专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5944020A Use of fructose-1 6-diphosphate as an inotrope drug after cardiopulmonary bypass surgery 失效
标题翻译：在体外循环手术后使用果糖-1,6-二磷酸作为肌内注射药物
公开(公告)号：US5944020A
公开(公告)日：1999-08-31
申请号：US943836
申请日：1997-10-03
申请人： Angel K. Markov , Paul J. Marangos , Anthony W. Fox
发明人： Angel K. Markov , Paul J. Marangos , Anthony W. Fox
IPC分类号： A61B17/00 , A61B19/00
CPC分类号： A61K31/7024 , A61B2017/00243
摘要： When fructose-1,6-diphosphate (FDP) is used as an inotropic drug in patients who have undergone surgery involving cardiopulmonary bypass, it can increase the pumping strength of a struggling heart, without increasing the heartbeat rate. As such, FDP can reduce the dosages of (and in some some cases eliminate the need for) other inotropic drugs such as dobutamine, epinephrin, or amrinone lactate, which have undesired and potentially dangerous side effects, mainly involving increasing the heartbeat rate, which imposes substantial additional stresses on hearts that are struggling to regain strength after cardiopulmonary bypass surgery.
摘要翻译：当使用果糖-1,6-二磷酸（FDP）作为肌力药物进行手术涉及体外循环的患者时，可以增加心脏的搏动力，而不增加心律。因此，FDP可以降低主要涉及增加心跳速率的（以及在某些情况下不需要）其它变力药物，例如多巴酚丁胺，肾上腺素或乳酸氨基肌醇酸，其具有不希望的和潜在的危险副作用，其中对心肺旁路手术后正在努力恢复力量的心脏施加了更多的压力。

2. 发明授权

US06312707B1 Treatment of sickle cell anemia crises with fructose-1,6-diphosphate as an analgesic drug 失效
标题翻译：用果糖-1,6-二磷酸作为镇痛药治疗镰状细胞性贫血危机
公开(公告)号：US06312707B1
公开(公告)日：2001-11-06
申请号：US09591786
申请日：2000-06-12
申请人： Angel K. Markov , Anthony W. Fox , Paul J. Marangos
发明人： Angel K. Markov , Anthony W. Fox , Paul J. Marangos
IPC分类号： A61F202
CPC分类号： A61K31/70
摘要： Fructose-1,6-diphosphate (FDP) has been shown, in double-blinded controlled clinical trials on patients with sickle cell anemia, to substantially reduce the pain suffered by such patients during the recurrent ischemic crises that are caused by red blood cell sickling. Tests on patients who have been hospitalized for such crises demonstrated that when they received an intravenous injection of FDP, they reported substantially lower pain levels during their hospital stays than control groups that received identical treatment without any FDP. Apparently, FDP has never previously been used or even tested in human clinical trials, to treat sickle cell anemia. In addition, FDP has never previously been reported to have any analgesic (pain-reducing) activity.
摘要翻译：在镰状细胞性贫血患者的双盲对照临床试验中，已经显示了果糖-1,6-二磷酸（FDP），以显着降低这种患者在由红细胞镰刀引起的复发性缺血性危机期间所遭受的疼痛。对这些危机进行住院治疗的患者的测试表明，当他们接受静脉注射FDP时，他们报告在住院期间疼痛水平明显低于不具有FDP的相同治疗对照组。显然，FDP从未在人类临床试验中从未被使用或甚至被测试，以治疗镰状细胞性贫血。此外，FDP从未有报道已经有任何止痛（减痛）活动。

3. 发明授权

US4703040A Treatment of adult respiratory distress syndrome (ARDS) using fructose diphosphate (FDP) 失效
标题翻译：使用二磷酸果糖（FDP）治疗成人呼吸窘迫综合征（ARDS）
公开(公告)号：US4703040A
公开(公告)日：1987-10-27
申请号：US785778
申请日：1985-10-08
申请人： Angel K. Markov
发明人： Angel K. Markov
IPC分类号： A61K9/10 , A61K31/66 , C07H11/04
CPC分类号： A61K31/7004
摘要： Fructose-1,6-diphosphate is administered intravenously to a mammalian subject experiencing adult respiratory distress syndrome (ARDS) in an amount sufficient to inhibit pulmonary microvascular damage.
摘要翻译：将果糖-1,6-二磷酸盐以足以抑制肺微血管损伤的量静脉内施用经历成人呼吸窘迫综合征（ARDS）的哺乳动物受试者。

