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1. 发明授权

US08029744B2 Method of liquid droplet formation and transport apparatus therefor and particle manipulating apparatus 有权
标题翻译：液滴形成方法及其输送装置及粒子操纵装置
公开(公告)号：US08029744B2
公开(公告)日：2011-10-04
申请号：US12084990
申请日：2006-03-07
申请人： Hideyuki Noda , Yoshinobu Kohara , Kenko Uchida
发明人： Hideyuki Noda , Yoshinobu Kohara , Kenko Uchida
IPC分类号： B01L3/00 , G01N11/00 , G01N21/00 , G01N13/00
CPC分类号： G01N35/1016 , B01F13/0071 , B01J19/0046 , B01J2219/00315 , B01J2219/00369 , B01J2219/00376 , B01J2219/00468 , B01J2219/005 , B01J2219/00648 , B01L3/0241 , B01L3/0289 , B01L2200/0605 , B01L2200/0647 , B01L2200/0673 , B01L2300/0838 , B01L2400/0487 , G01N2035/00574 , G01N2035/1046
摘要： The present invention provides an apparatus for efficiently transporting or dispensing transport objects including not only particles but also liquid samples. A liquid in a first liquid transport pipe (3) is fed at a liquid feed velocity (V1), and a liquid droplet is formed toward an open end of a second liquid transport pipe (4) disposed with an air gap (11) in between. The particle is released into the liquid droplet, so that the particle is enclosed in the liquid droplet. Suction with a liquid feed velocity (V2) is applied to the inside of the second liquid transport pipe. Since the relationship between V1 and V2 is V1
摘要翻译：本发明提供了一种用于有效地运输或分配运输物体的装置，不仅包括颗粒而且包括液体样品。第一液体输送管（3）中的液体以液体进料速度（V1）进给，并且朝向设置有气隙（11）的第二液体输送管（4）的开口端形成液滴之间。颗粒被释放到液滴中，使得颗粒被包围在液滴中。利用液体进料速度（V2）进行吸入被施加到第二液体输送管的内部。由于V1和V2之间的关系为V1

2. 发明申请

US20090020555A1 Method of Liquid Droplet Formation and Transport Apparatus Therefor and Particle Manipulating Apparatus 有权
标题翻译：液滴形成方法及其运输装置及其粒子操纵装置
公开(公告)号：US20090020555A1
公开(公告)日：2009-01-22
申请号：US12084990
申请日：2006-03-07
申请人： Hideyuki Noda , Yoshinobu Kohara , Kenko Uchida
发明人： Hideyuki Noda , Yoshinobu Kohara , Kenko Uchida
IPC分类号： B67D5/08
CPC分类号： G01N35/1016 , B01F13/0071 , B01J19/0046 , B01J2219/00315 , B01J2219/00369 , B01J2219/00376 , B01J2219/00468 , B01J2219/005 , B01J2219/00648 , B01L3/0241 , B01L3/0289 , B01L2200/0605 , B01L2200/0647 , B01L2200/0673 , B01L2300/0838 , B01L2400/0487 , G01N2035/00574 , G01N2035/1046
摘要： The present invention provides an apparatus for efficiently transporting or dispensing transport objects including not only particles but also liquid samples. A liquid in a first liquid transport pipe (3) is fed at a liquid feed velocity (V1), and a liquid droplet is formed toward an open end of a second liquid transport pipe (4) disposed with an air gap (11) in between. The particle is released into the liquid droplet, so that the particle is enclosed in the liquid droplet. Suction with a liquid feed velocity (V2) is applied to the inside of the second liquid transport pipe. Since the relationship between V1 and V2 is V1
摘要翻译：本发明提供了一种用于有效地运输或分配运输物体的装置，不仅包括颗粒而且包括液体样品。第一液体输送管（3）中的液体以液体进料速度（V1）进给，并且朝向设置有气隙（11）的第二液体输送管（4）的开口端形成液滴之间。颗粒被释放到液滴中，使得颗粒被包围在液滴中。利用液体进料速度（V2）进行吸入被施加到第二液体输送管的内部。由于V1和V2之间的关系为V1

