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11. 发明授权

US4734406A 3-pyridylmethylnaphthyl derivatives and composition containing them useful to inhibit thromboxane synthetase 失效
标题翻译： 3-吡啶基甲基萘基衍生物和含有它们的组合物可用于抑制凝血恶烷合成酶
公开(公告)号：US4734406A
公开(公告)日：1988-03-29
申请号：US838547
申请日：1986-03-11
申请人： Hans-Hermann Lau , Wilhelm Bartmann , Gerhard Beck , Gunther Wess
发明人： Hans-Hermann Lau , Wilhelm Bartmann , Gerhard Beck , Gunther Wess
IPC分类号： A61K31/44 , A61K31/4406 , A61K31/4418 , A61P7/02 , A61P43/00 , C07D213/26 , C07D213/30 , C07D213/42 , C07D213/50 , C07D213/53 , C07D213/55 , A61K31/535 , C07D413/10
CPC分类号： C07D213/30 , C07D213/26 , C07D213/42 , C07D213/55
摘要： Compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and Y have the indicated meanings, their physiologically tolerated acid addition salts, and a process for the preparation of these compounds, are described. The compounds inhibit thromboxane synthetase and can thus be used as medicaments.
摘要翻译：描述了其中R 1，R 2，R 3和Y具有指定含义的式I“I”化合物，其生理上耐受的酸加成盐，以及这些化合物的制备方法。该化合物可抑制血栓素合成酶，因此可用作药物。

12. 发明授权

US4296121A Novel prostaglandin derivatives of the .DELTA.2-PGF.sub.2 and .DELTA.2-PGE.sub.2 series and process for their manufacture 失效
标题翻译： DELTA 2-PGF2和DELTA 2-PGE2系列的新型前列腺素衍生物及其制造方法
公开(公告)号：US4296121A
公开(公告)日：1981-10-20
申请号：US62937
申请日：1979-08-02
申请人： Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch , Elmar Konz
发明人： Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch , Elmar Konz
IPC分类号： A61K31/23 , A61K31/19 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61P43/00 , C07C45/29 , C07C45/60 , C07C47/267 , C07C49/743 , C07C49/757 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/34 , C07D307/58 , C07D307/935 , C07D319/06 , C07D333/16 , C07D333/24 , A61K31/557 , C07C177/00 , C07D307/54
CPC分类号： C07D307/935 , C07C405/00 , C07C45/29 , C07C45/60 , C07C47/267 , C07C49/743 , C07C49/757 , C07D319/06 , Y10S514/822
摘要： What is disclosed are compounds of the formula ##STR1## which are structurally related to natural prostaglandins and a process for their manufacture. The compounds have valuable pharamacological properties and, therefore, they can be used as medicaments.
摘要翻译：公开的是具有结构上与天然前列腺素相关的式（I）＆gt; I的化合物及其制造方法。这些化合物具有宝贵的药理学性质，因此它们可以用作药物。

13. 发明授权

US4282222A 3-Piperidino or apiperazino-1-phenyl or 1-substituted phenyl isoquinoline and antidepressant compositions thereof 失效
标题翻译： 3-哌啶子基或哌嗪-1-基或1-取代的苯基异喹啉及其抗抑郁药组合物
公开(公告)号：US4282222A
公开(公告)日：1981-08-04
申请号：US75038
申请日：1979-09-12
申请人： Wilhelm Bartmann , Elmar Konz , Harry M. Geyer
发明人： Wilhelm Bartmann , Elmar Konz , Harry M. Geyer
IPC分类号： A61K31/47 , A61K31/472 , A61P25/08 , A61P25/24 , A61P25/26 , C07D217/22 , C07D401/04 , A61K31/495
CPC分类号： C07D217/22
摘要： Isoquinolines of the formula ##STR1## in which R.sub.1 is piperidino, piperazino or piperazino N-substituted thereof by alkyl of 1 to 4 carbon atoms, alkylene of 1 to 4 carbon atoms wherein said alkylene is substituted in turn by fluorobenzoyl, or CHO; R.sub.2 is phenyl or phenyl substituted by alkyl of 1 to 4 carbon atoms, halogen, amino or nitro; and R.sub.3 is hydrogen or halogen, a process for their preparation and medicaments containing the isoquinolines, especially the use of said medicaments as antidepressants.
摘要翻译：其中R 1是具有1至4个碳原子的烷基的哌啶子基，哌嗪子基或哌嗪基N-取代的异喹啉，其中所述亚烷基被氟代苯甲酰或CHO取代; R 2为苯基或被1至4个碳原子的烷基取代的苯基，卤素，氨基或硝基; R3为氢或卤素，其制备方法和含有异喹啉的药物，特别是所述药物用作抗抑郁药。

