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11. 发明申请

US20070138100A1 DETECTION SYSTEMS AND METHODS 有权
标题翻译：检测系统和方法
公开(公告)号：US20070138100A1
公开(公告)日：2007-06-21
申请号：US11678236
申请日：2007-02-23
申请人： Martin Hofmann , David Johnson
发明人： Martin Hofmann , David Johnson
IPC分类号： B01D15/08
CPC分类号： G01F23/2962 , G01F23/2965 , G01N30/76 , Y10T436/255 , G01N30/50
摘要： The application describes apparatus and methods using ultrasound transmitted through a chromatography column bed to determine the status of materials in the bed space, particularly during chromatography runs. Detected conditions include the profile of a band of eluting material—to see whether it is satisfactory—the arrival of a band of material at the column output, the fitness for use of the ed packing, the passage of different mobile phases, e.g. salt fronts, and other conditions. Aspects claimed include control processors and corresponding programmed products.
摘要翻译：本申请描述了使用超声波穿过色谱柱床的装置和方法，以确定床空间中材料的状态，特别是在层析运行期间。检测条件包括一系列洗脱材料的轮廓，以了解其是否令人满意 - 一列材料在柱输出中的到达，使用包装的适用性，不同流动相的通过，例如，盐面等条件。所要求的方面包括控制处理器和相应的编程产品。

12. 发明授权

US5726570A NMR measuring cell 失效
标题翻译： NMR测量池
公开(公告)号：US5726570A
公开(公告)日：1998-03-10
申请号：US758881
申请日：1996-12-02
申请人： Manfred Spraul , Martin Hofmann , Harald Schwalbe
发明人： Manfred Spraul , Martin Hofmann , Harald Schwalbe
IPC分类号： G01N30/34 , G01N30/62 , G01R33/30 , G01R3/00
CPC分类号： G01R33/307 , G01N2030/347 , G01N30/62
摘要： The invention concerns a NMR measuring cell, in particular one for a flow-through probe head (1) and having at least a first inlet opening (10) to introduce a first injected or pumped reaction liquid into the measuring cell (1) and a second inlet opening (11) for introduction of a second injected or pumped reaction liquid into the measuring cell (1). The measuring cell (1)is subdivided by means of an at least partially movable wall (2) into at least a first chamber (17) which communicates with the first inlet opening and a second Chamber (19) which communicates with the second inlet opening (11). The at least partially movable wall (2) is configured and adapted in such a fashion that directed motion thereof leads to a mixing together of the first reaction liquid separately stored in the first chamber (17) with the second reaction liquid separately stored in the second chamber (19). In accordance with the invention a rapid and homogeneous mixing-together of the two reaction liquids is achieved in milliseconds.
摘要翻译：本发明涉及一种NMR测量池，特别是一种用于流通探头（1）并具有至少一个第一入口（10）的入口开口（10），用于将第一注入或泵送的反应液体引入测量池（1）用于将第二注射或泵送的反应液体引入测量池（1）中的第二入口（11）。测量单元（1）借助于至少部分可移动的壁（2）被分为至少与第一入口开口连通的第一腔室（17）和与第二入口开口连通的第二腔室（19）（11）。所述至少部分可移动的壁（2）被构造和适配成这样的方式：其引导的运动导致分别储存在第一腔室（17）中的第一反应液体与分开存储在第二腔室室（19）。根据本发明，可以在几毫秒内实现两种反应液体的快速均匀混合。

13. 发明授权

US09023996B2 Anti-FLT3 antibodies 有权
标题翻译：抗FLT3抗体
公开(公告)号：US09023996B2
公开(公告)日：2015-05-05
申请号：US13518779
申请日：2010-12-23
申请人： Ludger Grosse-Hovest , Hans-Joerg Buehring , Martin Hofmann , Steffen Aulwurm , Grundram Jung
发明人： Ludger Grosse-Hovest , Hans-Joerg Buehring , Martin Hofmann , Steffen Aulwurm , Grundram Jung
IPC分类号： C07K16/28 , C07K16/30 , C12N5/10 , C12N15/13 , A61K39/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/72 , C07K2317/732
摘要： The present invention relates to anti-FLT3 antibodies with a modified Fc region comprising the amino acid substitutions 239D and 332E to enhance antibody-dependent cell cytotoxicity (ADCC) of these antibodies. The invention further relates to pharmaceutical compositions containing these antibodies, nucleic acids encoding these antibodies as well as methods of using such antibodies.
摘要翻译：本发明涉及具有包含氨基酸取代239D和332E的修饰的Fc区的抗FLT3抗体以增强这些抗体的抗体依赖性细胞毒性（ADCC）。本发明还涉及含有这些抗体的药物组合物，编码这些抗体的核酸以及使用这些抗体的方法。

