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1. 发明申请

US20020068015A1 Apparatus and method for control of ultrafiltration in extracorporeal treatment of blood 审中-公开
标题翻译：用于血液超声处理超滤的设备和方法
公开(公告)号：US20020068015A1
公开(公告)日：2002-06-06
申请号：US09961095
申请日：2001-09-24
发明人： Hans-Dietrich Polaschegg , Klaus Sodemann
IPC分类号： A61M001/14 , A61M037/00 , C02F001/44 , B01D061/00 , A61M001/36
CPC分类号： A61M1/16 , A61M1/1605 , A61M1/367 , A61M2205/3306 , A61M2205/50 , A61M2230/205 , A61M2230/207
摘要： An apparatus and method for alleviation of symptoms of inappropriate blood pressure and cramping from the removal of water during ultrafiltration hemodialysis and hemofiltration treatment. The invention uses oxygen concentration measured by sensors in various ways and at various points in the blood treatment circuitry to estimate parameters necessary to control the rate at which water is removed from the patient's blood.
摘要翻译：一种在超滤血液透析和血液滤过治疗过程中，减轻血压不正常症状并从去除水中抽搐的装置和方法。本发明使用传感器测量的氧浓度以各种方式和血液处理电路中的各个点估计必要的参数，以控制从患者血液中除去水的速率。

2. 发明申请

US20020044889A1 Integrated system for cardiopulmonary bypass and related methods 失效
标题翻译：心肺转流综合系统及相关方法
公开(公告)号：US20020044889A1
公开(公告)日：2002-04-18
申请号：US09877488
申请日：2001-06-08
发明人： Walid Najib Aboul-Hosn , Scott Youmans
IPC分类号： A61M001/14 , A61M001/36 , A61M037/00
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1034 , A61M1/1039 , A61M1/1086 , A61M1/3621 , A61M1/3666 , A61M1/3667 , A61M2205/3334 , A61M2209/082
摘要： An improved cardiopulmonary bypass system which consolidates and miniaturizes the entire CPB circuit on an integrated panel or box-type structure capable of being positioned within (or closely adjacent to) the sterile surgical field.
摘要翻译：一种改进的体外循环系统，其将集成的面板或箱式结构整合并使整个CPB电路小型化，该系统能够定位在无菌外科手术领域（或紧邻）无菌手术领域。

3. 发明申请

US20040081580A1 Use of nitric oxide and a device in the therapeutic management of pathogens in mammals 审中-公开
标题翻译：使用一氧化氮和一种装置来治疗哺乳动物病原体
公开(公告)号：US20040081580A1
公开(公告)日：2004-04-29
申请号：US10658665
申请日：2003-09-09
发明人： Doug Hole , Christopher Miller
IPC分类号： A61M001/14 , A61M037/00 , C02F001/44 , A61M001/36 , A61M001/34
CPC分类号： A61M1/3687 , A61K33/00 , A61M1/1698 , A61M2202/0275 , A61K2300/00
摘要： The present invention relates to a method for the systemic delivery of the nitric oxide moiety either as a dissolved gas or through the administration of nitric oxide donors in an extracorporeal circuit to reduce whole body bacterial contamination by pathogenic or toxic substrates. The utilization of an extracorporeal circuit with the entrainment of nitric oxide is viewed as a novel modality in the medical management of bacteremia (blood poisoning) and/or septicemia in mammals.
摘要翻译：本发明涉及一种全身性递送一氧化氮部分作为溶解气体或通过在体外循环中施用一氧化氮供体的方法，以减少病原体或有毒底物引起的全身细菌污染。使用伴有一氧化氮的体外循环被认为是哺乳动物菌血症（血液中毒）和/或败血症的医学管理中的一种新型方式。

4. 发明申请

US20020110485A1 Integrated blood handling system having active gas removal system and methods of use 失效
标题翻译：具有活性气体去除系统和使用方法的综合血液处理系统
公开(公告)号：US20020110485A1
公开(公告)日：2002-08-15
申请号：US09780923
申请日：2001-02-09
发明人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
IPC分类号： A61M001/14 , A61M037/00 , A61M001/36
CPC分类号： A61M1/3626 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1025 , A61M1/262 , A61M1/267 , A61M1/3606 , A61M1/3627 , A61M1/3666 , Y10S261/28
摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.
摘要翻译：提供了用于泵送和充氧血液的装置和方法，其包括气体去除系统。提供了一种集成血液处理单元，其中气体去除/血液过滤器，泵和血氧元件安装在公共壳体内。气体去除系统包括安装在壳体上以感测气体存在的传感器，并且当传感器检测到气体积聚时，阀可操作地耦合到传感器以从系统排出气体。

