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121. 发明授权

US06987215B1 Translation control elements for high-level protein expression in the plastids of higher plants and methods of use thereof 有权
公开(公告)号：US06987215B1
公开(公告)日：2006-01-17
申请号：US09762105
申请日：1999-08-03
申请人： Pal Maliga , Hiroshi Kuroda , Muhammad Sarwar Khan
发明人： Pal Maliga , Hiroshi Kuroda , Muhammad Sarwar Khan
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8223 , C07K14/415 , C12N15/8214 , C12N15/8216
摘要： DNA constructs containing translational control elements are provided. These 5′ regulatory segments facilitate high level expression of transgenes introduced into the plastids of higher plants.

122. 发明申请

US20050104183A1 Multi-chip module 有权
标题翻译：多芯片模块
公开(公告)号：US20050104183A1
公开(公告)日：2005-05-19
申请号：US10971042
申请日：2004-10-25
申请人： Hiroshi Kuroda , Shinpei Ishida
发明人： Hiroshi Kuroda , Shinpei Ishida
IPC分类号： H01L25/18 , H01L25/065 , H01L25/07 , H01L27/14
CPC分类号： H01L25/18 , H01L23/3121 , H01L24/73 , H01L2224/05571 , H01L2224/05573 , H01L2224/16225 , H01L2224/32145 , H01L2224/32225 , H01L2224/45144 , H01L2224/48137 , H01L2224/48227 , H01L2224/49171 , H01L2224/73203 , H01L2224/73204 , H01L2224/73253 , H01L2224/73265 , H01L2225/0651 , H01L2225/06517 , H01L2225/06575 , H01L2924/00014 , H01L2924/01021 , H01L2924/01079 , H01L2924/14 , H01L2924/1433 , H01L2924/15311 , H01L2924/30107 , H01L2924/00 , H01L2924/00012 , H01L2224/05599
摘要： Disclosed here is a multi-chip module enhanced in performance and reduced in size. A second semiconductor chip having bonding pads at the periphery of its surface is mounted over a first semiconductor chip laid out over a surface of a substrate back to back and a spacer is provided at a portion of the second semiconductor chip surface except for a predetermined area that includes the portion where the bonding pads are formed while a third semiconductor chip is mounted over the spacer, the third semiconductor having the same circuit function as the second semiconductor chip and oriented similarly to the second semiconductor chip. The bonding pads of the second and third semiconductor chips are connected to their corresponding electrodes formed over the substrate through bonding wires respectively, then the first to third semiconductor chips and the bonding wires provided over the substrate are all sealed by a sealing agent.
摘要翻译：这里公开了一种增强性能并减小尺寸的多芯片模块。具有在其表面周边的接合焊盘的第二半导体芯片安装在背面背面布置在基板的表面上的第一半导体芯片上，并且在除了预定区域之外的第二半导体芯片表面的一部分处设置间隔物其包括在第三半导体芯片安装在间隔物上时形成接合焊盘的部分，第三半导体具有与第二半导体芯片相同的电路功能，并且与第二半导体芯片类似地取向。第二和第三半导体芯片的焊盘分别通过接合线连接到形成在衬底上的对应电极，然后设置在衬底上的第一至第三半导体芯片和接合线都被密封剂密封。

123. 发明授权

US06657057B2 Process for production of methylcobalamin 失效
公开(公告)号：US06657057B2
公开(公告)日：2003-12-02
申请号：US10130797
申请日：2002-05-23
申请人： Yoshihiko Hisatake , Hiroshi Kuroda
发明人： Yoshihiko Hisatake , Hiroshi Kuroda
IPC分类号： C07H1104
CPC分类号： C07H23/00
摘要： The present invention provides an industrially excellent and novel process for producing methylcobalamin useful as medicines. Namely, it provides a process for producing methylcobalamin, which comprises the step of methylating cyanocobalamin or hydroxocobalamin in the presence of a reducing agent and a water-soluble methylating agent.

