专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

171. 发明授权

US08149505B2 Laser scanner device with limited test part accessibility 有权
标题翻译：具有有限测试部件可访问性的激光扫描仪装置
公开(公告)号：US08149505B2
公开(公告)日：2012-04-03
申请号：US12191137
申请日：2008-08-13
申请人： Frank Fischer , Harald Gebetsroither , Andreas Gfrörer , Andreas Schenk
发明人： Frank Fischer , Harald Gebetsroither , Andreas Gfrörer , Andreas Schenk
IPC分类号： G02B21/26
CPC分类号： G01N35/00029 , G01N15/1475 , G01N21/6458 , G02B21/0076 , G02B21/26 , G02B21/34 , Y10T436/112499
摘要： A laser scanner device (1) for imaging and/or measuring fluorescent samples located on slides and treated using fluorescent pigments includes a sample table (2) defining a sample plane (49) and a motorized transport device (3) for moving a slide from a storage unit (4) to the sample table (2) and back. The storage unit (4) includes one sample part (7) for sample slides (8) and one test part (9) for test slides (10), each having at least one depository (6) and being accessible during the operation of the laser scanner device (1) for the transport device (3). The test part (9) is implemented separately from the sample part (7) and as a test part magazine (9′) that is permanently connected to the laser scanner device (1) for one or more test slides (10).
摘要翻译：用于对位于载玻片上并使用荧光颜料处理的荧光样品进行成像和/或测量的激光扫描仪装置（1）包括限定样品平面（49）的样品台（2）和用于将载玻片从存储单元（4）到样品台（2）并返回。存储单元（4）包括用于样品载玻片（8）的一个样本部分（7）和用于测试滑块（10）的一个测试部分（9），每个具有至少一个托盘（6）并且在操作期间可访问用于输送装置（3）的激光扫描装置（1）。测试部件（9）与样品部分（7）分开实现，并且作为一个测试部件（9'）被固定地连接到用于一个或多个试验滑块（10）的激光扫描装置（1）。

172. 发明申请

US20110292383A1 MICRO CUVETTE ASSEMBLY AND USE THEREOF 有权
标题翻译： MICRO CUVETTE大会及其使用
公开(公告)号：US20110292383A1
公开(公告)日：2011-12-01
申请号：US13193149
申请日：2011-07-28
申请人： Walter Gotschy , Josef Grassl , Fritz Payr , Markus Schürf
发明人： Walter Gotschy , Josef Grassl , Fritz Payr , Markus Schürf
IPC分类号： G01N21/03
CPC分类号： G01N21/0303 , B01L3/5085 , B01L3/5088 , B01L2300/0654 , B01L2300/0829
摘要： Micro cuvette assembly for examining biological samples has a first partial plate with one or more first cuvette surfaces and a second partial plate opposite the first and which also has one or more second cuvette surfaces. In an active position of the assembly, the second cuvette surfaces are arranged parallel and in register with the first cuvette surfaces and are spaced apart from the first cuvette surfaces whereby one or more micro cuvettes are formed. The first and second partial plates also have openings arranged in register with the cuvette surfaces and transparent bodies are provided as the cuvette surfaces. The first and second plates are completely penetrated by these openings and the transparent bodies are manufactured from a different material than the partial plates and span the openings close to a first surface of the partial plates. The first and second cuvette surfaces of a micro cuvette in the active position are wetted by a liquid volume which has previously been applied to one of the cuvette surfaces so that the liquid volume is held between these two cuvette surfaces.
摘要翻译：用于检查生物样品的微量比色皿组件具有第一部分板，其具有一个或多个第一反应杯表面和与第一部分相对的第二部分板，并且还具有一个或多个第二反应杯表面。在组件的活动位置中，第二反应杯表面平行布置并与第一比色皿表面对准，并且与第一比色杯表面间隔开，由此形成一个或多个微量比色皿。第一和第二部分板还具有与反应杯表面对准布置的开口，并且提供透明体作为比色皿表面。第一和第二板被这些开口完全穿透，并且透明体由与局部板不同的材料制成，并且跨过部分板的第一表面附近的开口。在活动位置的微量比色皿的第一和第二比色皿表面被预先施加到其中一个比色皿表面的液体体积润湿，使得液体体积保持在这两个比色皿表面之间。