5. 发明申请

US20020057990A1 Pulsating pumping unit for a fluid, particularly blood 失效
标题翻译：用于流体，特别是血液的脉动泵送单元
公开(公告)号：US20020057990A1
公开(公告)日：2002-05-16
申请号：US09921012
申请日：2001-08-02
发明人： Nicola Ghelli , Fabrizio Mastrantonio , Ivo Panzani
IPC分类号： A61M001/14 , A61M001/36 , A61M037/00
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/1098
摘要： A pulsating pumping unit for a fluid, particularly blood, includes means suitable to draw the fluid from an intake connector in order to send it to a outlet connector. The means are contained in an enclosure provided with valves connected to the inlet and the outlet. The valve connected to the outlet has at least one duct passing through the wall of the enclosure, is open at the end that leads into the portion of space. The pumping unit has a flow control element comprising a band of elastic material fixed to the outer wall of the enclosure at the edges, so as to have a blind portion which faces the exit port of the duct and a portion provided with holes which faces the outer wall.
摘要翻译：用于流体，特别是血液的脉动泵送单元包括适于从进气连接器抽取流体以将其发送到出口连接器的装置。该装置包含在设置有连接到入口和出口的阀的外壳中。连接到出口的阀具有穿过外壳壁的至少一个管道，在通向空间部分的端部处是敞开的。泵送单元具有流量控制元件，该流量控制元件包括在边缘处固定到外壳的外壁的弹性材料带，以具有面向导管的出口的盲部和设有孔的部分，外墙。

6. 发明申请

US20040191117A1 Condensed perfusion circuit for cardiopulmonary bypass and cardioplegia 失效
标题翻译：凝血灌注电路用于心肺转流和心脏停搏
公开(公告)号：US20040191117A1
公开(公告)日：2004-09-30
申请号：US10403567
申请日：2003-03-31
发明人： Venkataramana Vijay , Kevin McCusker
IPC分类号： A61M037/00 , A61M001/36
CPC分类号： A61M1/3621 , A61M1/1698 , A61M1/3627 , A61M1/3664 , A61M1/3666 , A61M2202/047
摘要： A total condensed circuit for cardiopulmonary bypass and cardioplegia are provided, as well as methods of using the same. The total circuit includes a cardiopulmonary bypass portion including tubing and components which together have a substantially short path length and priming volume preferably under 800 ml. Thus, the opportunity for an inflammatory response caused by blood contacting plasticizers is minimized. The bypass circuit includes a shunt which bypasses a blood reservoir of the total circuit. The cardioplegia circuit infuses cardioplegia fluid into blood pulled from an oxygenator of the bypass circuit. According to the method, either or both of heart-lung bypass and cardioplegia can be performed with only minimal or no isotonic priming solution circulated into the patient. In addition, use of the shunt and reservoir together eliminate the possibility of air entering the circulation system upon kinking of the circuit.
摘要翻译：提供了用于心肺转流和心脏停搏的总体冷凝电路，以及使用它们的方法。总电路包括心肺旁路部分，其包括管和组件，它们一起具有基本上短的路径长度和优选低于800ml的起动体积。因此，由血液接触增塑剂引起的炎症反应的机会被最小化。旁路电路包括旁路总电路的血液储存器的分流器。心麻痹电路将心麻痹液注入从旁路回路充氧器拉出的血液中。根据该方法，可以仅使用循环到患者中的最小或不等渗启动溶液来执行心肺旁路和心麻痹中的任一者或两者。此外，使用分流器和水箱一起消除了空气在电路扭结时进入循环系统的可能性。

7. 发明申请

US20030024817A1 Equipment and method of local streaming potential measurement for monitoring the process of membrane fouling in hollow-fiber membrane filtrations 失效
标题翻译：局部流动电位测量的设备和方法，用于监测中空纤维膜过滤膜污染过程
公开(公告)号：US20030024817A1
公开(公告)日：2003-02-06
申请号：US09906696
申请日：2001-07-18
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人： Myung-Suk Chun , Jae-Jin Kim , Sang Yup Lee
IPC分类号： G01N027/26 , G01N001/18 , G01N031/22 , G01N031/16 , B32B027/04 , A61M001/36 , B32B005/18 , B32B005/02 , A61M001/14
CPC分类号： G01N27/60 , B01D61/12 , B01D61/22 , B01D65/08 , B01D65/10 , B01D2321/22 , Y10T436/25375
摘要： The present invention relates to an apparatus for monitoring the progress of membrane fouling that occurs on pores as well as on the surface of a membrane by means of variations of zeta potential (null) of a hollow-fiber membrane according to time passage of filtration of a suspension, wherein colloid particles, biopolymers and other inorganic particles are dispersed, and the method thereof. Moreover, the present invention also relates to a method to identify the effect of concentration polarization layer and cake layer which can vary according to the axial position of a hollow-fiber and the developing progress of a membrane fouling by measuring the position-dependent zeta potential of the hollow-fiber membrane.
摘要翻译：本发明涉及一种用于通过中空纤维膜的ζ电位（ζ）的变化来监测在孔和膜的表面上发生的膜污染进程的装置，其中分散有胶体颗粒，生物聚合物和其它无机颗粒的悬浮液及其方法。此外，本发明还涉及一种鉴定浓缩偏振层和滤饼层的效果的方法，其可以根据中空纤维的轴向位置而变化，并且通过测量位置依赖性ζ电位来测量膜污染的发展进展的中空纤维膜。

