataka Shirai , Hideyuki Noda , Tomoyuki Sakai , Kenko Uchida
发明人： Yoshinobu Kohara , Masataka Shirai , Hideyuki Noda , Tomoyuki Sakai , Kenko Uchida
IPC分类号： B01L3/00 , G01N21/03
CPC分类号： B01L3/0244 , B01F7/00258 , B01F11/0071 , B01F11/0258 , B01F13/0071 , B01L3/0251 , B01L3/0255 , B01L3/50 , B01L2300/0845 , B01L2300/089 , B01L2300/12 , G01N21/03 , G01N21/64 , G01N2021/0346 , G01N2021/035 , G01N2035/1037 , G01N2035/1046
摘要： The invention provides a method in which an annular or spiral droplet holder formed of wire is used to hold a droplet in a state of being hung therefrom or being contained therein. A means for moving the droplet holder is added to the droplet holder to enable droplet transfer. To merge two droplets, they are brought into contact. To drip the droplet held by a droplet holder formed of wire, the droplet holder is deformed using an external force. A light path which passes through a droplet is set to enable optical measurement. The present invention enables inexpensive, simple droplet transfer. An inexpensive, simple configuration for handling droplets in the fields of chemical analysis, biochemical analysis, and automatic blood analysis can be realized according to the present invention.
摘要翻译：本发明提供一种方法，其中使用由线形成的环形或螺旋液滴保持器将其悬挂在其中或被容纳在其中的状态。用于移动液滴保持器的装置被添加到液滴保持器以使液滴转移。为了合并两个液滴，它们被接触。为了滴落由线形成的液滴保持器保持的液滴，液滴保持器使用外力而变形。设置通过液滴的光路以进行光学测量。本发明可实现廉价的简单的液滴转印。根据本发明，可以实现用于处理化学分析，生化分析和自动血液分析领域中的液滴的廉价，简单的构造。

12. 发明授权

US08197751B2 Apparatus for chemiluminescent assay and detection 有权
公开(公告)号：US08197751B2
公开(公告)日：2012-06-12
申请号：US12976031
申请日：2010-12-22
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76 , G01N15/06 , G01N33/00 , G01N33/48 , G01N21/00 , G01N21/75
CPC分类号： C12Q1/04 , G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.

13. 发明申请

US20110091355A1 APPARATUS FOR CHEMILUMINESCENT ASSAY AND DETECTION 有权
标题翻译：用于荧光测定和检测的装置
公开(公告)号：US20110091355A1
公开(公告)日：2011-04-21
申请号：US12976031
申请日：2010-12-22
申请人： Hideyuki NODA , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki NODA , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76
CPC分类号： C12Q1/04 , G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译：一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。该装置包括：第一遮光箱，其具有样本容器保持器和其中的快门单元，所述快门单元包括部分地由板构件的运动形成的顶板和在其中具有光电检测器的第二遮光箱。虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。

14. 发明授权

US07879290B2 Apparatus for chemiluminescent assay and detection 有权
标题翻译：用于化学发光测定和检测的装置
公开(公告)号：US07879290B2
公开(公告)日：2011-02-01
申请号：US12034880
申请日：2008-02-21
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76 , G01N15/06 , G01N33/00 , G01N33/48 , G01N21/00 , G01N21/75
CPC分类号： C12Q1/04 , G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译：一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。该装置包括：第一遮光盒，其具有样品容器保持器和其中的快门单元，所述快门单元包括顶板，该顶板部分地通过板构件的运动和在其中具有光电检测器的第二遮光箱而形成。虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。

15. 发明申请

US20080239311A1 FLUORESCENCE DETECTION APPARATUS AND METHOD, AND PRISM USED THEREIN 有权
标题翻译：荧光检测装置及其使用方法
公开(公告)号：US20080239311A1
公开(公告)日：2008-10-02
申请号：US12051245
申请日：2008-03-19
申请人： Tsuyoshi SONEHARA , Takashi Anazawa , Kenko Uchida , Tomoyuki Sakai
发明人： Tsuyoshi SONEHARA , Takashi Anazawa , Kenko Uchida , Tomoyuki Sakai
IPC分类号： G01J3/30 , G02B5/08
CPC分类号： G01N21/6452 , G02B2207/113
摘要： In order to provide a fluorescence detection apparatus having a high sensitivity, a high processing capacity and a competitive edge in cost, the fluorescence detection apparatus according to this invention irradiate the sample with light so that the aspect ratio of the form of the irradiated region by light on the arrangement surface of the sample may be 1±0.1. The preferable form of irradiate region is not limited to one and varies to some extent depending on the item to be optimized. The form of irradiated region may be, for example, a circle, an equilateral triangle, a square, a regular hexagon and the like.
摘要翻译：为了提供具有高灵敏度，高处理能力和成本方面的竞争优势的荧光检测装置，根据本发明的荧光检测装置用光照射样品，使得照射区域的形式的纵横比由样品排列表面上的光可能为1±0.1。照射区域的优选形式不限于一个，并且根据要优化的项目而在一定程度上变化。照射区域的形式可以是例如圆形，等边三角形，正方形，正六边形等。

