专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

131. 发明授权

US08250020B2 Method and system for automated analysis of nuclear magnetic resonance spectra 有权
标题翻译：核磁共振谱自动分析方法与系统
公开(公告)号：US08250020B2
公开(公告)日：2012-08-21
申请号：US12461834
申请日：2009-08-26
申请人： Jiwen Li , Abraham Bernstein , Bjoern Heitmann , Michael Fey , Till Kuehn , Sandra Loss , James Masse , Konstantin Pervushin , Oskar Schett
发明人： Jiwen Li , Abraham Bernstein , Bjoern Heitmann , Michael Fey , Till Kuehn , Sandra Loss , James Masse , Konstantin Pervushin , Oskar Schett
IPC分类号： G06N5/00
CPC分类号： G01R33/4625 , G01N24/087 , G01R33/5608 , G06F19/703 , G06F19/707 , G06N5/046
摘要： A fully automatic, parameter free MR interpretation system is based on human logic emulation. Information is derived mainly from an MR spectrum with maximum confidence and in a similar way as a human expert. This is achieved by the combination of different expert systems that interpret certain MR spectral features as well as features from a proposed structure. The expert systems are dynamically linked to each other and the analysis is performed iteratively in all directions in a way that the expert systems can utilize all of the interpretations of all expert systems at all times. The expert system may generate not just a single result but rather lists of probability weighted hypotheses.
摘要翻译：全自动，无参数的MR解释系统基于人为逻辑仿真。信息主要来自具有最大信度的MR谱，与人类专家类似。这是通过解释某些MR谱特征以及来自所提出的结构的特征的不同专家系统的组合来实现的。专家系统彼此动态链接，并且分析在所有方向上迭代地执行，专家系统可以始终利用所有专家系统的所有解释。专家系统不仅可以产生单一的结果，而且可能产生概率加权假说的列表。

132. 发明授权

US08154292B2 Apparatus for carrying out DNP-NMR measurements with a compensation configuration and method for designing the compensation configuration 有权
标题翻译：用于以补偿配置进行DNP-NMR测量的设备和用于设计补偿配置的方法
公开(公告)号：US08154292B2
公开(公告)日：2012-04-10
申请号：US12458488
申请日：2009-07-14
申请人： Pierre-Alain Bovier , Robert Schauwecker , Daniel Eckert
发明人： Pierre-Alain Bovier , Robert Schauwecker , Daniel Eckert
IPC分类号： G01V3/00
CPC分类号： G01R33/62 , G01R33/281 , G01R33/30 , G01R33/3873 , G01R33/3875
摘要： An apparatus for DNP-NMR measurement on a sample, with a magnet configuration for producing a magnetic field in a first working volume and in, a second working volume with a magnetic field gradient in the direction of an axis (z) which extends through the second working volume, with a device for measuring MR signals, with a DNP excitation device, and with a positioning mechanism for transferring the sample, is characterized in that, near the second working volume, a compensation configuration made of magnetic material is mounted that, in the operating condition of the magnet configuration, produces a magnetic field gradient in the direction of the axis (z) in the second working volume that is between −90% and −110% of the magnetic field gradient of the same order of the stray field of the magnet configuration.
摘要翻译：一种用于在样品上进行DNP-NMR测量的装置，具有用于在第一工作体积中产生磁场的磁体构造和在沿着轴线（z）延伸的轴线（z）的方向上具有磁场梯度的第二工作体积第二工作体积，具有用于测量MR信号的装置，具有DNP激励装置，以及用于传送样品的定位机构，其特征在于，在第二工作体积附近，安装由磁性材料制成的补偿构造，在磁体结构的运行状态下，在第二工作容积中沿轴线方向（z）产生磁场梯度，该磁场梯度在杂散相同阶数的磁场梯度的-90％至-110％之间磁铁配置场。