8. 发明申请

US20020094300A1 Blood reservoir 有权
标题翻译：血库
公开(公告)号：US20020094300A1
公开(公告)日：2002-07-18
申请号：US09997171
申请日：2001-11-30
发明人： Kenji Yokoyama , Kazuhiko Takeuchi
IPC分类号： A61M001/14 , A61M001/36 , A61M037/00 , B01D035/28 , C02F001/00
CPC分类号： A61M1/3627 , A61M1/3632
摘要： A blood reservoir being capable of reducing damage to blood stored therein. The blood reservoir has a housing in the form of a box, and filtering and defoaming devices provided in the housing, i.e., a device for filtering and defoaming on blood suctioned from a surgical field (outside a heart), a device for filtering and defoaming on blood vented from the interior of the heart, and a device for filtering and defoaming on blood drawn off from a large vein. The vented blood flowing into the blood reservoir passes through a vented blood filtering member to be introduced into a blood storage space without contacting an antifoaming agent and foreign substances filtered off from the suctioned blood.
摘要翻译：血液贮存器能够减少存储在其中的血液的损伤。血液储存器具有壳体形式的壳体，以及设置在壳体中的过滤和消泡装置，即用于从外科手术领域（心脏外部）抽吸的血液进行过滤和消泡的装置，用于过滤和消泡的装置从心脏内部排出的血液，以及用于对从大静脉抽出的血液进行过滤和消泡的装置。流入血液储存器的排出的血液通过通气的血液过滤构件，以引入血液储存空间，而不会接触消泡剂和从抽吸的血液中滤出的异物。

9. 发明申请

US20040186410A1 Apparatus and method for down-regulating immune system mediators in blood 失效
标题翻译：用于下调血液中免疫系统介质的装置和方法
公开(公告)号：US20040186410A1
公开(公告)日：2004-09-23
申请号：US10390558
申请日：2003-03-17
发明人： Alan A. Davidner , Kimberly A. Walker , Scott R. Mallett
IPC分类号： A61M037/00 , A61M001/14 , A61M001/36
CPC分类号： A61M1/3681 , A61L2/0011 , A61M1/3431 , A61M1/3468 , A61M1/3472 , A61M1/3482 , A61M1/3683 , A61M2205/053 , A61M2205/75 , A61M2230/207
摘要： A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50-75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.
摘要翻译：提供了一种预防和治疗患者血液中败血症的方法和装置。体外系统包括用于灭活至少99％的血源性微生物的抗微生物装置，血液浓缩器/过滤单元以从患者血液中除去约50-75％的靶分子，以及过滤器单元以从筛选的患者血液中除去靶分子血浆滤液。靶分子由微生物以及患者的细胞产生。这些分子包括来自革兰氏阴性细菌的内毒素，来自革兰阴性和革兰氏阳性细菌的外毒素，以及来自金黄色葡萄球菌的RAP蛋白质介质，以及细胞介质如肿瘤坏死因子-α和白介素1-β，白细胞介素6，补体蛋白 C3a和C5a以及缓激肽。

10. 发明申请

US20040175292A1 Device for oxygenating blood in an extracorporeal circuit 有权
公开(公告)号：US20040175292A1
公开(公告)日：2004-09-09
申请号：US10804929
申请日：2004-03-19
申请人： Dideco S.p.A.
发明人： Nicola Ghelli , Edgardo Costa Maianti , Ivo Panzani
IPC分类号： A61M037/00 , A61M001/14 , A61M001/36
CPC分类号： B01D61/58 , A61M1/1625 , A61M1/1627 , A61M1/1629 , A61M1/1698 , A61M1/3627 , B01D63/02 , B01D2313/90 , Y10S128/03 , Y10S261/28
摘要： A device for oxygenating blood in an extracorporeal circuit includes a first structure suitable to delimit a portion of space-containing capillaries made of microporous membrane. The capillaries convey oxygen and are wet externally by blood flowing through a portion of space between an intake connector, which is connected to a venous line of the extracorporeal circuit, and a delivery connector. The device includes a second structure monolithically connected and contiguous to the first structure. The second structure is suitable to contain blood filtration means that divide the portion of space delimited thereby into a blood distribution chamber, provided with an air vent and connected to the delivery connector of the first structure, and a blood collection chamber provided with a delivery connector connected to the arterial line of the extracorporeal circuit.

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