16. 发明授权

US5523058A Ultrasonic irradiation apparatus and processing apparatus based thereon 失效
标题翻译：超声波照射装置及其处理装置
公开(公告)号：US5523058A
公开(公告)日：1996-06-04
申请号：US240733
申请日：1994-05-12
申请人： Shinichiro Umemura , Kenichi Kawabata , Kenko Uchida , Kenji Yasuda , Yasuo Wada , Atsushi Hiraiwa
发明人： Shinichiro Umemura , Kenichi Kawabata , Kenko Uchida , Kenji Yasuda , Yasuo Wada , Atsushi Hiraiwa
IPC分类号： A61B17/22 , A61N7/00 , A61N7/02 , B01F11/02 , A61B8/00 , B06B1/00
CPC分类号： A61N7/02 , A61B17/22004 , A61N2007/006 , A61N2007/0078 , A61N2007/0095
摘要： By providing an ultrasonic irradiation apparatus for generating acoustic cavitation efficiently, it is intended to realize an ultrasonic therapeutic apparatus for generating the action of cavitation on a living body suitable for medical treatment of malignant tumors and medical treatment of thrombi and calculi, an ultrasonic diagnostic apparatus for generating cavitation for emphasizing an ultrasonic echo image such as a blood flow and utilizing the reflection capability of the cavitation, an ultrasonic chemical reaction accelerating apparatus, an ultrasonic cleaning apparatus or an ultrasonic sterilizing apparatus. Irradiation focus/code signals for defining irradiated acoustic fields of a fundamental wave and a second harmonic wave as well as focus positions/acoustic pressure distribution forms of the respective waves are applied from an irradiation unit main control circuit to drive phase generating circuits. Generated drive phases are applied to drive signal generating circuits, generated drive signals are applied to element drive circuits and a group of fundamental frequency elements and a group of second harmonic elements are driven. The drive phases are controlled such that the fundamental wave and second harmonic wave are superimposed on each other in a medium near a focal point, thus generating acoustic caviation locally and efficiently.
摘要翻译： PCT No.PCT / JP93 / 01310 Sec。 371日期：1994年5月12日 102（e）日期1994年5月12日PCT提交1993年9月14日PCT公布。公开号WO94 / 06380 日期为1994年3月31日。通过提供用于有效产生声孔的超声波照射装置，旨在实现用于产生适于恶性肿瘤治疗的生物体上的空化作用的超声波治疗装置和血栓的治疗和结石，用于产生用于强调超声波回波图像如血流并利用空化反射能力的超声波诊断装置，超声波化学反应加速装置，超声波清洗装置或超声波消毒装置。用于定义基波和二次谐波的辐射声场以及各波的聚焦位置/声压分布形式的照射焦点/码信号从照射单元主控制电路施加到驱动相位产生电路。产生的驱动相位被施加到驱动信号发生电路，所产生的驱动信号被施加到元件驱动电路，并且一组基频元件和一组二次谐波元件被驱动。控制驱动相位使得基波和二次谐波在焦点附近的介质中彼此叠加，从而局部且有效地产生声空化。

17. 发明授权

US5183744A Cell handling method for cell fusion processor 失效
标题翻译：细胞融合处理器的细胞处理方法
公开(公告)号：US5183744A
公开(公告)日：1993-02-02
申请号：US425028
申请日：1989-10-23
申请人： Yoshio Kawamura , Shinji Tanaka , Kazuo Sato , Kenko Uchida , Hiroyuki Kohida
发明人： Yoshio Kawamura , Shinji Tanaka , Kazuo Sato , Kenko Uchida , Hiroyuki Kohida
IPC分类号： C12M1/32 , C12M3/00 , C12N13/00 , C12Q1/24
CPC分类号： C12Q1/24 , C12M35/02 , C12N13/00
摘要： A method and an apparatus for the treatment of particles or biological cells are disclosed, wherein the particles or cells are precipitated or ascended depending on the specific gravity of a liquid used, and the particles or cells are handled with the aid of a holding plate. A method and an apparatus for the fusion of particles or cells are also disclosed, wherein an electric voltage is loaded on a position between electrodes in a microchamber to fuse the particles or cells held in the microchamber.
摘要翻译：公开了一种用于处理颗粒或生物细胞的方法和装置，其中所述颗粒或细胞根据所用液体的比重而沉淀或上升，并且借助于保持板处理颗粒或细胞。还公开了一种用于熔化颗粒或细胞的方法和装置，其中电压被加载在微室中的电极之间的位置，以熔化保持在微室中的颗粒或细胞。