14. 发明授权

US4234584A Substituted phenylpiperazine derivatives 失效
标题翻译：取代的苯基哌嗪衍生物
公开(公告)号：US4234584A
公开(公告)日：1980-11-18
申请号：US44948
申请日：1979-06-04
申请人： Rudolf Lattrell , Wilhelm Bartmann , Hermann Gerhards
发明人： Rudolf Lattrell , Wilhelm Bartmann , Hermann Gerhards
IPC分类号： C07D209/08 , C07D209/34 , C07D215/38 , A61K31/495 , C07D401/12
CPC分类号： C07D209/08 , C07D209/34 , C07D215/38
摘要： Phenylpiperazine derivatives of the formula I ##STR1## in which R.sup.1 denotes hydrogen or C.sub.1 -C.sub.6 alkyl,R.sup.2 denotes hydrogen or one or several, identical or different substituents selected from the group of C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 alkoxy, halogen, trifluoromethyl, hydroxy, nitro, amino and methylene-dioxy,R.sup.3 denotes hydrogen, hydroxy, C.sub.1 -C.sub.6 alkanoyloxy, andn is 1 or 2,and the physiologically acceptable salts thereof, processes for their manufacture and medicaments containing or consisting of said compounds.
摘要翻译：式I的苯基哌嗪衍生物，其中R 1表示氢或C 1 -C 6烷基，R 2表示氢或一个或多个相同或不同的选自C 1 -C 6烷基，C 1 -C 6烷氧基，卤素，三氟甲基，羟基，硝基，氨基和亚甲基二氧基，R 3表示氢，羟基，C 1 -C 6烷酰氧基，n为1或2，以及其生理学上可接受的盐，其制备方法和含有或由所述化合物组成的药物。

15. 发明授权

US4198429A Esters of 5-methyl-10,11-dihydroprostaglandin-A.sub.1 失效
标题翻译： 5-甲基-10,11-二氢前列腺素-A1的酯
公开(公告)号：US4198429A
公开(公告)日：1980-04-15
申请号：US809432
申请日：1977-06-23
申请人： Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch , Bernward Scholkens
发明人： Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch , Bernward Scholkens
IPC分类号： A61K31/215 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07C177/00
CPC分类号： C07C405/00
摘要： Prostaglandin esters of the formula ##STR1## have valuable therapeutical properties.
摘要翻译：式“IMAGE”的前列腺素酯具有有价值的治疗特性。

16. 发明授权

US4078081A Cyclopentane derivatives manufacture 失效
标题翻译：环戊烷衍生物制造
公开(公告)号：US4078081A
公开(公告)日：1978-03-07
申请号：US582927
申请日：1975-06-02
申请人： Ulrich Lerch , Milos Babej , Wilhelm Bartmann , Rudolf Kunstmann
发明人： Ulrich Lerch , Milos Babej , Wilhelm Bartmann , Rudolf Kunstmann
IPC分类号： A61K31/21 , C07C67/00 , C07C401/00 , C07C405/00 , C07C177/00 , A61K31/19 , A61K31/215
CPC分类号： C07C405/00
摘要： The present invention relates to new cyclopentane derivatives having the formula ##STR1## and to a process for their manufacture. The compounds can be used as medicaments due to their antiprostaglandin effect.
摘要翻译：本发明涉及具有式“IMAGE”I的新环戊烷衍生物及其制备方法。这些化合物由于其抗前列腺素的作用可用作药物。

17. 发明授权

US4855323A Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases 失效
标题翻译：白三烯拮抗剂，其制备方法及其用于治疗疾病的用途
公开(公告)号：US4855323A
公开(公告)日：1989-08-08
申请号：US223129
申请日：1988-07-22
申请人： Gunther Wess , Wilhelm Bartmann , Gerhard Beck , Hiristo Anagnostopulos
发明人： Gunther Wess , Wilhelm Bartmann , Gerhard Beck , Hiristo Anagnostopulos
IPC分类号： A61K31/38 , A61K31/085 , A61K31/10 , A61K31/12 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/381 , A61K31/395 , A61K31/41 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P1/04 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C43/00 , C07C43/178 , C07C43/20 , C07C43/235 , C07C43/263 , C07C45/00 , C07C47/52 , C07C49/84 , C07C51/00 , C07C59/125 , C07C65/21 , C07C67/00 , C07C69/007 , C07C69/025 , C07C69/675 , C07C69/92 , C07C201/00 , C07C235/06 , C07C235/16 , C07C239/00 , C07C239/14 , C07C313/00 , C07C317/00 , C07C317/04 , C07C317/18 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/16 , C07C323/19 , C07C323/22 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/65 , C07D213/30 , C07D257/04 , C07D295/18 , C07D317/36 , C07D333/16
CPC分类号： C07D317/36 , A61K31/10 , A61K31/215 , C07C323/00
摘要： Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and X have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds, are described.
摘要翻译：白细胞三烯拮抗剂，其制备方法及其用于治疗其中R1，R2，R3，R4，R5和X具有指定含义的疾病的用途，其制备方法化合物，其作为药物的用途，以及基于这些化合物的药物。

