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11. 发明申请

US20100211618A1 EFFICIENT STORAGE OF DATA ALLOWING FOR MULTIPLE LEVEL GRANULARITY RETRIEVAL 有权
标题翻译：有效存储数据允许多级级别检索
公开(公告)号：US20100211618A1
公开(公告)日：2010-08-19
申请号：US12372733
申请日：2009-02-17
申请人： Darrell ANDERSON , David BROCK
发明人： Darrell ANDERSON , David BROCK
IPC分类号： G06F7/00 , G06F17/00
CPC分类号： G06F17/30598 , G05B23/0264 , G06F17/30548 , G06F17/30551
摘要： Data series are stored at multiple resolutions in a computer-readable data storage medium. In particular, time series data values of the data series are received with associated timestamps. Corresponding storage elements in the computer-readable data storage medium are identified based on the time stamps. Aggregate values are determined by summing the time series data values. The time series data values stored in the corresponding storage elements are replaced by the aggregate values. Combined data values of the aggregate values are stored in storage elements in the computer-readable storage medium at a first resolution and second resolution, where the second resolution is half of the first resolution.
摘要翻译：数据系列以多个分辨率存储在计算机可读数据存储介质中。特别地，以相关联的时间戳接收数据序列的时间序列数据值。基于时间戳来识别计算机可读数据存储介质中的相应存储元件。通过对时间序列数据值求和来确定汇总值。存储在相应存储元件中的时间序列数据值被聚合值替换。聚合值的组合数据值以第一分辨率和第二分辨率存储在计算机可读存储介质中的存储元件中，其中第二分辨率是第一分辨率的一半。

12. 发明申请

US20080095769A1 IDENTIFICATION OF UNIQUE BINDING INTERACTIONS BETWEEN CERTAIN ANTIBODIES AND THE HUMAN B7.1 AND B7.2 CO-STIMULATORY ANTIGENS 失效
公开(公告)号：US20080095769A1
公开(公告)日：2008-04-24
申请号：US11840591
申请日：2007-08-17
申请人： Darrell Anderson , Nabil Hanna , Peter Brams
发明人： Darrell Anderson , Nabil Hanna , Peter Brams
IPC分类号： A61K39/395 , A61P31/00 , A61P37/00 , C07K16/18 , C07K16/28
CPC分类号： C07K16/2827 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 receptor. Two of these antibodies, 16C10 and 7C10, significantly inhibit the production of IL-2, in spite of the existence of a second activating ligand B7.2 (CD86). Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 and/or B7.2 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signalling. These antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.

13. 发明申请

US20060275291A1 Identification of Unique Binding Interactions Between Certain Antibodies and the Human B7.1 and B7.2 Co-Stimulatory Antigens 有权
标题翻译：鉴定某些抗体与人B7.1和B7.2共刺激抗原之间的独特结合相互作用
公开(公告)号：US20060275291A1
公开(公告)日：2006-12-07
申请号：US11464133
申请日：2006-08-11
申请人： Darrell Anderson , Nabil Hanna , Peter Brams
发明人： Darrell Anderson , Nabil Hanna , Peter Brams
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2827 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 receptor. Two of these antibodies, 16C10 and 7C10, significantly inhibit the production of IL-2, in spite of the existence of a second activating ligand B7.2 (CD86). Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 and/or B7.2 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signalling. These antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.
摘要翻译：本发明涉及对人B7.1抗原（CD80）特异性并且能够抑制B7.1与CD28受体的结合并且不能抑制B7.1结合的抗体的鉴定到CTLA-4受体。尽管存在第二活化配体B7.2（CD86），但是这些抗体16C10和7C10中的两个显着抑制了IL-2的产生。阻断CD28和B7.1（CD80）之间的主要激活信号与这些抗体同时允许CTLA-4和B7.1和/或B7.2的未受损或一致的相互作用代表对阳性共刺激的组合拮抗作用，对负信号的激动作用。这些抗体可以用作特异性免疫抑制剂，例如用于治疗自身免疫性疾病和预防器官移植排斥。

