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11. 发明授权

US06440987B1 Antipruritic 有权
标题翻译：止痒药
公开(公告)号：US06440987B1
公开(公告)日：2002-08-27
申请号：US09970978
申请日：2001-10-04
申请人： Hiroshi Nagase , Takashi Endoh , Toshiaki Tanaka , Kuniaki Kawamura
发明人： Hiroshi Nagase , Takashi Endoh , Toshiaki Tanaka , Kuniaki Kawamura
IPC分类号： A61K31485
CPC分类号： A61K31/541 , A61K31/40 , A61K31/4025 , A61K31/435 , A61K31/485 , A61K31/5377 , C07D489/00 , C07D489/08
摘要： This invention provides an antipuritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphian quaternary ammonium salt derivative and a new morphian-N-oxide derivative which are useful in treating puritus complicated with some diseases.
摘要翻译：本发明提供了含有鸦片类κ受体激动剂作为有效成分的抗炎药，可用于治疗与某些疾病并发的荨麻疹的新的吗啉季铵盐衍生物和新的吗啉-N-氧化物衍生物。

12. 发明授权

US5348080A Latent heat storage apparatus and latent heat storage solution therefor 失效
标题翻译：潜热储存装置及潜热储存解决方案
公开(公告)号：US5348080A
公开(公告)日：1994-09-20
申请号：US808718
申请日：1991-12-17
申请人： Syoichi Kuroda , Soichiro Shibata , Nonyuki Shimamura , Shigetake Kawasaki , Keisuke Kasahara , Seiichi Sakuma , Fujio Komatsu , Masaya Ishikawa , Kunio Sugiyama , Mitsuo Mashimo , Yuzuru Shindo , Kuniaki Kawamura
发明人： Syoichi Kuroda , Soichiro Shibata , Nonyuki Shimamura , Shigetake Kawasaki , Keisuke Kasahara , Seiichi Sakuma , Fujio Komatsu , Masaya Ishikawa , Kunio Sugiyama , Mitsuo Mashimo , Yuzuru Shindo , Kuniaki Kawamura
IPC分类号： C09K5/02 , C09K5/06 , F25D16/00 , F28D20/00 , F28D20/02 , F25D17/02 , F28D21/00
CPC分类号： F25D16/00 , C09K5/063 , Y02E60/147
摘要： A latent heat storage apparatus is provided and a latent heat storage solution therefor stores and retrieves a cool heat substantially in or from a latent heat thereof necessary for air conditioning, cooling, refrigerating, and so forth. The latent heat storage apparatus has an aqueous solution of a plurality of inorganic salts as a latent heat storage solution in a heat storage tank, formed to retrieve a cold heat from a stored latent heat, the latent heat storage apparatus. The latent heat storage solution is formed of (N-1) kinds of inorganic salts in at least an N-component aqueous solution where N.gtoreq.3. The latent heat storage solution stores the cold heat as the latent heat thereof. The cold heat is retrievable from the stored latent heat at a desired temperature almost invariably within a range higher than the N-component eutectic point and lower than any one of binary eutectic points of salts with water. The concentration of each inorganic salt in the aqueous solution is represented in a tortuous eutectic plane including ice point of the N-component equilibria diagram, wherein the concentration range allows the cold heat to be retrieved at the specified temperature almost invariably from the latent heat of ice, binary eutectics with water and inorganic salts, or separated substances.
摘要翻译：提供了一种潜热蓄热装置，其潜热蓄热液储存和取出基本上在空调，冷却，冷藏等所需的潜热中或从其中提取冷热。潜热蓄热装置具有多个无机盐的水溶液作为蓄热池中的潜热储存溶液，其形成为从存储的潜热中回收冷热，潜热蓄热装置。潜热蓄积溶液由至少N = 3的N-成分水溶液中的（N-1）种无机盐形成。潜热储存溶液将冷热作为其潜热存储。冷热可以从所存储的潜热在所需温度下几乎总是在高于N-组分共晶点的范围内回收，并且低于任何一种与水的盐的二价共晶点。水溶液中的每种无机盐的浓度在包括N-组分平衡图的冰点的曲折共晶平面中表示，其中浓度范围允许冷热在规定温度下几乎总是从潜热冰，二元共晶与水和无机盐，或分离的物质。

