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1. 发明申请

US20120328612A1 ANTI-FLT3 ANTIBODIES AND METHODS OF USING THE SAME 有权
标题翻译：抗FLT3抗体及其使用方法
公开(公告)号：US20120328612A1
公开(公告)日：2012-12-27
申请号：US13518779
申请日：2010-12-23
申请人： Ludger Grosse-Hovest , Hans-Joerg Buehring , Martin Hofmann , Steffen Aulwurm , Grundram Jung
发明人： Ludger Grosse-Hovest , Hans-Joerg Buehring , Martin Hofmann , Steffen Aulwurm , Grundram Jung
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , C12N5/10 , A61P35/00 , C12N15/13 , C12N5/07
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/72 , C07K2317/732
摘要： The present invention relates to anti-FLT3 antibodies with a modified Fc region comprising the amino acid substitutions 239D and 332E to enhance antibody-dependent cell cytotoxicity (ADCC) of these antibodies. The invention further relates to pharmaceutical compositions containing these antibodies, nucleic acids encoding these antibodies as well as methods of using such antibodies.
摘要翻译：本发明涉及具有包含氨基酸取代239D和332E的修饰的Fc区的抗FLT3抗体以增强这些抗体的抗体依赖性细胞毒性（ADCC）。本发明还涉及含有这些抗体的药物组合物，编码这些抗体的核酸以及使用这些抗体的方法。

2. 发明申请

US20110285396A1 NMR MEASUREMENT APPARATUS WITH FLOW-THROUGH PROBEHEAD 有权
标题翻译： NMR测量装置与流量探头
公开(公告)号：US20110285396A1
公开(公告)日：2011-11-24
申请号：US12998713
申请日：2009-11-27
申请人： Martin Hofmann , Simon Benedict Duckett , Antonio Gianotti , Gary George Reginald Green
发明人： Martin Hofmann , Simon Benedict Duckett , Antonio Gianotti , Gary George Reginald Green
IPC分类号： G01R33/44
CPC分类号： G01R33/307 , G01R33/282 , G01R33/5605
摘要： The invention relates to a device (1, 21, 31, 41, 64) for the preparation and measurement of a nuclear spin reso nance (NMR) measurement sample (10), including—a flow-through NMR probehead (2), with a first tube (3) and a second tube (14) each for the supply and removal of a liquid NMR measurement sample (10),—at least one chamber (4, 22, 32) which is connected to one of the tubes (3, 14),—a sample inlet (5) for introducing the liquid measurement sample (10) into the device (1, 21, 31, 41, 64), wherein at least one chamber (4, 22, 32) has at least one connection for increasing (9, 24, 25, 42, 43, 46, 47) and releasing (8, 23, 27, 48a, 48b) the gas pressure, and in which at least one chamber (4, 22, 32) comprises means for mixing the liquid measurement sample (10) contained in the chamber (4, 22, 32) with a gas With the inventive device it is possible to reduce the measurement sample consumption when doing an NMR spectroscopic measurement on liquid measurement samples to which spin order can be catalytically transferred.
摘要翻译：本发明涉及一种用于制备和测量核自旋电阻（NMR）测量样品（10）的装置（1,21,31,41,64），包括 - 流通的NMR探针头（2），具有每个用于供应和去除液体NMR测量样品（10）的第一管（3）和第二管（14）; - 至少一个室（4,22,32），其连接到管中的一个 3，14）， - 用于将液体测量样品（10）引入到装置（1,21,31,41,64）中的样品入口（5），其中至少一个室（4,22,32）具有至少一个用于增加（9,24,25,42,43,46,47）和释放（8,23,27,48a，48b）气体压力的连接，并且其中至少一个室（4,22,32 ）包括用于将容纳在腔室（4,22,32）中的液体测量样品（10）与气体混合的装置利用本发明的装置，当对液体测量样品进行NMR光谱测量时，可以减少测量样品消耗，哪个spi n阶可以催化转移。

