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11. 发明授权

US5852175A P-selectin glycoprotein ligand blocking antibodies 失效
标题翻译： P-选择素糖蛋白配体阻断抗体
公开(公告)号：US5852175A
公开(公告)日：1998-12-22
申请号：US438280
申请日：1995-05-10
申请人： Richard D. Cummings , Kevin L. Moore , Rodger P. McEver
发明人： Richard D. Cummings , Kevin L. Moore , Rodger P. McEver
IPC分类号： A61K38/00 , C07K14/705 , C07K16/28 , C07K16/18
CPC分类号： C07K16/2896 , C07K14/705 , C07K14/70564 , C07K14/70596 , C07K16/2854 , A61K2039/505 , A61K38/00
摘要： P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of �.sup.3 H!glucosamine-labeled HL-60 cell extracts on immobilized P-selectin. This molecule was characterized and distinguished from other well-characterized neutrophil membrane proteins with similar apparent molecular mass. The purified ligand, or fragments thereof (including both the carbohydrate and protein components), or antibodies to the ligand, or fragments thereof, can be used as inhibitors of binding of P-selectin to cells.
摘要翻译：已经证明P-选择蛋白主要结合中性粒细胞和HL-60细胞上的单个主要糖蛋白配体，当通过印迹测定和通过[3 H]葡糖胺标记的HL-60细胞提取物对固定化P-选择素的亲和层析进行评估时。该分子的特征与其他具有相似表观分子量的其他具有良好表征的嗜中性粒细胞膜蛋白区别。纯化的配体或其片段（包括碳水化合物和蛋白质组分）或配体的抗体或其片段可用作P-选择素与细胞结合的抑制剂。

12. 发明授权

US5576300A Method for inhibition of human rotavirus infection 失效
标题翻译：抑制人类轮状病毒感染的方法
公开(公告)号：US5576300A
公开(公告)日：1996-11-19
申请号：US308883
申请日：1994-09-16
申请人： Pradip Mukerji , Pedro A. Prieto , Amanda E.-Y. Seo , Jeffrey H. Baxter , Richard D. Cummings
发明人： Pradip Mukerji , Pedro A. Prieto , Amanda E.-Y. Seo , Jeffrey H. Baxter , Richard D. Cummings
IPC分类号： A23L1/305 , A61K38/00 , C07K14/47 , C07K1/00
CPC分类号： C07K14/4732 , A23L33/19 , A61K38/00 , Y10S514/867 , Y10S530/832
摘要： A method of preventing or treating infection by human rotavirus by administering an enteral nutritional product containing either bovine .kappa.-casein or human .kappa.-casein at a concentration greater than that found in human or bovine milk and sufficient to inhibit infection of mammalian cells by human rotavirus.
摘要翻译：一种预防或治疗人轮状病毒感染的方法，其通过以大于人或牛奶中发现的浓度施用含有牛κ-酪蛋白或人κ-酪蛋白的肠内营养产品，并且足以抑制人轮状病毒感染哺乳动物细胞。

13. 发明授权

US07273754B2 Core 1 β3-galactosyltransferase specific molecular chaperones, nucleic acids, and methods of use thereof 失效
标题翻译：核心1β3-半乳糖基转移酶特异性分子伴侣，核酸及其使用方法
公开(公告)号：US07273754B2
公开(公告)日：2007-09-25
申请号：US10661049
申请日：2003-09-12
申请人： Richard D. Cummings , Tongzhong Ju
发明人： Richard D. Cummings , Tongzhong Ju
IPC分类号： C12N5/10 , C12N15/00 , C12N9/10 , C12N1/20 , C12Q1/48 , C12P21/06 , C07K14/00 , C07H21/04
CPC分类号： C07K14/47
摘要： Core 1 β3-galactosyl transferase specific molecular chaperones (Cosmc-1) and nucleic acids encoding the core 1 β3-galactosyl transferase specific molecular chaperones or proteins having core 1 β3-galactosyl transferase specific molecular chaperone activity are described. The polynucleotides encoding Cosmc-1 can be used to transform or transfect host cells for producing substantially pure forms of active forms of core 1 β3-galactosyl transferase and/or for use in an expression system for post-translational core 1 glycosylation of proteins or peptides produced within the expression system, for example, glycosylation via a β3-linkage, of an N-acetylgalactosamine linked to a serine, threonine or other linking amino acid on peptides or proteins requiring O-, N-, or S-linked glycosylation.
摘要翻译：描述了核心1β3-半乳糖基转移酶特异性分子伴侣（Cosmc-1）和编码核心1β3-半乳糖基转移酶特异性分子伴侣或具有核心1β3-半乳糖基转移酶特异性分子伴侣活性的蛋白质的核酸。编码Cosmc-1的多核苷酸可用于转化或转染宿主细胞，用于产生基本上纯的形式的核心β3-半乳糖基转移酶的活性形式和/或用于蛋白质或肽的翻译后核心糖基化的表达系统在表达系统中产生，例如，通过β3连接的糖基化，与需要O-，N-或S-连接的糖基化的肽或蛋白质上的丝氨酸，苏氨酸或其它连接氨基酸连接的N-乙酰半乳糖胺。