124. 发明授权

US06384065B1 Spiro compounds or salts thereof and preventives/remedies for autoimmune diseases and AP-1 inhibitors containing the same 失效
标题翻译：螺环化合物或其盐和自身免疫性疾病的预防药物/治疗剂及含有它们的AP-1抑制剂
公开(公告)号：US06384065B1
公开(公告)日：2002-05-07
申请号：US09674483
申请日：2000-11-08
申请人： Hisaaki Chaki , Yukihiko Aikawa , Mikako Miyajima , Morihiro Nishio , Hiroshi Kuroda , Keiichi Tanaka , Shuichi Hirono , Shunichi Shiozawa
发明人： Hisaaki Chaki , Yukihiko Aikawa , Mikako Miyajima , Morihiro Nishio , Hiroshi Kuroda , Keiichi Tanaka , Shuichi Hirono , Shunichi Shiozawa
IPC分类号： A61K31426
CPC分类号： C07D277/60 , A61K38/00 , C07D417/04 , C07D417/06 , C07D417/08 , C07D417/12 , C07D513/10 , C07K5/06139
摘要： The spiro compounds of the present invention represented by the general formula: wherein A, R2, R3, R4, R5, R6 and n are as defined in the specification, exhibit an AP-1 activity inhibitory action and, based on the AP-1 inhibitory action, suppresses the expression of a wide variety of genes and are useful as an agent for treating and preventing autoimmune diseases with lessoned side reactions.
摘要翻译：由以下通式表示的本发明的螺环化合物：其中A，R2，R3，R4，R5，R6和n如说明书中所定义，表现出AP-1活性抑制作用，并且基于AP-1 抑制作用，抑制多种基因的表达，并且可用作治疗和预防伴随着副反应的自身免疫疾病的药剂。

125. 发明授权

US06278113B1 Scanning probe microscope 失效
标题翻译：扫描探针显微镜
公开(公告)号：US06278113B1
公开(公告)日：2001-08-21
申请号：US09166790
申请日：1998-10-06
申请人： Ken Murayama , Takashi Shirai , Takafumi Morimoto , Hiroshi Kuroda , Harumasa Onozato , Tsuyoshi Nishigaki
发明人： Ken Murayama , Takashi Shirai , Takafumi Morimoto , Hiroshi Kuroda , Harumasa Onozato , Tsuyoshi Nishigaki
IPC分类号： H01J3720
CPC分类号： G01Q10/02 , G01Q10/04 , G01Q30/06 , H01J2237/20221 , Y10S977/872
摘要： A scanning probe microscope is provided with a probe tip directed to a sample surface, an XYZ fine movement mechanism for providing a relative positional change between the sample and the probe tip, and a displacement detecting section for detecting the displacement of the probe tip. The scanning probe microscope measures the surface characteristic of the sample by using a control signal. This control signal is generated on a signal outputted from the displacement detecting section and is used for keeping a state of a mutual action generated between the sample and the probe tip identical to a predetermined state, while the probe tip scans the surface of the sample based on the operation of the XYZ fine movement mechanism. Further, it comprises a moving section arranged on a standard surface of a microscope stage, which has the sample on an upper surface and moves along the standard surface based on a static pressure guide, a height-position control section for selectively supplying high-pressure fluid to the moving section so as to carry out the static pressure guide and controlling the height-position of the moving section to the standard surface, and an actuating mechanism for moving the moving section in directions parallel to the standard surface.
摘要翻译：扫描探针显微镜设置有指向样品表面的探针尖端，用于提供样品和探针尖端之间的相对位置变化的XYZ精细运动机构，以及用于检测探针尖端的位移的位移检测部。扫描探针显微镜通过使用控制信号测量样品的表面特性。该控制信号是从位移检测部输出的信号生成的，并且用于保持样品与探针尖端之间产生的相互作用的状态与预定状态相同，同时探针尖端基于样品的表面扫描关于XYZ精细机芯的操作。此外，它包括布置在显微镜载物台的标准表面上的移动部分，其具有在上表面上的样品并且基于静压导向件沿着标准表面移动;高度位置控制部分，用于选择性地供应高压流体移动到移动部分，以便执行静压引导件并将移动部分的高度位置控制到标准表面;以及致动机构，用于沿平行于标准表面的方向移动移动部分。