3. 发明授权

US08063640B2 Method and device for measuring a sample in an NMR spectrometer using a coupling configuration with a press fit cell having a capillary envelope fastener 有权
公开(公告)号：US08063640B2
公开(公告)日：2011-11-22
申请号：US12923321
申请日：2010-09-15
申请人： Martin Hofmann , Thorsten Marquardsen
发明人： Martin Hofmann , Thorsten Marquardsen
IPC分类号： G01V3/00
CPC分类号： G01R33/307 , B01L3/565 , B01L2300/02 , B01L2300/0838 , G01N30/6026 , G01N30/6039 , G01N30/6078
摘要： A method for measuring an sample in an NMR spectrometer uses a coupling configuration (1; 30) comprising a coupling element (3) and a supply capillary (2), wherein the coupling element (3) has a funnel-shaped section (5) which clamps an end (6) of the supply capillary (2). An envelope capillary (10) is provided into which the supply capillary (2) is inserted, wherein the end (6) of the supply capillary (2) projects past an end (11) of the envelope capillary (10), and the end (11) of the envelope capillary (10) is also clamped in the funnel-shaped section (5).

4. 发明申请

US20070271018A1 Driving dynamic control or regulating system and method for a two-track, two-axle motor vehicle 有权
标题翻译：驱动双轨，双轴汽车的动态控制或调节系统和方法
公开(公告)号：US20070271018A1
公开(公告)日：2007-11-22
申请号：US11882271
申请日：2007-07-31
申请人： Martin Hofmann , Klaus Webers
发明人： Martin Hofmann , Klaus Webers
IPC分类号： G06F19/00
CPC分类号： B60G21/0555 , B60G17/0152 , B60G17/0162 , B60G2400/208 , B60G2400/32 , B60G2400/822 , B60G2800/012
摘要： A system and method are provided for controlling or automatically controlling the driving dynamics of a two-track, two-axle motor vehicle having only one driven axle, which, for the rolling moment support, has a system for changing the distribution of the wheel contact forces to the left and right wheel respectively of each axle. The fractions of the rolling moment support taken over by the front axle and by the rear axle are changeable as a function of the drive torque provided by the drive assembly of the motor vehicle. For this purpose, a desired wheel contact force for the driven wheels can be determined from the drive torque, and by way of this desired wheel contact force, the distribution of the rolling torque support can be determined. A change of the distribution of the rolling moment support as a function of the drive torque of the drive assembly is preferably carried out only if the otherwise available contact force would otherwise not be sufficient for the transmission of the drive torque to the road. A slip control may be superimposed on this pilot control, which slip control seeks to minimize the deviation between the determined rotational speed difference of the driven wheels and the rotational speed difference corresponding to the respective driving condition.
摘要翻译：提供了一种用于控制或自动控制仅具有一个从动轴的双轨双轴汽车的驾驶动力学的系统和方法，其对于滚动力矩支撑具有用于改变车轮接触分布的系统各轴分别对左右轮的力。作为由机动车辆的驱动组件提供的驱动扭矩的函数，由前桥和后桥承受的滚动力矩支撑的分数是可变的。为此，可以根据驱动转矩确定从动轮的期望的车轮接触力，并且通过该期望的车轮接触力，可以确定滚动转矩支撑件的分布。优选地，仅当否则可用的接触力不足以将驱动扭矩传递到道路时，作为驱动组件的驱动扭矩的函数的滚动力矩支撑件的分布的改变才能实现。滑动控制可以叠加在该导向控制上，该滑动控制试图使所确定的从动轮的转速差与对应于相应行驶条件的转速差之间的偏差最小化。

5. 发明申请

US20050055136A1 Detection systems and methods 有权
标题翻译：检测系统和方法
公开(公告)号：US20050055136A1
公开(公告)日：2005-03-10
申请号：US10496940
申请日：2002-11-27
申请人： Martin Hofmann , David Johnson
发明人： Martin Hofmann , David Johnson
IPC分类号： G01F23/296 , G01N30/50 , G01N30/76 , G01N30/02
CPC分类号： G01F23/2962 , G01F23/2965 , G01N30/76 , Y10T436/255 , G01N30/50
摘要： The application describes apparatus and methods using ultrasound transmitted through a chromatography column bed to determine the status of materials in the bed space, particularly during chromatography runs. Detected conditions include the profile of a band of eluting material—to see whether it is satisfactory—the arrival of a band of material at the column output, the fitness for use of the ed packing, the passage of different mobile phases, e.g. salt fronts, and other conditions. Aspects claimed include control processors and corresponding programmed products.
摘要翻译：本申请描述了使用超声波穿过色谱柱床的装置和方法，以确定床空间中材料的状态，特别是在层析运行期间。检测条件包括一系列洗脱材料的轮廓，以了解其是否令人满意 - 一列材料在柱输出中的到达，使用包装的适用性，不同流动相的通过，例如，盐面等条件。所要求的方面包括控制处理器和相应的编程产品。