14. 发明授权

US07248050B2 NMR apparatus 有权
标题翻译： NMR装置
公开(公告)号：US07248050B2
公开(公告)日：2007-07-24
申请号：US11144777
申请日：2005-06-06
申请人： Martin Hofmann , Manfred Spraul
发明人： Martin Hofmann , Manfred Spraul
IPC分类号： G01V3/00
CPC分类号： G01R33/307 , G01R33/31
摘要： The invention concerns an NMR apparatus (1) comprising an NMR spectrometer (2) for sequential investigation of several samples in sample containers (6) of substantially identical geometrical design, at a measuring position (10) in the NMR spectrometer (2) comprising a supply line (8) for pneumatic supply of the sample containers (6) from a magazine (3) to the measuring position (10). The apparatus is characterized in that the magazine (3) is disposed within a temperature-controlled cabinet, in particular, a cold chamber (4) and the supply line (8) can be heated. This substantially increases the throughput of samples of the NMR apparatus (1) with simple technical means.
摘要翻译：本发明涉及一种NMR装置（1），其包括NMR光谱仪（2），用于在NMR光谱仪（2）中的测量位置（10）处对具有基本相同几何设计的样品容器（6）中的若干样品进行顺序研究，所述测量位置包括用于将样品容器（6）从料盒（3）向测量位置（10）气动供给的供应管线（8）。该装置的特征在于，盒（3）设置在温度控制的柜内，特别是冷室（4）中，并且可以加热供应管线（8）。这通过简单的技术手段大大增加了NMR装置（1）的样品的通过量。

15. 发明授权

US07096886B2 Multiport switching valve for a liquid flow system 有权
标题翻译：用于液体流动系统的多端口切换阀
公开(公告)号：US07096886B2
公开(公告)日：2006-08-29
申请号：US10650111
申请日：2003-08-26
申请人： Martin Hofmann
发明人： Martin Hofmann
IPC分类号： F16K11/072
CPC分类号： G01N30/20 , G01N2030/201 , G01N2030/204 , Y10T137/5762 , Y10T137/86863
摘要： A multiport switching valve for a liquid flow system is described, comprising a first member having a plurality of ports for connecting liquid lines thereto, a second member, connected with a first member and movable relative to the first member, the second member comprising a plurality of channels, wherein the channels are arranged such that, according to a selected relative position between the first and second member, one or more of said channel connect predetermined ones of the ports of the first member with one another in a liquid conducting manner. The first member comprises at least one group of ports arranged in one substantially straight line or at least two adjacent substantially parallel and substantially straight lines, and the second member comprises a plurality of segments, wherein the segments have one or more channels arranged therein, the channel or channels of each segment representing a predetermined connection scheme for connecting predetermined ones of the ports with one another.
摘要翻译：描述了一种用于液体流动系统的多端口切换阀，包括具有用于连接液体管线的多个端口的第一部件，与第一部件连接并可相对于第一部件移动的第二部件，第二部件包括多个的通道，其中所述通道被布置成使得根据所述第一和第二构件之间的选定的相对位置，所述通道中的一个或多个将所述第一构件的所述端口中的预定端口以液体导通方式彼此连接。第一构件包括布置在一个基本上直线或至少两个相邻的基本上平行和基本上直线的至少一组端口，并且第二构件包括多个段，其中段具有布置在其中的一个或多个通道，每个段的通道或通道表示用于将预定端口彼此连接的预定连接方案。

16. 发明申请

US20050280416A1 Method for introducing a liquid sample into an NMR spectrometer 有权
标题翻译：将液体样品引入NMR光谱仪的方法
公开(公告)号：US20050280416A1
公开(公告)日：2005-12-22
申请号：US11144779
申请日：2005-06-06
申请人： Martin Hofmann , Pius Fink
发明人： Martin Hofmann , Pius Fink
IPC分类号： G01R33/30 , G01V3/00
CPC分类号： G01R33/307
摘要： A method for introducing a liquid sample into an NMR spectrometer to measure an NMR spectrum of the liquid sample, wherein the liquid sample is injected into a supply line and wherein further liquids are supplied into the supply line following the liquid sample, which are separated from each other and from the liquid sample by gas bubbles is characterized in that the liquid sample is supplied via an injection inlet to a valve configuration whose output side can be connected to the supply line and the further liquids and gas are supplied to the valve configuration via supply lines, wherein a desired sequence of sample segments, gas bubbles and further liquid segments is generated through temporally matched switching of the valve configuration in the supply line and is supplied to the NMR spectrometer. The inventive method realizes supply of a liquid sample into an NMR spectrometer with rapid sample transfer while thereby preventing mixing and dilution of the individual segments.
摘要翻译：一种用于将液体样品引入NMR光谱仪中以测量液体样品的NMR光谱的方法，其中将液体样品注入供应管线，并且其中进一步的液体被供应到液体样品之后的供应管线中，其特征在于，液体样品通过注射入口供给到阀构造，其输出侧可以连接到供应管线，并且进一步的液体和气体经由供应管线，其中通过供应管线中的阀配置的时间匹配切换产生样品段，气泡和另外的液体段的期望序列，并将其提供给NMR光谱仪。本发明的方法实现了将液体样品供应到具有快速样品转移的NMR光谱仪中，从而防止各个片段的混合和稀释。

