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101. 发明授权

US6071964A Diclofenac/gamma-cyclodextrin inclusion compounds 失效
标题翻译：双氯芬酸/γ-环糊精包合物
公开(公告)号：US6071964A
公开(公告)日：2000-06-06
申请号：US155298
申请日：1999-05-11
申请人： Wilfried Fischer , Anna Sendl-Lang
发明人： Wilfried Fischer , Anna Sendl-Lang
IPC分类号： A61K9/16 , A61K9/28 , A61K9/46 , A61K31/195 , A61K31/196 , A61K47/48
CPC分类号： B82Y5/00 , A61K47/48969 , Y10S514/922
摘要： The object of the present invention is an oral drug preparation containing the .gamma.-cyclodextrin complex of diclofenac or pharmaceutically acceptable salts thereof, especially the sodium salt prepared by known methods, and by which the gastro-intestinal irritancy of diclofenac, at the same or improved bioavailability, can be considerably decreased.
摘要翻译： PCT No.PCT / EP97 / 01595 Sec。 371日期1999年5月11日 102（e）日期1999年5月11日PCT 1997年3月27日PCT公布。出版物WO97 / 35568 日本1997年10月2日本发明的目的是含有双氯芬酸的γ-环糊精复合物或其药学上可接受的盐，特别是通过已知方法制备的钠盐的口服药物制剂，其中双氯芬酸的胃肠刺激，相同或改善的生物利用度可以显着降低。

102. 发明授权

US6030953A Pharmaceutical composition containing chitosan 有权
标题翻译：含有壳聚糖的药物组合物
公开(公告)号：US6030953A
公开(公告)日：2000-02-29
申请号：US370845
申请日：1999-08-10
申请人： Jacques Bailly , Andre Fleury , Paul Hadvary , Hans Lengsfeld , Hans Steffen
发明人： Jacques Bailly , Andre Fleury , Paul Hadvary , Hans Lengsfeld , Hans Steffen
IPC分类号： C07D305/12 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/46 , A61K31/337 , A61K31/365 , A61K31/722 , A61K45/00 , A61K47/36 , A61P1/12 , A61P3/04 , A61P3/06 , A61P3/10 , A61P43/00 , A61K31/70 , A61K31/335 , A61K31/715
CPC分类号： A61K9/0095 , A61K31/365 , A61K47/36 , A61K9/0007 , A61K9/0056 , A61K9/1652 , Y10S514/922
摘要： The present invention provides orally administrable pharmaceutical compositions containing an inhibitor of gastrointestinal lipase, and at least one compound selected from the group consisting of chitosan, its derivatives and salts thereof. Methods are provided for preventing and treating anal leakage of oil in a patient to whom a composition containing an inhibitor of gastrointestinal lipase is orally administered.
摘要翻译：本发明提供含有胃肠脂肪酶抑制剂的口服给药的药物组合物和至少一种选自壳聚糖，其衍生物和盐的化合物。提供了用于预防和治疗口服给予含有胃肠脂肪酶抑制剂的组合物的患者的油的肛门泄漏的方法。

103. 发明授权

US6001874A Arthropod control composition for plant protection 失效
标题翻译：节肢动物控制植物保护组成
公开(公告)号：US6001874A
公开(公告)日：1999-12-14
申请号：US880072
申请日：1997-06-20
申请人： Dan Veierov
发明人： Dan Veierov
IPC分类号： A01N61/00 , A01N65/03 , A61K36/47 , A61K36/55 , A01N27/00 , A01N31/00 , A01N35/00 , A01N35/06 , A01N37/02 , A01N37/04 , A01N37/06 , A01N65/00
CPC分类号： A01N65/00 , A01N25/32 , A01N65/08 , A01N65/18 , A01N65/20 , Y10S514/922 , Y10S514/946 , Y10S514/974
摘要： A non-toxic arthropod control composition is disclosed for application to foliage for plant protection. The composition includes behavior interfering compounds, agricultural oil and/or surface active compounds and diluents. The behavior interfering compounds may be any known conventional compound capable of interrupting or altering the normal behavioral sequences of the target. The agricultural oil can be a vegetable oil.
摘要翻译：公开了一种无毒的节肢动物控制组合物用于植物保护用于叶子。组合物包括行为干扰化合物，农用油和/或表面活性化合物和稀释剂。干扰化合物的行为可以是能够中断或改变靶标正常行为序列的任何已知的常规化合物。农用油可以是植物油。

