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11. 发明授权

US07582486B2 Double resonance interrogation of grating-coupled waveguides 失效
标题翻译：光栅耦合波导的双共振询问
公开(公告)号：US07582486B2
公开(公告)日：2009-09-01
申请号：US11820068
申请日：2007-06-18
申请人： Jacques Gollier , Eric J. Mozdy , Garrett A. Piech
发明人： Jacques Gollier , Eric J. Mozdy , Garrett A. Piech
IPC分类号： G01N33/543
CPC分类号： G01N21/7743 , Y10S436/805
摘要： A method for using a double resonance effect within a grating-coupled waveguide (GCW) sensor, as generated from a light beam with a given span of wavelengths or angles, is provided. The method can be used for label-independent detection of biological and chemical agents, to interrogate biological-binding events or chemical reactions within a sensing region at increased sensitivity, and with decreased sensitivity to environmental perturbations. Also described is an optical interrogation system incorporating the method.
摘要翻译：提供了从具有给定的波长或角度的光束产生的在光栅耦合波导（GCW）传感器内使用双重共振效应的方法。该方法可用于生物和化学试剂的标签无关检测，以增加的灵敏度询问感测区域内的生物结合事件或化学反应，并且对环境扰动的敏感性降低。还描述了结合该方法的光学询问系统。

12. 发明授权

US07349590B2 Polarization modulation interrogation of grating-coupled waveguide sensors 失效
标题翻译：光栅耦合波导传感器的极化调制询问
公开(公告)号：US07349590B2
公开(公告)日：2008-03-25
申请号：US11236060
申请日：2005-09-26
申请人： Eric J. Mozdy
发明人： Eric J. Mozdy
IPC分类号： G02B6/00
CPC分类号： G01N21/7743 , G01N21/21 , G01N21/253 , G01N33/54373
摘要： An optical interrogation system and a GCW sensor are described herein that are used to determine whether a biological substance (e.g., cell, molecule, protein, drug) is located in a sensing region of the GCW sensor. The optical interrogation system includes a light source, a polarization modulator and a detection system. The light source outputs a polarized light beam and the polarization modulator modulates the polarized light beam and outputs a polarization-modulated light beam. The GCW sensor receives and converts the polarization-modulated light beam into an amplitude modulated light beam that is directed towards the detection system. The detection system receives the amplitude modulated light beam and demodulates the received amplitude modulated light beam by responding to signals at a modulation frequency of the polarization-modulated light beam and ignoring noise affecting the signals outside the modulation frequency to detect a resonant condition (e.g., resonant angle, resonant wavelength). The detected resonant condition that has a one-to-one relationship with the refractive index of the superstrate containing the biological substance is analyzed to determine whether or not the biological substance is located in the sensing region of the GCW sensor.
摘要翻译：本文描述了用于确定生物物质（例如，细胞，分子，蛋白质，药物）是否位于GCW传感器的感测区域中的光学询问系统和GCW传感器。光学询问系统包括光源，偏振调制器和检测系统。光源输出偏振光束，偏振光调制器调制偏振光束并输出偏振调制光束。 GCW传感器将偏振调制光束接收并转换成朝向检测系统的幅度调制光束。检测系统接收幅度调制光束并通过响应于偏振调制光束的调制频率处的信号来解调所接收的幅度调制光束，并且忽略影响调制频率之外的信号的噪声以检测谐振条件（例如，谐振角，谐振波长）。分析与包含生物物质的覆盖物的折射率具有一对一关系的检测到的共振条件，以确定生物物质是否位于GCW传感器的感测区域中。

13. 发明授权

US06865303B2 Method and apparatus for reducing multi-path interference in dispersion compensation systems 失效
标题翻译：用于减小色散补偿系统中的多径干扰的方法和装置
公开(公告)号：US06865303B2
公开(公告)日：2005-03-08
申请号：US10178800
申请日：2002-06-24
申请人： Eric J. Mozdy , William A. Wood
发明人： Eric J. Mozdy , William A. Wood
IPC分类号： H04B10/18 , G02F1/035
CPC分类号： G02B6/02261 , G02B6/0228 , G02B6/03633 , H04B10/2537
摘要： An optical apparatus comprises a dispersion compensating optical waveguide, and an optical pump that pumps the dispersion compensating optical waveguide with light. The light from the pump provides suitable selective gain to a fundamental mode of the dispersion compensating optical waveguide that multi-path interference is substantially reduced.A method of reducing multi-path interference comprises pumping a dispersion compensating optical waveguide with light to provide suitable selective gain to a fundamental mode of the dispersion compensating optical waveguide so that MPI from said dispersion compensating optical waveguide is significantly reduced.
摘要翻译：光学装置包括色散补偿光波导，以及用光泵浦色散补偿光波导的光泵。来自泵的光为色散补偿光波导的基本模式提供适当的选择增益，多径干涉被显着减小。一种减少多径干涉的方法包括用光泵浦色散补偿光波导以提供合适的选择增益到色散补偿光波导的基本模式，使得来自所述色散补偿光波导的MPI显着降低。

