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1. 发明授权

US09442110B2 Magnetic resonance system and method to detect and confirm analytes 有权
公开(公告)号：US09442110B2
公开(公告)日：2016-09-13
申请号：US12837308
申请日：2010-07-15
申请人： Suresh M. Menon , David E. Newman , Terry J. Henderson , J. Manuel Perez
发明人： Suresh M. Menon , David E. Newman , Terry J. Henderson , J. Manuel Perez
IPC分类号： G01N33/543 , G01N24/08 , G01R33/28 , G01R33/34 , G01R33/38 , G01R33/383 , G01R33/56
CPC分类号： G01N33/54333 , G01N24/08 , G01N24/084 , G01N33/54373 , G01R33/281 , G01R33/34053 , G01R33/3806 , G01R33/383 , G01R33/5601 , Y10S977/702 , Y10S977/773 , Y10S977/81 , Y10S977/92
摘要： A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the analyte.

2. 发明授权

US08795733B1 Cerium-oxide nanoparticle based device for the detection of reactive oxygen species and monitoring of chronic inflammation 有权
标题翻译：基于氧化铈纳米颗粒的器件，用于检测活性氧物质和监测慢性炎症
公开(公告)号：US08795733B1
公开(公告)日：2014-08-05
申请号：US13602611
申请日：2012-09-04
申请人： Jesus Manuel Perez , Charalambos Kaittanis , Atul Asati , Santimukul Santra
发明人： Jesus Manuel Perez , Charalambos Kaittanis , Atul Asati , Santimukul Santra
IPC分类号： A61K9/14
CPC分类号： A61K49/0093 , A61K49/0004 , A61K49/0054 , A61K49/1854 , A61K49/1857 , A61K49/1863
摘要： A polymer-coated cerium oxide based device and system is disclosed for detecting reactive oxygen species and monitoring chronic inflammation. The device and system encapsulate free therapeutic nanoparticle elements not present in a living body in a prosthetic or implantable unit. Embodiment one is a two-chamber structure with a reactive oxygen species (ROS) scavenging component on one end and at the opposite end is an imaging agent consisting of at least one of a fluorophore capable of fluorescence emission, a chemiluminescent agent, a magnetic relaxation agent and an X-ray contrast agent. Embodiment two is a single chamber device consisting of a multifunctional nanocomposite with a ROS-scavenging nanoparticle constituent (nanoceria) and a multimodal reporting nanoparticle component (i.e. Dex-IO-DiR). The device and system are utilized in treatment of diseases with a pro-inflammatory component, including, but not limited to, Crohn's disease, ulcerative colitis, inflammatory bowel disease, cystic fibrosis, arthritis, and cancer chemotherapy.
摘要翻译：公开了一种用于检测活性氧物质并监测慢性炎症的聚合物涂覆的氧化铈基装置和系统。该装置和系统封装在假体或可植入单元中不存在于生物体中的游离的治疗性纳米颗粒元件。实施方案一是在一端具有活性氧（ROS）清除组分的两室结构，相对端是由能够发荧光的荧光团，化学发光剂，磁弛豫中的至少一种构成的成像剂药剂和X射线造影剂。实施方案二是由具有ROS清除纳米颗粒组分（纳米碳）和多峰报告纳米颗粒组分（即Dex-IO-DiR）的多功能纳米复合材料组成的单室装置。该装置和系统用于治疗具有促炎成分的疾病，包括但不限于克罗恩病，溃疡性结肠炎，炎症性肠病，囊性纤维化，关节炎和癌症化疗。