13. 发明授权

US08637539B2 Remedies for neuropathic pain and model animals of neuropathic pain 有权
标题翻译：神经性疼痛和模型动物的神经性疼痛的补救措施
公开(公告)号：US08637539B2
公开(公告)日：2014-01-28
申请号：US11206489
申请日：2005-08-18
申请人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
发明人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： A61K31/485 , A61K31/4745 , C07D489/08
摘要： The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.
摘要翻译：本发明涉及神经性疼痛治疗剂，其含有作为活性成分的通式（I）表示的化合物或其药理学上可接受的酸加成盐：（其中R1，R2，R3，R4，R5，R6， R7，R8，A和B具有与说明书中描述的定义相同的定义）和通过给予（+） - 4a-（3-羟基苯基）-2-甲基-1,2,3,4 ，4a，5,12,12a-八氢 - 反 - 喹啉并[2,3-g]异喹啉。本发明使得可以进行神经性疼痛的药物治疗。也可以评价化合物对神经性疼痛的治疗效果。

14. 发明授权

US08470845B2 Analgesic and methods of treating pain 有权
标题翻译：止痛药和治疗疼痛的方法
公开(公告)号：US08470845B2
公开(公告)日：2013-06-25
申请号：US11667136
申请日：2005-11-04
申请人： Naoki Izumimoto , Kuniaki Kawamura , Toshikazu Komagata , Tadatoshi Hashimoto , Hiroshi Nagabukuro
发明人： Naoki Izumimoto , Kuniaki Kawamura , Toshikazu Komagata , Tadatoshi Hashimoto , Hiroshi Nagabukuro
IPC分类号： A61K31/44 , C07D221/22
CPC分类号： C07D489/08 , A61K31/485
摘要： An analgesic which may be applied to wide variety of pain from various causes is disclosed. The analgesic comprises as an effective ingredient a specific morphinan derivative having a nitrogen containing heterocyclic group, such as compound 1:
摘要翻译：公开了可以应用于各种原因的多种疼痛的止痛剂。止痛剂包含具有含氮杂环基的具体吗啡喃衍生物作为有效成分，例如化合物1：

15. 发明授权

US07370481B2 Apparatus and method for cooling super conductive body 失效
标题翻译：用于冷却超导体的装置和方法
公开(公告)号：US07370481B2
公开(公告)日：2008-05-13
申请号：US11532527
申请日：2006-09-16
申请人： Kuniaki Kawamura , Akito Machida , Masamitsu Ikeuchi , Kazuhiro Hattori , Kouichi Matsuo , Hideharu Yanagi
发明人： Kuniaki Kawamura , Akito Machida , Masamitsu Ikeuchi , Kazuhiro Hattori , Kouichi Matsuo , Hideharu Yanagi
IPC分类号： F17C5/00 , F25D23/12 , H01B12/00 , H01F6/06
CPC分类号： F25J1/0015 , F25C1/00 , F25D3/10 , F25J1/0221 , F25J1/0251 , F25J1/0276 , F25J2205/20 , F25J2205/30 , F25J2205/90 , F25J2210/42 , F25J2240/60
摘要： Liquid nitrogen is filled in a low temperature vessel; an ejector that sucks liquid nitrogen by blowing a cooling agent (liquid or gas) such as low temperature helium gas or liquid helium of pressure higher than in the space within the vessel is disposed in the vessel; the liquid nitrogen blown with the cooling agent is cooled by the cooling agent to become fine particles of solid nitrogen which fall down; and gas in a space of the vessel is discharged out of the vessel so as to maintain the pressure of the space higher than the atmospheric pressure. A gaseous phase of liquid nitrogen in an adiabatic vessel is depressurized to vaporize nitrogen in a liquid phase so that the temperature of the nitrogen reaches the triple point of nitrogen by lowering the temperature to thereby produce solid nitrogen by keeping the temperature at the triple point, and that the produced solid nitrogen is transformed into slush by stirring the content of the adiabatic vessel. A super conductive body formed of a material exhibiting a state of super conductance in the vicinity of the temperature of liquid nitrogen or of the temperature where liquid nitrogen and solid nitrogen coexist can be cooled by immersing the body in slush nitrogen held in an adiabatic vessel or flowing in an adiabatic pipe.
摘要翻译：液氮填充在低温容器中; 喷射器通过吹送诸如低温氦气或低于容器内的空间的压力的液氦的冷却剂（液体或气体）而吸入液氮; 用冷却剂吹入的液氮被冷却剂冷却，成为脱落的固体氮的细小颗粒; 并且将容器的空间中的气体排出容器，以保持空间的压力高于大气压力。将绝热容器中的氮气气相减压以使液相中的氮气蒸发，使得氮气的温度通过降低温度而达到氮的三重点，从而通过将温度保持在三重点来产生固体氮，并且通过搅拌绝热容器的内容物将所产生的固体氮转变成泥浆。在液氮温度附近或液氮和固态氮共存的温度下表现出超导状态的材料形成的超导体可以通过将本体浸入保持在绝热容器中的冰冷氮气中来冷却，或在绝热管中流动。