14. 发明授权

US07871811B2 Method for eliminating crosstalk between waveguide grating-based biosensors located in a microplate and the resulting microplate 失效
标题翻译：用于消除位于微板中的基于波导光栅的生物传感器与所得微板之间的串扰的方法
公开(公告)号：US07871811B2
公开(公告)日：2011-01-18
申请号：US11101096
申请日：2005-04-07
申请人： Ye Fang , Ann M. Ferrie , Norman H. Fontaine , Anthony G. Frutos , Eric J. Mozdy , Chuan-Che Wang , Po Ki Yuen
发明人： Ye Fang , Ann M. Ferrie , Norman H. Fontaine , Anthony G. Frutos , Eric J. Mozdy , Chuan-Che Wang , Po Ki Yuen
IPC分类号： C12M1/00 , C12Q1/68 , G01N1/00
CPC分类号： G01N21/7743 , G01N21/253
摘要： The present invention includes several methods for modifying the current processes of manufacturing optical sensing microplates that use continuous waveguide films to reduce/eliminate crosstalk between the biosensors that are incorporated within wells. The methods include (1) physically deteriorating/removing the waveguide film between individual biosensors; (2) chemically depositing highly absorbing materials within the waveguide film between individual biosensors; (3) patterning disordered (scattering) regions between the diffraction gratings that define individual biosensors; (4) using a specific mask and depositing individual patches of waveguide film, where each patch defines at least one biosensor. Each of these methods and several other methods described herein prevent the propagation of light between individual sensing regions, thereby eliminating optical crosstalk between the biosensors. The present invention also includes the resulting microplate.
摘要翻译：本发明包括几种用于修改制造光学感测微板的当前工艺的方法，其使用连续波导膜来减少/消除结合在孔内的生物传感器之间的串扰。所述方法包括（1）在各个生物传感器之间物理劣化/去除波导膜; （2）在各个生物传感器之间在波导膜内化学沉积高吸收材料; （3）在限定单个生物传感器的衍射光栅之间图形化无序（散射）区域; （4）使用特定掩模并沉积波导膜的各个贴片，其中每个贴片限定至少一个生物传感器。这些方法和本文所描述的其它方法中的每一种都防止光在各个感测区域之间的传播，从而消除了生物传感器之间的光学串扰。本发明还包括所得到的微孔板。

15. 发明申请

US20080207466A1 System for high throughput GPCR functional assay 失效
标题翻译：高通量GPCR功能测定系统
公开(公告)号：US20080207466A1
公开(公告)日：2008-08-28
申请号：US11893506
申请日：2007-08-16
申请人： Eric J. Mozdy , Hui Su , Qi Wu
发明人： Eric J. Mozdy , Hui Su , Qi Wu
IPC分类号： C40B30/10 , C40B60/12
CPC分类号： C40B60/12 , C40B30/10
摘要： A functional assay detection system for membrane bound proteins. The system comprises a biological array including a porous substrate having a plurality of membranes adhered thereto and a first side and a second side, a fluorescent labeling reagent configured to couple to the membrane bound proteins, a pulsed light assembly configured to excite the fluorescent labeling reagent, and a time-delayed imaging device configured to capture emitted fluorescence of the fluorescent labeling reagent. The pulsed light assembly is configured to excite the fluorescent labeling reagent from at least one of the first side and the second side of the porous substrate, and the fluorescent labeling reagent comprises a fluorophore that has an emission lifetime that is in the range of microseconds.
摘要翻译：用于膜结合蛋白的功能测定检测系统。该系统包括生物阵列，其包括多孔基底，其具有附着于其上的多个膜，第一侧和第二侧，构造成耦合到膜结合蛋白的荧光标记试剂;脉冲光组件，其被配置为激发荧光标记试剂以及被配置为捕获荧光标记试剂的发射荧光的时间延迟成像装置。脉冲光组件被配置为从多孔基底的第一侧和第二侧中的至少一个激发荧光标记试剂，并且荧光标记试剂包含具有在微秒范围内的发光寿命的荧光团。

