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101. 发明授权

US07009034B2 Biocompatible crosslinked polymers 有权
公开(公告)号：US07009034B2
公开(公告)日：2006-03-07
申请号：US10010715
申请日：2001-11-09
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Peter G. Edelman
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Peter G. Edelman
IPC分类号： C09F15/00 , C07K1/00 , C08G63/48 , A61K47/30
CPC分类号： A61K47/34 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K31/74 , A61K47/42 , A61L24/106 , A61L27/18 , A61L27/50 , A61L31/06 , C07K14/75 , C08G63/08 , C08G63/912 , C08L89/00 , G06K7/10831 , G06K2207/1016 , C08L2666/02
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.

102. 发明申请

US20050260723A1 Process of producing low molecular weight poly(hydroxyalkanoate)s from high molecular weight poly(hydroxyalkanoate)s 有权
标题翻译：从高分子量聚（羟基链烷酸酯）生产低分子量聚（羟基链烷酸酯）的方法
公开(公告)号：US20050260723A1
公开(公告)日：2005-11-24
申请号：US11129479
申请日：2005-05-16
申请人： Ga-Er Yu
发明人： Ga-Er Yu
IPC分类号： C08G63/78 , C08G63/81 , C08G63/91 , C12P7/62
CPC分类号： C08G63/81 , C08G63/912
摘要： In this invention, a process of thermal degradation of biodegradable bacterial polyesters poly(hydroxyalkanoate)s (PHAs) to lower molecular weight PHAs in controllable manner has been developed. The process involves using at least one additional component to ‘dilute’ the PHAs in the thermal degradation process, so that the process can be controlled in the senses of better heat transfer, better stirring, easier working up after the reaction. The relationship of processing time and the molecular weights of the products at a certain temperature was obtained so that it is possible to obtain the desired molecular weight products in the real production under the guidance of the relationship.
摘要翻译：在本发明中，开发了以可控制的方式将可生物降解的细菌聚酯聚（羟基链烷酸酯）（PHAs）热降解成较低分子量的PHA的方法。该方法包括在热降解过程中使用至少一种附加组分“稀释”PHAs，使得该方法可以在更好的传热，更好的搅拌，更容易的反应后的加工的感觉中进行控制。得到处理时间与产物在一定温度下的分子量的关系，从而可以在关系的指引下在实际生产中获得所需的分子量产物。

103. 发明申请

US20050203270A1 Functionalized polymers and their biomedical and pharmaceutical uses 审中-公开
标题翻译：功能化聚合物及其生物医药和药物用途
公开(公告)号：US20050203270A1
公开(公告)日：2005-09-15
申请号：US10510407
申请日：2003-04-03
申请人： Patrice Hildgen , Gregoire Leclair , Richard Quesnel
发明人： Patrice Hildgen , Gregoire Leclair , Richard Quesnel
IPC分类号： A61K9/16 , C08G63/08 , C08G63/91 , C08G65/22 , C08L71/02
CPC分类号： C08G65/22 , A61K9/1647 , C08G63/912 , C08L71/02 , C08L2203/02 , C08L2205/05 , C08L2666/18
摘要： Disclosed is a polymer of the formula I: wherein: Z is —O— or —NH—; R1 represents a non-functional backbone of a hydroxy acid or amino acid derived from a cyclic ester or diester or cyclic amide or diamide monomer (A); R2 represents a non-functional chain derived from an epoxide monomer (B), said chain ending with a graftable hydroxy or carboxylic group; n is the number of units derived from the monomers (A); m is the number of units derived from the monomers (B); and x is equal to n+m, the ratio m/x ranging from 0.005 to 0.30. Also disclosed is a process of preparing this functionalizable polymer to the hydroxy or carboxylic groups of which can be grafted a compound selected from the group consisting of: ligands specific to cellular receptors, such as Selectine E; lipids; peptides; polyethers; polyacrylates; natural polymers; polyosides; antigens or antibodies; salen; and cyclodextrins. The so grafted polymer can be used as carried or excipient in the biomedical and pharmaceutical fields.
摘要翻译：公开了式I的聚合物：其中：Z是-O-或-NH-; R 1代表衍生自环酯或二酯或环酰胺或二酰胺单体（A）的羟基酸或氨基酸的非官能主链; R 2表示衍生自环氧化物单体（B）的非官能链，所述链以可接枝的羟基或羧基为末端; n是衍生自单体（A）的单元数; m是衍生自单体（B）的单元数; x等于n + m，m / x的比例范围为0.005〜0.30。还公开了将该可官能化聚合物制备成羟基或羧基的方法，其可以接枝选自以下的化合物：对细胞受体特异性的配体，例如Selectine E; 脂质肽类聚醚聚丙烯酸酯; 天然聚合物; 多糖苷抗原或抗体; 萨伦和环糊精。所述接枝聚合物可用作生物医药领域的载体或赋形剂。

