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121. 发明授权

US07244808B2 Thiourethane-based optical material 有权
标题翻译：硫代氨基甲酸酯类光学材料
公开(公告)号：US07244808B2
公开(公告)日：2007-07-17
申请号：US10509765
申请日：2003-12-12
申请人： Mamoru Tanaka , Shigetoshi Kuma , Munehito Funaya , Seiichi Kobayashi
发明人： Mamoru Tanaka , Shigetoshi Kuma , Munehito Funaya , Seiichi Kobayashi
IPC分类号： C08G75/00 , C08G75/04
CPC分类号： C08G18/7642 , C08G18/3876 , G02B1/04 , C08L75/04 , C08L81/00
摘要： A composition for making a high-refractive-index resin contains a polythiol compound and a compound containing at least two iso(thio)cyanato groups, the polythiol compound having a dithioacetal, dithioketal, orthotrithioformic ester, or orthotetrathiocarbonic ester skeleton. The molar ratio of the mercapto group to the iso(thio)cyanato group in the composition is greater than 1.0 but not more than 3.0. A method for making a resin by curing the composition, a resin prepared by curing the composition, an optical element made from the resin, and a lens made from the optical element are also provided.
摘要翻译：用于制备高折射率树脂的组合物含有多硫醇化合物和含有至少两个异（硫）氰酸基的化合物，多硫醇化合物具有二硫缩醛，二硫缩酮，邻二硫代甲酸酯或邻四硫代碳酸酯骨架。组合物中巯基与异（硫）氰酸基的摩尔比大于1.0但不大于3.0。还提供了通过固化组合物制备树脂的方法，通过固化组合物制备的树脂，由树脂制成的光学元件和由光学元件制成的透镜。

122. 发明授权

US07189717B2 Medicinal compositions promoting bowel movement 失效
标题翻译：促进排便的药物成分
公开(公告)号：US07189717B2
公开(公告)日：2007-03-13
申请号：US10257091
申请日：2001-04-26
申请人： Masahiro Yasuda , Hitoshi Harada , Shuhei Miyazawa , Seiichi Kobayashi , Kokichi Harada , Takayuki Hida , Hisashi Shibata , Nobuyuki Yasuda , Osamu Asano , Yoshihiko Kotake
发明人： Masahiro Yasuda , Hitoshi Harada , Shuhei Miyazawa , Seiichi Kobayashi , Kokichi Harada , Takayuki Hida , Hisashi Shibata , Nobuyuki Yasuda , Osamu Asano , Yoshihiko Kotake
IPC分类号： A61K31/506
CPC分类号： A61K31/506 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/7076 , H04B10/112
摘要： The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2 receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof.
摘要翻译：本发明提供一种具有温和但强烈的排便促进作用而不引起腹泻的药物。也就是说，它提供了包含具有腺苷A 2受体拮抗作用的化合物，优选腺苷A 2b受体拮抗剂或其盐的排便促进剂。

123. 发明申请

US20050063767A1 Composite writing instrument 失效
标题翻译：复合书写工具
公开(公告)号：US20050063767A1
公开(公告)日：2005-03-24
申请号：US10944826
申请日：2004-09-21
申请人： Seiichi Kobayashi
发明人： Seiichi Kobayashi
IPC分类号： B43K27/00
CPC分类号： B43K7/03 , B43K24/146 , B43K24/163 , B43K25/028 , B43K27/12
摘要： In a composite writing instrument having mounted therein a plurality of writing means including at least one ball-point pen refill equipped with a tip of the ball-point pen at a top end and an ink reservoir section at a rear end so that writing tip portions may be alternately allowed to project and retreat from an front body top, a pumping type pressurization mechanism is provided behind the ball-point pen refill, and a rear end of ink is pressurized by way of knock operation in a situation where a tip end portion has projected from a body end, so as to help the ink flow towards the tip side.
摘要翻译：在一种其中安装有多个书写装置的复合书写工具中，所述书写装置包括至少一个圆珠笔笔芯，该圆珠笔笔芯配备有顶端的圆珠笔笔尖和后端的墨水储存部分，可以交替地从前体顶部突出和退避，在圆珠笔笔芯后面设置抽吸式加压机构，并且在前端部分的情况下通过敲击操作来加压墨水后端从身体端突出，以帮助墨流向尖端侧。

