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121. 发明申请

US20050281705A1 Methods, apparatuses, and applications for compliant membrane blood gas exchangers 有权
公开(公告)号：US20050281705A1
公开(公告)日：2005-12-22
申请号：US11211115
申请日：2005-08-24
申请人： J.D. Mortensen , Robert Schaap , Barry Bagley
发明人： J.D. Mortensen , Robert Schaap , Barry Bagley
IPC分类号： A61M1/16 , A61M1/14
CPC分类号： A61M1/16 , A61M1/1625 , A61M1/1698 , Y10S128/03 , Y10S261/28
摘要： A compliant blood gas exchanger is provided including a housing having a first end cap, a second end cap, and an elastomeric sidewall or sleeve extending there between forming a chamber. A hollow fiber assembly is disposed in the chamber. The hollow fiber assembly has a first mounting collar, a second mounting collar and a plurality of hollow fibers disposed there between. The first end cap is disposed in communication with the first mounting collar and the second end cap is disposed in communication with the second mounting collar. The end caps are connected to a gas inlet and a gas outlet. The chamber is in communication with a blood inlet and a blood outlet. The elastomeric sidewall is responsive to internal and external pressures affecting the chamber. The first chamber can also be placed adjacent to a second chamber and both chambers placed within a rigid outer housing. Thus, a dual-chamber pulsatile blood gas exchanger can be provided. That is, the second chamber may be in connection with a pump mechanism or vacuum mechanism such that the chamber creates a pulsatile flow within the first chamber.

122. 发明申请

US20050256442A1 Tubing set for blood handling system and methods of use 失效
公开(公告)号：US20050256442A1
公开(公告)日：2005-11-17
申请号：US11123659
申请日：2005-05-06
申请人： Thomas Rawles , A. Litzie , David Fallen , Steven Stringer
发明人： Thomas Rawles , A. Litzie , David Fallen , Steven Stringer
IPC分类号： A61M1/16 , A61M1/36 , A61M39/10 , A61M37/00
CPC分类号： A61M1/3643 , A61M1/1698 , A61M1/3621 , A61M1/3644 , A61M39/1011
摘要： A tubing set for use with a blood handling system is described that decreases the priming volume and surface area of the blood handling circuit, lowering the risk of hemodilution, platelet activation, and hemolysis. The tubing set also reduces the number of manual connections required, and uses quick-disconnect couplings to facilitate connections between the various lines, and between the lines and the arterial and venous cannulae.

123. 发明申请

US20050232811A1 Intravenous oxygenator 有权
标题翻译：静脉给药
公开(公告)号：US20050232811A1
公开(公告)日：2005-10-20
申请号：US10522331
申请日：2003-07-22
申请人： Rudiger Autschbach , Gjorgio Cattaneo , Helmut Reul
发明人： Rudiger Autschbach , Gjorgio Cattaneo , Helmut Reul
IPC分类号： A61M1/14 , A61M1/16 , A61M1/18 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1678 , A61M1/262
摘要： An intravenous oxygenator for enriching blood with oxygen, said oxygenator having a bundle of fibers, said fibers being each connected to a gas supply means through a first connection and to a gas evacuation means through a second connection, with the fiber bundle being twisted during operation by relative rotation of the first connections of the fibers relative to the second connections of the fibers about a longitudinal axis of the oxygenator. Further, an intravenous oxygenator for insertion into a vein, the connections being respectively connected to a first and to a second fiber holder and being displaceable along a longitudinal axis of the oxygenator, with the fiber holders being mounted so as to be rotatable relative to one another about the longitudinal axis of the oxygenator. Such a constellation permits particularly efficient gas exchange.
摘要翻译：一种用氧气富集血液的静脉给药器，所述充氧器具有一束纤维，所述纤维各自通过第一连接与气体供给装置连接，并通过第二连接与气体排出装置相连，纤维束在操作期间被扭曲通过纤维的第一连接相对于纤维围绕氧合器纵轴的相对旋转。此外，用于插入静脉的静脉内氧合器，所述连接分别连接到第一和第二纤维保持器，并且可沿着所述充氧器的纵向轴线移动，其中所述纤维保持器被安装成可相对于一个另一个关于氧合器的纵向轴线。这样的星座允许特别有效的气体交换。