104. 发明申请

US20050201974A1 Bioadhesive polymers with catechol functionality 审中-公开
标题翻译：具有儿茶酚功能的生物粘合剂聚合物
公开(公告)号：US20050201974A1
公开(公告)日：2005-09-15
申请号：US11009327
申请日：2004-12-09
申请人： Marcus Schestopol , Jules Jacob , Ryan Donnelly , Thomas Ricketts , Avinash Nangia , Edith Mathiowitz , Ze'ev Shaked
发明人： Marcus Schestopol , Jules Jacob , Ryan Donnelly , Thomas Ricketts , Avinash Nangia , Edith Mathiowitz , Ze'ev Shaked
IPC分类号： A61K9/00 , A61K9/20 , A61K31/74 , C08F8/32 , C08G63/91 , C09J135/00 , C09J167/00 , C09J167/04 , C09J201/06
CPC分类号： C08F8/32 , A61K9/0004 , A61K9/006 , A61K9/0065 , A61K9/204 , A61K9/2077 , A61K9/2081 , A61K9/2086 , C08G63/91 , C08G63/912 , C09J167/00 , C09J167/04 , C08F222/06
摘要： Polymers with improved bioadhesive properties and methods for improving bioadhesion of polymers have been developed. A compound containing an aromatic group which contains one or more hydroxyl groups is grafted onto a polymer or coupled to individual monomers. In one embodiment, the polymer is a biodegradable polymer. In another embodiment, the monomers may be polymerized to form any type of polymer, including biodegradable and non-biodegradable polymers. In some embodiments, the polymer is a hydrophobic polymer. In the preferred embodiment, the aromatic compound is catechol or a derivative thereof and the polymer contains reactive functional groups. In the most preferred embodiment, the polymer is a polyanhydride and the aromatic compound is the catechol derivative, DOPA. These materials display bioadhesive properties superior to conventional bioadhesives used in therapeutic and diagnostic applications. These bioadhesive materials can be used to fabricate new drug delivery or diagnostic systems with increased residence time at tissue surfaces, and consequently increase the bioavailability of a drug or a diagnostic agent. In a preferred embodiment, the bioadhesive material is a coating on a controlled release oral dosage formulation and/or forms a matrix in an oral dosage formulation.
摘要翻译：已经开发了具有改进的生物粘附性质的聚合物和改善聚合物生物粘附的方法。含有含有一个或多个羟基的芳族基团的化合物被接枝到聚合物上或与单独的单体偶联。在一个实施方案中，聚合物是可生物降解的聚合物。在另一个实施方案中，单体可以聚合以形成任何类型的聚合物，包括可生物降解和不可生物降解的聚合物。在一些实施方案中，聚合物是疏水性聚合物。在优选的实施方案中，芳族化合物是儿茶酚或其衍生物，并且聚合物含有反应性官能团。在最优选的实施方案中，聚合物是聚酐，芳族化合物是邻苯二酚衍生物DOPA。这些材料显示出比用于治疗和诊断应用的常规生物粘合剂优越的生物粘附性。这些生物粘附材料可用于制造具有增加的组织表面停留时间的新药物递送或诊断系统，并因此提高药物或诊断剂的生物利用度。在优选的实施方案中，生物粘附材料是在控释口服剂量制剂上的涂层和/或在口服剂量制剂中形成基质。

