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11. 发明授权

US07688505B2 Simultaneous observation of darkfield images and fluorescence using filter and diaphragm 有权
标题翻译：使用过滤器和隔膜同时观察暗场图像和荧光
公开(公告)号：US07688505B2
公开(公告)日：2010-03-30
申请号：US11636107
申请日：2006-12-08
申请人： Vitaly Vodyanoy , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Oleg Pustovyy
IPC分类号： G02B21/06 , G02B21/00
CPC分类号： G02B21/10 , G01N21/6458 , G01N2021/8822 , G02B5/005 , G02B21/16
摘要： An annular diaphragm and filter used for the simultaneous observation of darkfield images and fluorescence. The diaphragm has a variable diameter controlled by a lever and a removable filter. The diaphragm is used to adjust the amount of unfiltered incident light which produces darkfield images when directed on a sample. The removable filter is used to filter light to a particular frequency for producing fluorescence images. An Acousto-Optical Tunable Filter, or other such tunable filter may be used with the diaphragm. A method of using the diaphragm and filter is also disclosed.
摘要翻译：用于同时观察暗场图像和荧光的环形光阑和滤光片。隔膜具有由杠杆和可移除过滤器控制的可变直径。光阑用于调整在过滤后的入射光量，当入射到样品时会产生暗场图像。可拆卸的过滤器用于将光过滤到特定频率以产生荧光图像。声光调节滤光器或其他这样的可调滤光片可以与隔膜一起使用。还公开了使用隔膜和过滤器的方法。

12. 发明申请

US20070122799A1 Method of isolation and self-assembly of small protein particles from blood and other biological materials 有权
标题翻译：从血液和其他生物材料中分离和自组装小蛋白质颗粒的方法
公开(公告)号：US20070122799A1
公开(公告)日：2007-05-31
申请号：US11523250
申请日：2006-09-19
申请人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： G01N33/553 , G01N33/6893 , G01N33/6896 , G01N2510/00 , G01N2800/2828
摘要： Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are misfolded or partially misfolded proteins surrounding a metallic nanocluster, termed “proteon nucleation center” (PNC). Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form.
摘要翻译：提供了用于分离和操作存在于血液和其他生物材料中的错误折叠或部分错误折叠的蛋白质的组合物和方法。在本发明的一个方面，组合物（以下称为“蛋白质”）被称为“蛋白质成核中心”（PNC）的金属纳米簇周围的错误折叠或部分错误折叠的蛋白质。还提供了用于分离和操纵在血液和其他生物材料中形成本发明蛋白质的蛋白质成核中心（PNC）的组合物和方法。

13. 发明申请

US20050237605A1 Microscope illumination device and adapter therefor 有权
标题翻译：显微镜照明装置及适配器
公开(公告)号：US20050237605A1
公开(公告)日：2005-10-27
申请号：US11106819
申请日：2005-04-15
申请人： Vitaly Vodyanoy , Oleg Pustovyy , Thomas Hasling
发明人： Vitaly Vodyanoy , Oleg Pustovyy , Thomas Hasling
IPC分类号： G02B21/00 , G02B21/06 , G02B21/10 , G02B21/12 , G02B21/16
CPC分类号： G02B21/12 , G02B21/10 , G02B21/16
摘要： An illumination system for a microscope, including a light source for generating light to illuminate a sample for microscopic observation, at least one collimating lens for collimating light generated by the light source, and a darkfield condenser for receiving collimated light and directing a hollow cone of light onto the sample under observation. The system optionally includes an adapter for enhancing economy of light transmission from the light source to the specimen, the adapter having a centrally disposed spacer and a plurality of optical fibers surrounding the spacer, to generate a hollow cylinder of light for transmission to the darkfield condenser. The system provides improved resolution and contrast, and is well suited for adaptation to fluorescence microscopy techniques.
摘要翻译：一种用于显微镜的照明系统，包括用于产生用于照明用于显微镜观察的样品的光的光源，至少一个用于准直光源产生的光的准直透镜，以及用于接收准直光的暗场冷凝器，在观察下点亮样品。该系统可选地包括用于增强从光源到样本的光透射的经济性的适配器，适配器具有居中设置的间隔物和围绕间隔物的多个光纤，以产生中空圆柱形的光以传输到暗场冷凝器。该系统提供改进的分辨率和对比度，并且非常适合于适应荧光显微镜技术。

14. 发明申请

US20050142611A1 Method of isolation and self-assembly of small protein particles from blood and other biological materials 审中-公开
标题翻译：从血液和其他生物材料中分离和自组装小蛋白质颗粒的方法
公开(公告)号：US20050142611A1
公开(公告)日：2005-06-30
申请号：US11005416
申请日：2004-12-06
申请人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Alexandre Samoylov , Oleg Pustovyy
IPC分类号： C07K14/00 , C12P21/06 , G01N33/53
CPC分类号： G01N33/68
摘要： Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.
摘要翻译：提供了用于分离和操作存在于血液和其他生物材料中的错误折叠或部分错误折叠的蛋白质的组合物和方法。在本发明的一个方面，组合物（以下称为“蛋白质”）由错误折叠的蛋白质组成。还提供了用于分离和操纵在血液和其他生物材料中形成本发明蛋白质的蛋白质成核中心（PNC）的组合物和方法。在本发明的另一方面，PNC由金属纳米团簇组成。

