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131. 发明授权

US06875980B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06875980B2
公开(公告)日：2005-04-05
申请号：US10636767
申请日：2003-08-08
申请人： Robert Harold Bateman , Jeff Brown
发明人： Robert Harold Bateman , Jeff Brown
IPC分类号： H01J49/34 , H01J49/40 , H01J49/42
CPC分类号： H01J49/004 , H01J49/42
摘要： A mass spectrometer is disclosed wherein a relatively energetic pulse of ions having a relatively narrow spread of mass to charge ratios are ejected from a quadrupole ion trap and received in an ion trap upstream of a Time of Flight mass analyser. The ions are collisionally cooled within the ion trap and are pulsed out of the ion trap and into an extraction region of the Time of Flight mass analyser without substantially exciting the ions. This enables improved operation with the Time of Flight mass analyser. According to another embodiment, parent ions are fragmented and the resulting fragment ions are stored in two ion traps having different low mass cut-offs. The trapping system enables MS/MS experiments to be performed with a very high duty cycle.
摘要翻译：公开了一种质谱仪，其中具有相对较窄的质荷比扩散的相对高能的离子脉冲从四极离子阱排出并被接收在飞行时间质量分析器上游的离子阱中。离子在离子阱内被碰撞冷却，并从离子阱中脉冲出并进入飞行时间质量分析仪的提取区域，而基本上不激励离子。这可以通过“飞行时间”质量分析仪进行改进的操作。根据另一个实施方案，母体离子是碎片化的，所得到的碎片离子存储在具有不同低质量截止值的两个离子阱中。捕获系统能够以非常高的占空比执行MS / MS实验。

132. 发明申请

US20040232326A1 FAIMS apparatus having plural ion inlets and method therefore 失效
标题翻译：因此具有多个离子入口的FAIMS装置和方法
公开(公告)号：US20040232326A1
公开(公告)日：2004-11-25
申请号：US10861518
申请日：2004-06-07
申请人： Ionalytics Corporation
发明人： Roger Guevremont , Randy Purves , David Barnett , Kevin Mansfield
IPC分类号： H01J049/00
CPC分类号： H01J49/42 , G01N27/624 , H01J49/004 , H01J49/107
摘要： An apparatus for multiplexing ions from a plurality of ionization sources includes a FAIMS analyzer including an inner electrode and an outer electrode, the outer electrode having a plurality of spaced-apart ion inlet orifices and a single ion outlet orifice. A plurality of non-trapping FAIMS analyzers is disposed adjacent to the FAIMS analyzer. Each non-trapping FAIMS analyzer of the plurality of non-trapping FAIMS analyzers has a single ion outlet orifice in communication with one ion inlet orifice of the plurality of ion inlet orifices of the FAIMS analyzer, and each non-trapping FAIMS analyzer has a single ion inlet orifice for supporting introduction of ions into the non-trapping FAIMS. An electrical controller is provided in communication with the FAIMS, for providing conditions within the FAIMS for supporting transmission of at least some of the ions introduced into the FAIMS from one of the non-trapping FAIMS and for not supporting transmission of substantially all of the ions introduced simultaneously into the FAIMS from the other one of the non-trapping FAIMS.
摘要翻译：用于复用多个离子源的离子的装置包括FAIMS分析仪，其包括内部电极和外部电极，所述外部电极具有多个间隔开的离子入口孔和单个离子出口孔。多个非捕获FAIMS分析仪设置在FAIMS分析仪附近。多个非捕获FAIMS分析仪的每个非捕获FAIMS分析仪具有与FAIMS分析仪的多个离子入口孔中的一个离子入口孔连通的单个离子出口孔，并且每个非捕获FAIMS分析仪具有单个离子入口孔，用于支持将离子引入非捕获性FAIMS。提供与FAIMS通信的电气控制器，用于提供FAIMS内的条件，用于支持从非陷阱FAIMS之一引入到FAIMS中的至少一些离子的传输，并且不支持基本上所有离子的传输从另一个非捕获的FAIMS同时引入FAIMS。

