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    • 14. 发明申请
    • ABUSE RESISTANT MELT EXTRUDED FORMULATION HAVING REDUCED ALCOHOL INTERACTION
    • 具有降低酒精相互作用的抗菌熔体挤压配方
    • US20100172989A1
    • 2010-07-08
    • US12631010
    • 2009-12-04
    • Wolfgang RothAlexander BurstMartina ZietschWei LiuSandeep Dutta
    • Wolfgang RothAlexander BurstMartina ZietschWei LiuSandeep Dutta
    • A61K9/14A61K31/485A61P25/04
    • A61K9/2027A61K9/2031A61K9/2054A61K9/209A61K9/2095A61K31/167A61K31/192A61K31/277A61K31/485
    • The present invention relates to compositions for oral administration. The invention preferably comprises at least one abuse-resistant drug delivery composition for delivering a drug having potential for dose dumping in alcohol, related methods of preparing these dosage forms, and methods of treating a patient in need thereof comprising administering the inventive compositions to the patient. Most preferably, the dosage form includes verapamil. These formulations have reduced potential for abuse. In another formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.
    • 本发明涉及用于口服给药的组合物。 本发明优选包含至少一种用于递送具有在醇中倾倒剂量的药物的药物递送组合物,制备这些剂型的相关方法和治疗有需要的患者的方法包括将本发明组合物施用于患者 。 最优选地,剂型包括维拉帕米。 这些制剂减少了滥用的可能性。 在另一种制剂中,优选滥用相关药物是阿片样物质,非滥用相关药物是对乙酰氨基酚或布洛芬。 更优选地,阿片样物质是氢可酮,非滥用相关镇痛药是对乙酰氨基酚。 在某些优选的实施方案中,剂型的特征在于耐溶剂萃取; 篡改,破碎或研磨。 本发明的某些实施方案提供剂型,其提供药物释放的初始爆发,随后延长药物释放时间。