126. 发明授权

US06184533B2 Scanning probe microscope with the stage unit 失效
标题翻译：扫描探针显微镜与舞台单元
公开(公告)号：US06184533B2
公开(公告)日：2001-02-06
申请号：US09166850
申请日：1998-10-06
申请人： Takashi Shirai , Ken Murayama , Takafumi Morimoto , Hiroshi Kuroda , Harumasa Onozato
发明人： Takashi Shirai , Ken Murayama , Takafumi Morimoto , Hiroshi Kuroda , Harumasa Onozato
IPC分类号： H01J3720
CPC分类号： G01Q10/02 , Y10S977/872
摘要： A stage unit used for moving a sample comprises a vertical stage for moving a sample stand in a vertical direction, a horizontal stage for moving the vertical stage in a horizontal direction. In the stage unit, the horizontal stage is fixed on a horizontal slide surface of a surface table and the vertical stage is slidably arranged on the slide surface. The vertical stage is coupled with the horizontal stage by means of plate springs having strong rigidity in the horizontal direction and weak rigidity in the vertical direction. The whole rigidity of the stage unit is determined only by the vertical stage and is not subject to the effect of the rigidity of the sections included in the horizontal stage and the rigidity of a driving section as to each axis direction. The rigidity of the stage unit can be increased. The standstill rigidity of the stage unit is determined only by the rigidity of the vertical stage. All stages of the stage unit are not piled up. Therefore the height of stage unit can be decreased as low as possible.
摘要翻译：用于移动样品的平台单元包括用于沿垂直方向移动样品台的垂直平台，用于沿垂直方向移动垂直平台的水平台。在舞台单元中，水平台被固定在表台的水平滑动表面上，并且垂直平台可滑动地布置在滑动表面上。垂直平台通过在水平方向上具有强刚性和垂直方向的弱刚性的板簧与水平台相结合。舞台装置的整体刚度仅由垂直平台确定，并且不受包括在水平台中的部分的刚度和驱动部分对于每个轴线方向的刚性的影响。可以增加舞台装置的刚度。舞台装置的静止刚度仅由垂直舞台的刚度决定。舞台单元的所有阶段都不堆积。因此，台架单元的高度尽可能地降低。

127. 发明授权

US6028193A Method for producing aryl aklyl hydroperoxides 有权
标题翻译：芳基烯基氢过氧化物的制备方法
公开(公告)号：US6028193A
公开(公告)日：2000-02-22
申请号：US291988
申请日：1999-04-15
申请人： Terunori Fujita , Shigekazu Matsui , Toshihiro Takai , Hideto Matsuoka , Akifumi Kagayama , Hiroshi Kuroda , Masayasu Ishibashi , Hiroshi Iwasaki , Nobuya Hirokane
发明人： Terunori Fujita , Shigekazu Matsui , Toshihiro Takai , Hideto Matsuoka , Akifumi Kagayama , Hiroshi Kuroda , Masayasu Ishibashi , Hiroshi Iwasaki , Nobuya Hirokane
IPC分类号： C07F13/00 , C07C211/65 , C07C215/14 , C07C219/06 , C07C229/16 , C07C233/36 , C07C251/24 , C07C251/74 , C07C251/76 , C07C251/86 , C07C255/24 , C07C407/00 , C07C409/08 , C07C409/10 , C07C409/12 , C07D255/02 , C07D257/02 , C07D259/00 , C07F1/08 , C07F15/00 , C07D487/22 , C07C45/32
CPC分类号： C07C233/36 , C07C211/65 , C07C215/14 , C07C219/06 , C07C229/16 , C07C251/24 , C07C251/74 , C07C251/76 , C07C251/86 , C07C255/24 , C07C407/00 , C07C409/08 , C07C409/10 , C07C409/12 , C07D255/02 , C07D257/02 , C07D259/00
摘要： A method for producing aryl alkyl hydroperoxides which comprises selectively oxidizing an aryl alkyl hydrocarbon having the formula: ##STR1## wherein P and Q are hydrogen or an alkyl and may be the same or different from each other; x is an integer of 1-3; and Ar is an aromatic hydrocarbon group having a valence of x, with an oxygen-containing gas in the presence of a transition metal complex which contains, as a ligand, a cyclic polyfunctional amine compound having at least three nitrogen atoms in the ring forming molecular chain or an open chain polyfunctional amine compound having at least three nitrogen atoms in the main chain of the molecule.
摘要翻译：一种制备芳基烷基氢过氧化物的方法，其包括选择性氧化具有下式的芳基烷基烃：其中P和Q是氢或烷基并且可以彼此相同或不同; x是1-3的整数; 并且在具有含氧气体的过渡金属络合物存在下，Ar是具有x价的芳族烃基，其中所述过渡金属络合物在环形成分子中含有至少三个氮原子的环状多官能胺化合物链或在分子主链中具有至少三个氮原子的开链多官能胺化合物。

