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11. 发明授权

US5019379A Unsaturated polyanhydrides 失效
标题翻译：不饱和聚酐
公开(公告)号：US5019379A
公开(公告)日：1991-05-28
申请号：US80090
申请日：1987-07-31
申请人： Abraham J. Domb , Robert S. Langer
发明人： Abraham J. Domb , Robert S. Langer
IPC分类号： A61K9/20 , A61L24/00 , A61L24/04 , C08G67/04
CPC分类号： C08G67/04 , A61K9/2031 , A61L24/0042 , A61L24/046 , A61L2430/02
摘要： A class of unsaturated polyanhydrides having double bonds available for secondary polymerization is disclosed. A crosslinked material having improved or different physical and mechanical properties can be prepared from these polyanhydrides, via secondary polymerization. The synthesis and characteristics of one unsaturated polyanhydride based on fumaric acid and its copolymers with aliphatic and aromatic diacids, prepared by either the melt-polycondensation method or by solution polymerization, is described in detail.These polymers are well suited for use in controlled release drug delivery devices. The polymers can also be used as a bioerodible bone cement where the polymer is first cast as a solution onto a bone fracture and then crosslinked by radiation or radical polymerization to yield a strong, adhesive material.
摘要翻译：公开了一类具有可用于二次聚合的双键的不饱和聚酐。可以通过二次聚合从这些聚酐制备具有改善或不同物理和机械性能的交联材料。详细描述了通过熔融缩聚法或通过溶液聚合制备的一种不饱和聚酐与富马酸及其与脂族和芳族二酸的共聚物的合成和特性。这些聚合物非常适合用于控释药物递送装置。聚合物也可以用作生物可蚀解的骨水泥，其中首先将聚合物作为溶液浇铸到骨折上，然后通过辐射或自由基聚合进行交联以产生强的粘合剂材料。

12. 发明授权

US4999417A Biodegradable polymer compositions 失效
标题翻译：可生物降解的聚合物组合物
公开(公告)号：US4999417A
公开(公告)日：1991-03-12
申请号：US330588
申请日：1989-03-30
申请人： Abraham J. Domb
发明人： Abraham J. Domb
IPC分类号： A61K9/20 , C08G63/685 , C08G67/04
CPC分类号： C08G63/6856 , A61K9/2031 , A61K9/204 , C08G67/04
摘要： Biodegradable polyanhydrides or polyester compositions based on amino acids. The compositions may be used as carriers for drugs or the like or as the drug source itself. The polymers are prepared from amino acids which are modified to include an additional carboxylic acid group.
摘要翻译：基于氨基酸的可生物降解的聚酐或聚酯组合物。组合物可以用作药物等的载体或药物源本身。聚合物由经修饰以包含另外的羧酸基团的氨基酸制备。

13. 发明授权

US4888413A Poly(propylene glycol fumarate) compositions for biomedical applications 失效
标题翻译：用于生物医学应用的聚（丙二醇富马酸盐）组合物
公开(公告)号：US4888413A
公开(公告)日：1989-12-19
申请号：US142471
申请日：1988-01-11
申请人： Abraham J. Domb
发明人： Abraham J. Domb
IPC分类号： A61L27/00 , A61K9/20 , A61L24/00 , A61L24/04 , A61L27/18 , A61L27/58 , C08F283/01 , C08F299/04 , C08G63/52
CPC分类号： C08G63/52 , A61K9/204 , A61L24/0042 , A61L24/046 , A61L27/18 , A61L27/58
摘要： The present invention are highly reproducible poly(propylene glycol fumarate) compositions having a controlled end group ratio and range of molecular weights with minimal low molecular weight and excessively high molecular weight fractions, and methods for their manufacture. These compositions, having a preferred weight average molecular weight (Mw) of between about 500 and 3000 and a number average molecular weight (Mn) of between about 300 and 2000, are especially useful in biomedical applications such as in bone cements and tissue implants or glues. In the preferred embodiment, the polymer is prepared from propylene glycol (PG) and fumaric acid (FA) by one of three methods: melt polymerization using non-volatile starting materials; step polymerization where in each step the polymer is increased by the addition of two groups to the polymer ends; or under reaction conditions maintained so that only the condensation byproduct, water, is removed during the reaction, thereby keeping the ratio between PG and FA constant. Variations of the PPF polymers include polymers with increased sensitivity to hydrolysis through incorporation of lactic acid groups into the polymer and polymers formed from maleic acid, maleic anhydride, citraconic acid or citraconic anhydride.