105. 发明授权

US06933328B2 Composition of crosslinkable prepolymers for biodegradable implants 失效
标题翻译：可生物降解植入物的可交联预聚物的组成
公开(公告)号：US06933328B2
公开(公告)日：2005-08-23
申请号：US10239623
申请日：2001-04-03
申请人： Etienne Honoré Schacht
发明人： Etienne Honoré Schacht
IPC分类号： A61L27/16 , A61L27/54 , C08F290/06 , C08F290/14 , C08G63/91 , A61F2/00 , A61K6/08 , C08K3/26 , C08K3/32
CPC分类号： A61L27/54 , A61L27/16 , A61L2300/604 , C08F290/14 , C08G63/912
摘要： A composition suitable for preparing a biodegradable implant, comprising a crosslinkable multifunctional prepolymer having at least two polymerizable end groups, the said composition having a viscosity such that it is deformable at a temperature of 0° to 60° C. into a three-dimensional shape and being crosslinkable within the said temperature range. The prepolymer comprises a hydrophilic region and/or the composition further comprises an effective amount of a mineral biologically-active component delivery system and/or a biocompatible degradable porosity-inducing component.
摘要翻译：一种适于制备可生物降解植入物的组合物，其包含具有至少两个可聚合端基的可交联的多官能预聚物，所述组合物具有使其在0℃至60℃的温度下可变形成三维形状的粘度并且在所述温度范围内可交联。预聚物包括亲水区和/或组合物还包含有效量的矿物生物活性成分递送系统和/或生物相容的可降解孔隙诱导组分。

106. 发明申请

US20050153149A1 Aliphatic copolyester resin, a preparation method, an aliphatic polyester resin composition, uses thereof, a coating composition, a particle-state composition for agriculture and gardening coated by degradabel layer 失效
标题翻译：脂肪族共聚酯树脂，制备方法，脂肪族聚酯树脂组合物，其用途，涂料组合物，用于农业的颗粒状组合物和由降解层涂覆的园艺
公开(公告)号：US20050153149A1
公开(公告)日：2005-07-14
申请号：US10991658
申请日：2004-11-18
申请人： Masanori Sakane , Michiyo Nakai , Kunio Shimizu , Yasuteru Kajikawa , Masaaki Ito
发明人： Masanori Sakane , Michiyo Nakai , Kunio Shimizu , Yasuteru Kajikawa , Masaaki Ito
IPC分类号： B41M5/40 , B41M5/41 , B41M5/44 , B41M5/52 , C08G18/28 , C08G18/42 , C08G18/63 , C08G18/72 , C08G63/00 , C08G63/08 , C08G63/664 , C08G63/78 , C08G63/91 , C08L33/00 , C09D167/04 , C09D175/04 , C09D175/06 , G03G7/00 , B32B23/04
CPC分类号： G03G7/008 , B41M5/41 , B41M5/44 , B41M5/5272 , C08G18/284 , C08G18/4277 , C08G18/4286 , C08G18/631 , C08G18/728 , C08G63/00 , C08G63/08 , C08G63/664 , C08G63/78 , C08G63/912 , C08G2230/00 , C08G2310/00 , C08L33/00 , C09D167/04 , C09D175/04 , C09D175/06 , G03G7/0046 , Y10T428/31978 , C08L2666/02 , C08L2666/04
摘要： This invention relates to aliphatic polyesters having a controlled thermal decomposition, hydrolizability, and biodegradability, in which OH terminals and COOH terminals are decreased through a ring-opening polymerization of a lactone and lactide by a mono alcohol or a metal alkoxide, or by decreasing both terminals through combining polymer terminals with diisocyanate. From a composition containing the polyesters, this invention provides a controlled release composition for agriculture. From a resin primarily containing fatty acid cellulose ester derivatives, this invention provides a base film for a marking film without volatilization and plasticizer migration problems; a picture image formable heat-sensitive transfer recording material with excellent strippability, coloring concentration, and brightness; a conductive coating composition with excellent storage stability, adhesion, and conductivity; a single-liquid type coating for a moisture-curable graft copolymer, and a non-toxic and non-irritating coating composition with excellent dryability. The copolymers of this invention also have excellent heat and impact resistance.
摘要翻译：本发明涉及具有受控热分解，水解和生物降解性的脂肪族聚酯，其中OH末端和COOH末端通过单醇或金属醇盐通过内酯和丙交酯的开环聚合而降低，或通过减少两者终端通过将聚合物末端与二异氰酸酯结合。本发明由含有聚酯的组合物提供用于农业的控释组合物。本发明主要由脂肪酸纤维素酯衍生物构成的树脂，提供了没有挥发和增塑剂迁移的标记膜的基膜，具有优异的剥离性，着色浓度和亮度的图像形成的热敏转印记录材料; 具有优异的储存稳定性，粘合性和导电性的导电性涂料组合物; 用于湿气固化接枝共聚物的单液体型涂料和具有优异干燥性的无毒无刺激性涂料组合物。本发明的共聚物也具有优异的耐热和耐冲击性。