173. 发明申请

US20100301232A1 LASER SCANNER APPARATUS FOR FLUORESCENCE MEASUREMENTS 有权
公开(公告)号：US20100301232A1
公开(公告)日：2010-12-02
申请号：US12853484
申请日：2010-08-10
申请人： ANDREAS ERLBACHER , HARALD GEBETSROITHER , ANDREAS GFRORER , GYOERGY WENCZEL
发明人： ANDREAS ERLBACHER , HARALD GEBETSROITHER , ANDREAS GFRORER , GYOERGY WENCZEL
IPC分类号： G01J1/58
CPC分类号： G02B21/0076 , G02B5/04 , G02B26/105 , G02B27/141
摘要： The invention relates to a laser scanner apparatus (1) for imaging and/or measuring fluorescent samples which are located on specimen slides (8) and treated with two different fluorescent dyes and also to a corresponding method. This laser scanner apparatus (1) comprises a motor-driveable sample table (2) with a receptacle (34) for specimen slides (8) in a sample plane (49); at least one laser (51,52) and a first optical system (53) for providing two laser beams (54,55) of differing wavelength; a scanner means (72) comprising a scanner head (50) which can move in a direction of movement (75) and has an optical deflection element (56) for deflecting the laser beams (54,55) toward the sample; and a first objective (57) for focusing the laser beams (54,55) on the sample in the plane (49). The laser scanner apparatus (1) additionally comprises a second optical system (58) for forwarding to detectors (61,61′) emission beam bundles (59,60) which are triggered by the laser beams (54,55) on the sample and two detectors (61,61′) for detecting the emission beam bundles (59,60) of differing wavelength coming from the samples. The scanner means (72) also comprises a drive (71) and a counter oscillator (73), the scanner head (50) and counter oscillator (73) being connected to the drive (71) by means of connecting rods (70,70′) and each displaceably fastened to a linear guide (68). The drive (71) is implemented to bring the scanner head (50) into a rapid back-and-forth movement in a direction of movement (75). The counter oscillator (73) has a mass at least equivalent to the scanner head (50) for impulse compensation by a movement that is opposite to the scanner head (50). The optical deflection element (56) preferably causes spatial separation of two resulting focal points (65) by a distance δ and a spatial separation of the two emission beam bundles (59,60) that are non-parallel to each other and that are guided in the direction of the detectors (61,61′).

174. 发明授权

US07615370B2 System having device for preventing air bubbles in a hybridization chamber and corresponding method 有权
标题翻译：具有用于在杂交室中防止气泡的装置的系统和相应的方法
公开(公告)号：US07615370B2
公开(公告)日：2009-11-10
申请号：US10931432
申请日：2004-09-01
申请人： Wolfgang Streit , Gyoergy Wenczel , Waltraud Lamprecht , Heribert Eglauer
发明人： Wolfgang Streit , Gyoergy Wenczel , Waltraud Lamprecht , Heribert Eglauer
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/502723 , B01L3/50855 , B01L2200/0684 , B01L2300/0822 , B01L2300/14
摘要： The present invention relates to a system (1) having hybridization chambers (5) for hybridizing nucleic acid samples, proteins, or tissue sections immobilized on slides (27), each hybridization chamber (5) being defined as an essentially gap-shaped chamber, which is essentially fillable with a liquid, between one of these slides (27) and a cover (26), and the cover (26) being positioned in relation to the slide (27) in such a way that the hybridization chamber (5) is sealed to the surrounding air, the system (1) including a device for preventing air bubbles in the hybridization chambers (5). The system according to the present invention is distinguished in that this device for preventing air bubbles in the hybridization chambers (5) is implemented as a pressure device to build up a chamber pressure in the hybridization chambers (5), this chamber pressure lying above the normal atmospheric pressure existing in the surrounding air. The present invention additionally relates to a method for preventing air bubbles in the hybridization chambers (5) of such a system (1) and is distinguished in that, using a pressure device of this system (1), a chamber pressure is implemented in the hybridization chambers (5) which lies above the normal atmospheric pressure existing in the surrounding air.
摘要翻译：本发明涉及一种具有杂交室（5）的系统（1），用于将固定在载片（27）上的核酸样品，蛋白质或组织切片进行杂交，每个杂交室（5）被定义为基本间隙形的室，其基本上可用液体填充，在这些滑动件（27）中的一个和盖（26）之间，并且盖（26）相对于载玻片（27）定位成使得杂交室（5）密封到周围空气，系统（1）包括用于防止杂交室（5）中的气泡的装置。根据本发明的系统的特征在于，用于防止杂交室（5）中的气泡的装置被实施为用于在杂交室（5）中建立室压力的压力装置，该室压力位于周围空气中存在正常的大气压力。本发明还涉及一种用于防止这种系统（1）的杂交室（5）中的气泡的方法，其区别在于，使用该系统（1）的压力装置，在位于周围空气中存在的正常大气压力之上的杂交室（5）。