14. 发明授权

US09555238B2 Safe device for iontophoretic delivery of drugs 有权
标题翻译：用于离子电渗治疗药物的安全装置
公开(公告)号：US09555238B2
公开(公告)日：2017-01-31
申请号：US14155821
申请日：2014-01-15
申请人： Abraham J. Domb , Joseph Frucht-Pery , Mervyn Shapiro
发明人： Abraham J. Domb , Joseph Frucht-Pery , Mervyn Shapiro
IPC分类号： A61N1/30 , A61N1/04 , A61N1/32
CPC分类号： A61N1/303 , A61M37/00 , A61M2037/0007 , A61N1/025 , A61N1/0448 , A61N1/30 , A61N1/325
摘要： Provided is a device for iontophoretic delivery of a drug to or into a tissue, including an arrangement that prevents operation of the device at a current density that is higher than a predetermined value, the arrangement including first means responsive to a first data item, indicative of the surface area through which the current is to pass, as to set the maximal current allowed at the surface area indicated by the data item. Also provided is a method for iontophorectivally administering drug to or into a tissue, including determining a maximal allowed level of current density and preventing application of current density above the maximal allowed level.
摘要翻译：提供了一种用于将药物离子电渗疗法递送至组织或向组织中递送的装置，包括防止在高于预定值的电流密度下操作该装置的装置，该装置包括响应于第一数据项的第一装置，电流要通过的表面积，以设定由数据项所指示的表面积处允许的最大电流。还提供了一种用于向组织中或向组织中进行离子电积极施用药物的方法，包括确定电流密度的最大允许水平并防止施加电流密度高于最大允许水平。

15. 发明授权

US09161909B2 Adhesive compositions for the treatment of xerostomia 有权
标题翻译：用于治疗口腔干燥症的粘合剂组合物
公开(公告)号：US09161909B2
公开(公告)日：2015-10-20
申请号：US12757508
申请日：2010-04-09
申请人： Abraham J. Domb , Benny Brama , Boaz Mizrahi
发明人： Abraham J. Domb , Benny Brama , Boaz Mizrahi
IPC分类号： A61K9/20 , A61K9/00 , A61K31/22
CPC分类号： A61K9/006 , A61K9/2086 , A61K31/22
摘要： Compositions for the treatment of xerostomia, and methods of making and using thereof are disclosed herein. The compositions are typically in the form of a film or tablet, such as a double layer sticker tablet. The compositions adhere to a buccal surface or mucosal surface in the oral cavity for at least 15 minutes, preferably for at least 30 minutes. The compositions themselves are able to increase the levels of saliva in the mouth without the need for active agents, such sialogogic agents. The compositions optionally contain a non-lipid lubricant, a flavoring agent, and/or a buffering agent. The composition is generally effective at treating or ameliorating the effects of xerostomia for a time period ranging from at least 30 minutes up to eight hours following administration to the buccal or oral mucosa.
摘要翻译：本文公开了用于治疗口干燥症的组合物及其制备和使用方法。组合物通常为薄膜或片剂的形式，例如双层贴片片剂。组合物粘附在口腔中的口腔表面或粘膜表面至少15分钟，优选至少30分钟。组合物本身能够增加口中唾液的水平，而不需要活性剂，例如唾液酸剂。组合物任选地含有非脂润滑剂，调味剂和/或缓冲剂。组合物通常有效地治疗或改善口腔干燥症的作用在给药至颊或口腔粘膜后至少30分钟至8小时的时间段内。