16. 发明授权

US06323212B1 Morphinan derivative and its pharmaceutical applications 失效
公开(公告)号：US06323212B1
公开(公告)日：2001-11-27
申请号：US08108643
申请日：1997-02-10
申请人： Hiroshi Nagase , Koji Kawai , Kuniaki Kawamura , Jun Hayakawa , Takashi Endoh
发明人： Hiroshi Nagase , Koji Kawai , Kuniaki Kawamura , Jun Hayakawa , Takashi Endoh
IPC分类号： C07D48900
CPC分类号： C07D405/12 , C07D409/12 , C07D413/12 , C07D489/08
摘要： A morphinan derivative or its pharmacologically allowed acid addition salt represented with compound I, an analgesic and diuretic having its derivative or its salt as the active ingredient, and its production process are described. The compound of the present invention possesses strong analgesic activity and diuretic action as a highly selective &kgr;-opioid agonist, allowing it to be used as a useful analgesic and diuretic.

17. 发明授权

US5688433A Ammonia refrigerating machine, working fluid composition and method 失效
标题翻译：氨制冷机，工作液组成及方法
公开(公告)号：US5688433A
公开(公告)日：1997-11-18
申请号：US675513
申请日：1996-07-03
申请人： Keisuke Kasahara , Kuniaki Kawamura , Takashi Kaimai , Hisashi Yano
发明人： Keisuke Kasahara , Kuniaki Kawamura , Takashi Kaimai , Hisashi Yano
IPC分类号： C09K5/04 , C10M107/34 , C10M171/00 , F25B1/00 , F25B31/00 , C10M105/18
CPC分类号： C10M107/34 , C10M171/008 , F25B31/002 , C10M2209/107 , C10N2240/00 , C10N2240/22 , C10N2240/30 , C10N2240/50 , C10N2240/52 , C10N2240/54 , C10N2240/56 , C10N2240/58 , C10N2240/60 , C10N2240/66 , F25B2400/13 , F25B2400/23
摘要： The present invention provides a working fluid composition for a refrigerating machine obtained by mixing an ammonia refrigerant with a lubricating oil which is extremely excellent in solubility with the ammonia refrigerant, and a method for lubricating a refrigerating machine suitable for the use of the working fluid composition. The working fluid composition comprises a mixture of ammonia and one or more kinds of polyether compounds represented by the formula (I); the refrigerating machine is characterized by constituting a refrigerating cycle or a heat pump cycle through which the working fluid composition is circulated; and the method for lubricating a refrigerating compressor is characterized by lubricating the ammonia refrigerant compressor with the lubricating oil comprising one or more kinds of ether compounds represented by the formula (I) R.sub.1 --�--O--(PO).sub.m --(EO).sub.n --R.sub.2 !.sub.x (I) wherein R.sub.1 is a hydrocarbon group having 1 to 6 carbon atoms, R.sub.2 is an alkyl group having 1 to 6 carbon atoms, PO is an oxypropylene group, EO is an oxyethylene group, x is an integer of from 1 to 4, m is a positive integer, and n is 0 or a positive integer.
摘要翻译： PCT No.PCT / JP92 / 01551 Sec。 371日期1994年1月7日 102（e）日期1994年1月7日PCT 1991年11月27日PCT公布。第WO94 / 12594号公报日本1994年6月9日本发明提供了一种通过将氨制冷剂与氨制冷剂的溶解度极好的润滑油混合而获得的制冷机的工作流体组合物，以及适用于使用的冷冻机的润滑方法的工作流体组成。工作流体组合物包含氨和由式（I）表示的一种或多种聚醚化合物的混合物; 制冷机的特征在于构成工作流体组合物循环的制冷循环或热泵循环; 冷冻压缩机的润滑方法的特征在于，利用含有式（I）表示的一种或多种醚化合物的润滑油润滑氨制冷剂压缩机R1 - [ - O-（PO）m-（EO）n -R2] x（I）其中R1是具有1至6个碳原子的烃基，R2是具有1至6个碳原子的烷基，PO是氧化丙烯基，EO是氧化乙烯基，x是从 1〜4，m为正整数，n为0或正整数。

