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11. 发明授权

US08173781B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 失效
公开(公告)号：US08173781B2
公开(公告)日：2012-05-08
申请号：US12494472
申请日：2009-06-30
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： C07K16/00 , A61K39/395 , C12P21/08
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.

12. 发明授权

US08163282B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 失效
标题翻译：能够结合肝素结合表皮生长因子样生长因子的单克隆抗体
公开(公告)号：US08163282B2
公开(公告)日：2012-04-24
申请号：US12609434
申请日：2009-10-30
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： C07K16/00
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

13. 发明申请

US20130337505A1 MONOCLONAL ANTIBODY CAPABLE OF BINDING TO HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR 审中-公开
标题翻译：结合抗HEPARIN结合的单克隆抗体抗生长因子生长因子
公开(公告)号：US20130337505A1
公开(公告)日：2013-12-19
申请号：US13428787
申请日：2012-03-23
申请人： Eisuke MEKADA , Ryo IWAMOTO , Shingo MIYAMOTO , Kenya SHITARA , Akiko FURUYA , Kazuyasu NAKAMURA , Kumiko TAKAHASHI , Hiroshi ANDO , Kazuhiro MASUDA , Yuka SASAKI
发明人： Eisuke MEKADA , Ryo IWAMOTO , Shingo MIYAMOTO , Kenya SHITARA , Akiko FURUYA , Kazuyasu NAKAMURA , Kumiko TAKAHASHI , Hiroshi ANDO , Kazuhiro MASUDA , Yuka SASAKI
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a method for producing a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段的制备方法。

14. 发明申请

US20130003301A1 STACKED COOLER 审中-公开
标题翻译：堆垛机
公开(公告)号：US20130003301A1
公开(公告)日：2013-01-03
申请号：US13581296
申请日：2010-11-24
申请人： Shingo Miyamoto , Akio Kitami
发明人： Shingo Miyamoto , Akio Kitami
IPC分类号： H05K7/20
CPC分类号： H01L23/473 , H01L2924/0002 , H02M7/003 , H05K7/20927 , H01L2924/00
摘要： A stacked cooler includes a plurality of refrigerant flow passages and a plurality of semiconductor modules. The refrigerant flow passages and the semiconductor modules are stacked alternately, and each of opposite surfaces in a stacking direction of each of the semiconductor modules is in contact with a corresponding one of the refrigerant flow passages, thereby cooling the semiconductor modules. The semiconductor modules generate different amounts of heat. One or a plurality of the semiconductor modules and one or a plurality of the semiconductor modules are arranged in each of arrangement spaces adjacent to the refrigerant flow passages so that a difference in amount of heat generated between the respective arrangement spaces becomes small. Consequently, cooling capability is equalized throughout the respective arrangement spaces, enabling reduction in waste due to excessive cooling.
摘要翻译：堆叠冷却器包括多个制冷剂流动通道和多个半导体模块。制冷剂流动通道和半导体模块交替堆叠，并且每个半导体模块的层叠方向上的每个相对表面与相应的一个制冷剂流动通道接触，从而冷却半导体模块。半导体模块产生不同的热量。一个或多个半导体模块和一个或多个半导体模块布置在与制冷剂流动通道相邻的每个布置空间中，使得在各个排列空间之间产生的热量差异变小。因此，冷却能力在整个相应的布置空间中是相等的，从而能够减少由于过度冷却造成的浪费。

15. 发明申请

US20120177649A1 MONOCLONAL ANTIBODY CAPABLE OF BINDING TO HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR 失效
标题翻译：结合抗HEPARIN结合的单克隆抗体抗生长因子生长因子
公开(公告)号：US20120177649A1
公开(公告)日：2012-07-12
申请号：US13365769
申请日：2012-02-03
申请人： Eisuke MEKADA , Ryo IWAMOTO , Shingo MIYAMOTO , Kenya SHITARA , Akiko FURUYA , Kazuyasu NAKAMURA , Kumiko TAKAHASHI , Hiroshi ANDO , Kazuhiro MASUDA , Yuka SASAKI
发明人： Eisuke MEKADA , Ryo IWAMOTO , Shingo MIYAMOTO , Kenya SHITARA , Akiko FURUYA , Kazuyasu NAKAMURA , Kumiko TAKAHASHI , Hiroshi ANDO , Kazuhiro MASUDA , Yuka SASAKI
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

16. 发明申请

US20110230418A1 Anticancer Agent 有权
标题翻译：抗癌剂
公开(公告)号：US20110230418A1
公开(公告)日：2011-09-22
申请号：US11885080
申请日：2005-08-19
申请人： Eisuke Mekada , Shingo Miyamoto
发明人： Eisuke Mekada , Shingo Miyamoto
IPC分类号： A61K38/16 , A61P35/00
CPC分类号： A61K31/4745 , A61K31/337 , A61K38/164 , A61K45/06 , G08G1/015 , A61K2300/00
摘要： The present invention is an antineoplastic agent characterized by including at least one of taxol and taxol derivatives and a protein which is a mutant of diphtheria toxin, having an activity to inhibit a binding between HB-EGF and EGFR and substantially not having a toxicity of diphtheria toxin as active ingredients.
摘要翻译：本发明是一种抗肿瘤剂，其特征在于包括紫杉醇和紫杉醇衍生物中的至少一种和作为白喉毒素突变体的蛋白质，具有抑制HB-EGF与EGFR之间的结合并且基本上不具有白喉毒性的蛋白质毒素作为活性成分。