3. 发明申请

US20070207064A1 METHOD FOR TRANSFERRING DROPLET 有权
标题翻译：用于转移滴液的方法
公开(公告)号：US20070207064A1
公开(公告)日：2007-09-06
申请号：US11675749
申请日：2007-02-16
申请人： Yoshinobu Kohara , Masataka Shirai , Hideyuki Noda , Tomoyuki Sakai , Kenko Uchida
发明人： Yoshinobu Kohara , Masataka Shirai , Hideyuki Noda , Tomoyuki Sakai , Kenko Uchida
IPC分类号： B01L3/02
CPC分类号： B01L3/0244 , B01F7/00258 , B01F11/0071 , B01F11/0258 , B01F13/0071 , B01L3/0251 , B01L3/0255 , B01L3/50 , B01L2300/0845 , B01L2300/089 , B01L2300/12 , G01N21/03 , G01N21/64 , G01N2021/0346 , G01N2021/035 , G01N2035/1037 , G01N2035/1046
摘要： The invention provides a method in which an annular or spiral droplet holder formed of wire is used to hold a droplet in a state of being hung therefrom or being contained therein. A means for moving the droplet holder is added to the droplet holder to enable droplet transfer. To merge two droplets, they are brought into contact. To drip the droplet held by a droplet holder formed of wire, the droplet holder is deformed using an external force. A light path which passes through a droplet is set to enable optical measurement. The present invention enables inexpensive, simple droplet transfer. An inexpensive, simple configuration for handling droplets in the fields of chemical analysis, biochemical analysis, and automatic blood analysis can be realized according to the present invention.
摘要翻译：本发明提供一种方法，其中使用由线形成的环形或螺旋液滴保持器将其悬挂在其中或被容纳在其中的状态。用于移动液滴保持器的装置被添加到液滴保持器以使液滴转移。为了合并两个液滴，它们被接触。为了滴落由线形成的液滴保持器保持的液滴，液滴保持器使用外力而变形。设置通过液滴的光路以进行光学测量。本发明可实现廉价的简单的液滴转印。根据本发明，可以实现用于处理化学分析，生化分析和自动血液分析领域中的液滴的廉价，简单的构造。

4. 发明授权

US08293191B2 Method for transferring droplet 有权
标题翻译：液滴转移方法
公开(公告)号：US08293191B2
公开(公告)日：2012-10-23
申请号：US11675749
申请日：2007-02-16
申请人： Yoshinobu Kohara , Masataka Shirai , Hideyuki Noda , Tomoyuki Sakai , Kenko Uchida
发明人： Yoshinobu Kohara , Masataka Shirai , Hideyuki Noda , Tomoyuki Sakai , Kenko Uchida
IPC分类号： B01L3/00 , G01N21/03
CPC分类号： B01L3/0244 , B01F7/00258 , B01F11/0071 , B01F11/0258 , B01F13/0071 , B01L3/0251 , B01L3/0255 , B01L3/50 , B01L2300/0845 , B01L2300/089 , B01L2300/12 , G01N21/03 , G01N21/64 , G01N2021/0346 , G01N2021/035 , G01N2035/1037 , G01N2035/1046
摘要： The invention provides a method in which an annular or spiral droplet holder formed of wire is used to hold a droplet in a state of being hung therefrom or being contained therein. A means for moving the droplet holder is added to the droplet holder to enable droplet transfer. To merge two droplets, they are brought into contact. To drip the droplet held by a droplet holder formed of wire, the droplet holder is deformed using an external force. A light path which passes through a droplet is set to enable optical measurement. The present invention enables inexpensive, simple droplet transfer. An inexpensive, simple configuration for handling droplets in the fields of chemical analysis, biochemical analysis, and automatic blood analysis can be realized according to the present invention.
摘要翻译：本发明提供一种方法，其中使用由线形成的环形或螺旋液滴保持器将其悬挂在其中或被容纳在其中的状态。用于移动液滴保持器的装置被添加到液滴保持器以使液滴转移。为了合并两个液滴，它们被接触。为了滴落由线形成的液滴保持器保持的液滴，液滴保持器使用外力而变形。设置通过液滴的光路以进行光学测量。本发明可实现廉价的简单的液滴转印。根据本发明，可以实现用于处理化学分析，生化分析和自动血液分析领域中的液滴的廉价，简单的构造。