6. 发明授权

US06614228B2 Device for trapping at least one component of a chromatography flow in an LC/NMR environment 有权
标题翻译：用于在LC / NMR环境中捕获色谱流的至少一个组分的装置
公开(公告)号：US06614228B2
公开(公告)日：2003-09-02
申请号：US10014130
申请日：2001-10-24
申请人： Martin Hofmann , Manfred Spraul , Marcus Godejohann
发明人： Martin Hofmann , Manfred Spraul , Marcus Godejohann
IPC分类号： G01V300
CPC分类号： G01N30/84 , G01N2030/8417
摘要： A device for trapping at least one chromatography peak of a chromatography flow comprises at least one trapping column, an inlet capillary for leading the chromatography flow into the trapping column and an outlet capillary departing from the trapping column. A plurality of trapping columns are provided on a column carrier wherein the trapping columns are separately and selectively connectable to and/or removable from the inlet and outlet capillary.
摘要翻译：用于捕获色谱流程的至少一个色谱峰的装置包括至少一个捕集塔，用于引导色谱流入捕集塔的入口毛细管和离开捕集塔的出口毛细管。多个捕集柱设置在柱载体上，其中捕集柱分别且可选择性地连接到入口和出口毛细管和/或从入口和出口毛细管可移除。

7. 发明授权

US06402946B1 Device for feeding a chromatography flow 有权
标题翻译：用于进料色谱流的装置
公开(公告)号：US06402946B1
公开(公告)日：2002-06-11
申请号：US09697673
申请日：2000-10-26
申请人： Manfred Spraul , Martin Hofmann
发明人： Manfred Spraul , Martin Hofmann
IPC分类号： B01D1508
CPC分类号： G01N30/84 , G01N2030/324 , G01N2030/8411 , G01N30/10 , G01N30/78 , G01N30/20
摘要： A device for feeding a chromatography flow coming from a flow source, in particular from a liquid chromatography (LC) separating unit or a peak sampling or trapping unit, in part to at least a first decision detector unit and/or at least a first destination detector unit, and in part to at least a second destination detector unit is disclosed, including a first capillary line coming from the flow source, a second capillary line leading to the first decision detector unit, and/or to the first destination detector unit, and a third capillary line leading to the second destination detector unit, the first, second and third capillary line being connected with one another by means of a flow splitter splitting the flow coming from the first capillary line into two parts, a first part being fed into the second capillary line and the second part being fed into the third capillary line.
摘要翻译：用于将来自流动源，特别是来自液相色谱（LC）分离单元或峰值采样或捕获单元的色谱流进料部分提供给至少第一判定检测器单元和/或至少第一目的地的装置检测器单元，并且部分地至少包括第二目的地检测器单元，其包括来自流动源的第一毛细管线，通向第一判定检测器单元的第二毛细管线和/或第一目的地检测器单元，以及通向所述第二目的地检测器单元的第三毛细管线，所述第一，第二和第三毛细管线通过分流器将所述第一毛细管线的流分成两部分而彼此连接，第一部分被进给进入第二毛细管线，而第二部分被送入第三毛细管线。

8. 发明授权

US08123921B2 Method and device for the preparation of liquid samples in NMR spectroscopy using a combined titration and pH electrode 有权
标题翻译：在NMR光谱中使用联合滴定和pH电极制备液体样品的方法和装置
公开(公告)号：US08123921B2
公开(公告)日：2012-02-28
申请号：US12801298
申请日：2010-06-02
申请人： Gudrun Hofmann , Martin Hofmann
发明人： Gudrun Hofmann , Martin Hofmann
IPC分类号： G01N27/333
CPC分类号： G01N27/286 , Y10T436/116664
摘要： A method and device have an electrode rod (1; 21) for a pH meter. The electrode rod (1; 21) has a measuring end (2; 22) for immersion into a liquid test sample (31), wherein the measuring end (2; 22) has a pH measuring element, and wherein electrical feed lines (5) in the electrode rod (1; 21) extend towards the pH measuring element. A plurality of capillaries (8, 9, 10; 23) for feeding liquids and gas into the test sample (31) extend in the electrode rod (1; 21) and have outlet openings (11, 12, 13; 24) in the area of the measuring end (2; 22). The method and device facilitate and accelerate preparation of liquid test samples and adjustment of a pH value for small amounts of test samples or narrow sample containers in NMR spectroscopy applications.
摘要翻译：一种方法和装置具有用于pH计的电极棒（1; 21）。电极棒（1; 21）具有用于浸入液体测试样品（31）中的测量端（2; 22），其中测量端（2; 22）具有pH测量元件，并且其中电馈线）在电极棒（1; 21）中朝向pH测量元件延伸。用于将液体和气体供入到测试样品（31）中的多个毛细管（8,9,10,23）在电极棒（1; 21）中延伸，并具有出口开口（11,12,13; 24）测量端（2; 22）的面积。该方法和装置促进并加速液体试样的制备，并调节了在NMR光谱学应用中的少量测试样品或窄样品容器的pH值。