16. 发明授权

US07286221B2 Arrayed sensor measurement system and method 失效
标题翻译：阵列传感器测量系统及方法
公开(公告)号：US07286221B2
公开(公告)日：2007-10-23
申请号：US11019439
申请日：2004-12-21
申请人： Stephen J. Caracci , Norman H. Fontaine , Eric J. Mozdy , Po Ki Yuen
发明人： Stephen J. Caracci , Norman H. Fontaine , Eric J. Mozdy , Po Ki Yuen
IPC分类号： G01J3/00
CPC分类号： G01N21/253 , G01N2201/04 , G01N2201/10 , G02B27/1086
摘要： Optical interrogation systems and methods are described herein that are capable of measuring the angles (or changes in the angles) at which light reflects, transmits, scatters, or is emitted from an array of sensors or specimens that are distributed over a large area 2-dimensional array.
摘要翻译：本文描述了光学询问系统和方法，其能够测量光从其分布在大面积上的传感器或样本阵列2反射，透射，散射或发射的角度（或角度变化）维数组。

17. 发明授权

US07136550B2 Single-fiber launch/receive system for biosensing applications 失效
公开(公告)号：US07136550B2
公开(公告)日：2006-11-14
申请号：US10977520
申请日：2004-10-28
申请人： Eric J. Mozdy
发明人： Eric J. Mozdy
IPC分类号： G02B6/00 , G02B6/26 , G02B6/42
CPC分类号： G01N21/253 , G02B6/02 , G02B6/4246
摘要： An interrogation system and method are described herein which use a single-fiber launch/receive system for interrogating a biosensor (optical sensor) to detect the occurrence of a bio-chemical interaction (e.g., biological binding of ligands with analytes). In one embodiment, the single-fiber launch/receive system utilizes a multimode fiber to help interrogate the biosensor. In another embodiment, the single-fiber launch/receive system utilizes a downjacketed singlemode fiber to help interrogate the biosensor.

18. 发明授权

US06985664B2 Substrate index modification for increasing the sensitivity of grating-coupled waveguides 失效
标题翻译：用于增加光栅耦合波导的灵敏度的基板索引修改
公开(公告)号：US06985664B2
公开(公告)日：2006-01-10
申请号：US10632276
申请日：2003-08-01
申请人： Stephen J. Caracci , Mircea Despa , Eric J. Mozdy , Mark D. Salik
发明人： Stephen J. Caracci , Mircea Despa , Eric J. Mozdy , Mark D. Salik
IPC分类号： G02B6/10
CPC分类号： G01N21/7743
摘要： A grating-coupled waveguide (GCW) and a method are described herein that can be used to detect the presence of a biological substance (e.g., cell, drug, chemical compound) in a sensing region of the GCW. The GCW includes a substrate, a diffraction grating and a waveguide film that has a higher index of refraction than the substrate which has an index of refraction≦1.5. The relatively low-index substrate effectively increases the sensitivity of the GCW by causing the waveguide mode to shift towards a biological substance located in a sensing region above the waveguide film, thereby increasing the field strength of the mode's evanescent tail in this region. In one embodiment, an array of the GCWs are incorporated within the wells of a microplate.
摘要翻译：本文描述了可用于检测GCW感测区域中生物物质（例如细胞，药物，化合物）的存在的光栅耦合波导（GCW）和方法。 GCW包括具有比折射率<= 1.5的衬底更高的折射率的衬底，衍射光栅和波导膜。相对低折射率的衬底通过使波导模式朝向位于波导膜上方的感测区域中的生物物质移动，从而有效地增加了GCW的灵敏度，从而增加了该区域中模式的渐逝尾部的场强。在一个实施方案中，将GCW的阵列并入微板的孔内。

19. 发明授权

US5377348A System for searching a data base by creating a marking matrix in which two dimensional patterns control the search and selection 失效
标题翻译：用于通过创建其中二维模式控制搜索和选择的标记矩阵来搜索数据库的系统
公开(公告)号：US5377348A
公开(公告)日：1994-12-27
申请号：US893297
申请日：1992-06-04
申请人： Yau C. Lau , Eric J. Mozdy , John A. Oleszkiewicz
发明人： Yau C. Lau , Eric J. Mozdy , John A. Oleszkiewicz
IPC分类号： G06F17/30 , G06F15/40
CPC分类号： G06F17/30501 , G06F17/30483 , Y10S707/99933
摘要： A two dimensional matrix of marks indicating match or mismatch of one or more search arguments with the value of data elements accessed from a field common with all records of a database file. The matrix of marks created after one pass through all the records of the file is searched for a specified pattern which identifies records where the data element values, as between successive records, have a certain sequence as specified by the search arguments.
摘要翻译：标记的二维矩阵，指示一个或多个搜索参数的匹配或不匹配，以及从与数据库文件的所有记录共同的字段访问的数据元素的值。搜索一次通过文件的所有记录之后创建的标记矩阵，以识别记录，其中数据元素值与连续记录之间具有由搜索参数指定的特定序列的记录。

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