14. 发明申请

US20050129688A1 Monkey monoclonal antibodies specific to human B7.1 and/or B7.2 primatized forms thereof, pharmaceutical compositions containing, and use thereof as immunosuppressants 有权
标题翻译：针对人B7.1和/或B7.2的灵长类形式的特异性猴单克隆抗体，含有其的药物组合物及其作为免疫抑制剂的用途
公开(公告)号：US20050129688A1
公开(公告)日：2005-06-16
申请号：US10986780
申请日：2004-11-15
申请人： Darrell Anderson , Peter Brams , Nabil Hanna , William Shestowsky , Cheryl Heard
发明人： Darrell Anderson , Peter Brams , Nabil Hanna , William Shestowsky , Cheryl Heard
IPC分类号： C12N15/02 , A61K38/00 , A61K39/395 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/00 , C07K14/705 , C07K16/18 , C07K16/28 , C12N5/10 , C12N15/09 , C12P21/08 , C07K16/44 , C12N5/06
CPC分类号： C07K14/70532 , A61K38/00 , C07K16/2827
摘要： The present invention relates to the identification of macaque antibodies to human B7.1 and B7.2 by screening of phage display libraries or monkey heterohybridomas obtained using B lymphocytes from B7.1 and/or B7.2 immunized monkeys. More specifically, the invention provides four monkey monoclonal antibodies 7B6, 16C10, 7C10 and 20C9 which inhibit the B7:CD28 pathway and thereby function as effective immunosuppressants. The invention further provides the complete DNA and amino acid sequences of the light and heavy chain of three primatized antibodies derived from those monkey monoclonal antibodies which bind B7.1 and possibly B7.2, primatized 7C10, primatized 7B6 and primatized 16C10. These primatized and monkey antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.
摘要翻译：本发明涉及通过筛选使用B7.1和/或B7.2免疫的猴子的B淋巴细胞获得的噬菌体展示文库或猴杂合杂交瘤来鉴定人B7.1和B7.2的猕猴抗体。更具体地，本发明提供四种抑制B7：CD28途径的猴单克隆抗体7B6,16C10,7C10和20C9，从而起到有效的免疫抑制剂的作用。本发明进一步提供衍生自结合B7.1和可能B7.2，灵长类化7C10，灵长类化7B6和灵长类16C10的猴单克隆抗体的三种灵长类抗体轻链和重链的完整DNA和氨基酸序列。这些灵长类和猴抗体可以用作特异性免疫抑制剂，例如用于治疗自身免疫性疾病和预防器官移植排斥。

15. 发明授权

US06614764B1 Bridged network topology acquisition 有权
标题翻译：桥接网络拓扑采集
公开(公告)号：US06614764B1
公开(公告)日：2003-09-02
申请号：US09496294
申请日：2000-02-01
申请人： Thomas L. Rodeheffer , Darrell Anderson , Chandramohan A. Thekkath , Mark D. Lillibridge
发明人： Thomas L. Rodeheffer , Darrell Anderson , Chandramohan A. Thekkath , Mark D. Lillibridge
IPC分类号： H04J1500
CPC分类号： H04L45/02 , H04L12/462 , H04L41/12 , H04L45/04
摘要： A bridged network and a method for performing bridged network topology acquisition. The bridged network includes network segments and smart bridges having one or more ports. The network segments are interconnected by the smart bridges via the ports. Each of the smart bridges being configured to perform steps to accomplish the network topology acquisition. The method also performs steps to accomplish the network topology acquisition. The steps include an inventory construction that compiles a list of the ports that are connected to each of the network segments. Among the ports that are connected to any of the network segments the inventory construction respecting each port operates cooperatively so as to cause the list respecting each of the ports to converge rapidly to the state in which all the lists are similar and yielding a uniform segment inventory. The bridged network topology acquisition in each of the smart bridges operates cooperatively with the bridged network topology acquisition in other smart bridges in order to create a total network report from most recent segment inventories. The bridged network topology acquisition includes propagation, collection, and distribution. The bridges network topology acquisition affords better management of network topology changes.
摘要翻译：一种桥接网络和一种执行桥接网络拓扑采集的方法。桥接网络包括具有一个或多个端口的网段和智能桥。网段通过智能桥经由端口互连。每个智能桥被配置为执行完成网络拓扑获取的步骤。该方法还执行完成网络拓扑采集的步骤。这些步骤包括编制连接到每个网段的端口的列表的库存结构。在连接到任何网段的端口中，关于每个端口的库存结构协同工作，以使得关于每个端口的列表快速收敛到所有列表相似的状态并产生统一的段库存。每个智能桥中的桥接网络拓扑采集与其他智能桥中的桥接网络拓扑采集协同工作，以便创建来自最近段段清单的总网络报告。桥接网络拓扑采集包括传播，收集和分发。网桥拓扑收集可以更好地管理网络拓扑变化。

