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1. 发明申请

US20130337505A1 MONOCLONAL ANTIBODY CAPABLE OF BINDING TO HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR 审中-公开
标题翻译：结合抗HEPARIN结合的单克隆抗体抗生长因子生长因子
公开(公告)号：US20130337505A1
公开(公告)日：2013-12-19
申请号：US13428787
申请日：2012-03-23
申请人： Eisuke MEKADA , Ryo IWAMOTO , Shingo MIYAMOTO , Kenya SHITARA , Akiko FURUYA , Kazuyasu NAKAMURA , Kumiko TAKAHASHI , Hiroshi ANDO , Kazuhiro MASUDA , Yuka SASAKI
发明人： Eisuke MEKADA , Ryo IWAMOTO , Shingo MIYAMOTO , Kenya SHITARA , Akiko FURUYA , Kazuyasu NAKAMURA , Kumiko TAKAHASHI , Hiroshi ANDO , Kazuhiro MASUDA , Yuka SASAKI
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a method for producing a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段的制备方法。

2. 发明申请

US20120177649A1 MONOCLONAL ANTIBODY CAPABLE OF BINDING TO HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR 失效
标题翻译：结合抗HEPARIN结合的单克隆抗体抗生长因子生长因子
公开(公告)号：US20120177649A1
公开(公告)日：2012-07-12
申请号：US13365769
申请日：2012-02-03
申请人： Eisuke MEKADA , Ryo IWAMOTO , Shingo MIYAMOTO , Kenya SHITARA , Akiko FURUYA , Kazuyasu NAKAMURA , Kumiko TAKAHASHI , Hiroshi ANDO , Kazuhiro MASUDA , Yuka SASAKI
发明人： Eisuke MEKADA , Ryo IWAMOTO , Shingo MIYAMOTO , Kenya SHITARA , Akiko FURUYA , Kazuyasu NAKAMURA , Kumiko TAKAHASHI , Hiroshi ANDO , Kazuhiro MASUDA , Yuka SASAKI
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/22 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要翻译：需要用于治疗与HB-EGF升高有关的疾病的药物。本发明提供了结合细胞膜结合的HB-EGF，膜型HB-EGF和分泌型HB-EGF的单克隆抗体或其抗体片段。

3. 发明申请

US20110034673A1 MONOCLONAL ANTIBODY CAPABLE OF BINDING TO HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR 失效
公开(公告)号：US20110034673A1
公开(公告)日：2011-02-10
申请号：US12609434
申请日：2009-10-30
申请人： Eisuke MEKADA , Ryo IWAMOTO , Shingo MIYAMOTO , Kenya SHITARA , Akiko FURUYA , Kazuyasu NAKAMURA , Kumiko TAKAHASHI , Hiroshi ANDO , Kazuhiro MASUDA , Yuka SASAKI
发明人： Eisuke MEKADA , Ryo IWAMOTO , Shingo MIYAMOTO , Kenya SHITARA , Akiko FURUYA , Kazuyasu NAKAMURA , Kumiko TAKAHASHI , Hiroshi ANDO , Kazuhiro MASUDA , Yuka SASAKI
IPC分类号： C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/04
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.

4. 发明申请

US20140218158A1 REACTOR 审中-公开
标题翻译：反应堆
公开(公告)号：US20140218158A1
公开(公告)日：2014-08-07
申请号：US14171467
申请日：2014-02-03
申请人： Shingo MIYAMOTO
发明人： Shingo MIYAMOTO
IPC分类号： H01F27/28
CPC分类号： H01F27/306 , H01F27/022 , H01F27/2852 , H01F37/00
摘要： A reactor includes a ring-shaped core, a bobbin, two coils. The bobbin includes a first part that includes two first tubular sections and a first flange and includes a second part that includes two second tubular sections and a second flange. Each of base ends of the first tubular sections is coupled to the first flange and each of base ends of the two second tubular sections is coupled to the second flange. Each of the first tubular sections includes a tongue section extending from a distal end of the first tubular section and fitting into a distal end of the second tubular section. Each of the two coils is wound around a corresponding one of the first tubular sections and a corresponding one of the second tubular sections of the bobbin.
摘要翻译：反应器包括环形芯，线圈架，两个线圈。线轴包括包括两个第一管状部分和第一凸缘的第一部分，并且包括包括两个第二管状部分和第二凸缘的第二部分。第一管状部分的每个基端部联接到第一凸缘，并且两个第二管状部分的每个基端部联接到第二凸缘。每个第一管状部分包括从第一管状部分的远端延伸并配合到第二管状部分的远端的舌部分。两个线圈中的每一个缠绕在第一管状部分中的相应一个和线轴的相应一个第二管状部分中。

5. 发明申请

US20230035343A1 METHOD FOR PREDICTING ONSET OF CHORIOAMNIONITIS 有权
公开(公告)号：US20230035343A1
公开(公告)日：2023-02-02
申请号：US17782059
申请日：2020-12-04
申请人： Shingo MIYAMOTO , Daichi URUSHIYAMA , Kenichiro HATA
发明人： Shingo MIYAMOTO , Daichi URUSHIYAMA , Fusanori YOTSUMOTO , Kenichiro HATA
IPC分类号： C12Q1/689 , C12Q1/6869
摘要： Provided is a method for predicting the onset of chorioamnionitis, which may predict the onset of chorioamnionitis with high sensitivity. The method including obtaining a base sequence data group of a 16S ribosomal RNA gene in a sample from the vagina of a subject; detecting the presence of a bacterium selected from a bacterial group represented by G1 below based on the data group obtained; and associating the sample with the likelihood of onset of chorioamnionitis based on the number of bacterial species detected. The bacterial group G1: Finegoldia magna; Streptococcus anginosus; Aerococcus christensenii; Lactobacillus jensenii; Ureaplasma parvum; Prevotella disiens; Lactobacillus vaginalis; Prevotella buccalis; Dialister micraerophilus; Atopobium vaginae; Prevotella bivia; Prevotella amnii; Anaerococcus lactolytcus; Streptococcus agalactiae; Anaerococcus tetradius; Bacteroides fragilis; Gardnerella vaginalis; Mycoplasma hominis; and Sneathia sanguinegens.

6. 发明申请

US20220288132A1 METHOD FOR PREPARATION OF BLASTOCYST 有权
公开(公告)号：US20220288132A1
公开(公告)日：2022-09-15
申请号：US17690559
申请日：2022-03-09
申请人： Shingo Miyamoto
发明人： Shingo MIYAMOTO , Katsuro TACHIBANA , Toyofumi HIRAKAWA , Fumitoshi KOGA
IPC分类号： A61K35/54 , C12N5/073
摘要： Provided a method for preparing a blastocyst. The method includes culturing a fertilized egg in a culture medium containing bubbles containing a reducing gas. The reducing gas may contain at least one selected from the group consisting of hydrogen, carbon monoxide, nitrogen monoxide, and hydrogen sulfide. The bubbles may have an average particle size of from 10 nm to 1,000 nm.

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