104. 发明授权

US5897864A Method for treating sexual dysfunction disorders with compositions containing ginkgo biloba 失效
标题翻译：用含有银杏的组合物治疗性功能障碍障碍的方法
公开(公告)号：US5897864A
公开(公告)日：1999-04-27
申请号：US863175
申请日：1997-05-23
申请人： Alan J. Cohen
发明人： Alan J. Cohen
IPC分类号： A61K36/16 , A61K35/78
CPC分类号： A61K36/16 , Y10S514/922
摘要： A method for treating sexual dysfunction in a patient taking antidepressant medication is described, comprising administering an effective amount of ginkgo biloba to the patient. A method for treating sexual dysfunction in a patient taking anti-hypertensive medication is described, comprising administering an effective amount of ginkgo biloba to the patient. A method for treating sexual dysfunction in menopausal or perimenopausal patients is described, comprising administering an effective amount of ginkgo biloba to the patient. A method for treating sexual dysfunction that is not caused by a medication is described. A method for enhancing sexual response and performance is described. The invention further encompasses an antidepressant composition for the treatment of a patient in need of antidepressant therapy which comprises an amount of antidepressant sufficient to alleviate the depression and an amount of Ginkgo Biloba sufficient to alleviate any sexual dysfunction associated with the antidepressant.
摘要翻译：描述了一种在服用抗抑郁药物的患者中治疗性功能障碍的方法，包括向患者施用有效量的银杏叶。描述了一种在服用抗高血压药物的患者中治疗性功能障碍的方法，包括向患者施用有效量的银杏叶。描述了一种治疗绝经期或围绝经期患者的性功能障碍的方法，包括向患者施用有效量的银杏叶。描述用于治疗不是由药物引起的性功能障碍的方法。描述了一种增强性反应和性能的方法。本发明还包括用于治疗需要抗抑郁治疗的患者的抗抑郁组合物，其包含足以减轻抑郁症的量的抗抑郁药和足以减轻与抗抑郁药有关的任何性功能障碍的量的银杏叶。

105. 发明授权

US5773478A Composition comprising methylphenidate and another drug 失效
公开(公告)号：US5773478A
公开(公告)日：1998-06-30
申请号：US679878
申请日：1996-07-15
申请人： Andrew John McGlashan Richards , Nicholas Robert Pope
发明人： Andrew John McGlashan Richards , Nicholas Robert Pope
IPC分类号： C07D211/34 , A61K31/445 , A61K31/4458 , A61K33/00 , A61K45/00 , A61K45/06 , A01N33/02 , A01N43/06 , A61K9/16 , A61K31/135
CPC分类号： A61K45/06 , A61K31/445 , A61K31/4458 , A61K33/00 , Y10S514/81 , Y10S514/813 , Y10S514/922
摘要： A method of treating a subject that is undergoing methylphenidate therapy and concomitant therapy with another drug undergoes or interferes with P.sub.450 metabolism, wherein the methylphenidate is d-threo-methylphenidate.