4. 发明授权

US6074658A Treatment of sickle cell anemia crises with fructose-1, 6-diphosphate as an analgesic drug 失效
标题翻译：用果糖-1,6-二磷酸作为止痛药治疗镰状细胞性贫血危机
公开(公告)号：US6074658A
公开(公告)日：2000-06-13
申请号：US943688
申请日：1997-10-03
申请人： Angel K. Markov , Anthony W. Fox , Paul J. Marangos
发明人： Angel K. Markov , Anthony W. Fox , Paul J. Marangos
IPC分类号： A61K31/70 , A61F2/02
CPC分类号： A61K31/70
摘要： Fructose-1,6-diphosphate (FDP) has been shown, in double-blinded controlled clinical trials on patients with sickle cell anemia, to substantially reduce the pain suffered by such patients during the recurrent ischemic crises that are caused by red blood cell sickling. Tests on patients who have been hospitalized for such crises demonstrated that when they received an intravenous injection of FDP, they reported substantially lower pain levels during their hospital stays than control groups that received identical treatment without any FDP. Apparently, FDP has never previously been used or even tested in human clinical trials, to treat sickle cell anemia. In addition, FDP has never previously been reported to have any analgesic (pain-reducing) activity.
摘要翻译：在镰状细胞性贫血患者的双盲对照临床试验中，已经显示了果糖-1,6-二磷酸（FDP），以显着降低这种患者在由红细胞镰刀引起的复发性缺血性危机期间所遭受的疼痛。对这些危机进行住院治疗的患者的测试表明，当他们接受静脉注射FDP时，他们报告在住院期间疼痛水平明显低于不具有FDP的相同治疗对照组。显然，FDP从未在人类临床试验中从未被使用或甚至被测试，以治疗镰状细胞性贫血。此外，FDP从未有报道已经有任何止痛（减痛）活动。

5. 发明授权

US5858985A Treatment of asthma with fructose-1,6-diphosphate 失效
标题翻译：用果糖-1,6-二磷酸治疗哮喘
公开(公告)号：US5858985A
公开(公告)日：1999-01-12
申请号：US943438
申请日：1997-10-03
申请人： Angel K. Markov
发明人： Angel K. Markov
IPC分类号： A61K31/70 , C07H11/04
CPC分类号： C07H11/04 , A61K31/70 , Y10S514/826
摘要： Fructose-1,6-diphosphate (FDP), a sugar-phosphate compound, can be useful in treating asthma, when administered as an inhalable drug, either by itself or as a component of a mixed formulation. On a cellular level, inhalable FDP appears to offer at least four beneficial effects for asthma sufferers: (1) it reduces histamine release by activated mast cells; (2) it suppresses production of oxygen free radicals by polymorphonuclear cells; (3) it helps suppress the activation and proliferation of T-lymphocytes; and, (4) it helps reduce the expression of interleukin compounds by T-lymphocytes. All four effects have been measured and shown to occur in animal and/or human tests, and these effects render FDP likely to help reduce and retard the progressive worsening of asthma that occurs in many sufferers. In addition, when tested in inhalable form on humans, FDP was shown to increase bronchial flow rates. All of these effects are beneficial, and can help asthma patients treated with FDP use asthma-control drugs which impose less stress on the user than more potent, aggressive asthma-control drugs.
摘要翻译：果糖-1,6-二磷酸（FDP），糖 - 磷酸盐化合物，当作为可吸入药物本身或作为混合制剂的组分施用时，可用于治疗哮喘。在细胞水平上，可吸入的FDP似乎对哮喘患者至少提供四种有益效果：（1）它减少活化的肥大细胞的组胺释放; （2）通过多形核细胞抑制氧自由基的产生; （3）有助于抑制T淋巴细胞的活化和增殖; 和（4）它有助于减少T淋巴细胞白介素化合物的表达。已经测量并显示所有四种效应都在动物和/或人体试验中发生，这些作用使得FDP可能有助于减少和阻止许多患者发生的哮喘的进行性恶化。此外，当以可吸入形式对人进行测试时，FDP显示增加支气管流速。所有这些效果都是有益的，并且可以帮助用FDP治疗的哮喘患者使用哮喘控制药物，对使用者施加的压力较较有效，有效的哮喘控制药物更少。