128. 发明授权

US5945572A Method for producing aryl alkyl hydroperoxides 有权
标题翻译：芳基烷基氢过氧化物的制备方法
公开(公告)号：US5945572A
公开(公告)日：1999-08-31
申请号：US172653
申请日：1998-10-15
申请人： Terunori Fujita , Shigekazu Matsui , Toshihiro Takai , Hideto Matsuoka , Akifumi Kagayama , Hiroshi Kuroda , Masayasu Ishibashi , Hiroshi Iwasaki , Nobuya Hirokane
发明人： Terunori Fujita , Shigekazu Matsui , Toshihiro Takai , Hideto Matsuoka , Akifumi Kagayama , Hiroshi Kuroda , Masayasu Ishibashi , Hiroshi Iwasaki , Nobuya Hirokane
IPC分类号： C07F13/00 , C07C211/65 , C07C215/14 , C07C219/06 , C07C229/16 , C07C233/36 , C07C251/24 , C07C251/74 , C07C251/76 , C07C251/86 , C07C255/24 , C07C407/00 , C07C409/08 , C07C409/10 , C07C409/12 , C07D255/02 , C07D257/02 , C07D259/00 , C07F1/08 , C07F15/00 , C07C29/50 , C07C27/10 , C07C27/16
CPC分类号： C07C233/36 , C07C211/65 , C07C215/14 , C07C219/06 , C07C229/16 , C07C251/24 , C07C251/74 , C07C251/76 , C07C251/86 , C07C255/24 , C07C407/00 , C07C409/08 , C07C409/10 , C07C409/12 , C07D255/02 , C07D257/02 , C07D259/00
摘要： A method for producing aryl alkyl hydroperoxides which comprises selectively oxidizing an aryl alkyl hydrocarbon having the formula: ##STR1## wherein P and Q are hydrogen or an alkyl and may be the same or different from each other; x is an integer of 1-3; and Ar is an aromatic hydrocarbon group having a valence of x, with an oxygen-containing gas in the presence of a transition metal complex which contains, as a ligand, a cyclic polyfunctional amine compound having at least three nitrogen atoms in the ring forming molecular chain or an open chain polyfunctional amine compound having at least three nitrogen atoms in the main chain of the molecule.
摘要翻译：一种制备芳基烷基氢过氧化物的方法，其包括选择性氧化具有下式的芳基烷基烃：其中P和Q是氢或烷基并且可以彼此相同或不同; x是1-3的整数; 并且在具有含氧气体的过渡金属络合物存在下，Ar是具有x价的芳族烃基，其中所述过渡金属络合物在环形成分子中含有至少三个氮原子的环状多官能胺化合物链或在分子主链中具有至少三个氮原子的开链多官能胺化合物。