5. 发明授权

US09834806B2 Microbe-collecting carrier cartridge, carrier treating apparatus, and method of measuring microbes 有权
公开(公告)号：US09834806B2
公开(公告)日：2017-12-05
申请号：US13001465
申请日：2009-06-25
申请人： Hideyuki Noda , Masahiro Okanojo , Kenko Uchida , Norihito Kuno
发明人： Hideyuki Noda , Masahiro Okanojo , Kenko Uchida , Norihito Kuno
IPC分类号： C12M1/00 , C12M1/34 , C12Q1/06 , C12Q1/00 , B01L3/00 , G01N1/22
CPC分类号： C12Q1/008 , B01L3/502 , B01L2300/0681 , B01L2300/069 , B01L2300/1805 , B01L2400/0487 , G01N1/2208 , G01N1/2273
摘要： A disposable microbe-collecting carrier cartridge and a carrier treating apparatus which efficiently convert microbes collected on a carrier into a solution and prevent variations in the amount of retrieval of microbes upon concentration on a filter are provided. A cartridge formed of an upper lid having a plurality of through holes, a container in an inverted-cone shape having both of a liquid storage sink unit having a filter at the bottom and an air suction path, and a support base for setting up a thermoplastic carrier, and a carrier treating apparatus formed of a dispensing nozzle for liquid supply, a liquid supply mechanism, a liquid heating mechanism, and a suction pump for filtration are prepared. Warm water is supplied onto the filter set up on a bottom surface of the inverted-cone-shaped. The contact with the warm water causes the carrier to be solated filtered through the filter.

6. 发明授权

US08197751B2 Apparatus for chemiluminescent assay and detection 有权
公开(公告)号：US08197751B2
公开(公告)日：2012-06-12
申请号：US12976031
申请日：2010-12-22
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76 , G01N15/06 , G01N33/00 , G01N33/48 , G01N21/00 , G01N21/75
CPC分类号： C12Q1/04 , G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.

7. 发明申请

US20110091355A1 APPARATUS FOR CHEMILUMINESCENT ASSAY AND DETECTION 有权
标题翻译：用于荧光测定和检测的装置
公开(公告)号：US20110091355A1
公开(公告)日：2011-04-21
申请号：US12976031
申请日：2010-12-22
申请人： Hideyuki NODA , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki NODA , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76
CPC分类号： C12Q1/04 , G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译：一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。该装置包括：第一遮光箱，其具有样本容器保持器和其中的快门单元，所述快门单元包括部分地由板构件的运动形成的顶板和在其中具有光电检测器的第二遮光箱。虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。

8. 发明授权

US07879290B2 Apparatus for chemiluminescent assay and detection 有权
标题翻译：用于化学发光测定和检测的装置
公开(公告)号：US07879290B2
公开(公告)日：2011-02-01
申请号：US12034880
申请日：2008-02-21
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76 , G01N15/06 , G01N33/00 , G01N33/48 , G01N21/00 , G01N21/75
CPC分类号： C12Q1/04 , G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译：一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。该装置包括：第一遮光盒，其具有样品容器保持器和其中的快门单元，所述快门单元包括顶板，该顶板部分地通过板构件的运动和在其中具有光电检测器的第二遮光箱而形成。虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。

9. 发明授权

US08334144B2 Apparatus for chemiluminescent assay and detection 有权
标题翻译：用于化学发光测定和检测的装置
公开(公告)号：US08334144B2
公开(公告)日：2012-12-18
申请号：US13478527
申请日：2012-05-23
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76 , G01N21/00 , G01N21/75
CPC分类号： C12Q1/04 , G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译：一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。该装置包括：第一遮光箱，其具有样本容器保持器和其中的快门单元，所述快门单元包括部分地由板构件的运动形成的顶板和在其中具有光电检测器的第二遮光箱。虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。

10. 发明申请

US20080261294A1 APPARATUS FOR CHEMILUMINESCENT ASSAY AND DETECTION 有权
标题翻译：用于荧光测定和检测的装置
公开(公告)号：US20080261294A1
公开(公告)日：2008-10-23
申请号：US12034880
申请日：2008-02-21
申请人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
发明人： Hideyuki Noda , Satoshi Ozawa , Masahiro Okanojo , Kenko Uchida
IPC分类号： G01N21/76 , C12M1/36
CPC分类号： C12Q1/04 , G01N21/76
摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
摘要翻译：一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。该装置包括：第一遮光盒，其具有样品容器保持器和其中的快门单元，所述快门单元包括顶板，该顶板部分地通过板构件的运动和在其中具有光电检测器的第二遮光箱而形成。虽然没有实现测量，但是关闭快门单元以阻止杂散光入射到光电检测器，并且在实施测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入通孔使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。

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