15. 发明申请

US20050137136A1 Biospecific probes against Salmonella 审中-公开
标题翻译：针对沙门氏菌的生物特异性探针
公开(公告)号：US20050137136A1
公开(公告)日：2005-06-23
申请号：US10835405
申请日：2004-04-29
申请人： Valery Petrenko , Iryna Sorokulova , Bryan Chin , James Barbaree , Vitaly Vodyanoy , I-Hsuan Chen , Alexandre Samoylov
发明人： Valery Petrenko , Iryna Sorokulova , Bryan Chin , James Barbaree , Vitaly Vodyanoy , I-Hsuan Chen , Alexandre Samoylov
IPC分类号： A61K38/00 , C07H21/04 , C07K7/06 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00 , C07H21/04 , Y02A50/481
摘要： Compositions and methods for binding to Salmonella bacteria are provided. The compositions comprise peptide sequences which bind to Salmonella bacteria with high specificity. The compositions are useful in identification, detection, and isolation of Salmonella bacteria. The compositions are also useful for the delivery of a wide variety of compounds to Salmonella bacteria or their vicinity. Such compounds include nucleotides, proteins (including, for example, toxins), liposomes, and small molecule pharmaceuticals. The compositions are also useful in identifying bacterial cell surface markers to which the compositions bind.
摘要翻译：提供了结合沙门菌的组合物和方法。组合物包含以高特异性结合沙门氏菌的肽序列。该组合物可用于鉴定，检测和分离沙门氏菌。所述组合物还可用于将多种化合物递送至沙门氏菌或其附近。这些化合物包括核苷酸，蛋白质（包括例如毒素），脂质体和小分子药物。组合物还可用于鉴定组合物结合的细菌细胞表面标志物。

16. 发明授权

US07551349B2 High resolution optical microscope with cardioid condenser for brightfield and darkfield illumination 有权
标题翻译：高分辨率光学显微镜，用于明场和暗场照明的心形聚光镜
公开(公告)号：US07551349B2
公开(公告)日：2009-06-23
申请号：US11607369
申请日：2006-12-01
申请人： Vitaly Vodyanoy , Arnold Vainrub , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Arnold Vainrub , Oleg Pustovyy
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G01N21/6458 , G01N2021/8825
摘要： The present invention is an improved illumination system which achieves enhanced spatial resolution and contrast in the observation of small objects. The enhanced performance is achieved by using a metal-halide light source, a power conservative pre-condenser optics train, an annular diaphragm, a cardioid annular condenser, and an adjustable light-filtering iris. These features are also intended to be used with a direct-view light optical microscope. A method of manufacturing and using the improved illumination system is also disclosed.
摘要翻译：本发明是一种改进的照明系统，其在观察小物体时实现了增强的空间分辨率和对比度。通过使用金属卤化物光源，功率保守的预冷凝器光学系列，环形光阑，心形环形冷凝器和可调节的光过滤虹膜来实现增强的性能。这些特征也用于直视光学显微镜。还公开了一种制造和使用改进的照明系统的方法。

17. 发明申请

US20070242335A1 Translational filter, shutter, aperture apparatus for selecting and combining filtered and unfiltered light 审中-公开
标题翻译：平移滤光片，快门，孔径设备，用于选择和组合过滤和未过滤的光
公开(公告)号：US20070242335A1
公开(公告)日：2007-10-18
申请号：US11708877
申请日：2007-02-20
申请人： Thomas Hasling , Vitaly Vodyanoy , Oleg Pustovyy
发明人： Thomas Hasling , Vitaly Vodyanoy , Oleg Pustovyy
IPC分类号： G02B26/02
CPC分类号： G01N21/6458 , G02B5/22 , G02B21/06 , G02B26/008 , G02B26/023 , G02B27/0905 , G02B27/0994
摘要： A method and apparatus for filtering and mixing light is provided. The apparatus comprises a translational filter, aperture and shutter. A light beam and the translational filter, aperture and shutter are moved relative to each other to precisely control the proportions of filtered, unobstructed and blocked light. A method for precisely controlling the proportions of filtered, unobstructed and blocked light is also provided. Optional accessories include additional translational filters, apertures and shutters, light guides, relay lenses, microscopes, computers, motors for controlling the positions of the components, focusing lenses, and mechanical shutters.
摘要翻译：提供了一种用于过滤和混合光的方法和装置。该装置包括平移滤光器，光圈和快门。光束和平移滤光器，光圈和快门相对于彼此移动以精确地控制滤光的，无障碍的和阻挡的光的比例。还提供了一种用于精确控制过滤，无障碍和阻挡光的比例的方法。可选配件包括附加的平移滤光片，孔和百叶窗，光导，中继透镜，显微镜，计算机，用于控制部件位置的电动机，聚焦透镜和机械百叶窗。

