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11. 发明授权

US5249241A Real-time automated scene display for infrared cameras 失效
标题翻译：红外摄像机的实时自动化场景显示
公开(公告)号：US5249241A
公开(公告)日：1993-09-28
申请号：US728907
申请日：1991-07-09
申请人： Jerry Silverman , Jonathan Mooney , William Ewing , Darryl Sato
发明人： Jerry Silverman , Jonathan Mooney , William Ewing , Darryl Sato
IPC分类号： G06T5/40
CPC分类号： G06T5/40 , G06T5/009 , G06T2207/10048 , H04N5/33
摘要： A histogram projection system which automatically optimizes, tracks changes in luminance and adjusts in real time the display of wide dynamic range imagery from IR cameras. It is computationally simpler than and offers markedly superior results to the standard available technique for this purpose, histogram equalization. The new technique assigns display dynamic range equally to each occupied intensity level in the raw data in contrast to the old procedure which assigns dynamic range in proportion to the number of pixels at given levels. Less shot noise and greater resolution of image detail for smaller objects or targets are the main improvements from the new algorithm. By the expedient of undersampling the image pixels in carrying out the histogram processing, one can in effect gradually increase the degree of dynamic range assigned to majority or background pixel levels, thereby enhancing the contrast in background regions when desired.
摘要翻译：直方图投影系统，自动优化，跟踪亮度变化，并实时调整红外摄像机的宽动态范围图像的显示。它的计算简单，并提供了显着优越的结果与标准可用的技术为此目的，直方图均衡。新技术将原始数据中的每个占据的强度级别均匀地分配显示动态范围，这与旧程序相比较，该过程与给定级别的像素数量成比例地分配动态范围。较小的对象或目标的图像细节较少的散粒噪声和更高的分辨率是新算法的主要改进。通过在进行直方图处理时对图像像素进行欠采样的方法，实际上可以逐渐增加分配给多数或背景像素级的动态范围的程度，从而当需要时增强背景区域中的对比度。

12. 发明授权

US08967162B2 Compact, recyclable, multi-layered dental flossing device and packaging therefore 有权
标题翻译：因此，紧凑，可回收，多层牙线切割装置和包装
公开(公告)号：US08967162B2
公开(公告)日：2015-03-03
申请号：US14267265
申请日：2014-05-01
申请人： William Ewing
发明人： William Ewing
IPC分类号： A61C15/00 , A61C15/04 , A61Q11/00
CPC分类号： A61C15/041 , A61C15/00 , A61C15/043 , A61Q11/00
摘要： A compact, recyclable dental flossing device in the form of a multi-layered elongated filament or strip of a resin which has physical characteristics such that, when elongated or drawn to stop, possesses a substantially increased length and tensile strength and a reduced thickness suitable for flossing teeth.
摘要翻译：具有物理特征的多层细长长丝或树脂条形式的紧凑的，可回收的牙线清洁装置，其特征在于当伸长或拉伸停止时具有基本上增加的长度和拉伸强度以及适于牙线牙线

13. 发明申请

US20070287670A1 HUMAN GLUCAGON-LIKE PEPTIDE-1 MIMICS AND THEIR USE IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS 审中-公开
标题翻译：人类GLUCAGON-LIKE PEPTIDE-1 MIMICS及其在治疗糖尿病及相关病症中的应用
公开(公告)号：US20070287670A1
公开(公告)日：2007-12-13
申请号：US11740031
申请日：2007-04-25
申请人： Sesha Natarajan , Claudio Mapelli , Margarita Bastos , Michael Bernatowicz , Ving Lee , William Ewing
发明人： Sesha Natarajan , Claudio Mapelli , Margarita Bastos , Michael Bernatowicz , Ving Lee , William Ewing
IPC分类号： A61K38/10 , A61K38/05 , A61K38/06 , A61P3/00 , C07K7/00 , C07K7/08 , C07K7/06 , A61P3/10 , A61K38/07 , A61K38/08
CPC分类号： A61K45/06 , A61K38/00 , C07K14/605
摘要： The present invention provides novel human glucagon-like peptide-1 (GLP-1) peptide mimics that mimic the biological activity of the native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP activity. Further, the present invention provides novel, chemically modified peptides that not only stimulate insulin secretion in type II diabetics, but also produce other beneficial insulinotropic responses. These synthetic peptide GLP-1 mimics exhibit increased stability to proteolytic cleavage making them ideal therapeutic candidates for oral or parenteral administration.
摘要翻译：本发明提供了模拟天然GLP-1肽的生物学活性的新型人胰高血糖素样肽-1（GLP-1）肽模拟物，因此可用于治疗或预防与GLP活性相关的疾病或病症。此外，本发明提供新颖的化学修饰的肽，其不仅刺激II型糖尿病患者的胰岛素分泌，而且产生其它有益的促胰岛素反应。这些合成肽GLP-1模拟物表现出增加的蛋白水解切割的稳定性，使其成为口服或肠胃外给药的理想治疗候选物。