124. 发明授权

US06770734B2 Polythiol compound 有权
标题翻译：多硫醇化合物
公开(公告)号：US06770734B2
公开(公告)日：2004-08-03
申请号：US10316180
申请日：2002-12-11
申请人： Mamoru Tanaka , Shigetoshi Kuma , Seiichi Kobayashi , Yoshinobu Kanemura
发明人： Mamoru Tanaka , Shigetoshi Kuma , Seiichi Kobayashi , Yoshinobu Kanemura
IPC分类号： C08G7504
CPC分类号： C07C321/14 , C08G18/288 , C08G18/3876 , C08G18/775 , C08G59/66 , C08G75/04 , C08G75/045 , C08L81/02 , G02B1/04 , Y02P20/55 , C08L75/04 , C08L71/00
摘要： A polymerizable composition for a lens with a high refractive index comprising at least one polythiol compound represented general formula (1): R—(SH2SH)n (1) where R is an organic residue except an aromatic group and n is an integer of at least 1, having at least two intramolecular mercapto groups and at least one compound having an intramolecular functional group which can react with a mercapto group; a resin prepared by polymerizing the composition; an optical element and a lens made of the resin; and a process for preparing a thiol compound comprising the steps of reacting a compound represented by general formula (2): HS—R1(—S—R2)m (2) where m is an integer of at least 1; R1 represents an aromatic, aliphatic, alicyclic or heterocyclic organic residue or aliphatic, alicyclic or heterocyclic organic residue with an aromatic ring or a sulfur atom in its chain; and R2 represents a protective group, with a compound having a functional group which can react with a mercapto group, and then converting —S—R2 into —SH.
摘要翻译：一种高折射率透镜的可聚合组合物，其包含至少一种通式（1）表示的多硫醇化合物：其中R是芳族基团以外的有机残基，n是至少为1的整数，具有至少两个分子内巯基和至少一种具有可与巯基反应的分子内官能团的化合物; 通过聚合组合物制备的树脂; 光学元件和由树脂制成的透镜; 以及制备硫醇化合物的方法，包括使通式（2）表示的化合物：其中m为至少1的整数; R 1表示其链中具有芳环或硫原子的芳族，脂族，脂环族或杂环的有机残基或脂族，脂环族或杂环的有机残基; R 2表示保护基，具有可与巯基反应的官能团的化合物，然后将-S-R 2转化为-SH。

125. 发明授权

US06703388B2 Nitrogen-containing tricyclic compounds and drugs containing the same 失效
标题翻译：含氮三环化合物和含有这些化合物的药物
公开(公告)号：US06703388B2
公开(公告)日：2004-03-09
申请号：US10201952
申请日：2002-07-25
申请人： Mitsuaki Miyamoto , Tatsuya Yoshiuchi , Keizo Sato , Makoto Kaino , Masayuki Tanaka , Motohiro Soejima , Katsuhiro Moriya , Yoshinori Sakuma , Koji Yamada , Kokichi Harada , Yukio Nishizawa , Seiichi Kobayashi , Makoto Okita , Koichi Katayama
发明人： Mitsuaki Miyamoto , Tatsuya Yoshiuchi , Keizo Sato , Makoto Kaino , Masayuki Tanaka , Motohiro Soejima , Katsuhiro Moriya , Yoshinori Sakuma , Koji Yamada , Kokichi Harada , Yukio Nishizawa , Seiichi Kobayashi , Makoto Okita , Koichi Katayama
IPC分类号： A61K31551
CPC分类号： C07D417/06 , C07D279/22 , C07D279/24 , C07D417/12 , C09B21/00 , C09B57/08
摘要： A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) effective against diseases in which histamine, leukotrienes, etc. participate and effective in preventing or treating diseases in which chemical mediators such as histamine and leukotrienes participate, for example, asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy and food allergy.
摘要翻译：苯并噻嗪，吖啶酮肟，吖啶酮肟，腙酮腙和二苯并二氮杂衍生物，其对组胺，白细胞三烯等参与并有效预防或治疗化学介质如组胺和白三烯参与的疾病有效，例如哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，花粉症，胃肠道过敏和食物过敏。