106. 发明授权

US5747461A Synergistic administration of cyclosporine and fructose diphosphate 失效
标题翻译：协同作用的环孢菌素和二磷酸果糖
公开(公告)号：US5747461A
公开(公告)日：1998-05-05
申请号：US280374
申请日：1994-07-26
申请人： Angel K. Markov
发明人： Angel K. Markov
IPC分类号： A61K38/13 , A61K31/70
CPC分类号： A61K38/13 , Y10S514/885 , Y10S514/922
摘要： This invention discloses a method of using fructose-1,6-diphosphate (FDP) to help suppress the rejection of internal organs such as kidneys, hearts, etc. At least three major advantages of FDP in conjunction with organ transplants have been identified: (1) FDP can help reduce the unwanted proliferation of certain types of stimulated lymphocytes which would otherwise pose a risk of attacking the non-self cells in the transplanted organ; (2) FDP can also potentiate the effectiveness of cyclosporine as a transplant-protecting immunosuppressant, thereby allowing a reduction in CSA dosages, which in turn can reduce the likelihood and the severity of toxic side effects and other dangers of CSA treatment; (3) FDP can also reduce the amount of damage inflicted on an organ during the removal and storage steps required in organ transplantation.
摘要翻译：本发明公开了一种使用果糖-1,6-二磷酸（FDP）来帮助抑制诸如肾脏，心脏等内部器官的排斥反应的方法。已经确定了FDP与器官移植联合的至少三个主要优点：（ 1）FDP可以帮助减少某些类型的刺激淋巴细胞的不想要的增殖，否则这些淋巴细胞将会侵袭移植器官中的非自体细胞的风险; （2）FDP还可以增强环孢菌素作为移植保护免疫抑制剂的有效性，从而减少CSA剂量，从而降低CSA治疗的毒副作用和其他危害的可能性和严重性; （3）FDP还可以减少器官移植所需的移除和储存步骤对器官造成的伤害。

107. 发明授权

US5661142A Anti-emetic composition 失效
标题翻译：反兴奋剂组成
公开(公告)号：US5661142A
公开(公告)日：1997-08-26
申请号：US634083
申请日：1996-04-17
申请人： David M. Naeger
发明人： David M. Naeger
IPC分类号： A61K31/57 , A61K31/56
CPC分类号： A61K31/57 , A61K31/166 , Y10S514/872 , Y10S514/922
摘要： The invention relates to an anti-emetic composition that comprises dexamethasone (DEX), metoclopramide (MTC) and an antihistamine or an anticholinergic agent. In a particular embodiment, a composition containing DEX:MTC:diphenhydramine in a relative weight ratio of about 1:1:2.5, respectively, is found to be effective in providing relief from the discomfort caused by symptoms of both vomiting and nausea in all patients receiving the composition. Alternatively, an effective composition may contain DEX:MTC:scopolamine in a relative weight ratio of about 1:1:0.025, respectively. Other effective compositions and methods of their use are also disclosed.
摘要翻译：本发明涉及包含地塞米松（DEX），甲氧氯普胺（MTC）和抗组胺剂或抗胆碱能剂的抗呕吐组合物。在一个具体实施方案中，发现分别以相对重量比为约1:1:2.5的含有DEX：MTC：苯海拉明的组合物有效地缓解了所有患者的呕吐和恶心症状引起的不适接收组合。或者，有效组合物可以分别含有相对重量比为约1:1:0.025的DEX：MTC：东莨菪碱。还公开了其使用的其它有效组合物和方法。

108. 发明授权

US5646186A Retinoid composition 失效
标题翻译：类视黄醇组成
公开(公告)号：US5646186A
公开(公告)日：1997-07-08
申请号：US241446
申请日：1994-05-17
申请人： Jonas C. T. Wang , Stephen J. Wisniewski
发明人： Jonas C. T. Wang , Stephen J. Wisniewski
IPC分类号： A61K8/365 , A61K8/67 , A61K31/07 , A61K31/19 , A61Q19/00
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/671 , A61K2800/75 , Y10S514/844 , Y10S514/922 , Y10S514/974
摘要： This invention relates to skin care compositions containing retinoids which are generally applied topically to improve the quality of the skin. More particularly, this invention relates to skin care compositions comprising retinol (Vitamin A alcohol) and further comprising irritation ameliorating quantities of glycolic acid.
摘要翻译：本发明涉及含有类维生素A的皮肤护理组合物，其通常以局部施用以改善皮肤的质量。更具体地说，本发明涉及包含视黄醇（维生素A醇）并进一步包含刺激性改善量的乙醇酸的护肤组合物。