107. 发明申请

US20050090401A1 Aliphatic copolyester resin, a preparation method, an aliphatic polyester resin composition, uses thereof, a coating composition, a particle-state composition for agriculture and gardening coated by degradable layer 失效
标题翻译：脂肪族共聚酯树脂，制备方法，脂肪族聚酯树脂组合物，其用途，涂料组合物，用于农业的颗粒状组合物和由可降解层涂覆的园艺
公开(公告)号：US20050090401A1
公开(公告)日：2005-04-28
申请号：US10992524
申请日：2004-11-18
申请人： Masanori Sakane , Michiyo Nakai , Kunio Shimizu , Yasuteru Kajikawa , Masaaki Ito
发明人： Masanori Sakane , Michiyo Nakai , Kunio Shimizu , Yasuteru Kajikawa , Masaaki Ito
IPC分类号： B41M5/40 , B41M5/41 , B41M5/44 , B41M5/52 , C08G18/28 , C08G18/42 , C08G18/63 , C08G18/72 , C08G63/00 , C08G63/08 , C08G63/664 , C08G63/78 , C08G63/91 , C08L33/00 , C09D167/04 , C09D175/04 , C09D175/06 , G03G7/00 , C08G63/02 , A01N25/10
CPC分类号： G03G7/008 , B41M5/41 , B41M5/44 , B41M5/5272 , C08G18/284 , C08G18/4277 , C08G18/4286 , C08G18/631 , C08G18/728 , C08G63/00 , C08G63/08 , C08G63/664 , C08G63/78 , C08G63/912 , C08G2230/00 , C08G2310/00 , C08L33/00 , C09D167/04 , C09D175/04 , C09D175/06 , G03G7/0046 , Y10T428/31978 , C08L2666/02 , C08L2666/04
摘要： In the present invention, there are obtained aliphatic polyesters having a controlled thermal decomposing property, hydrolizability, and biodegradability, in which OH terminals and COOH terminals are decreased to 50% and 30%, respectively, through a ring-opening polymerization of a lactone and lactide by a mono alcohol having a high boiling point or a metal alkoxide, or by further decreasing both terminals through combining produced polymer terminals with a diisocyanate and, from a composition containing the polyesters, there is obtained a particle-state composition for agriculture and gardening in which a duration period of a fertilizing effect can be controlled, and which is not remained in soil by decomposition. From a resin primarily containing fatty acid cellulose ester derivatives, there are obtained a base film for a marking film which does not include a problem such as volatilization and migration of a plasticizer and a picture image formable heat-sensitive transfer recording material which is excellent in strippability, coloring concentration, and brightness, a conductive coating composition which is excellent in storage stability, adhesion, and conductivity, a single-liquid type coating and a moisture-curable graft copolymer, and a coating composition which have a non toxicity and nonirritating property and which are excellent in dryability. A copolymer in which average chain length in lactone and lactide units are controlled is excellent in heat resistance and impact resistance.
摘要翻译：在本发明中，通过内酯的开环聚合，得到具有受控的热分解性，水解性和生物降解性的脂肪族聚酯，其中OH末端和COOH末端分别降低至50％和30％通过具有高沸点的单醇或金属醇盐的丙交酯，或者通过将产生的聚合物末端与二异氰酸酯组合而进一步减少两个末端，并且从含有聚酯的组合物获得农业和园艺的颗粒状组合物可以控制施肥持续时间，并且不会被分解留在土壤中。从主要含有脂肪酸纤维素酯衍生物的树脂，得到不含有增塑剂的挥发，迁移，图像形成性热敏转印记录材料等的问题的标记膜用基膜，剥离性，着色浓度和亮度，保存稳定性，粘合性和导电性优异的导电性涂料组合物，单液型涂布和湿润性接枝共聚物，以及具有非毒性和无刺激性的涂料组合物并且其干燥性优异。控制内酯和丙交酯单元的平均链长的共聚物的耐热性和耐冲击性优异。