126. 发明授权

US06630463B2 Heterocycle-containing carboxylic acid derivative and drug containing the same 失效
标题翻译：含有杂环的羧酸衍生物和含有它们的药物
公开(公告)号：US06630463B2
公开(公告)日：2003-10-07
申请号：US09910068
申请日：2001-07-23
申请人： Kouichi Kikuchi , Katsuya Tagami , Hiroyuki Yoshimura , Shigeki Hibi , Mitsuo Nagai , Shinya Abe , Makoto Okita , Takayuki Hida , Seiko Higashi , Naoki Tokuhara , Seiichi Kobayashi
发明人： Kouichi Kikuchi , Katsuya Tagami , Hiroyuki Yoshimura , Shigeki Hibi , Mitsuo Nagai , Shinya Abe , Makoto Okita , Takayuki Hida , Seiko Higashi , Naoki Tokuhara , Seiichi Kobayashi
IPC分类号： A61K31404
CPC分类号： C07D401/04 , C07D209/14 , C07D231/12 , C07D241/24 , C07D241/44 , C07D249/10 , C07D401/14 , C07D403/04 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I): wherein A represents, for example, a heteroaryl group which contains at least one nitrogen atom and may have a substituent, B represents, for example, a heteroarylene group, a —CONH— group or a group represented by the formula —CR6═CR7— in which R6 and R7 represents H, a lower alkyl group or the like, D represents an arylene group, a heteroarylene group or the like, n1 stands for 0 or 1, M represents, for example, a hydroxyl group or a lower alkoxy group; or a physiologically acceptable salt thereof. As a retinoic-related compound replacing retinoic acid, it permits the provision of a preventive and/or therapeutic for various diseases.
摘要翻译：描述了由下式（I）表示的含杂环羧酸衍生物：其中A表示例如含有至少一个氮原子并且可以具有取代基的杂芳基，B表示例如亚杂芳基 -CONH-基或由式-CR 6 = CR 7表示的基团，其中R 6和R 7表示H，低级烷基等，D表示亚芳基基团，亚杂芳基等，n1表示0或1，M表示例如羟基或低级烷氧基; 或其生理上可接受的盐。作为视黄酸相关化合物代替视黄酸，它允许为各种疾病提供预防和/或治疗。

127. 发明授权

US06265510B1 Thiol and sulfur-containing O-(meth)acrylate compounds and use thereof 有权
标题翻译：硫醇和含硫O-（甲基）丙烯酸酯化合物及其用途
公开(公告)号：US06265510B1
公开(公告)日：2001-07-24
申请号：US09590015
申请日：2000-06-09
申请人： Seiichi Kobayashi , Nobuya Kawauchi , Toshiyuki Suzuki , Masao Imai , Kenichi Fujii
发明人： Seiichi Kobayashi , Nobuya Kawauchi , Toshiyuki Suzuki , Masao Imai , Kenichi Fujii
IPC分类号： C08F12602
CPC分类号： C08F20/38 , C07C323/12 , C07C327/28 , C07C333/04 , C07D333/22 , G02B1/041 , C08L33/14
摘要： A sulfur-containing O-(meth)acrylate compound of the following formula (1) is useful as a starting material for a resin composition used in optical applications such as a lens; wherein R represents hydrogen atom or methyl group; 1 represents an integer from 1 to 3; B is when B is n is 2; m is 1 or 2; A is selected from the following groups: wherein m represents 1 or 2; each ring may be substituted by one or more alkyl, alkylthio or alkoxy groups having 1 or 2 carbon atoms; p and q are 0 or 1, while m is 1 when p is 1; when B is n is 1; m is 2 or 3; A is selected from the following groups: —(CH2)r—S—(CH2)r—, —(CH2)r—S—S—(CH2)r—, —(CH2)r—S—(CH2)s—S—(CH2)r— and wherein r and s are an integer from 1 to 3; when B is n is 1; m is 2; A is selected from the following groups: —(CH2)r—S—(CH2)r—, —(CH2)r—S—S—(CH2)r— and —(CH2)r—S—(CH2)s—S—(CH2)r— wherein r and s are an integer from 1 to 3.
摘要翻译：下式（1）的含硫O-（甲基）丙烯酸酯化合物可用作用于光学应用如透镜的树脂组合物的起始原料;其中R表示氢原子或甲基; 1表示1〜3的整数， B是当B是n是2时; m为1或2; A选自以下基团：其中m表示1或2; 每个环可以被一个或多个具有1或2个碳原子的烷基，烷硫基或烷氧基取代; p和q为0或1，而当p为1时，m为1; B为n时为1; m为2或3; A选自以下基团： - （CH 2）r -S-（CH 2）r - ， - （CH 2）r SS-（CH 2）r - ， - （CH 2）r S-（CH 2）s S-（CH 2）r - s为1〜3的整数; B为n时为1; m为2; A选自以下基团： - （CH 2）r -S-（CH 2）r - ， - （CH 2）r SS-（CH 2）r - 和 - （CH 2）r S-（CH 2）s S-（CH 2） s为1〜3的整数。