133. 发明授权

US06794640B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06794640B2
公开(公告)日：2004-09-21
申请号：US10301710
申请日：2002-11-22
申请人： Robert Harold Bateman , Jeff Brown , Anthony James Gilbert
发明人： Robert Harold Bateman , Jeff Brown , Anthony James Gilbert
IPC分类号： H01J4900
CPC分类号： H01J49/004 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap such as a 3D quadrupole field ion trap upstream of a pusher electrode of an orthogonal acceleration Time of Flight mass analyzer. According to a first embodiment bunches of ions are released from the ion trap and the pusher electrode is energised after a delay time which is progressively varied. According to a second embodiment ions are released from the ion trap in reverse order of mass to charge ratio with the ions having the largest mass to charge ratio being released first. By appropriate release of the ions from the ion trap it is possible to ensure that substantially all of the ions arrive at the pusher electrode at substantially the same time. According to both embodiments it is possible to achieve a duty cycle approaching 100% across a large range of mass to charge ratios.
摘要翻译：公开了一种质谱仪，其包括质量选择性离子阱，例如正交加速时间飞行质量分析仪的推进器电极上游的3D四极场离子阱。根据第一实施例，一束离子从离子阱中释放出来，并且推进器电极在逐渐变化的延迟时间之后通电。根据第二实施方案，离子从离子阱以与质荷比最大的离子的质荷比相反的顺序被释放。通过从离子阱适当释放离子，可以确保基本上所有的离子基本上同时到达推动器电极。根据两个实施例，可以实现在大范围的质荷比之间接近100％的占空比。

134. 发明申请

US20040173740A1 Method of selectively inhibiting reaction between ions 失效
标题翻译：选择性抑制离子之间反应的方法
公开(公告)号：US20040173740A1
公开(公告)日：2004-09-09
申请号：US10485807
申请日：2004-02-04
发明人： Scott A. McLuckey , Gavin E. Reid , James Mitchell Wells
IPC分类号： H01J049/00
CPC分类号： H01J49/424 , H01J49/0063 , H01J49/0072 , H01J49/0077 , H01J49/04 , H01J49/42
摘要： A method of inhibiting the reaction between ions of opposite polarity is disclosed. The method includes exposing a population of ions to a resonance excitation frequency during a mass-to-charge altering reaction between a first subpopulation of ions and a second subpopulation of ions, the resonance excitation frequency being tuned to inhibit the mass-to-charge altering reaction between an ion of the first subpopulation of ions having a predetermined mass-to-charge ratio and an ion of the second subpopulation of ions so that when an ion of the first subpopulation of ions attains the predetermined mass-to-charge ratio, the ion having the predetermined mass-to-charge ratio is selectively inhibited from reacting with ions of the second subpopulation of ions.
摘要翻译：公开了抑制相反极性的离子之间的反应的方法。该方法包括在离子的第一亚群和第二亚离子群之间的质量 - 电荷改变反应期间将离子群体暴露于共振激发频率，谐振激发频率被调谐以抑制质量 - 电荷改变具有预定质荷比的第一亚群的离子与第二子离子群的离子之间的反应，使得当离子的第一亚群离子达到预定的质荷比时，选择性地抑制具有预定质荷比的离子与第二亚离子群的离子反应。

135. 发明申请

US20040079873A1 Mass spectrometer 有权
公开(公告)号：US20040079873A1
公开(公告)日：2004-04-29
申请号：US10636767
申请日：2003-08-08
发明人： Robert Harold Bateman , Jeff Brown
IPC分类号： H01J049/34
CPC分类号： H01J49/004 , H01J49/42
摘要： A mass spectrometer is disclosed wherein a relatively energetic pulse of ions having a relatively narrow spread of mass to charge ratios are ejected from a quadrupole ion trap and received in an ion trap upstream of a Time of Flight mass analyser. The ions are collisionally cooled within the ion trap and are pulsed out of the ion trap and into an extraction region of the Time of Flight mass analyser without substantially exciting the ions. This enables improved operation with the Time of Flight mass analyser. According to another embodiment, parent ions are fragmented and the resulting fragment ions are stored in two ion traps having different low mass cut-offs. The trapping system enables MS/MS experiments to be performed with a very high duty cycle.