3. 发明授权

US08795731B1 Cerium oxide nanoparticle-based device for the detection of reactive oxygen species and monitoring of chronic inflammation 有权
标题翻译：基于氧化铈纳米粒子的器件，用于检测活性氧物质和监测慢性炎症
公开(公告)号：US08795731B1
公开(公告)日：2014-08-05
申请号：US12924976
申请日：2010-10-08
申请人： Jesus Manuel Perez , Charalambos Kaittanis , Atul Asati , Santimukul Santra
发明人： Jesus Manuel Perez , Charalambos Kaittanis , Atul Asati , Santimukul Santra
IPC分类号： A61K9/14
CPC分类号： A61K49/0019 , A61B5/411 , A61B5/686 , A61K9/0024 , A61K9/5138 , A61K45/06 , A61K49/0032 , A61K49/0034
摘要： A polymer-coated cerium oxide based device and system is disclosed for detecting reactive oxygen species and monitoring chronic inflammation. The device and system encapsulate free therapeutic nanoparticle elements not present in a living body in a prosthetic or implantable unit. Embodiment one is a two-chamber structure with a reactive oxygen species (ROS) scavenging component on one end and at the opposite end is an imaging agent consisting of at least one of a fluorophore capable of fluorescence emission, a chemiluminescent agent, a magnetic relaxation agent and an X-ray contrast agent. Embodiment two is a single chamber device consisting of a multifunctional nanocomposite with a ROS-scavenging nanoparticle constituent (nanoceria) and a multimodal reporting nanoparticle component (i.e. Dex-IO-DiR). The device and system are utilized in treatment of diseases with a pro-inflammatory component, including, but not limited to, Crohn's disease, ulcerative colitis, inflammatory bowel disease, cystic fibrosis, arthritis, and cancer chemotherapy.
摘要翻译：公开了一种用于检测活性氧物质并监测慢性炎症的聚合物涂覆的氧化铈基装置和系统。该装置和系统封装在假体或可植入单元中不存在于生物体中的游离的治疗性纳米颗粒元件。实施方案一是在一端具有活性氧（ROS）清除组分的两室结构，相对端是由能够发荧光的荧光团，化学发光剂，磁弛豫中的至少一种构成的成像剂药剂和X射线造影剂。实施方案二是由具有ROS清除纳米颗粒组分（纳米碳）和多峰报告纳米颗粒组分（即Dex-IO-DiR）的多功能纳米复合材料组成的单室装置。该装置和系统用于治疗具有促炎成分的疾病，包括但不限于克罗恩病，溃疡性结肠炎，炎症性肠病，囊性纤维化，关节炎和癌症化疗。

4. 发明授权

US08685977B2 Chemical compounds 失效
标题翻译：化合物
公开(公告)号：US08685977B2
公开(公告)日：2014-04-01
申请号：US13179585
申请日：2011-07-11
申请人： Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot
发明人： Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot
IPC分类号： A01N43/58 , A61K31/50 , A01N43/40 , A61K31/435 , A01N43/56 , A61K31/415 , A01N43/36 , A61K31/40
CPC分类号： C07C311/51 , C07C2601/02 , C07D231/12 , C07D233/60 , C07D237/08
摘要： The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译：本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。更具体地，本发明涉及式（I）的新的磺酰胺Nav1.7抑制剂：或其药学上可接受的盐，其中Ar1，X，R1，R2，R3，R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。