18. 发明授权

US5651257A Working fluid composition and method for lubricating ammonia refrigerating machine 失效
标题翻译：氨制冷机润滑油的组成及工作方法
公开(公告)号：US5651257A
公开(公告)日：1997-07-29
申请号：US469707
申请日：1995-06-06
申请人： Keisuke Kasahara , Kuniaki Kawamura , Takashi Kaimai , Hisashi Yano
发明人： Keisuke Kasahara , Kuniaki Kawamura , Takashi Kaimai , Hisashi Yano
IPC分类号： C10M107/34 , C10M171/00 , F25B1/10 , F25B9/00 , F25B31/00 , F25B39/02 , F25B40/00 , F25B43/02
CPC分类号： C10M107/34 , C10M171/008 , F25B31/002 , C10M2209/105 , C10M2209/107 , C10N2220/02 , C10N2240/00 , C10N2240/22 , C10N2240/30 , C10N2240/50 , C10N2240/52 , C10N2240/54 , C10N2240/56 , C10N2240/58 , C10N2240/60 , C10N2240/66 , F25B1/10 , F25B2400/13 , F25B2400/23 , F25B39/02 , F25B40/00 , F25B9/002
摘要： The present invention provides a working fluid composition for a refrigerating machine obtained by mixing an ammonia refrigerant with a lubricating oil which is extremely excellent in solubility with the ammonia refrigerant. The working fluid composition comprises a mixture of ammonia and one or more kinds of polyether compounds; the refrigerating machine is characterized by constituting a refrigerating cycle or a heat pump cycle through which the working fluid composition is circulated.
摘要翻译：本发明提供了一种制冷机的工作流体组合物，其通过将氨制冷剂与与氨制冷剂的溶解度极好的润滑油混合而获得。工作流体组合物包含氨和一种或多种聚醚化合物的混合物; 制冷机的特征在于构成工作流体组合物循环的制冷循环或热泵循环。

19. 发明授权

US07652025B2 Remedies for sepsis 失效
标题翻译：败血症的治疗方法
公开(公告)号：US07652025B2
公开(公告)日：2010-01-26
申请号：US10477062
申请日：2002-05-08
申请人： Tomohiko Suzuki , Hideaki Inada , Yoshitaka Yoshizawa , Kuniaki Kawamura , Toshiaki Tanaka
发明人： Tomohiko Suzuki , Hideaki Inada , Yoshitaka Yoshizawa , Kuniaki Kawamura , Toshiaki Tanaka
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： A61K31/40 , A61K31/485 , A61K38/00 , C07D489/08 , C07K5/1016
摘要： A therapeutic agent for sepsis and various symptoms accompanying sepsis (such as septic shock, disseminated intravascular coagulation syndrome, adult respiratory distress syndrome and multiple organ dysfunction) is disclosed. The therapeutic agent for sepsis according to the present invention comprises as an effective ingredient an opioid κ receptor agonist compound such as (−)-17-(cyclopropylmethyl)-3,14β-dihydroxy-4,5α-epoxy-6β[N-methyl-trans-3-(3-furyl)acrylamide] oxide derivative. The opioid κ receptor agonist compound may be administered as it is or in the form of a pharmaceutical composition prepared by mixing the compound with a known pharmaceutically acceptable acid, carrier or vehicle orally or parenterally.
摘要翻译：公开了脓毒症和伴随脓毒症的各种症状的治疗剂（例如脓毒性休克，弥散性血管内凝血综合征，成人呼吸窘迫综合征和多器官功能障碍）。根据本发明的败血症治疗剂包括作为有效成分的阿片样物质κ受体激动剂化合物，例如（ - ） - 17-（环丙基甲基）-3,14β-二羟基-4,5α-环氧-6β-[N-甲基（3-呋喃基）丙烯酰胺]氧化物衍生物。阿片样物质κ受体激动剂化合物可以原样或以通过将化合物与已知的药学上可接受的酸，载体或载体口服或胃肠外混合制备的药物组合物的形式进行给药。

20. 发明授权

US06583151B2 Remedies for drug addiction 有权
标题翻译：药物成瘾的补救措施
公开(公告)号：US06583151B2
公开(公告)日：2003-06-24
申请号：US09297364
申请日：1999-07-12
申请人： Hiroshi Nagase , Takashi Endoh , Tsutomu Suzuki , Kuniaki Kawamura , Koji Oshima , Hideaki Inada
发明人： Hiroshi Nagase , Takashi Endoh , Tsutomu Suzuki , Kuniaki Kawamura , Koji Oshima , Hideaki Inada
IPC分类号： A61K314748
CPC分类号： A61K31/485 , C07D489/08
摘要： A method for treating drug dependence comprising administering, as the active ingredient, an opioid &kgr; receptor agonist of a compound represented by the following formula, is disclosed wherein A and the R terms are herein defined.
摘要翻译：一种治疗药物依赖性的方法，包括给予作为活性成分的由下式表示的化合物的阿片样物质κ受体激动剂，其中A和R术语在本文中定义。

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