133. 发明申请

US20100271025A1 Device for highly precise synchronization of the NMR transmission frequency to the resonance frequency of an NMR line while taking into consideration a non-constant RF phase 有权
标题翻译：用于在考虑非恒定RF相位时将NMR传输频率与NMR谱线的谐振频率进行高精度同步的装置
公开(公告)号：US20100271025A1
公开(公告)日：2010-10-28
申请号：US12662388
申请日：2010-04-14
申请人： Arthur Schwilch , Michael Schenkel
发明人： Arthur Schwilch , Michael Schenkel
IPC分类号： G01R33/48
CPC分类号： G01R33/31 , G01R33/36 , G01R33/3607 , G01R33/389
摘要： A device that comprises an RF generator (29), an NMR transmission (20) and reception system (21) and a first control loop (28), with which the frequency fRF of the RF generator is synchronized with the resonance frequency f0 of an NMR line, wherein, from the signal of the RF generator, a train of excitation pulses (EX) of the repetition frequency fm is generated, with which nuclear spins of a certain resonance frequency of an associated NMR line are excited quasi-continuously (CW) and, in the times between the excitation pulses, the NMR signal is received (AQ), wherein the period time 1/fm is chosen to be much smaller than the relaxation time of the NMR line, preferably shorter than 1/10 of the relaxation time, and the NMR signal UD mixed down into the low-frequency range is used, with the help of the first control loop, to closed-loop-control the value of the transmission frequency (=frequency lock) or the value of the B0 field (=field lock) in such a way that the frequency and phase of the RF generator and the NMR line match as precisely as possible, characterized in that a phase shifter (22) that rotates the radio-frequency phase of the NMR transmission and reception system in the first control loop by the value Δφ is controlled by a second control loop (27) whose input signal comes from a signal extraction stage (25, 26) that extracts the saw-tooth AC component of the signal UD and maintains this input signal at zero by closed-loop control. In this way, the influence of the RF phase on the synchronization process can be taken into consideration to improve the precision with which the resonance frequency of an NMR line is synchronized.
摘要翻译：一种包括RF发生器（29），NMR传输（20）和接收系统（21）以及第一控制环路（28）的装置，RF发生器的频率fRF与RF发生器的谐振频率f0同步 NMR线，其中，根据RF发生器的信号，产生一系列重复频率f m的激励脉冲（EX），与之相关联的NMR线的某个共振频率的核自旋被准星激励（CW ），并且在激发脉冲之间的时间内接收NMR信号（AQ），其中周期时间1 / fm被选择为远小于NMR线的弛豫时间，优选短于NMR线的1/10 松弛时间和混合到低频范围内的NMR信号UD，在第一个控制环路的帮助下，使用闭环控制传输频率（=频率锁定）的值或 B0字段（=字段锁）以这样的方式使频率和相位射频发生器和NMR线路尽可能精确地匹配，其特征在于：使所述第一控制回路中的所述NMR发射和接收系统的射频相位旋转的移相器（22）的值＆Dgr; 由第二控制回路（27）控制，其输入信号来自提取信号UD的锯齿AC分量的信号提取级（25,26），并通过闭环控制将该输入信号保持在零。以这种方式，可以考虑RF相对同步过程的影响，以提高NMR线的共振频率同步的精度。

134. 外观设计

USD624660S1 Holder for sample containers 有权
公开(公告)号：USD624660S1
公开(公告)日：2010-09-28
申请号：US29357899
申请日：2010-03-18
申请人： Kurt Himmelsbach , Bent Grossniklaus
设计人： Kurt Himmelsbach , Bent Grossniklaus