5. 发明授权

US08333993B1 Synthesis of polymer coated ceria nanoparticles for biomedical applications 有权
标题翻译：用于生物医学应用的聚合物包被的二氧化铈纳米颗粒的合成
公开(公告)号：US08333993B1
公开(公告)日：2012-12-18
申请号：US11965343
申请日：2007-12-27
申请人： Jesus Manuel Perez , Atul Asati , Sudip Nath
发明人： Jesus Manuel Perez , Atul Asati , Sudip Nath
IPC分类号： A61K9/14
CPC分类号： A61K9/5161 , A61K33/00
摘要： Procedures and methods for synthesizing biodegradable polymer coated nanoceria result in stable nanoparticle preparations in aqueous systems and physiological relevant colloidal solutions, such as phosphate buffer saline. The coated nanoceria preparations increase the nanoparticle concentration in aqueous or colloidal solutions as most needed for antioxidant, free-radical scavenger, and autocatalytic biomedical applications, including, biological, pharmacological and potential clinical use. To meet this need, a facile synthetic procedure for preparation of a biodegradable polymer-coated nanoceria is disclosed; the preferred biodegradable polymer is dextran. The synthesis method occurs under ambient conditions in an aqueous phase without the use of surfactants and results in a monodispersed preparation that is dextran-coated as determined by dynamic light scattering (DLS). Preliminary characterization of polymer coated nanoceria by XPS, TEM, XRD, and the like shows that these nanoparticles have the necessary physical properties for the desired biological potency, such as Ce+4/Ce+3 mixed valence state.
摘要翻译：用于合成可生物降解的聚合物包衣纳米片的方法和方法导致水性体系中的稳定的纳米颗粒制剂和生理相关的胶体溶液，例如磷酸盐缓冲盐水。包被的纳米制品增加了水溶胶或胶体溶液中的纳米颗粒浓度，这是抗氧化剂，自由基清除剂和自动催化生物医学应用中最需要的，包括生物学，药理学和潜在的临床应用。为了满足这种需要，公开了一种用于制备可生物降解的聚合物包被的纳米抗菌剂的简便的合成方法; 优选的可生物降解的聚合物是葡聚糖。合成方法在环境条件下在水相中发生，而不使用表面活性剂，并导致通过动态光散射（DLS）测定的葡聚糖涂覆的单分散制剂。通过XPS，TEM，XRD等对聚合物包被的纳米片的初步表征显示，这些纳米颗粒具有所需的生物效能的物理性能，例如Ce + 4 / Ce + 3混合价态。

6. 发明申请

US20120270201A1 Dynamic User Interface for Use in an Audience Response System 审中-公开
标题翻译：用于受众响应系统的动态用户界面
公开(公告)号：US20120270201A1
公开(公告)日：2012-10-25
申请号：US13512479
申请日：2010-11-30
申请人： Christopher M. Cacioppo , Brian Prendergast , Manuel Perez
发明人： Christopher M. Cacioppo , Brian Prendergast , Manuel Perez
IPC分类号： G09B5/04
摘要： An audience response system with dynamic user interfaces and methods of using such an audience response system. The audience response system includes a wireless aggregation point and multiple remote handsets communicatively coupled to that wireless aggregation point. The remote handsets may be used (e.g., by students) to answer questions (e.g., posed by a teacher). At least some of the remote handsets may include user interfaces that include user input interface elements that are configurable via the wireless aggregation point. Additionally, the user interfaces of at least some of the remote handsets may provide feedback to the students regarding their interaction with the remote handsets.
摘要翻译：具有动态用户界面的观众响应系统和使用这样的观众响应系统的方法。观众响应系统包括通信地耦合到该无线聚合点的无线聚合点和多个远程手机。可以使用远程手机（例如，由学生）来回答问题（例如由教师提出的）。远程手机中的至少一些可以包括包括可经由无线聚合点配置的用户输入接口元件的用户界面。此外，远程手机中的至少一些的用户界面可以向学生提供与远程手机的交互的反馈。

7. 外观设计

USD656095S1 Tray 有权
公开(公告)号：USD656095S1
公开(公告)日：2012-03-20
申请号：US29352988
申请日：2009-12-30
申请人： Christopher M. Cacioppo , Manuel Perez , Hector Padilla , Timothy Higgins , Louis Frank Genatossio , Rick Burnham , Dan DeOreo
设计人： Christopher M. Cacioppo , Manuel Perez , Hector Padilla , Timothy Higgins , Louis Frank Genatossio , Rick Burnham , Dan DeOreo

