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11. 发明授权

US5592666A Method and system for storing and retrieving data from a multidimensional array using database pointers 失效
标题翻译：使用数据库指针从多维数组中存储和检索数据的方法和系统
公开(公告)号：US5592666A
公开(公告)日：1997-01-07
申请号：US331914
申请日：1994-10-31
申请人： Manuel Perez
发明人： Manuel Perez
IPC分类号： G06F17/30 , G06F12/00
CPC分类号： G06F17/30961 , Y10S707/99943
摘要： A system and method for storing within, and retrieving from, a computer database values of a multidimensional array in which storage locations are allocated within each storage node of the database corresponding to a dimension of the array only for the database-pointers actually stored within the storage node. An indicium is stored with each database-pointer to identify the element of the array's dimension to which the database-pointer corresponds. In an alternative embodiment, a sub-storage area, with sub-storage locations allocated for each of the elements of the dimension to which the storage node corresponds, is associated with each storage node, and an indicium is stored within each sub-storage location indicating whether a database-pointer exists in the associated storage node corresponding to the associated element. A hierarchial table of calculation rules also is provided for determining values which are calculated from other values within the array. Each of the table's rules defines one or more storage locations within the array and provides a formula for calculating the values applicable to those locations.
摘要翻译：一种用于在计算机数据库内存储数据库数据库的系统和方法，其中存储位置在数据库的每个存储节点内被分配给数据库的维度中仅存储在数据库指针内的多维数组值存储节点。与每个数据库指针一起存储一个标记，以标识数据库指针对应的数组的维度的元素。在替代实施例中，具有为存储节点对应的维度的每个元素分配的子存储位置的子存储区域与每个存储节点相关联，并且将标记存储在每个子存储位置指示相关联的存储节点中是否存在数据库指针。还提供了计算规则的分层表，用于确定从阵列内的其他值计算的值。每个表的规则定义阵列中的一个或多个存储位置，并提供计算适用于这些位置的值的公式。

12. 发明授权

US5319777A System and method for storing and retrieving information from a multidimensional array 失效
标题翻译：用于从多维数组存储和检索信息的系统和方法
公开(公告)号：US5319777A
公开(公告)日：1994-06-07
申请号：US598373
申请日：1990-10-16
申请人： Manuel Perez
发明人： Manuel Perez
IPC分类号： G06F17/24 , G06Q10/10 , G06F15/40
CPC分类号： G06Q10/10 , G06F17/246 , Y10S707/99952
摘要： A system and method for connecting electronic spreadsheets through a local area network are provided in which the spreadsheet programs are separate from the databases upon which they operate. The databases are multidimensional with each cell or datum identified by a unique set of element identifiers. The system and method allow users to create and control their own spreadsheet models while working with one, consistent pool of information. Changes in data effected by one user are reflected in the spreadsheets of all users, thereby guaranteeing consistent results for an entire work group at all times. Access restriction parameters for each user for each element of each dimension of the database also are provided. Multiple levels of consolidation values for each dimension of the database are calculated and updated automatically.
摘要翻译：提供了通过局域网连接电子电子表格的系统和方法，其中电子表格程序与它们操作的数据库分开。数据库是多维的，每个单元格或基准由一组唯一的元素标识符标识。系统和方法允许用户创建和控制自己的电子表格模型，同时使用一个一致的信息池。一个用户影响的数据变化反映在所有用户的电子表格中，从而保证整个工作组始终保持一致的结果。还提供了数据库每个维度的每个元素的每个用户的访问限制参数。自动计算和更新数据库每个维度的多个级别的合并值。

13. 发明授权

US4586483A Adjustable dual venturi assembly 失效
标题翻译：可调式双文丘里组件
公开(公告)号：US4586483A
公开(公告)日：1986-05-06
申请号：US626224
申请日：1984-06-29
申请人： Manuel Perez
发明人： Manuel Perez
IPC分类号： F23D14/64 , F24C3/04
CPC分类号： F23D14/64
摘要： An adjustable dual mixing assembly specifically configured for use with a dual burner gas grill including a burner element having a pair of gas supply tubes affixed thereto in spaced relationship relative to each other and a pair of corresponding gas supply nozzles in spaced relationship relative to each other and to the pair of gas supply tubes, the adjustable dual mixing assembly comprising a pair of mixing tubes corresponding to the pair of gas supply tubes and the pair of gas supply nozzles, each mixing tube comprising an inner substantially cylindrical base member telescopingly and rotatably disposed within the corresponding gas supply tubes and an outer arcuate gas supply member corresponding to the pair of gas supply nozzles and a securing device including a first locking element attached to each of the two mixing tubes and a second locking element attached to each of the gas supply tubes such that each of the two mixing tubes may be adjusted longitudinally and laterally between corresponding gas supply tubes and gas supply nozzles permitting one of the predetermined first locking elements to engage a corresponding second locking element to secure the corresponding mixing tube to the gas supply tube in operative relationship with the corresponding gas supply nozzle.
摘要翻译：一种可调节双重混合组件，其特别构造成与双燃烧器气体格栅一起使用，其包括燃烧器元件，该燃烧器元件具有相对于彼此间隔开的关系固定在其上的一对气体供给管，以及一对相对于彼此间隔开的相应气体供给喷嘴以及一对气体供给管，所述可调节双重混合组件包括对应于所述一对气体供应管和所述一对气体供应喷嘴的一对混合管，每个混合管包括可伸缩地旋转地设置的内部基本上圆柱形的基部构件在对应的气体供应管和对应于一对气体供应喷嘴的外部弧形气体供应构件和固定装置之间，固定装置包括附接到两个混合管中的每一个的第一锁定元件和附接到每个气体供应源的第二锁定元件管，使得两个混合管中的每一个可以在其间纵向和横向调节相应的气体供应管和气体供应喷嘴允许预定的第一锁定元件中的一个接合相应的第二锁定元件，以将相应的混合管固定到与相应的气体供应喷嘴有效关系的气体供应管。