17. 发明授权

US06671053B1 Illumination measuring device 失效
标题翻译：照明测量装置
公开(公告)号：US06671053B1
公开(公告)日：2003-12-30
申请号：US10009589
申请日：2001-12-11
申请人： Arno Euteneuer , Harald Giessen , Martin Hofmann
发明人： Arno Euteneuer , Harald Giessen , Martin Hofmann
IPC分类号： G01B902
CPC分类号： G01J9/04 , G01J11/00
摘要： In a method for influencing and measuring pulsed electromagnetic illumination, e.g. parallel laser light (L), said illumination or light can be spatially divided, in particular, in an autocorrelator comprising a beam receptor (12), can be recombined behind said beam receptor by a superposition or focusing device (18 or 58) and can be detected in the recombinant area by a detector (20). As the transmission system (52), the beam receptor comprises beam profile dividers in a penetrable housing (50), in the form of at least two transmission parts (54; 56), with or in which separate, preferably parallel component beams (S, T) can be modified in their time-based beam characteristics, before being recombined. The inventive beam receptor (12) preferably has at least a two-part mirror (22), plate (32), chamber or crystal system (42) comprising a beam profile divider (14, 24, 34, 44) which creates or leaves unchanged a base component beam (S), whilst the time-based characteristics of this or every other component beam (T) in a neighbouring beam profile divider (16, 26, 36, 46) can be controlled in a different manner, in order to effect, in particular, reflection or transmission delays and/or changes to the optical paths.
摘要翻译：在用于影响和测量脉冲电磁照明的方法中，例如，平行激光（L），所述照明或光可以在空间上划分，特别是在包括光束接收器（12）的自相关器中，可以通过叠加或聚焦装置（18或58）在所述光束接收器的后面重新组合，并且可以通过检测器（20）在重组区域中检测。作为传动系统（52），梁接收器包括在可穿透壳体（50）中的梁型材分隔件，其形式为至少两个传动部件（54; 56），其具有或分开的，优选地平行的部件梁（S ，T）可以在其重新组合之前以其基于时间的光束特性进行修改。本发明的光束接收器（12）优选地具有至少两部分反射镜（22），板（32），室或晶体系统（42），其包括产生或离开的光束分布分隔器（14,24,34,44）基本分量光束（S）不变，而相邻光束分布分割器（16,26,36,46）中的该或每个其它分量光束（T）的基于时间的特性可以以不同的方式按照特别是影响光路的反射或传输延迟和/或变化。

18. 发明授权

US5118186A Method and apparatus for adjusting the sighting device in weapon systems 失效
标题翻译：用于调整武器系统中的信号装置的方法和装置
公开(公告)号：US5118186A
公开(公告)日：1992-06-02
申请号：US652663
申请日：1991-02-08
申请人： Josef Schratzenstaller , Otto Ambrosius , Martin Hofmann , Heinz-Gunther Franz , Horst Laucht , Robert Rieger , Reinhard Seiferth
发明人： Josef Schratzenstaller , Otto Ambrosius , Martin Hofmann , Heinz-Gunther Franz , Horst Laucht , Robert Rieger , Reinhard Seiferth
IPC分类号： F41G3/32
CPC分类号： F41G3/326 , F41G3/323
摘要： A method and apparatus for adjusting an aiming telescope and a laser range finder with a weapon system which is equipped with a weapon computer, a data memory and a computer-controlled graticule adjusting device. Laser beams are fired consecutively by a collimation line testing device and by the laser range finder, into a collimator. A reference reticle or an aiming graticule of the aiming telescope are aligned with the laser beam images in the collimator, and the aligned position is stored in the data memory.
摘要翻译：一种用于调整瞄准望远镜和具有武器系统的激光测距仪的方法和装置，其配备有武器计算机，数据存储器和计算机控制的刻度调节装置。激光束由准直线测试装置和激光测距仪连续射出成准直仪。瞄准望远镜的参考掩模版或瞄准刻线与准直仪中的激光束图像对准，对准位置存储在数据存储器中。