135. 发明授权

US07718135B2 Sample holder for holding and transporting a sample vial within an NMR apparatus and automatic supply device for the automated exchange of NMR sample vials and method of operation thereof 有权
标题翻译：用于在NMR装置内保持和运送样品瓶的样品架和用于NMR样品瓶的自动交换的自动供给装置及其操作方法
公开(公告)号：US07718135B2
公开(公告)日：2010-05-18
申请号：US11700944
申请日：2007-02-01
申请人： Kurt Himmelsbach , Franco Sestito
发明人： Kurt Himmelsbach , Franco Sestito
IPC分类号： B01L9/00
CPC分类号： G01R33/307 , Y10S505/844 , Y10T436/24
摘要： A sample holder for fixing and transporting a sample vial (1) within an NMR configuration comprising an outer shell (4) and a continuous hollow space disposed inside the outer shell (4) and extending along its axis for receiving the sample vial, is characterized in that a clamping device that can be switched on and off and a switching element (6) are provided inside the hollow space, wherein, in the activated state, the clamping device fixes a sample vial (1) that is introduced into the sample holder, the switching element (6) can be operated from the outside, and the clamping device can be deactivated using the switching element (6) such that, in the deactivated state, the sample vial (1) inserted into- or removed from the sample holder is not fixed. Such a sample holder may be used to realize an automatic supply device for changing NMR sample vials which has a very compact structure and can be mounted using little space.
摘要翻译：用于在包括外壳（4）和布置在外壳（4）内部并沿着其轴线延伸以接收样品瓶的连续中空空间的NMR构型内固定和运送样品瓶（1）的样品保持器被表征其特征在于，可以在所述中空空间内设置能够接通和断开的夹紧装置和开关元件（6），其中，在所述启动状态下，所述夹紧装置固定导入到所述样品架中的样品瓶（1），可以从外部操作开关元件（6），并且可以使用开关元件（6）使夹紧装置停用，使得在停用状态下，样品瓶（1）插入或从样品中移出持有人不固定这种样品保持器可以用于实现用于改变NMR样品瓶的自动供应装置，其具有非常紧凑的结构并且可以使用很小的空间来安装。

136. 发明授权

US07612563B2 Flow-through microfluidic nuclear magnetic resonance(=NMR)-chip 有权
标题翻译：流通微流核磁共振（= NMR）芯片
公开(公告)号：US07612563B2
公开(公告)日：2009-11-03
申请号：US11905637
申请日：2007-10-03
申请人： Charles Massin , Michael Fey
发明人： Charles Massin , Michael Fey
IPC分类号： G01V3/00
CPC分类号： G01R33/302 , G01R33/307
摘要： A flow-through microfluidic NMR-chip comprising a substrate (5) which is planar in an yz-plane with a sample chamber (2) within the substrate (5), the sample chamber (2) being elongated and having walls which run parallel to the z-direction, the substrate (5) having a thickness in x-direction of a Cartesian xyz-coordinate system between 100 μm and 2 mm, and at least one planar receiving and/or transmission coil (1, 1′) with conductor sections (11) the coil (1, 1′) being arranged at least on one planar surface of the substrate (5), wherein the extension of the sample chamber (2) along the z-direction exceeds the extension of the coil (1) along the z-direction is characterized in that the extension of the coil (1, 1′) along the z-direction is larger than its extension along the y-direction. The inventive NMR-chip facilitated NMR-spectroscopic measurements with improved resolution, sensitivity as well as B1 homogeneity.
摘要翻译：一种流通微流体NMR芯片，包括在衬底（5）内具有样品室（2）的yz平面平面的衬底（5），样品室（2）是细长的并具有平行的壁在z方向上，基板（5）具有在100m和2mm之间的笛卡尔xyz坐标系的x方向上的厚度，以及至少一个平面接收和/或传输线圈（1,1'），具有导体部分（11），所述线圈（1,1'）布置在所述基板（5）的至少一个平坦表面上，其中所述样品室（2）沿着z方向的延伸超过所述线圈 1）沿着z方向的特征在于，线圈（1,1'）沿着z方向的延伸大于沿着y方向的延伸。本发明的NMR芯片促进了NMR光谱测量，具有改进的分辨率，灵敏度以及B1同质性。