14. 发明授权

US07223845B2 Synthetic glycosulfopeptides and methods of synthesis thereof 失效
标题翻译：合成糖磺肽及其合成方法
公开(公告)号：US07223845B2
公开(公告)日：2007-05-29
申请号：US11121731
申请日：2005-05-04
申请人： Richard D. Cummings , Rodger P. McEver
发明人： Richard D. Cummings , Rodger P. McEver
IPC分类号： C07H3/06 , A61K31/70 , A61K38/14
CPC分类号： C07K14/70596 , C07K9/00
摘要： A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewisx group or a sialyl Lewisa group. In a preferred version the GSPs have an O-glycan comprising a β1,6 linkage to a GalNAc. The present invention further contemplates in vitro methods of the synthesis of these GSPs without the use of the cells and methods of their use in vivo as powerful anti-inflammatory antithrombotic, or anti-metastatic compounds. The invention also contemplates a method of synthesizing oligosaccharides by cleaving the glycan from the GSP.
摘要翻译：一类具有一个或多个硫酸化酪氨酸残基的合成糖基多肽（GSP）和与该肽连接的聚糖，该聚糖优选包含唾液酸路易斯基团或唾液酸基路易斯 / SUP>组。在优选的版本中，GSP具有包含与GalNAc的β1,6键的O-聚糖。本发明还考虑了不使用细胞的这些GSP的合成的体外方法及其在体内用于强力抗炎抗凝血或抗转移化合物的方法。本发明还考虑了通过从GSP切割聚糖来合成寡糖的方法。

15. 发明授权

US06261788B1 Diagnostic assays for infectious parasitic helminths 失效
标题翻译：传染性寄生蠕虫的诊断试验
公开(公告)号：US06261788B1
公开(公告)日：2001-07-17
申请号：US09400563
申请日：1999-09-21
申请人： Richard D. Cummings , Anthony Kwame Nyame
发明人： Richard D. Cummings , Anthony Kwame Nyame
IPC分类号： G01N3353
CPC分类号： G01N33/569 , G01N33/5308 , G01N33/56905 , Y10S435/975
摘要： Species of schistosoma , such as schistosoma mansoni, S. japonicum and S. haematobium, which infect humans and animals, synthesize the Lewisx (Lex), lacdiNAc (LDN) and fucosylated LDN (LDNF) carbohydrate antigens. Parasitic helminths other than schistosomes, such as Dirofilaria immitis (responsible for heartworm), Fasciola hepatica (a liver fluke) and Haemonchus contortus (intestinal fluke) also synthesize the LDN and LDNF antigens, but they do not synthesize, or synthesize only undetectable amounts of, Lex antigen. The differential detection and abundance of the Lex, LDN and LDNF antigens in sera and other bodily fluids of individuals is diagnostic of the presence of active and/or previous infections from schistosomes and other parasitic helminths. The present invention is directed to methods of differential detection and diagnosis of parasitic helminth infections, and kits for use in such methods.
摘要翻译：感染人类和动物的血吸虫血吸虫属物种如曼氏血吸虫，日本血吸虫和沙门氏菌合成Lewisx（Lex），lacdiNAc（LDN）和岩藻糖基化的LDN（LDNF）碳水化合物抗原。除血吸虫之外的寄生虫蠕虫（如负责心虫病），肝脏Fasciola hepatica（肝吸虫）和血矛线虫（Henkechus contortus，肠道吸虫）也合成LDN和LDNF抗原，但不合成或仅合成不可检测量的，Lex抗原。个体血清和其他体液中Lex，LDN和LDNF抗原的差异检测和丰度是诊断血吸虫和其他寄生蠕虫的活性和/或先前感染的存在。本发明涉及寄生蠕虫感染的差异检测和诊断方法以及用于这些方法的试剂盒。