16. 发明申请

US20140128836A1 SAFE DEVICE FOR IONTOPHORETIC DELIVERY OF DRUGS 有权
标题翻译：用于静脉输送药物的安全装置
公开(公告)号：US20140128836A1
公开(公告)日：2014-05-08
申请号：US14155821
申请日：2014-01-15
申请人： Abraham J. DOMB , Joseph FRUCHT-PERY , Mervyn SHAPIRO
发明人： Abraham J. DOMB , Joseph FRUCHT-PERY , Mervyn SHAPIRO
IPC分类号： A61N1/30
CPC分类号： A61N1/303 , A61M37/00 , A61M2037/0007 , A61N1/025 , A61N1/0448 , A61N1/30 , A61N1/325
摘要： Provided is a device for iontophoretic delivery of a drug to or into a tissue, including an arrangement that prevents operation of the device at a current density that is higher than a predetermined value, the arrangement including first means responsive to a first data item, indicative of the surface area through which the current is to pass, as to set the maximal current allowed at the surface area indicated by the data item. Also provided is a method for iontophorectivally administering drug to or into a tissue, including determining a maximal allowed level of current density and preventing application of current density above the maximal allowed level.
摘要翻译：提供了一种用于将药物离子电渗疗法递送至组织或向组织中递送的装置，包括防止在高于预定值的电流密度下操作该装置的装置，该装置包括响应于第一数据项的第一装置，电流要通过的表面积，以设定由数据项所指示的表面积处允许的最大电流。还提供了一种用于向组织中或向组织中进行离子电积极施用药物的方法，包括确定电流密度的最大允许水平并防止施加电流密度高于最大允许水平。

17. 发明授权

US08535645B2 Antimicrobial nanoparticulate additives forming non-leachable sustained antimicrobial polymeric compositions 有权
标题翻译：抗微生物纳米颗粒添加剂形成不可浸出的持续抗微生物聚合物组合物
公开(公告)号：US08535645B2
公开(公告)日：2013-09-17
申请号：US11794492
申请日：2006-01-01
申请人： Abraham J. Domb , Ervin Weiss , Nurit Beyth , Ira Farber , Michael Perez Davidi
发明人： Abraham J. Domb , Ervin Weiss , Nurit Beyth , Ira Farber , Michael Perez Davidi
IPC分类号： A61K8/00 , A61K9/14 , C11D1/62
CPC分类号： A61K6/083 , A01N25/12 , A01N33/12 , A01N37/12 , A61K6/0008 , A61K6/0023 , A61K6/0032 , A61K6/0067 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/208 , A61L2300/404 , A61L2300/408 , A61L2300/624 , C08L39/02 , C08L33/08 , C08L5/08
摘要： A particle including at least one aliphatic polymer having anti-microbially active quaternary ammonium groups chemically bound thereto, is provided. The particle may be used to inhibit populations of microorganisms and biofilms. Also provided are methods for the preparation of such particles and uses thereof for the inhibition of microorganisms.
摘要翻译：提供了包含至少一种具有与其结合的具有抗微生物活性季铵基团的脂族聚合物的颗粒。该颗粒可用于抑制微生物和生物膜的种群。还提供了制备这种颗粒的方法及其用于抑制微生物的用途。

18. 发明授权

US08480647B2 Delivery device for delivering bioactive agents to internal tissue in a body 有权
标题翻译：用于将生物活性剂递送到身体内部组织的输送装置
公开(公告)号：US08480647B2
公开(公告)日：2013-07-09
申请号：US12599823
申请日：2008-05-13
申请人： Shaul Shohat , Eli Machlev , Dana Haimovich , Abraham J. Domb
发明人： Shaul Shohat , Eli Machlev , Dana Haimovich , Abraham J. Domb
IPC分类号： A61M31/00 , A61M29/00
CPC分类号： A61M25/10 , A61L29/146 , A61L29/148 , A61L29/16 , A61L2300/232 , A61L2300/25 , A61L2300/252 , A61L2300/258 , A61L2300/30 , A61L2300/604 , A61M25/1029 , A61M2025/0056 , A61M2025/0681 , A61M2025/105 , A61M2025/1054 , A61M2025/1088
摘要： A device and method for administering a bioactive agent to internal tissue in a body, by introducing a balloon in a deflated condition into the body, inflating the balloon, introducing the bioactive agent into the balloon at the time of, after, or before the inflation of the balloon, and delivering the bioactive agent from the balloon to the tissue.
摘要翻译：一种将生物活性剂施用于身体内部组织的装置和方法，通过将处于放气状态的气囊引入体内，使气囊膨胀，在膨胀之前，之后或之前将生物活性剂引入气囊中并将生物活性剂从气囊输送到组织。