14. 发明申请

US20060287324A1 Bicyclic heterocycles as cannabinoid-1 receptor modulators 有权
标题翻译：双环杂环作为大麻素-1受体调节剂
公开(公告)号：US20060287324A1
公开(公告)日：2006-12-21
申请号：US11455039
申请日：2006-06-16
申请人： Chongqing Sun , Yanting Huang , Doree Sitkoff , Taekyu Lee , William Ewing
发明人： Chongqing Sun , Yanting Huang , Doree Sitkoff , Taekyu Lee , William Ewing
IPC分类号： A61K31/503 , A61K31/4745 , C07D487/04 , C07D471/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formula: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein A, B, R1, R2, R3 and R8 are described herein.
摘要翻译：本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的治疗剂。所述化合物具有以下通式：包括所有前药，溶剂化物，药学上可接受的盐和立体异构体，其中A，B，R 1，R 2，R 3 本文描述了本文和/或 8。

15. 发明申请

US20060155126A1 Bicyclic heterocycles as cannabinoid receptor modulators 有权
标题翻译：双环杂环作为大麻素受体调节剂
公开(公告)号：US20060155126A1
公开(公告)日：2006-07-13
申请号：US11330541
申请日：2006-01-12
申请人： Chongqing Sun , William Ewing , Richard Sulsky , Yanting Huang
发明人： Chongqing Sun , William Ewing , Richard Sulsky , Yanting Huang
IPC分类号： C07D471/02 , C07D487/02
CPC分类号： C07D471/04
摘要： The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R3a, R4, A, B, n, Y and Z are described herein.
摘要翻译：本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的治疗剂。该化合物具有通式I：包括所有前药，药学上可接受的盐和立体异构体，R 1，R 2，R 3，R 3，本文描述了SUP，3a，R 4，A，B，n，Y和Z。

16. 发明申请

US20060154958A1 Bicyclic heterocycles as cannabinoid receptor modulators 有权
标题翻译：双环杂环作为大麻素受体调节剂
公开(公告)号：US20060154958A1
公开(公告)日：2006-07-13
申请号：US11330657
申请日：2006-01-12
申请人： Richard Sulsky , William Ewing
发明人： Richard Sulsky , William Ewing
IPC分类号： A61K31/4745 , C07D498/02
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04
摘要： The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R3a, R4, A, B, and n are described herein.
摘要翻译：本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的治疗剂。该化合物具有通式I：包括所有前药，药学上可接受的盐和立体异构体，R 1，R 2，R 3，R 3，本文中描述了SUP，3a，R 4，A，B和n。

17. 发明申请

US20050043339A1 Dihydropyrimidone inhibitors of calcium channel function 有权
标题翻译：二氢嘧啶酮抑制剂钙通道功能
公开(公告)号：US20050043339A1
公开(公告)日：2005-02-24
申请号：US10897215
申请日：2004-07-22
申请人： Natesan Murugesan , Gregory Bisacchi , William Ewing , Guixue Yu , Zhengxiang Gu , Todd Friends , Minsheng Zhang
发明人： Natesan Murugesan , Gregory Bisacchi , William Ewing , Guixue Yu , Zhengxiang Gu , Todd Friends , Minsheng Zhang
IPC分类号： A61K20060101 , A61K31/513 , C07D43/02
CPC分类号： C07D239/28 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12
摘要： Compounds having the formula, enantiomers, diastereomers, solvates and salts thereof, where R1, R2, R3, R4, A, X, and J are described herein, are inhibitors of calcium channel function, and are useful in treating calcium channel-dependent disorders, including hypertension.
摘要翻译：具有式的对映异构体，非对映异构体，溶剂合物和盐的化合物，其中R 1，R 2，R 3，R 4，A，X和J如本文所述，是钙通道的抑制剂功能，并且可用于治疗钙通道依赖性疾病，包括高血压。