18. 发明申请

US20070127117A1 High resolution optical microscope 有权
标题翻译：高分辨率光学显微镜
公开(公告)号：US20070127117A1
公开(公告)日：2007-06-07
申请号：US11607369
申请日：2006-12-01
申请人： Vitaly Vodyanoy , Arnold Vainrub , Oleg Pustovyy
发明人： Vitaly Vodyanoy , Arnold Vainrub , Oleg Pustovyy
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G01N21/6458 , G01N2021/8825
摘要： The present invention is an improved illumination system which achieves enhanced spatial resolution and contrast in the observation of small objects. The enhanced performance is achieved by using a metal-halide light source, a power conservative pre-condenser optics train, an annular diaphragm, a cardioid annular condenser, and an adjustable light-filtering iris. These features are also intended to be used with a direct-view light optical microscope. A method of manufacturing and using the improved illumination system is also disclosed.
摘要翻译：本发明是一种改进的照明系统，其在观察小物体时实现了增强的空间分辨率和对比度。通过使用金属卤化物光源，功率保守的预冷凝器光学系列，环形光阑，心形环形冷凝器和可调节的光过滤虹膜来实现增强的性能。这些特征也用于直视光学显微镜。还公开了一种制造和使用改进的照明系统的方法。

19. 发明申请

US20070072308A1 Methods of forming monolayers of phage-derived products and uses thereof 失效
标题翻译：形成噬菌体衍生产物的单层的方法及其用途
公开(公告)号：US20070072308A1
公开(公告)日：2007-03-29
申请号：US11604537
申请日：2006-11-27
申请人： Valery Petrenko , Vitaly Vodyanoy , Jennifer Sykora
发明人： Valery Petrenko , Vitaly Vodyanoy , Jennifer Sykora
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , B82Y5/00 , B82Y30/00
摘要： Methods and compositions for identifying and characterizing the affinity of one or more ligands of a peptide are provided. In particular, a “stripped phage ligand sensor device” (SPLSD) is provided comprising a sensor coupled to a binding element of interest. Binding elements of the invention comprise phage which in most embodiments express a peptide of interest on the phage surface. Assays using the SPLSD allow detection and quantitation of ligands. Also provided are improved methods for forming monolayers using phage. In particular, methods for the formation of monolayers using “stripped phage” are provided. Further provided are monolayers and Langmuir-Blodgett films formed by the methods of the invention as well as substrates having deposited thereon the films of the invention. The monolayers, films and substrates of the invention are useful as components of biosensors and/or chemosensors.
摘要翻译：提供了用于鉴定和表征肽的一个或多个配体的亲和力的方法和组合物。特别地，提供了“剥离的噬菌体配体传感器装置”（SPLSD），其包括耦合到感兴趣的结合元件的传感器。本发明的结合元件包含噬菌体，其在大多数实施方案中在噬菌体表面上表达感兴趣的肽。使用SPLSD的测定允许检测和定量配体。还提供了使用噬菌体形成单层的改进方法。特别地，提供了使用“剥离噬菌体”形成单层的方法。还提供了通过本发明的方法形成的单层和Langmuir-Blodgett膜以及在其上沉积有本发明的膜的基底。本发明的单层，薄膜和底物可用作生物传感器和/或化学传感器的组分。

20. 发明申请

US20060172332A1 Use of protective natural polymers to isolate and preserve biological material 失效
标题翻译：使用保护性天然聚合物来分离和保存生物材料
公开(公告)号：US20060172332A1
公开(公告)日：2006-08-03
申请号：US11341152
申请日：2006-01-27
申请人： Vitaly Vodyanoy , James Barbaree , Bryan Chin , William Neely , Suram Pathirana , Timothy Braden
发明人： Vitaly Vodyanoy , James Barbaree , Bryan Chin , William Neely , Suram Pathirana , Timothy Braden
IPC分类号： C12Q1/68 , G01N33/53 , G01N1/30
CPC分类号： G01N33/548 , A01N1/02 , A01N1/0221 , G01N1/30
摘要： Compositions and methods for the reversible preservation of biological samples are provided. The compositions include natural polymers such as pullulan or acacia gum, including derivations and modifications thereof, which are usefull as a reversible preservation solution. A method is provided for using pullulan or Acacia Gum to isolate and reversibly preserve a biological specimen in a dormant state at room temperature for an extended period with minimal damage to the specimen. The compositions and methods disclosed may also be used to create reversibly preserved biological specimens and biological receptors for use in biosensors.
摘要翻译：提供了可逆保存生物样品的组合物和方法。组合物包括天然聚合物，例如支链淀粉或阿拉伯树胶，包括其衍生和修饰，其作为可逆保存溶液是有用的。提供了一种使用支链淀粉或相思胶来隔离和可逆地将室温下的休眠状态的生物样品长时间保持在最小损伤标本的方法。所公开的组合物和方法也可用于产生用于生物传感器的可逆保存的生物标本和生物受体。

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