8. 发明申请

US20110012596A1 Magnetic Resonance System and Method To Detect and Confirm Analytes 有权
标题翻译：磁共振系统和检测和确认分析物的方法
公开(公告)号：US20110012596A1
公开(公告)日：2011-01-20
申请号：US12837308
申请日：2010-07-15
申请人： Suresh M. Menon , David E. Newman , Terry J. Henderson , J. Manuel Perez
发明人： Suresh M. Menon , David E. Newman , Terry J. Henderson , J. Manuel Perez
IPC分类号： G01R33/44
CPC分类号： G01N33/54333 , G01N24/08 , G01N24/084 , G01N33/54373 , G01R33/281 , G01R33/34053 , G01R33/3806 , G01R33/383 , G01R33/5601 , Y10S977/702 , Y10S977/773 , Y10S977/81 , Y10S977/92
摘要： A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the analyte.
摘要翻译：提供了一种基于磁共振测量来检测目标分析物的系统和方法。磁性结构产生具有与分析物相当的尺寸的不同的磁场区域。当分析物结合在那些区域时，来自样品的磁共振信号发生变化，导致分析物的检测。

9. 发明授权

US07781228B2 Magnetic resonance system and method to detect and confirm analytes 有权
标题翻译：磁共振系统和方法来检测和确认分析物
公开(公告)号：US07781228B2
公开(公告)日：2010-08-24
申请号：US11335995
申请日：2006-01-20
申请人： Suresh M. Menon , David E. Newman , Terry J. Henderson , J. Manuel Perez
发明人： Suresh M. Menon , David E. Newman , Terry J. Henderson , J. Manuel Perez
IPC分类号： G01N27/00 , G01N33/553
CPC分类号： G01N33/54333 , G01N24/08 , G01N24/084 , G01N33/54373 , G01R33/281 , G01R33/34053 , G01R33/3806 , G01R33/383 , G01R33/5601 , Y10S977/702 , Y10S977/773 , Y10S977/81 , Y10S977/92
摘要： A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the analyte.
摘要翻译：提供了一种基于磁共振测量来检测目标分析物的系统和方法。磁性结构产生具有与分析物相当的尺寸的不同的磁场区域。当分析物结合在那些区域时，来自样品的磁共振信号发生变化，导致分析物的检测。

10. 发明授权

US5592666A Method and system for storing and retrieving data from a multidimensional array using database pointers 失效
标题翻译：使用数据库指针从多维数组中存储和检索数据的方法和系统
公开(公告)号：US5592666A
公开(公告)日：1997-01-07
申请号：US331914
申请日：1994-10-31
申请人： Manuel Perez
发明人： Manuel Perez
IPC分类号： G06F17/30 , G06F12/00
CPC分类号： G06F17/30961 , Y10S707/99943
摘要： A system and method for storing within, and retrieving from, a computer database values of a multidimensional array in which storage locations are allocated within each storage node of the database corresponding to a dimension of the array only for the database-pointers actually stored within the storage node. An indicium is stored with each database-pointer to identify the element of the array's dimension to which the database-pointer corresponds. In an alternative embodiment, a sub-storage area, with sub-storage locations allocated for each of the elements of the dimension to which the storage node corresponds, is associated with each storage node, and an indicium is stored within each sub-storage location indicating whether a database-pointer exists in the associated storage node corresponding to the associated element. A hierarchial table of calculation rules also is provided for determining values which are calculated from other values within the array. Each of the table's rules defines one or more storage locations within the array and provides a formula for calculating the values applicable to those locations.
摘要翻译：一种用于在计算机数据库内存储数据库数据库的系统和方法，其中存储位置在数据库的每个存储节点内被分配给数据库的维度中仅存储在数据库指针内的多维数组值存储节点。与每个数据库指针一起存储一个标记，以标识数据库指针对应的数组的维度的元素。在替代实施例中，具有为存储节点对应的维度的每个元素分配的子存储位置的子存储区域与每个存储节点相关联，并且将标记存储在每个子存储位置指示相关联的存储节点中是否存在数据库指针。还提供了计算规则的分层表，用于确定从阵列内的其他值计算的值。每个表的规则定义阵列中的一个或多个存储位置，并提供计算适用于这些位置的值的公式。

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