9. 发明申请

US20080011108A1 Coupling configuration, in particular, a press fit cell having a capillary envelope fastener 审中-公开
标题翻译：耦合结构，特别是具有毛细管膜紧固件的压配合单元
公开(公告)号：US20080011108A1
公开(公告)日：2008-01-17
申请号：US11812821
申请日：2007-06-22
申请人： Martin Hofmann
发明人： Martin Hofmann
IPC分类号： G01N35/10 , B01L3/00
CPC分类号： G01R33/307 , B01L3/565 , B01L2300/02 , B01L2300/0838 , G01N30/6026 , G01N30/6039 , G01N30/6078
摘要： A coupling configuration (1; 30) comprising a coupling element (3) and a supply capillary (2), wherein the coupling element (3) has a funnel-shaped section (5) which clamps an end (6) of the supply capillary (2), is characterized in that an envelope capillary (10) is provided into which the supply capillary (2) is inserted, wherein the end (6) of the supply capillary (2) projects past an end (11) of the envelope capillary (10), and the end (11) of the envelope capillary (10) is also clamped in the funnel-shaped section (5). The supply capillary is properly fixed in the coupling element and safely protected from capillary breakage.
摘要翻译：包括耦合元件（3）和供应毛细管（2）的联接结构（1; 30），其中所述耦合元件（3）具有漏斗形部分（5），所述漏斗形截面（5）夹持所述供应毛细管（2）的特征在于，提供包封毛细管（10），所述供应毛细管（2）插入其中，其中所述供应毛细管（2）的端部（6）突出通过所述外壳的端部（11）毛细管（10）和包络毛细管（10）的端部（11）也夹在漏斗状部分（5）中。供应毛细管被适当地固定在联接元件中，并且安全地防止毛细管破裂。

10. 发明授权

US07250767B2 Method for introducing a liquid sample into an NMR spectrometer 有权
标题翻译：将液体样品引入NMR光谱仪的方法
公开(公告)号：US07250767B2
公开(公告)日：2007-07-31
申请号：US11144779
申请日：2005-06-06
申请人： Martin Hofmann , Pius Fink
发明人： Martin Hofmann , Pius Fink
IPC分类号： G01V3/00
CPC分类号： G01R33/307
摘要： A method for introducing a liquid sample into an NMR spectrometer to measure an NMR spectrum of the liquid sample, wherein the liquid sample is injected into a supply line and wherein further liquids are supplied into the supply line following the liquid sample, which are separated from each other and from the liquid sample by gas bubbles is characterized in that the liquid sample is supplied via an injection inlet to a valve configuration whose output side can be connected to the supply line and the further liquids and gas are supplied to the valve configuration via supply lines, wherein a desired sequence of sample segments, gas bubbles and further liquid segments is generated through temporally matched switching of the valve configuration in the supply line and is supplied to the NMR spectrometer. The inventive method realizes supply of a liquid sample into an NMR spectrometer with rapid sample transfer while thereby preventing mixing and dilution of the individual segments.
摘要翻译：一种用于将液体样品引入NMR光谱仪中以测量液体样品的NMR光谱的方法，其中将液体样品注入供应管线，并且其中进一步的液体被供应到液体样品之后的供应管线中，其特征在于，液体样品通过注射入口供给到阀构造，其输出侧可以连接到供应管线，并且进一步的液体和气体经由供应管线，其中通过供应管线中的阀配置的时间匹配切换产生样品段，气泡和另外的液体段的期望序列，并将其提供给NMR光谱仪。本发明的方法实现了将液体样品供应到具有快速样品转移的NMR光谱仪中，从而防止各个片段的混合和稀释。

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