16. 发明授权

US6124267A O-glycan inhibitors of selectin mediated inflammation derived from PSGL-1 失效
标题翻译：来自PSGL-1的选择素介导的炎症的O-聚糖抑制剂
公开(公告)号：US6124267A
公开(公告)日：2000-09-26
申请号：US63237
申请日：1998-04-20
申请人： Rodger P. McEver , Richard D. Cummings , Kevin L. Moore
发明人： Rodger P. McEver , Richard D. Cummings , Kevin L. Moore
IPC分类号： C07K14/705 , C07K16/28 , A61K31/70
CPC分类号： C07K16/2896 , C07K14/705 , C07K2317/34
摘要： Tyrosine sulfate on PSGL-1, particularly at least one of residues 46, 48 and 51, functions in conjunction with sialylated and fucosylated glycans, most preferably Thr-57, to mediate high affinity binding to P-selectin. PSGL-1 O-glycans have been determined to consist of disialylated or neutral forms of the core-2 tetrasaccharide Gal.beta.1.fwdarw.4GlcNAc.beta.1.fwdarw.6(Gal.beta.1.fwdarw.3)GalNAcOH. A minority of the O-glycans are .alpha.1,3 fucosylated that occur as two major species containing the sialyl Lewis x antigen--one species is a disialylated monofucosylated glycan: Fuc.alpha.1 .dwnarw. 3 NeuAc.alpha.2.fwdarw.3Gal.beta.1.fwdarw.4GlcNAc.beta.1 .dwnarw. 6 NeuAc.alpha.2.fwdarw.3Gal.beta.1.fwdarw.3GalNAc-R, and the other is a monosialylated, trifucosylated glycan having a polylactosamine backbone: Fuc.alpha.l .dwnarw. 3 NeuAc.alpha.2.fwdarw.3Gal.beta.1.fwdarw.4GlcNAc.beta.1.fwdarw.3Gal.beta.1.fwdarw. Fuc.alpha.l Fuc.alpha.l .dwnarw. .dwnarw. 3 3 4GlcNAc.beta.1.fwdarw.3Gal.beta.1.fwdarw.4GlcNAc.beta.1 .dwnarw. 6 Gal.beta.1.fwdarw.3GalNAc-R wherein R=H, OH, another sugar or an aglycone such as an amino acid, peptide, or polypeptide. The O-glycans defined herewith can be used to inhibit inflammation mediated by P-selectin.
摘要翻译： PSGL-1上的酪氨酸硫酸盐，特别是残基46,48和51中的至少一个，与唾液酸化和岩藻糖基化聚糖结合起来，最优选Thr-57，以介导与P-选择素的高亲和力结合。已经确定PSGL-1 O-聚糖由二核苷酸或中性形式的核心二糖Galβ1-> 4GlcNAcβ1-> 6（Galβ1-> 3）GalNAcOH组成。少数O聚糖是α1,3-岩藻糖基化的，它们作为含有唾液酸基路易斯x抗原的两种主要物质发生，一种是二唾液酸化单糖基化聚糖： - Fucα1 - ＆darr＆ - 3 - NeuAc alpha 2-> 3Gal beta 1-> 4GlcNAc beta 1 - ＆darr＆ - 6 - NeuAc alpha 2-> 3Gal beta 1-> 3GalNAc-R， - 另一种是具有多聚乳糖胺骨架的单唾液酸化的三糖基聚糖： - Fucα1 - ＆amp; alpha 2-> 3Gal beta 1-> 4GlcNAc beta 1-> 3Gal beta 1-> - - Fuc alpha l Fuc alpha l - ＆darr＆＆darr＆ - 3 3 - 4GlcNAc beta 1-> 3Gal beta 1-> 4GlcNAc beta 1 - ＆darr＆ 6-Galβ1-> 3GalNAc-R - 其中R = H，OH，另一种糖或糖苷配基如氨基酸，肽或多肽。本文定义的O-聚糖可用于抑制P-选择素介导的炎症。