124. 发明授权

US06936221B1 Method of forming gas-enriched fluid 失效
标题翻译：形成富集气体的方法
公开(公告)号：US06936221B1
公开(公告)日：2005-08-30
申请号：US09468471
申请日：1999-12-21
申请人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
发明人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
IPC分类号： A61M1/16 , A61M1/36 , A61M25/00 , A61M1/34 , A61M37/00
CPC分类号： A61M1/3626 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M25/0028 , A61M25/0029 , A61M2025/0031 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2202/0476 , B01F3/04758 , C01B13/02 , Y10S261/28 , A61M2202/0007
摘要： A method for forming a gas-enriched fluid is provided. The method includes a step of providing a mixing chamber having a first inlet, a second inlet, and an outlet. A first fluid is delivered into the mixing chamber via the first inlet and flows vertically. A second fluid having a liquid phase supersaturated with a gas is delivered to the mixing chamber via the second inlet to mix with the first fluid and from the gas-enriched fluid.
摘要翻译：提供了一种形成富含气体的流体的方法。该方法包括提供具有第一入口，第二入口和出口的混合室的步骤。第一流体经由第一入口输送到混合室中并垂直流动。具有用气体过饱和的液相的第二流体经由第二入口输送到混合室，以与第一流体和富含气体的流体混合。

125. 发明申请

US20050182349A1 Modified organ support devices 有权
标题翻译：改良器官支持装置
公开(公告)号：US20050182349A1
公开(公告)日：2005-08-18
申请号：US11050398
申请日：2005-02-02
申请人： Peter Linde , Winfred Williams
发明人： Peter Linde , Winfred Williams
IPC分类号： A01N1/00 , A01N1/02 , A61M1/14 , A61M1/16 , A61M1/32 , A61M1/34 , A61M1/36 , A61M31/00 , A61M37/00 , B01D11/00 , C02F1/44 , C12M1/00 , C12M3/00
CPC分类号： A61M1/16 , A01N1/02 , A01N1/0247 , A61M1/1698 , A61M1/32 , A61M1/3468 , A61M1/3472 , A61M1/3482 , A61M1/3489 , A61M1/3603 , A61M2202/0208
摘要： Methods and devices are provided that improve the function of organ support devices, and also provided are improved methods of treating conditions associated with hemodynamic instability.
摘要翻译：提供了改善器官支持装置的功能的方法和装置，并且还提供了治疗与血液动力学不稳定性相关的病症的改进方法。

126. 发明申请

US20050061742A1 Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in physiologic fluids 审中-公开
标题翻译：用于降低生理液中促炎症或抗炎刺激物或介质的水平的装置，系统和方法
公开(公告)号：US20050061742A1
公开(公告)日：2005-03-24
申请号：US10981055
申请日：2004-11-04
申请人： James Brady , James Winchester , Vadim Davankov , Maria Tsyurupa , Ludmila Pavlova , Frank Norris , Peter Quartararo , Jamie Salsberg
发明人： James Brady , James Winchester , Vadim Davankov , Maria Tsyurupa , Ludmila Pavlova , Frank Norris , Peter Quartararo , Jamie Salsberg
IPC分类号： A01N1/02 , A61M1/16 , A61M1/28 , A61M1/34 , A61M1/36 , B01D15/00 , B01D39/04 , B01J20/26 , B01J20/32 , C02F1/44
CPC分类号： A61M1/28 , A61M1/16 , A61M1/1678 , A61M1/1696 , A61M1/1698 , A61M1/281 , A61M1/284 , A61M1/34 , A61M1/3403 , A61M1/3486 , A61M1/3679 , A61M1/3681 , A61M2202/0421 , B01D15/00 , B01D39/04 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/265 , B01J20/267 , B01J20/28016 , B01J20/3064 , B01J20/321 , B01J20/3248 , B01J20/3251 , B01J20/3272 , B01J20/3274 , B01J2220/58 , A61M2202/0057
摘要： Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in physiologic fluid by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of pro-inflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators.
摘要翻译：装置，系统和方法通过选择性吸附降低生理液中促炎症或抗炎刺激物或介质的水平。器官，系统和方法适用于在促炎症或抗炎刺激物或介质发生异常水平或不协调或过度相互作用的情况下，或在诱导或有可能引起异常生产促炎症炎性或抗炎刺激物或介质。装置，系统和方法用于预防，控制，减少或减轻与促炎症或抗炎刺激剂或介体的异常水平或不协调或过度相互作用相关的炎症反应和疾病状态的严重性。