129. 发明授权

US5902345A Method and apparatus for controller power train of motor vehicle 失效
标题翻译：机动车控制器动力传动系统的方法及装置
公开(公告)号：US5902345A
公开(公告)日：1999-05-11
申请号：US20862
申请日：1998-02-09
申请人： Toshimichi Minowa , Hiroshi Kuroda , Satoru Kuragaki , Kenichirou Kurata , Tatsuya Ochi
发明人： Toshimichi Minowa , Hiroshi Kuroda , Satoru Kuragaki , Kenichirou Kurata , Tatsuya Ochi
IPC分类号： B60R21/00 , B60K28/14 , B60K31/00 , B60T7/12 , B60T8/174 , B60T13/66 , B60W10/00 , B60W10/04 , B60W10/06 , B60W10/10 , B60W10/18 , B60W10/184 , B60W30/00 , B60W30/08 , B60W40/02 , B60W40/06 , B60W40/072 , B60W40/076 , B60W40/10 , B60W40/107 , F02D9/10 , F02D29/02 , F16H61/18 , F16H63/50 , G01S13/93 , G06F7/00 , G06F17/00
CPC分类号： B60W30/08 , B60K31/0008 , B60T13/66 , B60T7/12 , B60W10/06 , B60W10/18 , B60W40/06 , B60T2210/24 , B60W2530/16 , B60W2550/12 , B60W2550/142 , B60W2550/143 , B60W2550/148 , B60W2550/402 , B60W2720/106 , G01S2013/9342 , G01S2013/9346 , G01S2013/9353 , Y02T10/52
摘要： The vehicle power train control method and apparatus according to the invention secures both operability and safety by controlling an actual acceleration/deceleration to a target acceleration/deceleration requested by a driver under safe traveling condition, and changing the target acceleration/deceleration so as to take precedence for safe traveling if the driver encounters a dangerous traveling condition. According to the invention, acceleration/deceleration and speed of a motor vehicle are detected; a target acceleration/deceleration is determined; and a road condition such as a road gradient or presence or absence of a forward motor vehicle is detected to decide whether the road condition is dangerous. The target acceleration is changed if the condition is decided to be dangerous.
摘要翻译：根据本发明的车辆动力传动系控制方法和装置通过控制驾驶员在安全行驶状态下所要求的目标加速/减速的实际加速/减速来改变目标加速度/减速度，从而确保操作性和安全性。如果驾驶员遇到危险的旅行状况，则可以安全行驶。根据本发明，检测到机动车辆的加速/减速和速度; 确定目标加速/减速; 并且检测道路状况如道路坡度或前进机动车辆的存在或不存在，以确定道路状况是否是危险的。如果条件被确定为危险，则改变目标加速度。

130. 发明授权

US5752214A Method and apparatus for controller power train of motor vehicle 失效
公开(公告)号：US5752214A
公开(公告)日：1998-05-12
申请号：US654971
申请日：1996-05-28
申请人： Toshimichi Minowa , Hiroshi Kuroda , Satoru Kuragaki , Kenichirou Kurata , Tatsuya Ochi
发明人： Toshimichi Minowa , Hiroshi Kuroda , Satoru Kuragaki , Kenichirou Kurata , Tatsuya Ochi
IPC分类号： B60R21/00 , B60K28/14 , B60K31/00 , B60T7/12 , B60T8/174 , B60T13/66 , B60W10/00 , B60W10/04 , B60W10/06 , B60W10/10 , B60W10/18 , B60W10/184 , B60W30/00 , B60W30/08 , B60W40/02 , B60W40/06 , B60W40/072 , B60W40/076 , B60W40/10 , B60W40/107 , F02D9/10 , F02D29/02 , F16H61/18 , F16H63/50 , G01S13/93 , B60K41/28
CPC分类号： B60W30/08 , B60K31/0008 , B60T13/66 , B60T7/12 , B60W10/06 , B60W10/18 , B60W40/06 , B60T2210/24 , B60W2530/16 , B60W2550/12 , B60W2550/142 , B60W2550/143 , B60W2550/148 , B60W2550/402 , B60W2720/106 , G01S2013/9342 , G01S2013/9346 , G01S2013/9353 , Y02T10/52
摘要： The vehicle power train control method and apparatus according to the invention secures both operability and safety by controlling an actual acceleration/deceleration to a target acceleration/deceleration requested by a driver under safe traveling condition, and changing the target acceleration/deceleration so as to take precedence for safe traveling if the driver encounters a dangerous traveling condition. According to the invention, acceleration/deceleration and speed of a motor vehicle are detected; a target acceleration/deceleration is determined; and a road condition such as a road gradient or presence or absence of a forward motor vehicle is detected to decide whether the road condition is dangerous. The target acceleration is changed if the condition is decided to be dangerous.

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