19. 发明授权

US08766631B2 NMR measurement apparatus with flow-through probehead 有权
标题翻译： NMR测量装置，带有流通式探头
公开(公告)号：US08766631B2
公开(公告)日：2014-07-01
申请号：US12998713
申请日：2009-11-27
申请人： Martin Hofmann , Simon Benedict Duckett , Antonio Gianotti , Gary George Reginald Green
发明人： Martin Hofmann , Simon Benedict Duckett , Antonio Gianotti , Gary George Reginald Green
IPC分类号： G01V3/00
CPC分类号： G01R33/307 , G01R33/282 , G01R33/5605
摘要： The invention relates to a device (1, 21, 31, 41, 64) for the preparation and measurement of a nuclear spin resonance (NMR) measurement sample (10), including—a flow-through NMR probehead (2), with a first tube (3) and a second tube (14) each for the supply and removal of a liquid NMR measurement sample (10),—at least one chamber (4, 22, 32) which is connected to one of the tubes (3, 14),—a sample inlet (5) for introducing the liquid measurement sample (10) into the device (1, 21, 31, 41, 64), wherein at least one chamber (4, 22, 32) has at least one connection for increasing (9, 24, 25, 42, 43, 46, 47) and releasing (8, 23, 27, 48a, 48b) the gas pressure, and in which at least one chamber (4, 22, 32) comprises means for mixing the liquid measurement sample (10) contained in the chamber (4, 22, 32) with a gas With the inventive device it is possible to reduce the measurement sample consumption when doing an NMR spectroscopic measurement on liquid measurement samples to which spin order can be catalytically transferred.
摘要翻译：本发明涉及一种用于制备和测量核自旋共振（NMR）测量样品（10）的装置（1,21,31,41,64），其包括流通的NMR探针头（2），其中具有第一管（3）和第二管（14），每个用于供应和去除液体NMR测量样品（10）; - 至少一个室（4,22,32），其连接到管中的一个，14）， - 用于将所述液体测量样品（10）引入所述装置（1,21,31,41,64）中的样品入口（5），其中至少一个室（4,22,32）至少具有一个用于增加（9,24,25,42,43,46,47）和释放（8,23,27,48a，48b）气体压力的连接，并且其中至少一个室（4,22,32）包括用于将容纳在腔室（4,22,32）中的液体测量样品（10）与气体混合的装置利用本发明的装置，当对其中的液体测量样品进行NMR光谱测量时，可以减少测量样品消耗，旋转可以催化转移。

20. 发明申请

US20110006770A1 Method and device for measuring a sample in an NMR spectrometer using a coupling configuration with a press fit cell having a capillary envelope fastener 有权
标题翻译：用于使用具有毛细管膜紧固件的压配合单元的耦合结构在NMR光谱仪中测量样品的方法和装置
公开(公告)号：US20110006770A1
公开(公告)日：2011-01-13
申请号：US12923321
申请日：2010-09-15
申请人： Martin Hofmann , Thorsten Marquardsen
发明人： Martin Hofmann , Thorsten Marquardsen
IPC分类号： G01R33/48
CPC分类号： G01R33/307 , B01L3/565 , B01L2300/02 , B01L2300/0838 , G01N30/6026 , G01N30/6039 , G01N30/6078
摘要： A method for measuring an sample in an NMR spectrometer uses a coupling configuration (1; 30) comprising a coupling element (3) and a supply capillary (2), wherein the coupling element (3) has a funnel-shaped section (5) which clamps an end (6) of the supply capillary (2). An envelope capillary (10) is provided into which the supply capillary (2) is inserted, wherein the end (6) of the supply capillary (2) projects past an end (11) of the envelope capillary (10), and the end (11) of the envelope capillary (10) is also clamped in the funnel-shaped section (5).
摘要翻译：用于在NMR光谱仪中测量样品的方法使用包括耦合元件（3）和供应毛细管（2）的耦合结构（1; 30），其中耦合元件（3）具有漏斗形截面（5）其夹紧供应毛细管（2）的端部（6）。提供了一种信封毛细管（10），其中插入供应毛细管（2），其中供应毛细管（2）的端部（6）突出穿过包络毛细管（10）的端部（11），并且端部信封毛细管（10）的（11）也夹在漏斗形部分（5）中。

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