137. 发明授权

US07606019B2 Magnet coil system with active drift compensation for two independent current paths 有权
标题翻译：具有两个独立电流路径的有源漂移补偿的磁体线圈系统
公开(公告)号：US07606019B2
公开(公告)日：2009-10-20
申请号：US12068038
申请日：2008-02-01
申请人： Rolf Spreiter , Patrik Vonlanthen
发明人： Rolf Spreiter , Patrik Vonlanthen
IPC分类号： H01F6/00
CPC分类号： H01F6/005 , G01R33/3815 , H01F6/008 , Y10S505/851
摘要： A magnet coil system (2) which is at least partially superconducting at a cryogenic temperature, comprising at least two partial coils (3, 4, 5) which are connected in series and are each bridged by a superconducting switch (6, 7, 8), such that the partial coils form independent electric loops (11, 12, 13) when the superconducting switches (6, 7, 8) are closed, is characterized in that two electric loops (11, 12) have a common section and a flux pump (10) is provided which is circuited in the common section (14) of the electric loops (11, 12) of two partial coils (3, 4), wherein the sum of the currents of the two partial coils (3, 4) flows through the flux pump (10) in the operating state. In this fashion, the drifts of two independent electric loops can be compensated for with a few devices.
摘要翻译：一种在低温下至少部分地超导的电磁线圈系统（2），包括至少两个串联连接并且由超导开关（6,7,8）桥接的部分线圈（3,4,5）），使得当超导开关（6,7,8）闭合时，部分线圈形成独立的电回路（11,12,13），其特征在于两个电气回路（11,12）具有公共部分和提供了在两个部分线圈（3,4）的电气回路（11,12）的公共部分（14）中进行耦合的通量泵（10），其中两个部分线圈（3， 4）在操作状态下流过助焊剂泵（10）。以这种方式，两个独立电路的漂移可以用几个装置来补偿。

138. 发明授权

US07564244B2 RF resonator system and method for tuning an RF resonator system 有权
标题翻译： RF谐振器系统和用于调谐RF谐振器系统的方法
公开(公告)号：US07564244B2
公开(公告)日：2009-07-21
申请号：US11979755
申请日：2007-11-08
申请人： Nicolas Freytag
发明人： Nicolas Freytag
IPC分类号： G01V3/00
CPC分类号： G01R33/3628 , G01R33/34007 , G01R33/34023 , G01R33/34061 , G01R33/34092 , G01R33/341
摘要： A radio-frequency (RF) resonator system, in particular, for a magnetic resonance (MR) probe, comprising at least one RF resonator with a substrate, on which a conductive structure is applied, wherein the conductive structure comprises regions of capacitive and inductive elements, is characterized in that the conductive structure is coated at least in the regions of the capacitive elements with at least one dielectric layer that covers the regions of the capacitive elements at least partially, wherein the local thickness of at least one of the dielectric layers is set in dependence on the resonance frequency of the uncoated RF resonator, on a defined resonance frequency of the resonator once it is coated, on the dielectric constant of the substrate and on the dielectric constant of the materials of the dielectric layers. The inventive resonator system can be set to the required resonance frequency quickly, at low cost, reversibly, and with high precision and at the same time the dielectric strength of the resonator system is increased.
摘要翻译：特别是用于磁共振（MR）探针的射频（RF）谐振器系统，其包括具有衬底的至少一个RF谐振器，其上施加导电结构，其中导电结构包括电容和电感的区域元件的特征在于，导电结构至少在电容元件的区域中涂覆有至少一个电介质层，至少部分地覆盖电容元件的区域，其中至少一个电介质层的局部厚度依赖于未涂覆的RF谐振器的谐振频率，一旦涂覆了谐振器的谐振频率，就定义在基底的介电常数和电介质层材料的介电常数上。本发明的谐振器系统可以以低成本，可逆地并且以高精度快速地设置为所需的谐振频率，并且同时增加了谐振器系统的介电强度。