16. 发明授权

US08504551B2 Serving advertisements based on content 有权
公开(公告)号：US08504551B2
公开(公告)日：2013-08-06
申请号：US13084332
申请日：2011-04-11
申请人： Darrell Anderson , Paul Buchheit , Alexander Paul Carobus , Yingwei Cui , Jeffrey A. Dean , Georges R. Harik , Deepak Jindal , Narayanan Shivakumar
发明人： Darrell Anderson , Paul Buchheit , Alexander Paul Carobus , Yingwei Cui , Jeffrey A. Dean , Georges R. Harik , Deepak Jindal , Narayanan Shivakumar
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30454 , G06Q30/02 , G06Q30/0251 , Y10S707/944 , Y10S707/99945 , Y10S707/99948
摘要： Advertisers are permitted to put targeted ads on page on the web (or some other document of any media type). The present invention may do so by (i) obtaining content that includes available spots for ads, (ii) determining ads relevant to content, and/or (iii) combining content with ads determined to be relevant to the content.

17. 发明授权

US08090951B2 Systems and methods for transparent configuration authentication of networked devices 有权
标题翻译：网络设备透明配置认证的系统和方法
公开(公告)号：US08090951B2
公开(公告)日：2012-01-03
申请号：US10627270
申请日：2003-07-25
申请人： Úlfar Erlingsson , Xavier Boyen , Darrell Anderson , Wayne Gray
发明人： Úlfar Erlingsson , Xavier Boyen , Darrell Anderson , Wayne Gray
IPC分类号： H04L9/32
CPC分类号： H04L63/12 , G06F21/10 , G06F21/60 , G06Q20/401 , H04L63/08 , H04L63/123 , H04L63/20 , H04L2209/608 , H04N1/32144 , H04N21/8358
摘要： Methods and systems are disclosed for providing secure transmissions across a network comprising a transmitting device and a receiving device. At the transmitting device, a stream of watermark bits is generated. Next, a plurality of watermarks is generated, each of the plurality of watermarks comprising an index number and a portion of the stream of watermark bits. The watermarks are inserted into each header of a plurality of outgoing packets. At the receiving device, the plurality of outgoing packets are received and it is determined if a received packet is valid based on the watermark in the header of the received packet. The stream of watermark bits may be generated using a stream cipher such as RC4, a block cipher such as 3DES in CBC mode, or other equivalent pseudo-random stream generating techniques.
摘要翻译：公开了用于通过包括发射设备和接收设备的网络提供安全传输的方法和系统。在发送装置，生成水印比特流。接下来，生成多个水印，多个水印中的每一个包括索引号和水印比特流的一部分。水印被插入到多个输出分组的每个报头中。在接收装置中，接收多个输出分组，并且基于接收分组的报头中的水印确定接收到的分组是否有效。可以使用诸如RC4的流密码，CBC模式中的诸如3DES的块密码或其他等效的伪随机流生成技术来生成水印比特流。

18. 发明授权

US07734624B2 Serving advertisements based on content 有权
标题翻译：根据内容投放广告
公开(公告)号：US07734624B2
公开(公告)日：2010-06-08
申请号：US11487117
申请日：2006-07-14
申请人： Darrell Anderson , Paul Buchheit , Alexander Paul Carobus , Yingwei Cui , Jeffrey A. Dean , Georges R. Harik , Deepak Jindal , Narayanan Shivakumar
发明人： Darrell Anderson , Paul Buchheit , Alexander Paul Carobus , Yingwei Cui , Jeffrey A. Dean , Georges R. Harik , Deepak Jindal , Narayanan Shivakumar
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30454 , G06Q30/02 , G06Q30/0251 , Y10S707/944 , Y10S707/99945 , Y10S707/99948
摘要： Advertisers are permitted to put targeted ads on page on the web (or some other document of any media type). The present invention may do so by (i) obtaining content that includes available spots for ads, (ii) determining ads relevant to content, and/or (iii) combining content with ads determined to be relevant to the content.
摘要翻译：允许广告商在网页上放置有针对性的广告（或任何媒体类型的其他文档）。本发明可以通过（i）获得包括广告的可用点的内容，（ii）确定与内容相关的广告，和/或（iii）将内容与确定为与内容相关的广告组合。