14. 发明申请

US20210228733A1 METHODS AND COMPOSITIONS FOR THERANOSTIC NANOPARTICLES 有权
公开(公告)号：US20210228733A1
公开(公告)日：2021-07-29
申请号：US17228286
申请日：2021-04-12
申请人： Annette Khaled , Jesus Manuel Perez Figueroa , Santimukul Santra , Charalambos Kaittanis , Oscar Santiesteban , Jan Grimm , Hampton Sessions
发明人： Annette Khaled , Jesus Manuel Perez Figueroa , Santimukul Santra , Charalambos Kaittanis , Oscar Santiesteban , Jan Grimm , Hampton Sessions
IPC分类号： A61K47/68 , A61K45/06 , A61K51/10 , A61K51/12 , A61K38/08 , A61K38/10 , A61K47/69
摘要： Disclosed are compositions and methods for identifying a solid tumor cell target. Compositions and methods for treating prostate cancer are also disclosed. Further, cancer therapeutic compositions comprising CT20p are disclosed. Nanoparticles that are conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein are disclosed.

15. 发明授权

US10543614B2 Structural butt finger joint for flat boards 有权
公开(公告)号：US10543614B2
公开(公告)日：2020-01-28
申请号：US15537000
申请日：2015-12-15
申请人： Manuel Perez-Romero , Jaime Tarazona-Lizarraga
发明人： Manuel Perez-Romero , Jaime Tarazona-Lizarraga
IPC分类号： B27F1/16 , B27M3/00 , F16B12/04
摘要： A structural joint for attaching two boards by their butts, achieving the correct transmission of forces between them by means of a staggered configuration of the butts thereof to increase the contact surface between both boards, allowing the mutual coupling thereof, both being aligned and coplanar, and at least one of the steps of both boards having a finger profile to further increase the contact surface between both boards.

16. 发明授权

US10510263B2 Dynamically configurable audience response system 有权
公开(公告)号：US10510263B2
公开(公告)日：2019-12-17
申请号：US13574060
申请日：2011-01-19
申请人： Christopher M. Cacioppo , Brian Prendergast , Manuel Perez , David J. Dean
发明人： Christopher M. Cacioppo , Brian Prendergast , Manuel Perez , David J. Dean
IPC分类号： G09B5/08 , G09B7/02 , H04W8/24 , H04M1/725
摘要： A dynamically configurable audience response system includes multiple handsets communicatively coupled to a wireless aggregation point. Each handset includes at least one dynamically configurable operating parameter, such as a handset ID that identifies that handset, one or more parameters defining a communication channel that the handset can use to communicate with the wireless aggregation point, and/or one or more parameters defining various keys that the handset can use to establish a communication link with the wireless aggregation point. In some embodiments, the operating parameters associated with the handsets may be defined dynamically via the wireless aggregation point and without any user interaction with the handset. Additionally, or alternatively, in some embodiments, in order to define, or redefine, the operating parameters associated with the handsets, the dynamically configurable audience response system may include a handset configuration station, via which the operating parameters of the handsets may be defined.

17. 发明申请

US20160074434A1 Application Device for Inducing Cytotoxicity to Tumor Cells Via Coated Cerium Oxide Nanoparticles 审中-公开
标题翻译：通过涂覆的氧化铈纳米颗粒诱导肿瘤细胞的细胞毒性的应用装置
公开(公告)号：US20160074434A1
公开(公告)日：2016-03-17
申请号：US14862559
申请日：2015-09-23
申请人： Jesus Manuel Perez , Atul Asati , Santimukul Santra , Charalambos Kaittanis
发明人： Jesus Manuel Perez , Atul Asati , Santimukul Santra , Charalambos Kaittanis
IPC分类号： A61K33/24 , A61K9/50
CPC分类号： A61K33/24 , A61K9/5138 , A61K9/5161
摘要： Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines. In contrast, minimal toxicity is observed when they localize into the cytoplasm or do not enter the cells.
摘要翻译：正常细胞和癌细胞中纳米囊的差异表面电荷依赖性定位在纳米颗粒的毒性特征中起关键作用。具有正，负和中性的不同表面电荷的工程表面包覆的氧化铈纳米颗粒为正常和癌细胞系提供治疗结果。结果表明，具有阳性或中性电荷的纳米药物进入研究的大部分细胞系，而具有负电荷的纳米药物主要在癌细胞系中内化。此外，在进入细胞后，根据纳米颗粒的表面电荷，将纳米片定位于不同的细胞区室（例如细胞质和溶酶体）。纳米颗粒的内化和亚细胞定位在纳米颗粒细胞毒性谱中起关键作用，当它们定位在癌细胞系的溶酶体中时显示出显着的毒性。相比之下，当它们定位到细胞质中或不进入细胞时，观察到最小的毒性。