17. 发明授权

US4201188A Solar collector and heat trap 失效
标题翻译：太阳能集热器和热阱
公开(公告)号：US4201188A
公开(公告)日：1980-05-06
申请号：US902857
申请日：1978-05-04
申请人： Richard D. Cummings
发明人： Richard D. Cummings
IPC分类号： F24J2/22 , F24J2/46 , F24J3/02
CPC分类号： F24J2/464 , F24J2/22 , Y02B10/20 , Y02E10/44
摘要： A solar collector unit of triangular transverse cross section is provided with a corrugated heat trap element on at least the rear vertical wall of the collector. The heat trap element has a V-shaped cross section, the angle of the V being in the range of about 35.degree. to about 55.degree.. The heat trap element, in part, serves to increase the effective heat transfer surface of the collector at relatively little expense. Additionally, the corrugated member serves as a channel for direction of the flow of fluid to be heated through the collector.
摘要翻译：三角形横截面的太阳能收集器单元在收集器的至少后垂直壁上设置有波纹状热阱元件。吸热元件具有V形横截面，V的角度在约35°至约55°的范围内。热阱元件部分地用于以相对较小的成本增加收集器的有效传热表面。此外，波纹状部件作为用于通过收集器加热的流体流动方向的通道。

18. 发明授权

US09772337B2 Compositions and methods for functional gylcomics 有权
公开(公告)号：US09772337B2
公开(公告)日：2017-09-26
申请号：US13885916
申请日：2011-11-22
申请人： Richard D. Cummings , David F. Smith , Xuezheng Song
发明人： Richard D. Cummings , David F. Smith , Xuezheng Song
IPC分类号： G01N33/92 , C07C237/34 , C07H15/18 , C40B40/12
CPC分类号： G01N33/92 , C07B2200/11 , C07C237/34 , C07H15/18 , C40B40/12
摘要： The disclosure relates to labeling glycans and glycosphingolipids from undefined mixtures with chemical moieties that emit light when exposed to electromagnetic radiation and uses of these labeled glycans and glycosphingolipids in microarrays for research and diagnostic purposes. In certain embodiments, the disclosure relates to derivatizing glycosphingolipids with a marker.

19. 发明申请

US20130331280A1 COMPOSITIONS AND METHODS FOR FUNCTIONAL GYLCOMICS 审中-公开
标题翻译：功能性GYLCOMICS的组成和方法
公开(公告)号：US20130331280A1
公开(公告)日：2013-12-12
申请号：US13885916
申请日：2011-11-22
申请人： Richard D. Cummings , David F. Smith , Xuezheng Song
发明人： Richard D. Cummings , David F. Smith , Xuezheng Song
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , C07B2200/11 , C07C237/34 , C07H15/18 , C40B40/12
摘要： The disclosure relates to labeling glycans and glycosphingolipids from undefined mixtures with chemical moieties that emit light when exposed to electromagnetic radiation and uses of these labeled glycans and glycosphingolipids in microarrays for research and diagnostic purposes. In certain embodiments, the disclosure relates to derivatizing glycosphingolipids with a marker.
摘要翻译：本公开涉及从暴露于电磁辐射时发出光的化学部分的未定义混合物中标记聚糖和糖鞘糖，并将这些标记的聚糖和糖鞘糖在微阵列中用于研究和诊断目的。在某些实施方案中，本公开涉及用具有标记物衍生鞘糖脂。

20. 发明授权

US07470776B2 Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof 失效
标题翻译：白细胞滚动的糖基多肽抑制剂及其使用方法
公开(公告)号：US07470776B2
公开(公告)日：2008-12-30
申请号：US11716922
申请日：2007-03-12
申请人： Richard D. Cummings , Rodger P. McEver
发明人： Richard D. Cummings , Rodger P. McEver
IPC分类号： A61K31/70 , A61K38/14
CPC分类号： C07H3/06 , A61K38/08 , A61K38/14 , C07K9/00 , C07K9/001 , C07K9/005 , C07K14/705 , C07K14/70596
摘要： Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and sialyated, fucosylated N-acetyllactosamino glycans. The glycosulfopeptides may be conjugated or complexed to other compounds for enhancing serum half-life or for controlled release, for example. Examples of conditions treated include inflammation, ischemia-reperfusion injury, rheumatoid arthritis, atherosclerosis, leukocyte-mediated lung injury, restenosis, and thrombosis.
摘要翻译：描述了用于治疗以白细胞转动为特征的病症的化合物，组合物和方法。所述化合物含有包含硫酸化酪氨酸和唾液酸化的岩藻糖化N-乙酰基乳糖氨基聚糖的糖链多肽结构。例如，糖磺肽可以与其它化合物缀合或络合以增强血清半衰期或控制释放。治疗条件的实例包括炎症，缺血再灌注损伤，类风湿性关节炎，动脉粥样硬化，白细胞介导的肺损伤，再狭窄和血栓形成。

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