19. 发明申请

US20070128185A1 IDENTIFICATION OF UNIQUE BINDING INTERACTIONS BETWEEN CERTAIN ANTIBODIES AND THE HUMAN B7.1 AND B7.2 CO-STIMULATORY ANTIGENS 失效
标题翻译：识别某些抗体与人B7.1和B7.2共刺激抗原之间的独特结合相互作用
公开(公告)号：US20070128185A1
公开(公告)日：2007-06-07
申请号：US11553302
申请日：2006-10-26
申请人： Darrell Anderson , Nabil Hanna , Peter Brams
发明人： Darrell Anderson , Nabil Hanna , Peter Brams
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/00 , A61K38/00 , A61K2039/505 , C07K14/70532 , C07K16/2827 , C07K2317/21 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 receptor. Two of these antibodies, 16C10 and 7C10, significantly inhibit the production of IL-2, in spite of the existence of a second activating ligand B7.2 (CD86). Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-I and b7.1 and/or B7.2 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signalling. These antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.
摘要翻译：本发明涉及对人B7.1抗原（CD80）特异性并且能够抑制B7.1与CD28受体的结合并且不能抑制B7.1结合的抗体的鉴定到CTLA-4受体。尽管存在第二活化配体B7.2（CD86），但是这些抗体16C10和7C10中的两个显着抑制了IL-2的产生。使用这些抗体阻断CD28和B7.1（CD80）之间的主要激活信号，同时允许CTLA-1和b7.1和/或B7.2的未受损或一致的相互作用代表对阳性共刺激的组合拮抗作用，对负信号的激动作用。这些抗体可以用作特异性免疫抑制剂，例如用于治疗自身免疫性疾病和预防器官移植排斥。

20. 发明申请

US20120036367A1 Systems and Methods for Transparent Configuration Authentication of Networked Devices 有权
标题翻译：网络设备透明配置认证的系统和方法
公开(公告)号：US20120036367A1
公开(公告)日：2012-02-09
申请号：US13213943
申请日：2011-08-19
申请人： Ûlfar ERLINGSSON , Xavier Boyen , Darrell Anderson , Wayne Gray
发明人： Ûlfar ERLINGSSON , Xavier Boyen , Darrell Anderson , Wayne Gray
IPC分类号： H04L9/32
CPC分类号： H04L63/12 , G06F21/10 , G06F21/60 , G06Q20/401 , H04L63/08 , H04L63/123 , H04L63/20 , H04L2209/608 , H04N1/32144 , H04N21/8358
摘要： Methods and systems are disclosed for providing secure transmissions across a network comprising a transmitting device and a receiving device. At the transmitting device, a stream of watermark bits is generated. Next, a plurality of watermarks is generated, each of the plurality of watermarks comprising an index number and a portion of the stream of watermark bits. The watermarks are inserted into each header of a plurality of outgoing packets. At the receiving device, the plurality of outgoing packets are received and it is determined if a received packet is valid based on the watermark in the header of the received packet. The stream of watermark bits may be generated using a stream cipher such as RC4, a block cipher such as 3DES in CBC mode, or other equivalent pseudo-random stream generating techniques.
摘要翻译：公开了用于通过包括发射设备和接收设备的网络提供安全传输的方法和系统。在发送装置，生成水印比特流。接下来，生成多个水印，多个水印中的每一个包括索引号和水印比特流的一部分。水印被插入到多个输出分组的每个报头中。在接收装置中，接收多个输出分组，并且基于接收分组的报头中的水印确定接收到的分组是否有效。水印比特流可以使用诸如RC4的流密码，CBC模式中的诸如3DES的块密码或其他等效的伪随机流生成技术来生成。

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