175. 发明授权

US07575937B2 Device and method for disposing pipette syringes in a system used for manipulating liquid samples 有权
标题翻译：在用于操作液体样品的系统中设置移液器注射器的装置和方法
公开(公告)号：US07575937B2
公开(公告)日：2009-08-18
申请号：US11630181
申请日：2005-05-30
申请人： Markus Wiggli , Fred Schinzel , Bronwen Forster
发明人： Markus Wiggli , Fred Schinzel , Bronwen Forster
IPC分类号： G01N35/10
CPC分类号： G01N35/1067 , Y10T436/2575
摘要： A device and method for situating pipette or dispenser tips in a system for manipulating liquid samples, has a robot manipulator for orienting the tips relative to sample containers, drives for moving the robot manipulator and processors for controlling movements and actions of the robot manipulator and/or the tips. At least two tips are situated at an axial distance from each another, on at least two blocks on an arm of the robot manipulator. The axial distance corresponds to a grid spacing of wells of a microplate. At least one of the blocks is individually movable in an X direction and in a Y direction. The method allows time-saving pipetting over of liquid samples between diverse sample containers, such as between sample tubes and microplates having 24, 96, 384, or 1536 wells.
摘要翻译：用于将移液管或分配器尖端定位在用于操纵液体样品的系统中的装置和方法具有用于相对于样本容器定向尖端的机器人操纵器，用于移动机器人操纵器的驱动器和用于控制机器人操纵器的运动和动作的驱动器和/ 或提示。至少两个尖端位于机器人操纵器的臂上的至少两个块上彼此轴向距离处。轴向距离对应于微板的孔的网格间距。至少一个块可以在X方向和Y方向上单独移动。该方法允许在不同样品容器之间的液体样品上进行移液，例如在样品管和具有24,96,384或1536孔的微孔板之间。

176. 发明授权

US07476361B2 Microfluidics devices and methods of diluting samples and reagents 有权
标题翻译：微流体装置和稀释样品和试剂的方法
公开(公告)号：US07476361B2
公开(公告)日：2009-01-13
申请号：US10746821
申请日：2003-12-24
申请人： Gregory Kellogg , Timothy Johnson , Eric Schilling
发明人： Gregory Kellogg , Timothy Johnson , Eric Schilling
IPC分类号： G01N1/18 , G01N1/38 , G01N9/30
CPC分类号： G01N21/07 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01F2215/0431 , B01L3/5025 , B01L3/5027 , B01L3/50273 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2300/0806 , B01L2400/0406 , B01L2400/0409 , Y10T436/111666 , Y10T436/25625 , Y10T436/2575
摘要： This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. These assays may be performed for a variety of purposes, including but not limited to screening of drug candidate compounds, life sciences research, and clinical and molecular diagnostics. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.
摘要翻译：本发明涉及用于进行微量分析和微合成分析和方法的方法和装置。本发明提供一种用于操纵平台的微系统平台和显微操纵装置，所述平台利用由平台旋转产生的向心力，以激励通过微通道的流体运动。这些测定可以用于多种目的，包括但不限于候选化合物的筛选，生命科学研究以及临床和分子诊断。提供了用于执行各种微分析或微合成方法中的任何一种的本发明装置的特异性方法。