18. 发明授权

US08334144B2 Apparatus for chemiluminescent assay and detection 有权
标题翻译：用于化学发光测定和检测的装置
公开(公告)号：US08334144B2
公开(公告)日：2012-12-18
申请号：US13478527
申请日：2012-05-23
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76 , G01N21/00 , G01N21/75
CPC分类号： C12Q1/04 , G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译：一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。该装置包括：第一遮光箱，其具有样本容器保持器和其中的快门单元，所述快门单元包括部分地由板构件的运动形成的顶板和在其中具有光电检测器的第二遮光箱。虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。

19. 发明授权

US08029744B2 Method of liquid droplet formation and transport apparatus therefor and particle manipulating apparatus 有权
标题翻译：液滴形成方法及其输送装置及粒子操纵装置
公开(公告)号：US08029744B2
公开(公告)日：2011-10-04
申请号：US12084990
申请日：2006-03-07
申请人： Hideyuki Noda , Yoshinobu Kohara , Kenko Uchida
发明人： Hideyuki Noda , Yoshinobu Kohara , Kenko Uchida
IPC分类号： B01L3/00 , G01N11/00 , G01N21/00 , G01N13/00
CPC分类号： G01N35/1016 , B01F13/0071 , B01J19/0046 , B01J2219/00315 , B01J2219/00369 , B01J2219/00376 , B01J2219/00468 , B01J2219/005 , B01J2219/00648 , B01L3/0241 , B01L3/0289 , B01L2200/0605 , B01L2200/0647 , B01L2200/0673 , B01L2300/0838 , B01L2400/0487 , G01N2035/00574 , G01N2035/1046
摘要： The present invention provides an apparatus for efficiently transporting or dispensing transport objects including not only particles but also liquid samples. A liquid in a first liquid transport pipe (3) is fed at a liquid feed velocity (V1), and a liquid droplet is formed toward an open end of a second liquid transport pipe (4) disposed with an air gap (11) in between. The particle is released into the liquid droplet, so that the particle is enclosed in the liquid droplet. Suction with a liquid feed velocity (V2) is applied to the inside of the second liquid transport pipe. Since the relationship between V1 and V2 is V1
摘要翻译：本发明提供了一种用于有效地运输或分配运输物体的装置，不仅包括颗粒而且包括液体样品。第一液体输送管（3）中的液体以液体进料速度（V1）进给，并且朝向设置有气隙（11）的第二液体输送管（4）的开口端形成液滴之间。颗粒被释放到液滴中，使得颗粒被包围在液滴中。利用液体进料速度（V2）进行吸入被施加到第二液体输送管的内部。由于V1和V2之间的关系为V1

20. 发明申请

US20100167281A1 SEQUENCE ANALYSIS METHOD 审中-公开
标题翻译：序列分析方法
公开(公告)号：US20100167281A1
公开(公告)日：2010-07-01
申请号：US12389151
申请日：2009-02-19
申请人： Maiko Tanabe , Chihiro Uematsu , Hirokazu Nishida , Kenko Uchida
发明人： Maiko Tanabe , Chihiro Uematsu , Hirokazu Nishida , Kenko Uchida
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2521/501 , C12Q2565/301
摘要： It is intended to provide an assay for the presence, absence or amount of a nucleic-acid fragment having a certain nucleotide sequence, for example, a polyA length, a difference in the number of repetition of a direct repeat sequence (e.g., microsatellite), single nucleotide substitution (or single nucleotide polymorphism), and nucleotide sequence insertion or deletion, and to provide a genetic testing using the same. The present invention relates to a nucleotide analysis method, comprising: hybridizing at least two probes to a nucleic-acid fragment; ligating the at least two probes using ligase; exchanging, to ATP, pyrophosphoric acid produced through the ligation reaction; and detecting chemiluminescence reaction dependent on the ATP.
摘要翻译：旨在提供具有某一核苷酸序列的核酸片段的存在，不存在或量的测定，例如polyA长度，直接重复序列（例如，微卫星）的重复次数的差异，，单核苷酸取代（或单核苷酸多态性）和核苷酸序列插入或缺失，并提供使用其的遗传检测。本发明涉及一种核苷酸分析方法，包括：将至少两个探针与核酸片段杂交; 使用连接酶连接至少两个探针; 通过连接反应产生的ATP，焦磷酸交换; 并根据ATP检测化学发光反应。

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