18. 发明授权

US06329139B1 Automated sorting system for matrices with memory 失效
标题翻译：具有存储器的矩阵的自动排序系统
公开(公告)号：US06329139B1
公开(公告)日：2001-12-11
申请号：US08912998
申请日：1997-08-11
申请人： Michael P. Nova , John E. Lillig , Kanchana Sanjaya Gunesekera Karunaratne , William Ewing , Yozo Satoda , Hanan Potash
发明人： Michael P. Nova , John E. Lillig , Kanchana Sanjaya Gunesekera Karunaratne , William Ewing , Yozo Satoda , Hanan Potash
IPC分类号： C12Q168
CPC分类号： G11C13/0019 , B01J19/0046 , B01J2219/00283 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00319 , B01J2219/00333 , B01J2219/00344 , B01J2219/00454 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/00554 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/50255 , B01L3/50825 , B01L3/5453 , B01L2300/022 , B01L2300/0609 , B01L2400/0655 , B82Y10/00 , C07H21/00 , C07K1/00 , C07K1/04 , C07K1/047 , C08J7/16 , C08J2327/12 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , C40B70/00 , G01N33/542 , G01N33/54353 , G01N33/54393 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G01N2333/9121 , G01N2500/00 , G11C13/0014 , G11C13/025 , G11C2213/81
摘要： Automated drug discovery protocols, or partially automated protocols, in which matrices with memories serve as the platform on which all manipulations are performed or serve as the repository of information that is transferred to other memories as the synthesized compounds are processed and screened. Also provided are automated drug discovery units for use in the protocols. The units provide a means for seamless data tracking and include instrumentation and vials with memories for information transfer to other memories in a unit. The units, which are provided herein, include some or all of the following: an automated or manual sorter, microvessels, which contain memories, an automated or semi-automated synthesizer, a microvessel washer/dryer, a manual or automated cleaver for removing compounds from the matrix with memory microvessels, and associated software. The memories may be any of any type, including electromagnetically encodable memories and optical memories, or combinations thereof. The memories may be pre-encoded or may be encodabie during, after or before processing. Also provided are manual and automated methods for sorting matrices with memories.
摘要翻译：自动药物发现协议或部分自动化协议，其中具有记忆的矩阵作为执行所有操作的平台，或者当作为合成化合物被处理和筛选时被传送到其他存储器的信息库。还提供了用于协议的自动化药物发现单元。这些单元为无缝数据跟踪提供了一种手段，其中包括仪器和样品瓶，用于将信息传输到单元中的其他存储器。这里提供的单元包括以下部分或全部：自动或手动分拣机，包含记忆的微血管，自动或半自动合成器，微血清洗涤器/干燥器，用于去除化合物的手动或自动切割器从具有记忆微血管的矩阵和相关联的软件。存储器可以是任何类型的存储器，包括电磁编码存储器和光存储器，或其组合。存储器可以被预编码，或者可以在处理期间，之后或之前编码。还提供了用于使用存储器排序矩阵的手动和自动化方法。

19. 发明授权

US6048563A Reduced viscosity, low ash modified guar and process for producing same 失效
标题翻译：粘度降低，灰分改良瓜尔胶及其生产方法
公开(公告)号：US6048563A
公开(公告)日：2000-04-11
申请号：US034057
申请日：1998-03-03
申请人： William Ewing Swartz , Craig Alan Hoppe , James Thomas Elfstrum
发明人： William Ewing Swartz , Craig Alan Hoppe , James Thomas Elfstrum
IPC分类号： A23L29/238 , A23L1/0526
CPC分类号： A23L29/238
摘要： Functionally modified guar products are provided, particularly for food grade applications, which are characterized by reduced viscosity, low ash and high fiber content, and are prepared by a high shear treatment under acid conditions at elevated temperature.
摘要翻译：提供功能改性的瓜尔胶产品，特别是用于食品级应用，其特征在于粘度降低，灰分低和纤维含量高，并且通过高温剪切处理在酸性条件下在高温下制备。

20. 发明授权

US2042707A Weather strip 失效
公开(公告)号：US2042707A
公开(公告)日：1936-06-02
申请号：US1435035
申请日：1935-04-02
申请人： WILLIAM EWING JAMES
发明人： WILLIAM EWING JAMES
IPC分类号： E06B7/232
CPC分类号： E06B7/232

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