139. 发明授权

US07501822B2 Cooled NMR probe head with flexible cooled connecting conduit 有权
标题翻译：冷却的NMR探头具有柔性冷却连接导管
公开(公告)号：US07501822B2
公开(公告)日：2009-03-10
申请号：US11730765
申请日：2007-04-04
申请人： Marco Sacher , Daniel Marek , Tobias Leutenegger , Daniel Guy Baumann , Ralf Haueisen
发明人： Marco Sacher , Daniel Marek , Tobias Leutenegger , Daniel Guy Baumann , Ralf Haueisen
IPC分类号： G01V3/00
CPC分类号： G01R33/34046 , G01R33/30 , G01R33/34015 , G01R33/34092 , G01R33/3415
摘要： A magnetic resonance (MR) probe head comprises a detecting device with at least one antenna system which is cryogenically cooled by a cooling device, and a cooled preamplifier in a preamplifier housing which is spatially separated from the detecting device, and a thermally insulating connecting means via which the detecting device and the preamplifier housing are connected, wherein the connecting means comprises at least one cooling line for supplying and/or returning a cooling fluid, and with at least one RF line for transmitting the electric signals. The connecting means is implemented as a mechanically flexible connecting line with mechanically flexible RF lines and cooling lines disposed therein. The MR probe head is easy to handle and can be highly sensitive, wherein the detecting device can be quickly installed, removed and put into operation.
摘要翻译：磁共振（MR）探针头包括具有至少一个由冷却装置低温冷却的天线系统的检测装置，以及在与检测装置空间上分离的前置放大器壳体中的冷却前置放大器，以及隔热连接装置检测装置和前置放大器壳体通过其连接，其中连接装置包括用于供应和/或返回冷却流体的至少一条冷却管线，以及用于传输电信号的至少一条RF线。连接装置实现为机械柔性的连接线，其中机械地柔性RF线路和冷却线路设置在其中。 MR探头易于处理，可灵敏度高，可快速安装，拆卸和投入使用。

140. 发明授权

US07408353B2 Cooled NMR probe head which can be coupled 有权
标题翻译：冷却的NMR探头可以耦合
公开(公告)号：US07408353B2
公开(公告)日：2008-08-05
申请号：US11727670
申请日：2007-03-28
申请人： Daniel Marek , Marco Sacher , Tobias Leutenegger
发明人： Daniel Marek , Marco Sacher , Tobias Leutenegger
IPC分类号： G01V3/00
CPC分类号： G01R33/34046 , G01R33/30 , G01R33/302 , G01R33/34092 , G01R33/3415
摘要： A magnetic resonance (MR) probe head comprises a detecting device (3) with at least one antenna system which is cryogenically cooled by a cooling device, a cooled preamplifier (16) in a preamplifier housing (15a, 15b) which is spatially separated from the detecting device (3), and a thermally insulating connecting means via which the detecting device (3) and the preamplifier housing (15a, 15b) are connected, wherein the connecting means (15c) comprises at least one cooling line (9a, 9b, 53a, 53b) for supplying and/or returning a cooling fluid, and at least one RF line (10, 52) for transmitting electric signals. The connecting means (15c), including its RF and cooling lines (10, 52, 9a, 9b, 53a, 53b), can be separated from the preamplifier housing (15a, 15b) by a coupling. The MR probe head is an open system which can be used in a universal fashion through use of different measuring inserts. The system can be expanded for further measuring configurations at little cost and can be easily handled in a time-saving fashion with an optional arrangement having a flexible connecting line.
摘要翻译：磁共振（MR）探头包括具有至少一个由冷却装置低温冷却的天线系统的检测装置（3），在空间上的前置放大器壳体（15a，15b）中的冷却前置放大器（16）与所述检测装置（3）分离，以及隔热连接装置，所述检测装置（3）和所述前置放大器壳体（15a，15b）经由所述隔热连接装置连接，其中所述连接装置（15c）包括至少一个冷却用于供应和/或返回冷却流体的线路（9a，9b，53a，53b）以及用于传输电信号的至少一个RF线路（10,52）。包括其RF和冷却管线（10,52,99a，9b，53a，53b）的连接装置（15c）可以通过联接与前置放大器壳体（15a，15b）分离。 MR探头是一种开放系统，可以通过使用不同的测量插件以通用方式使用。该系统可以以较少的成本进行扩展，用于进一步的测量配置，并且可以以具有柔性连接线的可选布置以节省时间方式容易地处理。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式