19. 发明申请

US20100260703A1 INJECTABLE BIODEGRADABLE POLYMER COMPOSITIONS FOR SOFT TISSUE REPAIR AND AUGMENTATION 失效
标题翻译：用于软组织修复和补充的可注射的生物可降解聚合物组合物
公开(公告)号：US20100260703A1
公开(公告)日：2010-10-14
申请号：US12678492
申请日：2008-10-05
申请人： Lior Yankelson , Abraham J. Domb
发明人： Lior Yankelson , Abraham J. Domb
IPC分类号： A61K31/765 , A61P13/00 , A61P17/00 , A61F2/02
CPC分类号： A61L27/58 , A61L27/18 , A61L27/50 , A61L2400/06 , C08L67/04
摘要： Methods for soft tissue repair and/or augmentation using injectable, biodegradable polymers are described herein. In one embodiment, the polymer compositions are liquid or pastes at room temperature. In a preferred embodiment, the polymer composition contains liquid or pasty hydroxy fatty acid-based copolyesters, polyester-anhydrides, or combinations thereof. The viscosity of the polymers increases upon contact with bodily fluid to form a solid or semisolid implant suitable for soft tissue repair and/or augmentation. In another embodiment, the polymer composition contains particles of a polymer stereocomplex. One or more active agents may be incorporated into the polymer compositions. Suitable classes of active agents include local anesthetics, anti-inflammatory agents, antibiotics, analgesics, growth factors and agents that induce and/or enhance growth of tissue within the filled cavity or control the growth of a certain type of tissue, and combinations thereof. The polymer compositions may also contain one or more additives or excipients that modify the physical and/or mechanical properties of the polymer. The polymer compositions are typically administered by injection. The injectable polymers can be used for a variety of soft tissue repair and augmentation procedures.
摘要翻译：本文描述了使用可注射的可生物降解的聚合物进行软组织修复和/或增加的方法。在一个实施方案中，聚合物组合物在室温下为液体或糊状物。在优选的实施方案中，聚合物组合物含有液体或糊状羟基脂肪酸基共聚酯，聚酯酸酐或其组合。当与体液接触时，聚合物的粘度增加，以形成适于软组织修复和/或增加的固体或半固体植入物。在另一个实施方案中，聚合物组合物含有聚合物立体络合物的颗粒。一种或多种活性剂可以并入聚合物组合物中。合适类别的活性剂包括局部麻醉剂，抗炎剂，抗生素，止痛剂，生长因子和诱导和/或增强填充腔内组织生长或控制某种类型组织生长的试剂及其组合。聚合物组合物还可以含有改变聚合物的物理和/或机械性能的一种或多种添加剂或赋形剂。聚合物组合物通常通过注射施用。可注射聚合物可用于各种软组织修复和增强程序。

20. 发明申请

US20100247644A1 ADHESIVE COMPOSITIONS FOR THE TREATMENT OF XEROSTOMIA 有权
标题翻译：用于治疗XEROSTOMIA的粘合剂组合物
公开(公告)号：US20100247644A1
公开(公告)日：2010-09-30
申请号：US12757508
申请日：2010-04-09
申请人： Abraham J. Domb , Benny Brama , Boaz Mizrahi
发明人： Abraham J. Domb , Benny Brama , Boaz Mizrahi
IPC分类号： A61K9/20 , A61K31/232 , A61K31/661 , A61K31/79 , A61K31/23 , A61P43/00
CPC分类号： A61K9/006 , A61K9/2086 , A61K31/22
摘要： Compositions for the treatment of xerostomia, and methods of making and using thereof are disclosed herein. The compositions are typically in the form of a film or tablet, such as a double layer sticker tablet. The compositions adhere to a buccal surface or mucosal surface in the oral cavity for at least 15 minutes, preferably for at least 30 minutes. The compositions themselves are able to increase the levels of saliva in the mouth without the need for active agents, such sialogogic agents. The compositions optionally contain a non-lipid lubricant, a flavoring agent, and/or a buffering agent. The composition is generally effective at treating or ameliorating the effects of xerostomia for a time period ranging from at least 30 minutes up to eight hours following administration to the buccal or oral mucosa.
摘要翻译：本文公开了用于治疗口干燥症的组合物及其制备和使用方法。组合物通常为薄膜或片剂的形式，例如双层贴片片剂。组合物粘附在口腔中的口腔表面或粘膜表面至少15分钟，优选至少30分钟。组合物本身能够增加口中唾液的水平，而不需要活性剂，例如唾液酸剂。组合物任选地含有非脂润滑剂，调味剂和/或缓冲剂。组合物通常有效地治疗或改善口腔干燥症的作用在给药至颊或口腔粘膜后至少30分钟至8小时的时间段内。

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