177. 发明授权

US07425311B2 Holding device 有权
标题翻译：保持装置
公开(公告)号：US07425311B2
公开(公告)日：2008-09-16
申请号：US10465429
申请日：2003-06-18
申请人： Andreas Gfrörer , Josef Grassl , Wolfgang Streit
发明人： Andreas Gfrörer , Josef Grassl , Wolfgang Streit
IPC分类号： B01L9/00 , B01L3/00 , G01N21/00 , A47G1/06
CPC分类号： B01L3/50855 , B01F5/10 , B01F11/0071 , B01F13/0059 , B01F15/00123 , B01F15/00318 , B01F15/00396 , B01F15/0244 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L9/06 , B01L2200/0689 , B01L2300/0636 , B01L2300/0822 , B01L2300/0877 , B33Y80/00
摘要： A holding device for at least one object carrier, the object carrier being suitable to receive one or more organic and/or inorganic samples and comprising materials such as glass, plastic, silicon, pyrolytic graphite, and/or metal, this holding device being configured to be gripped by grippers of a robot. The holding device comprising two essentially parallel lengthwise walls and two essentially parallel transverse walls which extend substantially at right angles from the lengthwise walls. Holding devices according to preferred embodiments are constructed in a frame shape, wherein the lengthwise and transverse walls define a frame surrounding at least one opening which completely transverses the device. Holding devices according to further embodiments are constructed a plate shape, in that the region between the lengthwise walls and transverse walls is implemented as a carrying surface. All embodiments comprising gripping surfaces on the external surface profile of the lengthwise and transverse walls.
摘要翻译：一种用于至少一个物体载体的保持装置，所述物体载体适于接收一种或多种有机和/或无机样品并且包括诸如玻璃，塑料，硅，热解石墨和/或金属的材料，该保持装置被配置被机器人的夹具夹住。保持装置包括两个基本上平行的纵向壁和两个基本上平行的横向壁，其从纵向壁基本上以直角延伸。根据优选实施例的保持装置被构造成框架形状，其中纵向和横向壁限定围绕完全横穿装置的至少一个开口的框架。根据其他实施例的保持装置被构造为板形，其中纵向壁和横向壁之间的区域被实现为承载表面。所有实施例包括在纵向和横向壁的外表面轮廓上抓握表面。

178. 发明授权

US07419836B2 Device and method for observing reactions in samples 有权
标题翻译：用于观察样品反应的装置和方法
公开(公告)号：US07419836B2
公开(公告)日：2008-09-02
申请号：US10760829
申请日：2004-01-20
申请人： Markus Schuerf , Harald Gebetsroither , Andreas Erlbacher
发明人： Markus Schuerf , Harald Gebetsroither , Andreas Erlbacher
IPC分类号： G01N21/00
CPC分类号： G01N21/253 , G01N21/6452 , G01N21/76
摘要： The present invention relates to a device (1) for observing reactions in samples (2), to which a reagent (3) is added, and/or a method which is based on the use of this device. The device includes at least one first optical device (4) for observing samples (2) in the direction of a first optical axis (5) and in a first observation region (6) penetrated by the first optical axis; a first device (7) for receiving receptacles (8) containing samples (2) and for aligning samples in these receptacles in relation to the first optical axis (5); and an injection device (10) for adding liquids (3) to samples (2) and an illumination device (17) for irradiating the samples (2) with excitation light of a first wavelength. In this case, the injection device (10) is preferably positioned between the first optical device (4) and the receptacles (8) and includes at least one injector opening (11) of an injector needle (12) positioned in the observation region (6) of the first optical device (4) and a supply line (13) assigned thereto. The device (1) according to the present invention is characterized in that the injection device (10) for adding liquids (3) to samples (2) includes a tray (24) which is implemented for carrying and positioning the at least one injector needle (12) and its supply line (13).
摘要翻译：本发明涉及一种用于观察添加有试剂（3）的样品（2）中的反应的装置（1）和/或基于使用该装置的方法。该装置包括至少一个第一光学装置（4），用于沿第一光轴（5）的方向观察样品（2）和在被第一光轴穿过的第一观察区域（6）中; 第一装置（7），用于接收容纳样品（2）的容器（8）并用于相对于所述第一光轴（5）将所述容器中的样品对准; 以及用于向样品（2）中加入液体（3）和用于用第一波长的激发光照射样品（2）的照明装置（17）的注射装置（10）。在这种情况下，注射装置（10）优选地定位在第一光学装置（4）和容器（8）之间，并且包括位于观察区域（11）中的注射器针头（12）的至少一个注射器开口（11）第一光学装置（4）的电源线（6）和分配给其的电源线（13）。根据本发明的装置（1）的特征在于，用于向样品（2）添加液体（3）的注射装置（10）包括托盘（24），其被实施用于承载和定位至少一个注射针（12）及其供应管线（13）。