128. 发明授权

US5915871A Ball-point pen cap 失效
标题翻译：圆珠笔帽
公开(公告)号：US5915871A
公开(公告)日：1999-06-29
申请号：US927361
申请日：1997-09-09
申请人： Seiichi Kobayashi , Kazuhiko Furukawa , Hiroaki Koyama , Toru Kitao
发明人： Seiichi Kobayashi , Kazuhiko Furukawa , Hiroaki Koyama , Toru Kitao
IPC分类号： B43K1/08 , B43K5/18 , B43K23/12 , B43K23/08
CPC分类号： B43K5/1818 , B43K1/086 , B43K1/088 , B43K23/12 , B43K23/122 , B43K5/18 , B43K5/1881
摘要： A pen cap having at least two engaging portions (59f, 59r) specifically adapted to engage a receiving-side engaging portion (51f) formed on the mouthpiece-side end (7) of a hollow barrel and a receiving-side engaging portion (51r) formed on the tail-plug-side end of the hollow barrel (9), respectively. The engaging portions on the cap are at different locations along the cap's longitudinal axis. Furthermore, the engaging portions on the cap have their engaging surfaces disposed radially outward at different distances relative to the cap's longitudinal axis.
摘要翻译：一种具有至少两个接合部分（59f，59r）的笔帽，其特别适于与形成在中空筒的接口侧端部（7）上的接收侧接合部分（51f）接合，以及接收侧接合部分（51r ）分别形成在中空筒（9）的尾塞侧端部。帽上的接合部分沿着帽的纵向轴线处于不同的位置。此外，盖上的接合部分具有相对于盖的纵向轴线以不同的距离径向向外设置的接合表面。