136. 发明授权

US06610976B2 Method and apparatus for improved signal-to-noise ratio in mass spectrometry 失效
标题翻译：在质谱中提高信噪比的方法和装置
公开(公告)号：US06610976B2
公开(公告)日：2003-08-26
申请号：US10232100
申请日：2002-08-28
申请人： Brian T. Chait , Andrew N. Krutchinsky
发明人： Brian T. Chait , Andrew N. Krutchinsky
IPC分类号： H01J4900
CPC分类号： H01J49/42
摘要： A method and apparatus for increasing the signal-to-noise ratio in a range of mass-to-charge ratios of a mass spectrum. Initially ions of interest and background ions having mass-to-charge ratios within the range of mass-to-charge ratios are generated. The ions of interest and the background ions are then subjected to an activation energy sufficient to cause dissociation of background ions to an extent greater than the dissociation of the ions of interest. The dissociation of the background ions causes the background ions to have mass-to-charge ratios that fall outside of the range of mass-to-charge ratios. The mass-to-charge ratios of the ions of interest are then detected.
摘要翻译：一种用于在质谱的质荷比范围内提高信噪比的方法和装置。最初产生了质荷比在离子质荷比范围内的感兴趣离子和背景离子。然后将感兴趣的离子和背景离子进行足够的活化能，使得背景离子的离解程度大于感兴趣离子的离解程度。背景离子的离解导致背景离子具有落在质荷比范围之外的质荷比。然后检测感兴趣的离子的质荷比。

137. 发明申请

US20030132377A1 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20030132377A1
公开(公告)日：2003-07-17
申请号：US10301710
申请日：2002-11-22
发明人： Robert Harold Bateman , Jeff Brown , Anthony James Gilbert
IPC分类号： H01J049/00
CPC分类号： H01J49/004 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap such as a 3D quadrupole field ion trap upstream of a pusher electrode of an orthogonal acceleration Time of Flight mass analyser. According to a first embodiment bunches of ions are released from the ion trap and the pusher electrode is energised after a delay time which is progressively varied. According to a second embodiment ions are released from the ion trap in reverse order of mass to charge ratio with the ions having the largest mass to charge ratio being released first. By appropriate release of the ions from the ion trap it is possible to ensure that substantially all of the ions arrive at the pusher electrode at substantially the same time. According to both embodiments it is possible to achieve a duty cycle approaching 100% across a large range of mass to charge ratios.
摘要翻译：公开了一种质谱仪，其包括质量选择性离子阱，例如正交加速时间飞行质量分析仪的推进器电极上游的3D四极场离子阱。根据第一实施例，一束离子从离子阱中释放出来，并且推进器电极在逐渐变化的延迟时间之后通电。根据第二实施方案，离子从离子阱以与质荷比最大的离子的质荷比相反的顺序被释放。通过从离子阱适当释放离子，可以确保基本上所有的离子基本上同时到达推动器电极。根据两个实施例，可以实现在大范围的质荷比之间接近100％的占空比。

138. 发明授权

US06586730B1 Plasma ion source mass spectrometer 失效
标题翻译：等离子体离子源质谱仪
公开(公告)号：US06586730B1
公开(公告)日：2003-07-01
申请号：US09505428
申请日：2000-02-16
申请人： Seiji Kamimura , Isamu Takekoshi , Yasushi Terui , Yasuaki Takada , Takayuki Nabeshima , Minoru Sakairi
发明人： Seiji Kamimura , Isamu Takekoshi , Yasushi Terui , Yasuaki Takada , Takayuki Nabeshima , Minoru Sakairi
IPC分类号： H01J4900
CPC分类号： H01J49/282 , H01J49/04 , H01J49/42
摘要： A compact, easy-to-use device is provided which takes in a sample over a shorter distance, the sample introducing time is shortened, and contamination is prevented when the sample is introduced. A burner for generating a plasma, a deflecting portion provided with parallel electrodes for deflecting ions, and an analyzer room for performing mass separation of the deflected ions, these being disposed in a plane in the horizontal direction, and a sample setting portion for setting a sample, a peristaltic pump for aspirating the sample and the burner for introducing and burning the aspirated sample are disposed in a plane in the vertical direction relative to the aforesaid plane. The sample is supplied to the burner from below, and the ions generated by the plasma are made to flow on a horizontal plane.
摘要翻译：提供了一种紧凑，易于使用的装置，其在较短距离内吸收样品，缩短了样品引入时间，并且在引入样品时防止污染。用于产生等离子体的燃烧器，设置有用于偏转离子的平行电极的偏转部分和用于进行偏转离子的质量分离的分析器室，这些离子被设置在水平方向的平面中;以及样品设定部，样品，抽吸样品的蠕动泵和用于引入和燃烧吸气样品的燃烧器相对于上述平面设置在垂直方向上的平面中。将样品从下方供应到燃烧器，并且使由等离子体产生的离子在水平面上流动。