6. 发明授权

US5747461A Synergistic administration of cyclosporine and fructose diphosphate 失效
标题翻译：协同作用的环孢菌素和二磷酸果糖
公开(公告)号：US5747461A
公开(公告)日：1998-05-05
申请号：US280374
申请日：1994-07-26
申请人： Angel K. Markov
发明人： Angel K. Markov
IPC分类号： A61K38/13 , A61K31/70
CPC分类号： A61K38/13 , Y10S514/885 , Y10S514/922
摘要： This invention discloses a method of using fructose-1,6-diphosphate (FDP) to help suppress the rejection of internal organs such as kidneys, hearts, etc. At least three major advantages of FDP in conjunction with organ transplants have been identified: (1) FDP can help reduce the unwanted proliferation of certain types of stimulated lymphocytes which would otherwise pose a risk of attacking the non-self cells in the transplanted organ; (2) FDP can also potentiate the effectiveness of cyclosporine as a transplant-protecting immunosuppressant, thereby allowing a reduction in CSA dosages, which in turn can reduce the likelihood and the severity of toxic side effects and other dangers of CSA treatment; (3) FDP can also reduce the amount of damage inflicted on an organ during the removal and storage steps required in organ transplantation.
摘要翻译：本发明公开了一种使用果糖-1,6-二磷酸（FDP）来帮助抑制诸如肾脏，心脏等内部器官的排斥反应的方法。已经确定了FDP与器官移植联合的至少三个主要优点：（ 1）FDP可以帮助减少某些类型的刺激淋巴细胞的不想要的增殖，否则这些淋巴细胞将会侵袭移植器官中的非自体细胞的风险; （2）FDP还可以增强环孢菌素作为移植保护免疫抑制剂的有效性，从而减少CSA剂量，从而降低CSA治疗的毒副作用和其他危害的可能性和严重性; （3）FDP还可以减少器官移植所需的移除和储存步骤对器官造成的伤害。

7. 发明授权

US5039665A Use of fructose-1,6-diphosphate for treating myocardial infarction 失效
标题翻译：使用果糖-1,6-二磷酸治疗心肌梗死
公开(公告)号：US5039665A
公开(公告)日：1991-08-13
申请号：US576154
申请日：1990-08-29
申请人： Angel K. Markov
发明人： Angel K. Markov
IPC分类号： C07H11/04
CPC分类号： C07H11/04
摘要： The invention relates to methods of treatment of patients with heat disorders using fructose-1,6-diphosphate.
摘要翻译：本发明涉及使用果糖-1,6-二磷酸治疗患有热障碍的患者的方法。

8. 发明授权

US4757052A Method of preserving blood 失效
标题翻译：保血方法
公开(公告)号：US4757052A
公开(公告)日：1988-07-12
申请号：US784381
申请日：1985-10-04
申请人： Angel K. Markov
发明人： Angel K. Markov
IPC分类号： C07H11/04 , A61K31/66 , A61K31/70 , C12P19/24
CPC分类号： C07H11/04 , Y10S514/832 , Y10S514/833
摘要： The invention relates to methods of treatment of patients with heart disorders and methods of preserving stored blood using fructose-1,6-diphosphate.
摘要翻译：本发明涉及治疗心脏病患者的方法和使用果糖-1,6-二磷酸保存储存血液的方法。

9. 发明授权

US4546095A Use of fructose-1,6-diphosphate for treating myocardial infarction 失效
标题翻译：使用果糖-1,6-二磷酸治疗心肌梗死
公开(公告)号：US4546095A
公开(公告)日：1985-10-08
申请号：US414551
申请日：1982-09-03
申请人： Angel K. Markov
发明人： Angel K. Markov
IPC分类号： C07H11/04 , A61K31/66 , A61K31/70 , C12P19/24
CPC分类号： C07H11/04
摘要： The invention relates to the treatment of heart disorders. Disruption of heart action or occulision of heart artery results in oxygen deprivation and aerobic metabolism ceases. Unless effective treatment is administered acidosis renders anaerobic metabolism inactive and irreversible tissue damage occurs.Fructose-1,6-diphosphate is used as a therapeutic agent for treating mammalian subjects experiencing myocardial infection in order to prevent ischemic tissue from irreversible tissue damage.
摘要翻译：本发明涉及心脏病的治疗。心脏动作或心脏动脉闭塞导致氧气缺乏和有氧代谢停止。除非有效治疗，否则酸中毒使无氧代谢无效，并发生不可逆组织损伤。果糖-1,6-二磷酸被用作治疗经历心肌感染的哺乳动物受试者的治疗剂，以防止缺血组织不可逆组织损伤。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式