108. 发明授权

US06867248B1 Polyhydroxyalkanoate compositions having controlled degradation rates 有权
标题翻译：具有受控降解速率的聚羟基链烷酸酯组合物
公开(公告)号：US06867248B1
公开(公告)日：2005-03-15
申请号：US10403244
申请日：2003-03-28
申请人： David P. Martin , Frank Skraly , Simon F. Williams
发明人： David P. Martin , Frank Skraly , Simon F. Williams
IPC分类号： A61K9/16 , A61K47/48 , A61L15/26 , A61L17/10 , A61L17/12 , A61L24/00 , A61L26/00 , A61L27/18 , A61L27/34 , A61L27/58 , A61L29/06 , A61L31/06 , A61L31/14 , C08G63/06 , C08G63/64 , C08G63/685 , C08G63/688 , C08G63/91 , C08K5/00 , C12N5/00 , C12P7/62 , C08L67/04
CPC分类号： C12P7/625 , A61K9/1647 , A61K47/593 , A61K47/6957 , A61L15/26 , A61L17/10 , A61L17/12 , A61L24/0042 , A61L26/0019 , A61L26/009 , A61L27/18 , A61L27/34 , A61L27/58 , A61L29/06 , A61L31/06 , A61L31/148 , C08G63/06 , C08G63/64 , C08G63/6852 , C08G63/6882 , C08G63/912 , C08K5/0033 , C12N5/0068 , C12N2533/30 , C08L67/04
摘要： Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physiological conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.
摘要翻译：已经开发了具有受控降解速率的生物相容性聚羟基链烷酸酯组合物。在一个实施方案中，聚羟基链烷酸酯含有改变降解速率的添加剂。在另一个实施方案中，聚羟基链烷酸酯由单体的混合物形成或包括侧链基团或其主链中的修饰以改变其降解速率。在另一个实施方案中，聚羟基链烷酸酯被化学改性。用于制造增加孔隙率或暴露表面积的装置的方法可用于改变降解性。例如，如通过实施例所证明的，多孔聚羟基链烷酸酯可以使用产生孔，空隙或间隙的方法，例如乳液或喷雾干燥技术，或者在聚合物内含有可浸出或可冷冻干燥的颗粒。实例描述了包括泡沫，涂层，网格和微粒的聚（4HB）组合物。如实施例所示，这些聚羟基链烷酸酯组合物在生理条件下在期望的时间范围内具有非常有利的机械性能以及生物相容性和降解性。这些聚羟基链烷酸酯材料提供比目前可获得的更广泛的聚羟基链烷酸酯降解速率。还描述了用于处理这些材料的方法，特别是用于治疗，预防或诊断应用，或可植入或注射的装置。

109. 发明申请

US20040127640A1 Composition, method and use of bi-functional biomaterials 有权
标题翻译：双功能生物材料的组成，方法和用途
公开(公告)号：US20040127640A1
公开(公告)日：2004-07-01
申请号：US10654623
申请日：2003-09-04
发明人： Angela M. Belcher , Christine J. Schmidt , Kiley P. H. Miller , Archit Sanghvi
IPC分类号： C08G063/48 , C08G063/91
CPC分类号： C08G63/912 , C07K14/47 , C12N11/06 , Y10S530/808 , Y10S530/815
摘要： The present invention includes a bifunctional specificity structure that includes a peptide linker having a first and a second binding domain, wherein the first binding domain is selective for a first biomaterial and the second binding domain is selective for a second biomaterial. The present invention also includes a method of making and identifying the bifunctional structure of the present invention and methods of using the same.
摘要翻译：本发明包括双功能特异性结构，其包括具有第一和第二结合结构域的肽接头，其中所述第一结合结构域对于第一生物材料是选择性的，并且所述第二结合结构域对于第二生物材料是选择性的。本发明还包括制备和鉴定本发明的双功能结构的方法及其使用方法。

110. 发明申请

US20040106781A1 Pyridine and related ligand compounds, functionalized nanoparticulate composites and methods of preparation 失效
标题翻译：吡啶和相关配体化合物，官能化纳米颗粒复合材料及其制备方法
公开(公告)号：US20040106781A1
公开(公告)日：2004-06-03
申请号：US10643015
申请日：2003-08-18
发明人： Todd S. Emrick , Habib Skaff
IPC分类号： C08G063/48 , C08G063/91
CPC分类号： C08K9/04 , C08G63/912 , Y10S977/773 , Y10S977/774 , Y10S977/81 , Y10S977/813 , Y10S977/825 , Y10S977/827 , Y10T428/2982
摘要： Nanoparticulate composites and dispersion thereof using novel polymeric ligand compounds, in certain embodiments in conjunction with pyridinyl moieties coupling the nanoparticulate and ligand.
摘要翻译：在某些实施方案中，使用新型聚合物配体化合物与纳米颗粒和配体偶联的吡啶基部分结合使用纳米微粒复合材料及其分散体。

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