18. 发明授权

US09109249B2 Microbe detection via hybridizing magnetic relaxation nanosensors 有权
标题翻译：通过杂交磁弛豫纳米传感器进行微生物检测
公开(公告)号：US09109249B2
公开(公告)日：2015-08-18
申请号：US14118834
申请日：2012-05-21
申请人： Saleh Naser , J. Manuel Perez , Charalambos Kaittanis
发明人： Saleh Naser , J. Manuel Perez , Charalambos Kaittanis
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C12Q1/6825 , C12Q1/6816 , C12Q1/689 , C12Q2563/143 , C12Q2563/155 , C12Q2565/607
摘要： Disclosed herein are methods and materials for facilitating the detection of nucleic acid analytes of interest. Specifically exemplified herein are methods for detecting mycobacterial microorganisms, namely Mycobacterium avium spp. paratuberculosis. Also disclosed is new hybridizing magnetic relaxation nanosensor (hMRS) particularly adapted to detect a target nucleic acid analyte of interest.
摘要翻译：本文公开了用于促进感兴趣的核酸分析物的检测的方法和材料。本文具体举例说明检测分枝杆菌微生物，即鸟分枝杆菌（Mycobacterium avium spp）的方法。副结核病还公开了特别适合于检测感兴趣的靶核酸分析物的新的杂交磁性松弛纳米传感器（hMRS）。

19. 发明授权

US08817324B2 Method and system for aggregating print jobs 有权
标题翻译：聚合打印作业的方法和系统
公开(公告)号：US08817324B2
公开(公告)日：2014-08-26
申请号：US13700831
申请日：2010-06-11
申请人： Fabio Giannetti , Benjamin I. Dempster , Kok-Wei Koh , Alysha Naples , Jose Manuel Perez
发明人： Fabio Giannetti , Benjamin I. Dempster , Kok-Wei Koh , Alysha Naples , Jose Manuel Perez
IPC分类号： G06K15/00 , G06F3/12 , H04N1/00 , G06K15/02
CPC分类号： G06K15/024 , G06F3/1204 , G06F3/1251 , G06F3/1262 , G06F3/1264 , G06F3/1282
摘要： The present disclosure provides methods and systems for aggregating print jobs of different lengths and/or customers to decrease the need for rewinding and splicing operations. An exemplary embodiment provides a method that comprises identifying individual label-printing jobs (1-8) that can be aggregated onto a roll of substrate (302), and forming an aggregated label-printing job (300). In the aggregated label-printing job (300) a longest print job (8) is imposed adjacent to a first end of the roll of substrate (302), and one or more shorter print jobs (2, 5, 7) are imposed adjacent to the longest print job (8) in the direction of a second end of the roll of substrate (302).
摘要翻译：本公开提供了用于聚合不同长度和/或客户的打印作业的方法和系统，以减少对倒卷和拼接操作的需要。示例性实施例提供了一种方法，其包括识别可以聚集到基底卷（302）上的各个标签印刷作业（1-8），以及形成聚集的标签印刷作业（300）。在聚合标签打印作业（300）中，在基板卷（302）的第一端附近施加最长的打印作业（8），并且将相邻的一个或多个较短的打印作业（2,5,7）施加到最长的打印作业（8）在基板卷（302）的第二端的方向上。

20. 发明授权

US08772343B2 Chemical compounds 失效
标题翻译：化合物
公开(公告)号：US08772343B2
公开(公告)日：2014-07-08
申请号：US13808658
申请日：2011-07-06
申请人： Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Manuel Perez-Pacheco , David James Rawson , Robert Ian Storer , Nigel Alan Swain
发明人： Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Manuel Perez-Pacheco , David James Rawson , Robert Ian Storer , Nigel Alan Swain
IPC分类号： A01N41/06 , A61K31/18 , C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00
CPC分类号： A61K31/444 , A61K31/18 , A61K31/4164 , A61K31/4418 , A61K45/06 , C07C311/13 , C07C311/51 , C07D213/64 , C07D213/65 , C07D213/69 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D401/12
摘要： The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula 10 (I):(I) or a pharmaceutically acceptable salt thereof, wherein Z, R1, R2, R3, R4 and R5 are as defined in the description. Nav1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译：本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。更具体地，本发明涉及式10（I）：（I）的新型磺酰胺Nav1.7抑制剂或其药学上可接受的盐，其中Z，R1，R2，R3，R4和R5如说明书中所定义。 Nav1.7抑制剂可用于治疗各种各样的疾病，特别是疼痛。

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