17. 发明授权

US07851601B2 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor 有权
标题翻译：能够结合肝素结合表皮生长因子样生长因子的单克隆抗体
公开(公告)号：US07851601B2
公开(公告)日：2010-12-14
申请号：US12329946
申请日：2008-12-08
申请人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
发明人： Eisuke Mekada , Ryo Iwamoto , Shingo Miyamoto , Kenya Shitara , Akiko Furuya , Kazuyasu Nakamura , Kumiko Takahashi , Hiroshi Ando , Kazuhiro Masuda , Yuka Sasaki
IPC分类号： C12P21/04 , C07K16/00 , A61K39/395 , C07H21/04
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

18. 发明申请

US20140218158A1 REACTOR 审中-公开
标题翻译：反应堆
公开(公告)号：US20140218158A1
公开(公告)日：2014-08-07
申请号：US14171467
申请日：2014-02-03
申请人： Shingo MIYAMOTO
发明人： Shingo MIYAMOTO
IPC分类号： H01F27/28
CPC分类号： H01F27/306 , H01F27/022 , H01F27/2852 , H01F37/00
摘要： A reactor includes a ring-shaped core, a bobbin, two coils. The bobbin includes a first part that includes two first tubular sections and a first flange and includes a second part that includes two second tubular sections and a second flange. Each of base ends of the first tubular sections is coupled to the first flange and each of base ends of the two second tubular sections is coupled to the second flange. Each of the first tubular sections includes a tongue section extending from a distal end of the first tubular section and fitting into a distal end of the second tubular section. Each of the two coils is wound around a corresponding one of the first tubular sections and a corresponding one of the second tubular sections of the bobbin.
摘要翻译：反应器包括环形芯，线圈架，两个线圈。线轴包括包括两个第一管状部分和第一凸缘的第一部分，并且包括包括两个第二管状部分和第二凸缘的第二部分。第一管状部分的每个基端部联接到第一凸缘，并且两个第二管状部分的每个基端部联接到第二凸缘。每个第一管状部分包括从第一管状部分的远端延伸并配合到第二管状部分的远端的舌部分。两个线圈中的每一个缠绕在第一管状部分中的相应一个和线轴的相应一个第二管状部分中。

19. 发明申请

US20130292097A1 COOLING APPARATUS 审中-公开
标题翻译：冷却装置
公开(公告)号：US20130292097A1
公开(公告)日：2013-11-07
申请号：US13976219
申请日：2011-01-27
申请人： Shingo Miyamoto
发明人： Shingo Miyamoto
IPC分类号： F01P1/00
CPC分类号： F01P1/00 , B60K1/04 , B60K6/448 , B60K6/52 , B60K11/06 , B60K2001/005 , B60K2001/0416 , B60K2001/045 , B60L1/003 , B60L1/02 , B60L3/003 , B60L50/16 , B60L50/61 , B60L58/26 , B60L2210/40 , B60L2240/36 , H01M10/613 , H01M10/625 , H01M10/6563 , H05K7/20909 , Y02T10/6217 , Y02T10/6243 , Y02T10/6265 , Y02T10/7005 , Y02T10/705 , Y02T10/7077 , Y02T10/7241 , Y02T90/16
摘要： There is provided a cooling apparatus capable of efficiently cooling a plurality of heat-generating devices. The cooling apparatus is a cooling apparatus for cooling a plurality of heat-generating devices mounted on a vehicle, the vehicle having a hollow space that can accommodate a spare tire. The cooling apparatus includes: a cooling-air passage disposed adjacent to the hollow space; a battery disposed in the cooling-air passage; an inverter disposed in the hollow space; and a fan for supplying air to the cooling-air passage. A communicating portion that provides communication between the cooling-air passage and the hollow space is fowled in a wall portion of the cooling-air passage that faces the hollow space.
摘要翻译：提供了能够有效地冷却多个发热装置的冷却装置。冷却装置是用于冷却安装在车辆上的多个发热装置的冷却装置，该车辆具有可容纳备用轮胎的中空空间。冷却装置包括：与中空空间相邻设置的冷却风通道; 设置在冷却风通道中的电池; 设置在中空空间中的逆变器; 以及用于向冷却空气通道供应空气的风扇。在冷却风通道与中空空间之间提供连通的连通部分在冷空气通道的面向中空空间的壁部分中摇摆。

20. 发明授权

US08533196B2 Information processing device, processing method, computer program, and integrated circuit 有权
标题翻译：信息处理装置，处理方法，计算机程序和集成电路
公开(公告)号：US08533196B2
公开(公告)日：2013-09-10
申请号：US13499740
申请日：2011-07-06
申请人： Shingo Miyamoto , Kouji Miura , Shunji Harada
发明人： Shingo Miyamoto , Kouji Miura , Shunji Harada
IPC分类号： G06F17/30
CPC分类号： G06F17/30265
摘要： An information processing device that attaches common accompanying data to a content group composed of contents. The information processing device acquires the contents, acquires one or more characteristics of each acquired content and searches among reference data items in order to acquire one or more reference data items that each include any of the one or more characteristics, each reference data item having attached thereto at least one attribute used for identifying the reference data item, the reference data items being data other than the contents. The information processing device then specifies, among the attributes attached to the acquired one or more reference data items, an attribute that also pertains to the contents, uses the specified attribute as an attribute for identifying each of the contents, and attaches the specified attribute to each of the contents.
摘要翻译：一种信息处理设备，其将公共附带数据附加到由内容组成的内容组。信息处理装置获取内容，获取每个获取的内容的一个或多个特征，并在参考数据项之间进行搜索，以获取每个包括一个或多个特征中的任一个的一个或多个参考数据项，每个参考数据项已附加至少一个用于识别参考数据项的属性，参考数据项是除内容之外的数据。然后，信息处理装置在附加到所获取的一个或多个参考数据项的属性中指定也属于内容的属性，使用指定的属性作为用于标识每个内容的属性，并将指定的属性附加到每个内容。

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