139. 发明授权

US06483244B1 Method of fast start and/or fast termination of a radio frequency resonator 有权
标题翻译：无线电频率谐振器的快速启动和/或快速终止的方法
公开(公告)号：US06483244B1
公开(公告)日：2002-11-19
申请号：US09868751
申请日：2001-07-31
申请人： Eizo Kawato , Li Ding
发明人： Eizo Kawato , Li Ding
IPC分类号： H03B512
CPC分类号： H01J49/022 , H01J49/42 , H03B11/10
摘要： A method of fast start and/or fast termination of a radio frequency resonator, which has a coil, a capacitor and two switches with internal resistance wherein one end of the switches is connected to a junction of the coil and the capacitor where a RF voltage is provided, and another end of each switch is connected to high voltage power supplies with opposite polarities, a fast start being achieved by closing one of the switches for a short period of time for fast start, and a fast termination being obtained by closing both switches for a while.
摘要翻译：一种具有线圈，电容器和具有内部电阻的两个开关的射频谐振器的快速启动和/或快速终止的方法，其中开关的一端连接到线圈和电容器的结，RF电压并且每个开关的另一端连接到具有相反极性的高压电源，快速启动是通过闭合其中一个开关短时间来快速启动的，并且通过闭合两者来获得快速终止切换一会儿

140. 发明申请

US20020030159A1 MS/MS scan methods for a quadrupole/time of flight tandem mass spectrometer 有权
标题翻译：用于四极杆/飞行时间串联质谱仪的MS / MS扫描方法
公开(公告)号：US20020030159A1
公开(公告)日：2002-03-14
申请号：US09864872
申请日：2001-05-25
发明人： Igor Chernushevich , Bruce Thomson
IPC分类号： H01J049/40
CPC分类号： H01J49/40 , H01J49/004 , H01J49/401 , H01J49/42 , H01J49/421 , H01J49/4225
摘要： There is provided a method of effecting mass analysis on an ion stream, the method comprising passing the ion stream through a first mass resolving spectrometer, to select parent ions having a first desired mass-to-charge ratio. The parent ions are then subject to collision-induced dissociation (CID) to generate product ions, and the product Ions and any remaining parent ions are trapped the CID and trapping can be carried out together in a linear ion trap. Periodically pulses of the trapped ions are released into a time of flight (TOF) instrument to determine the mass-to-charge ratio of the ions. The delay between the release of the pulses and the initiation of the push-pull pulses of the TOF instrument are adjusted to maximize the duty cycle efficiency and hence the sensitivity for a selected ion with a desired mass-to-charge ratio. This technique can be used to optimize the performance for a parent ion scan, and MRM scan or a neutral loss scan.
摘要翻译：提供了一种对离子流进行质量分析的方法，该方法包括使离子流通过第一质谱分析光谱仪，以选择具有第一期望的质荷比的母体离子。母体离子然后经受碰撞诱导的解离（CID）以产生产物离子，并且产物离子和任何剩余的母体离子被捕获到CID并且捕获可以一起在线性离子阱中进行。捕获的离子的周期脉冲被释放到飞行时间（TOF）仪器中以确定离子的质荷比。脉冲的释放和TOF器件的推挽脉冲的启动之间的延迟被调整以最大化占空比效率，并因此使具有期望的质荷比的选定离子的灵敏度最大化。该技术可用于优化父离子扫描，MRM扫描或中性损失扫描的性能。

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