109. 发明授权

US5616347A Chlorine dioxide skin medicating compositions for preventing irritation 失效
标题翻译：二氧化氯皮肤用于预防刺激的皮肤护理组合物
公开(公告)号：US5616347A
公开(公告)日：1997-04-01
申请号：US388622
申请日：1995-02-14
申请人： Howard Alliger , Habib Roozdar
发明人： Howard Alliger , Habib Roozdar
IPC分类号： A61K33/20 , A61K36/886 , A01N59/00 , A61K33/40
CPC分类号： A61K33/20 , A61K36/886 , Y10S514/922
摘要： The present invention relates to the discovery that the inclusion of effective amounts of an irritation reducing compound selected from the group consisting of allantoin, glycerine, aloe vera and mixtures, thereof, in a chlorine dioxide generating composition will substantially reduce skin irritation which is caused by chlorine dioxide exposure to the skin.
摘要翻译：本发明涉及在二氧化氯生成组合物中包含有效量的选自尿囊素，甘油，芦荟及其混合物的刺激性还原化合物的发现，将显着降低皮肤刺激，这是由二氧化氯暴露于皮肤。

110. 发明授权

US5525606A Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines 失效
标题翻译：取代的06-苄基胍和6（4） - 苄氧基嘧啶
公开(公告)号：US5525606A
公开(公告)日：1996-06-11
申请号：US283953
申请日：1994-08-01
申请人： Robert C. Moschel , Anthony E. Pegg , M. Eileen Dolan , Mi-Young Chae
发明人： Robert C. Moschel , Anthony E. Pegg , M. Eileen Dolan , Mi-Young Chae
IPC分类号： A61K31/505 , A61K31/52 , A61K31/522 , A61K31/53 , A61P35/00 , A61P43/00 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/50 , C07D251/52 , C07D473/06 , C07D473/18 , C07D473/40 , C07D487/04 , C07D473/04
CPC分类号： C07D239/47 , C07D239/48 , C07D239/50 , C07D251/52 , C07D473/06 , C07D473/18 , C07D473/40 , C07D487/04 , Y10S514/922
摘要： The present invention provides 8-substituted O.sup.6 -benzylguanines of the formula ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are as defined in the specification, and 4(6)-substituted 2-amino-5-nitro-6(4)-benzyloxypyrimidine, and 4(6)-substituted 2-amino-5-nitroso-6(4)-benzyloxypyrimidine derivatives which have been found to be effective AGT inactivators, as well as pharmaceutical compositions comprising such derivatives along with a pharmaceutically acceptable carrier. The present invention further provides a method of enhancing the chemotherapeutic treatment of tumor cells in a mammal with an antineoplastic alkylating agent which causes cytotoxic lesions at the O.sup.6 -position of guanine, by administering to a mammal an effective amount of one of the aforesaid derivatives, 2,4-diamino-6-benzyloxy-s-triazine, 5-substituted 2,4-diamino-6-benzyloxypyrimidines, or 8-aza-O.sup.6 -benzylguanine, and administering to the mammal an effective amount of an antineoplastic alkylating agent which causes cytotoxic lesions at the O.sup.6 -position of guanine.
摘要翻译：本发明提供了式（I）的8-取代的O6-苄基胍，其中R1，R2和R3如说明书中所定义，和4（6） - 取代的2-氨基-5-硝基-6（4） - 苄氧基嘧啶和已被发现是有效的AGT灭活剂的4（6） - 取代的2-氨基-5-亚硝基-6（4） - 苄氧基嘧啶衍生物，以及包含这些衍生物以及药学上可接受的载体的药物组合物。本发明还提供了一种通过向哺乳动物施用有效量的上述衍生物之一来增强哺乳动物中肿瘤细胞的化学治疗方法，所述抗肿瘤烷化剂通过在鸟嘌呤的O6位引起细胞毒性损伤， 2,4-二氨基-6-苄氧基-s-三嗪，5-取代的2,4-二氨基-6-苄氧基嘧啶或8-氮杂-O6-苄基鸟嘌呤，并向哺乳动物施用有效量的抗肿瘤烷化剂，在鸟嘌呤的O6位引起细胞毒性病变。

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