127. 发明授权

US06855291B2 Method of blood oxygenation 失效
标题翻译：血氧合法
公开(公告)号：US06855291B2
公开(公告)日：2005-02-15
申请号：US10384301
申请日：2003-03-07
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M1/16 , A61M1/36 , A61M1/14 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create the gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membranes(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
摘要翻译：提供了一种用于血氧的装置和方法。该装置包括具有第一入口以容纳气体过饱和流体例如生理盐水的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。联接到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到其中，以产生气体过饱和流体，其通过出口被去除。去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。或者，血液可以由泵提供给高压中空纤维或其他类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成含氧血液，再次输送到患者或其他部位。

128. 发明授权

US06849235B2 Method of forming gas-enriched fluid 有权
标题翻译：形成富集气体的方法
公开(公告)号：US06849235B2
公开(公告)日：2005-02-01
申请号：US10388292
申请日：2003-03-13
申请人： Stephen E. Myrick , Mark S. Buhr
发明人： Stephen E. Myrick , Mark S. Buhr
IPC分类号： A61M1/16 , A61M1/36 , A61M37/00 , B01D47/06 , F02M69/02
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： A method for gas-supersaturating fluids, e.g., physiologic saline, includes providing a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 psi; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet.
摘要翻译：用于气体过饱和流体例如生理盐水的方法包括提供具有用于接收流体的第一入口的腔室; 接收来自气体供应源的气体（例如氧气）的第二入口，其将腔室内的压力保持在预定水平，有利地为约600psi; 以及有利地联接到毛细管组件的出口。耦合到第一入口的雾化喷嘴有利地在腔室内产生细小的液滴，气体扩散到该液体中，以产生气体过饱和流体，该气体过饱和流体收集在雾化器喷嘴下方的室内，以通过出口排出。

129. 发明申请

US20050004480A1 Mobile heart-lung machine 有权
标题翻译：移动心肺机
公开(公告)号：US20050004480A1
公开(公告)日：2005-01-06
申请号：US10839126
申请日：2004-05-06
申请人： Karsten Kirchhof
发明人： Karsten Kirchhof
IPC分类号： A61M1/16 , A61M1/36 , A61B5/02
CPC分类号： A61M1/3621 , A61M1/1698 , A61M1/3666 , A61M1/3667 , A61M2205/12 , A61M2205/8206
摘要： The present invention provides a heart-lung machine which can be carried by one person and can be used independently from an external power supply, consisting of at least three modules (1, 2, 3), wherein a first module (1) contains the blood circulating elements which are necessary for the function of a heart-lung machine, a second module (2) contains a pump drive (9) and an electronic measuring equipment and a control logic (11) and a third module (3) contains the programming unit (14), whereas the second unit is separably connected to the first and the third module.
摘要翻译：本发明提供一种可以由一个人携带并且可以独立于由至少三个模块（1,2,3）组成的外部电源使用的心肺机器，其中第一模块（1）包含血液循环元件对于心肺机器的功能是必需的，第二模块（2）包含泵驱动器（9）和电子测量设备以及控制逻辑（11）和第三模块（3）编程单元（14），而第二单元可分离地连接到第一和第三模块。

130. 发明申请

US20040219060A1 Device and methods for processing blood in extracorporeal circulation 审中-公开
标题翻译：用于处理体外循环血液的装置和方法
公开(公告)号：US20040219060A1
公开(公告)日：2004-11-04
申请号：US10804583
申请日：2004-03-18
发明人： Edgardo Costa Maianti , Nicola Ghelli , Ivo Panzani
IPC分类号： A61M001/14 , A61M037/00 , A61M001/34 , A61M001/36
CPC分类号： A61M1/3627 , A61M1/1006 , A61M1/101 , A61M1/1698 , A61M1/3606 , A61M1/3666 , A61M1/3667
摘要： A device for processing blood in extracorporeal blood circuit, which comprises, integrated in a single monolithic assembly, a bubble trap, a centrifugal pump, a heat exchanger, an oxygenator and an arterial filter.
摘要翻译：用于处理体外血液回路中的血液的装置，其包括集成在单个整体组件中的气泡阱，离心泵，热交换器，氧合器和动脉过滤器。

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