129. 发明授权

US5908876A Optical resin composition comprising a thiourethane prepolymer and use thereof 失效
标题翻译：包含硫代氨基甲酸酯预聚物的光学树脂组合物及其用途
公开(公告)号：US5908876A
公开(公告)日：1999-06-01
申请号：US831534
申请日：1997-04-07
申请人： Kenichi Fujii , Nobuya Kawauchi , Toshiyuki Suzuki , Seiichi Kobayashi , Masao Imai
发明人： Kenichi Fujii , Nobuya Kawauchi , Toshiyuki Suzuki , Seiichi Kobayashi , Masao Imai
IPC分类号： C08F2/50 , C08F283/00 , C08F291/18 , C08G18/38 , G02B1/04 , C08L75/04 , C08L81/04
CPC分类号： C08G18/3876 , C08F283/006 , C08F291/18 , G02B1/041
摘要： Disclosed are: (1) an optical resin composition comprising Component A: a thiourethane prepolymer compound prepared by reacting a polythiol compound having at least 3 functional groups and an intramolecular sulfide bond, with a polyisocyanate compound in a molar ratio of --SH to --NCO ranging from 3.0 to 7.0 Component B: at least one (meth)acrylate compound having at least 2 functional groups; and Component C: a compound radically polymerizable with Components A and B, in 10 to 50% by weight, 35 to 70% by weight, and 5 to 30% by weight, respectively; (2) a preparation process for an optical resin by photopolymerization; (3) an optical resin; and (4) a prepolymer suitable for Component A. The composition is a novel, rapidly polymerizable composition for an optical resin. Furthermore, a resin prepared by curing the composition not only has a high refractive index and a high Abbe number, but also is excellent in transparency and optical homogeneity.
摘要翻译：公开的是：（1）一种光学树脂组合物，其包含组分A：通过使具有至少3个官能团和分子内硫键的多硫醇化合物与-SH至-NCO的摩尔比的多异氰酸酯化合物反应制备的硫代氨基甲酸酯预聚物化合物 3.0至7.0组分B：至少一种具有至少2个官能团的（甲基）丙烯酸酯化合物; 和组分C：组分A和B可自由基聚合的化合物，分别为10至50重量％，35至70重量％和5至30重量％（2）通过光聚合制备光学树脂的制备方法; （3）光学树脂; 和（4）适用于组分A的预聚物。该组合物是用于光学树脂的新型快速聚合组合物。此外，通过固化该组合物制备的树脂不仅具有高折射率和高阿贝数，而且透明性和光学均匀性也优异。

130. 发明授权

US5890825A Composite writing instrument 失效
标题翻译：复合书写工具
公开(公告)号：US5890825A
公开(公告)日：1999-04-06
申请号：US821407
申请日：1997-03-21
申请人： Hidehei Kageyama , Yoshio Noguchi , Seiichi Kobayashi , Naoki Sekuguchi
发明人： Hidehei Kageyama , Yoshio Noguchi , Seiichi Kobayashi , Naoki Sekuguchi
IPC分类号： B43K29/02 , B43K24/14 , B43K24/18 , B43K27/02 , B43K27/00
CPC分类号： B43K24/146 , B43K27/02
摘要： A composite writing instrument comprising a writing instrument mechanism having a plurality of refills and a rod-like delivery mechanism, the composite writing instrument comprising middle shaft provided between a front shaft and a rear shaft, return springs having one end terminated at the middle shaft to urge the refills, respectively, backward; sliding cams mounted at rear portions of the refills and terminated at the other ends of the return springs to be urged backward, a cam body having at a front portion a cam operating portion which presses the rear end of either of the sliding cams to selectively advance the refills; a guide tube rotatably engaging the cam body and having a guide groove in the axial direction; a slider formed in the guide tube holding a rod-like article and being slidable in the axial direction along the guide groove of the guide tube, the cam body being provided with an engaging portion which engages the middle shaft so as to be slidable in the direction of the front shaft and be rotatable, the cam body further being formed with a helical groove in an inner periphery at the rear portion thereof, and the slider being provided with an engaging projection in engagement with the helical groove of the cam body, whereby the rotation of the cam body is controlled about the middle shaft by engagement of an engaging piece formed at the rear end of the middle shaft and a projection of the cam body.
摘要翻译：一种复合书写工具，包括具有多个填充物的书写工具机构和杆状输送机构，所述复合书写工具包括设置在前轴和后轴之间的中间轴，所述复合书写工具的一端终止于中间轴至分别推荐笔芯; 安装在再补充件的后部并且终止于复位弹簧的另一端的滑动凸轮被向后推动，凸轮体在前部具有凸轮操作部分，该凸轮操作部分压紧任一个滑动凸轮的后端以选择性地前进补笔引导管，其可旋转地接合所述凸轮体并且在轴向方向上具有引导槽; 滑动件，其形成在所述引导管中，所述引导管保持杆状物品，并且沿着所述引导管的引导槽沿轴向滑动，所述凸轮主体设置有接合所述中轴的接合部，以便能够在所述引导管中滑动前轴的方向可旋转，凸轮体的后部在其内周部还形成有螺旋槽，滑块设有与凸轮体的螺旋槽接合的接合突起，由此通过形成在中轴的后端处的接合件和凸轮体的突起的接合来使凸轮体的旋转被控制在中轴的周围。

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