18. 发明授权

US4260763A Isoquinoline aldehydes 失效
标题翻译：异喹啉醛
公开(公告)号：US4260763A
公开(公告)日：1981-04-07
申请号：US20410
申请日：1979-03-14
申请人： Wilhelm Bartmann , Elmar Konz , Hansjorg Kruse
发明人： Wilhelm Bartmann , Elmar Konz , Hansjorg Kruse
IPC分类号： A61K31/47 , A61K31/472 , A61P25/08 , A61P25/20 , C07D217/22 , C07D401/04 , C07D217/16
CPC分类号： C07D217/22
摘要： Isoquinoline-4-aldehydes of the formula ##STR1## in which X denotes bromine or chlorine, R.sub.1 is phenyl optionally mono- or disubstituted by halogen, hydroxy, nitro, amino, or amino substituted by one or two aliphatic, cycloaliphatic or aromatic hydrocarbon radicals having from 2 to 18 carbon atoms, the nitrogen atom possibly being included in a heterocyclic ring, acyl amino, alkyl or alkoxy each having from 1 to 6 carbon atoms, benzoyloxy, or trifluoromethyl, or is pyridyl or thienyl;R.sub.2 is hydrogen, halogen, hydroxy, alkyl or alkoxy having from 1 to 6 carbon atoms, nitro, amino, benzyloxy, methylene dioxy or ethylene dioxy andm is 1 or 2;which are effective in the treatment of spasms and as tranquilizers.
摘要翻译：式为“IMAGE”的异喹啉-4-醛，其中X表示溴或氯，R1是任选被卤素，羟基，硝基，氨基或被一个或两个脂族，脂环族或芳族烃基取代的氨基单或二取代的苯基具有2至18个碳原子，可能包含在杂环中的氮原子，各自具有1至6个碳原子的酰基氨基，烷基或烷氧基，苯甲酰氧基或三氟甲基，或者是吡啶基或噻吩基; R2是氢，卤素，羟基，具有1至6个碳原子的烷基或烷氧基，硝基，氨基，苄氧基，亚甲基二氧基或亚乙基二氧基，m是1或2; 这在治疗痉挛和止痛药方面是有效的。

19. 发明授权

US4260611A Isoquinoline derivatives 失效
标题翻译：异喹啉衍生物
公开(公告)号：US4260611A
公开(公告)日：1981-04-07
申请号：US76204
申请日：1979-09-17
申请人： Wilhelm Bartmann , Elmar Konz
发明人： Wilhelm Bartmann , Elmar Konz
IPC分类号： A61K31/47 , A61K31/472 , A61K31/495 , A61P9/06 , A61P25/18 , A61P29/00 , C07D217/22 , C07D217/24 , C07D217/26 , C07D217/14 , C07D217/16
CPC分类号： C07D217/26 , C07D217/22
摘要： Isoquinoline derivatives of the formula ##STR1## wherein the substituent is such as chlorine or bromine; R.sub.1 is phenyl etc.; R.sub.2 is hydrogen, halogen etc.; R.sub.3 is e.g. aminoalkyl and their use as medicaments, in particular as antidepressants.
摘要翻译：式（I）的异喹啉衍生物，其中取代基如氯或溴; R1是苯基等; R2是氢，卤素等; R3是例如氨基烷基及其作为药物的用途，特别是抗抑郁药。

20. 发明授权

US4098815A Novel analogues of prostanoic acids not occurring in nature 失效
标题翻译：没有发生在自然中的先天性的新型模拟物
公开(公告)号：US4098815A
公开(公告)日：1978-07-04
申请号：US751951
申请日：1976-12-17
申请人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
发明人： Milos Babej , Wilhelm Bartmann , Gerhard Beck , Ulrich Lerch
IPC分类号： C07C45/56 , C07C45/66 , C07C405/00 , C07C177/00
CPC分类号： C07C405/00 , C07C45/567 , C07C45/66 , Y10S514/826
摘要： The present invention relates to novel not naturally occurring analogues of prostanoic acids of the formula ##STR1## as well as a process for their preparation. The compounds of the invention have valuable pharmacological properties similar to those of the natural prostaglandins and therefore can be used as medicaments.

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