179. 发明授权

US07264432B2 Device and method for transferring objects 有权
标题翻译：用于传输对象的设备和方法
公开(公告)号：US07264432B2
公开(公告)日：2007-09-04
申请号：US10886887
申请日：2004-07-08
申请人： Markus Wiggli , Hanspeter Romer , Peter Muerset , Gregor Batliner , Fred Schinzel , Alois Oberholzer
发明人： Markus Wiggli , Hanspeter Romer , Peter Muerset , Gregor Batliner , Fred Schinzel , Alois Oberholzer
IPC分类号： B65H5/00
CPC分类号： G01N35/04 , G01N35/00732 , G01N35/0099 , G01N2035/041 , G01N2035/0415 , G01N2035/0417 , G01N2035/0424 , G01N2035/0425
摘要： A device for transferring and characterizing objects positions the object on a horizontal work field. The device includes at least one rail extending parallel to the X direction and a displacement unit, movable back and forth in the X direction, having a motorized gripping mechanism for grasping an object. A processor for controlling movements of the displacement unit and actions of the gripping mechanism is distinguished in that the displacement unit includes a carrying device, movable together therewith along the rail, for transferring objects in the X direction. The carrying device is a plate for carrying objects moved onto this carrying plate using the gripping mechanism. According to a method of the invention, objects are moved onto the plate of the carrying device, transferred in the X direction, and deposited again at a second position.
摘要翻译：用于传输和表征对象的设备将对象放置在水平工作字段上。该装置包括平行于X方向延伸的至少一个轨道和可在X方向前后移动的位移单元，具有用于抓握物体的机动夹持机构。用于控制位移单元的移动的处理器和夹持机构的动作的区别在于，位移单元包括沿着轨道一起可移动的运送装置，用于沿X方向传送物体。携带装置是用于使用夹持机构携带移动到该承载板上的物体的板。根据本发明的方法，将物体移动到携带装置的板上，在X方向上传送，并再次沉积在第二位置。

180. 发明授权

US07223610B2 Direct phosphorylation state monitoring on biomolecules 有权
标题翻译：直接磷酸化状态监测生物分子
公开(公告)号：US07223610B2
公开(公告)日：2007-05-29
申请号：US10820404
申请日：2004-04-08
申请人： Klaus Doering
发明人： Klaus Doering
IPC分类号： G01N33/53
CPC分类号： G01N33/582 , C12Q1/42 , C12Q1/485 , Y10S436/80
摘要： Method for measuring the presence or absence of chemical groups, in particular phosphate groups, attached to biological molecules in a sample in which these molecules are tagged with fluorescent markers and these fluorescent markers are activated by means of irradiating the sample with light. The method is characterized by the following steps: a) Use of a fluorescent marker, the fluorescence lifetime of which assumes a different value depending upon the presence or absence of phosphate groups attached to the biomolecule; b) Measurement of the fluorescence lifetime of the fluorescent marker attached to a biomolecule and selected in accordance with Step a); c) Classification of the biomolecules in accordance with the presence or absence of phosphate groups attached to these, based on the different lifetime of each.
摘要翻译：测量这些分子用荧光标记物标记的样品中附着于生物分子的化学基团，特别是磷酸酯基团的存在或不存在的方法通过用光照射样品来激活。该方法的特征在于以下步骤：a）使用荧光标记物，其荧光寿命取决于连接到生物分子上的磷酸基团的存在或不存在而具有不同的值; b）测量连接到生物分子并根据步骤a）选择的荧光标记的荧光寿命; c）根据每种生物分子的不同寿命，根据附着于其上的磷酸酯基团的存在或不存在生物分子的分类。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式