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101. 发明申请

US20090081296A1 Extracorporeal cell-based therapeutic device and delivery system 审中-公开
标题翻译：体外细胞治疗装置和输送系统
公开(公告)号：US20090081296A1
公开(公告)日：2009-03-26
申请号：US12228895
申请日：2008-08-15
申请人： H. David Humes , Deborah Buffington , Gretchen Hageman
发明人： H. David Humes , Deborah Buffington , Gretchen Hageman
IPC分类号： A61K9/10 , A61K35/12 , C12N5/06 , A61M1/36
CPC分类号： A61M1/3653 , A61M1/1678 , A61M1/1696 , A61M1/1698 , A61M1/28 , A61M1/284 , A61M1/285 , A61M1/3687 , A61M1/3689 , A61M2202/09
摘要： Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in response to a dynamic physiologic environment. One embodiment includes long hollow fibers in which a layer of cells are grown within the intraluminal volume or within a double hollow-filled chamber. Another embodiment includes a wafer or a series of wafers providing a substrate onto which cells are grown. The wafer(s) are inserted into a device. A device may deliver a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation and/or may deliver a member of different cell products. The device is adapted to secure viable cells which produce and secrete the pre-selected molecule into blood or fluid. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel or body cavity the device of the invention.
摘要翻译：公开了基于体外细胞的治疗装置和递送系统，其提供了响应于动态生理环境而由活细胞产生的生物活性分子的治疗递送的方法。一个实施方案包括长的中空纤维，其中细胞层在腔内体积内生长或在双重中空填充的室内生长。另一个实施例包括晶片或一系列晶片，其提供生长细胞的基底。将晶片插入设备中。装置可以将预先选择的分子例如激素递送到哺乳动物的体循环中和/或递送不同细胞产物的成员。该装置适于将产生和分泌预先选择的分子的活细胞固定到血液或流体中。本发明还提供了一种用于经皮引入本发明的装置的预选血管或体腔的微创方法。

102. 发明申请

US20090018629A1 Heat exchanger, method for manufacturing the same, and heart-lung machine 有权
标题翻译：换热器，制造方法及心肺机
公开(公告)号：US20090018629A1
公开(公告)日：2009-01-15
申请号：US10584478
申请日：2005-02-07
申请人： Shinichi Yoshida , Minoru Tanaka , Tomokazu Niitsuma
发明人： Shinichi Yoshida , Minoru Tanaka , Tomokazu Niitsuma
IPC分类号： A61F7/12 , F28D7/00 , B23P15/26 , F28F9/02
CPC分类号： F28F9/0229 , A61M1/1698 , A61M1/369 , A61M2205/366 , F28D7/1653 , F28F2265/16 , Y10T29/49391
摘要： In a heat exchanger including a plurality of tubes 1 through which a first fluid passes, a housing 2 in which the tubes 1 are installed, and sealing members for sealing a second fluid that flows over surfaces of the tubes 1, the housing 2 includes an inlet 4 for introducing the second fluid therein and a first outlet 5 and second outlets 6 for discharging the second fluid, and the sealing members include a first sealing member 3a positioned on one of end sides of the tubes 1, a second sealing member 3b positioned on the other end side of the tubes 1, and a third sealing member 3c positioned between the first and second sealing members 3a and 3b. The third sealing member 3c is provided so that a gap 7 is provided between the first sealing member 3a and the third sealing member 3c while another gap 7 is provided between the second sealing member 3b and the third sealing member 3c, and that a flow path for the second fluid is formed therein. The second outlets 6 are provided so as to be connected to the gaps 7.
摘要翻译：在包括第一流体通过的多个管1的热交换器中，安装管1的壳体2和用于密封在管1的表面上流动的第二流体的密封构件，壳体2包括用于在其中引入第二流体的入口4和用于排出第二流体的第一出口5和第二出口6，并且密封构件包括位于管1的一端的第一密封构件3a，第二密封构件3b定位在管1的另一端侧和位于第一密封件3a和第二密封件3b之间的第三密封件3c。第三密封构件3c设置成在第一密封构件3a和第三密封构件3c之间设置有间隙7，而在第二密封构件3b和第三密封构件3c之间设置有间隙7，因为在其中形成第二流体。第二出口6设置成与间隙7连接。

103. 发明授权

US07470396B2 Device and method for establishing an artificial isolated circulation in a target area of a human or animal body 有权
标题翻译：在人体或动物身体的目标区域建立人造隔离循环的装置和方法
公开(公告)号：US07470396B2
公开(公告)日：2008-12-30
申请号：US10670999
申请日：2003-09-25
申请人： Andreas Meiser , Achim Mumme
发明人： Andreas Meiser , Achim Mumme
IPC分类号： A61M1/00 , A61M37/00 , A61M5/00 , A61B5/08
CPC分类号： A61M1/3621 , A61M1/1698 , A61M1/3658 , A61M2202/0241
摘要： A device for establishing an isolated perfusion including a pump arrangement, a venous catheter, and an arterial catheter, for establishing an artificial circulation in a target area of a human or animal body, which artificial circulation is isolated from the systemic circulation. The device has first means for feeding an analysis gas into the artificial circulation, and second means for monitoring whether a blood exchange takes place between the artificial circulation and the systemic circulation.
摘要翻译：一种用于建立包括泵装置，静脉导管和动脉导管的隔离灌注的装置，用于在人体或动物体的目标区域中建立人造循环，该人工循环与全身循环分离。该装置具有用于将分析气体进料到人造循环中的第一装置，以及用于监测人造循环和全身循环之间是否发生血液交换的第二装置。

104. 发明授权

US07458952B2 Integrated cardiopulmonary bypass system for open and closed bypass circuits 有权
标题翻译：用于开闭式旁路回路的综合体外循环系统
公开(公告)号：US07458952B2
公开(公告)日：2008-12-02
申请号：US11273626
申请日：2005-11-14
申请人： Venkataramana Vijay
发明人： Venkataramana Vijay
IPC分类号： A61M37/00 , A61M1/00
CPC分类号： A61M1/3666 , A61M1/1006 , A61M1/101 , A61M1/1087 , A61M1/1096 , A61M1/1698 , A61M1/3627 , A61M1/3667
摘要： A completely integrated cardiopulmonary bypass system includes a common casing provided with a reservoir, a venous air trap, oxygenator, heat-exchanger and a pump. This totally integrated system provides for volume sequestration and for bypassing the reservoir without use of a shunt. The system also provides for open or closed circuit operation, thereby permitting the volume sequestration. The closed circuit operation has a venous air trap for air removal, thus retaining the safety features of both open reservoir and closed-venous air trap systems.
摘要翻译：完全一体化的心肺旁路系统包括设置有储存器，静脉空气阱，氧合器，热交换器和泵的共同壳体。这种完全集成的系统提供体积隔离和绕过储存器而不使用分流器。该系统还提供开路或闭路操作，从而允许体积隔离。闭路操作具有用于空气移除的静脉空气阱，从而保持开放式储存器和闭合静脉空气阱系统的安全特征。

105. 发明授权

US07431754B2 Artificial lung 有权
标题翻译：人造肺
公开(公告)号：US07431754B2
公开(公告)日：2008-10-07
申请号：US11179743
申请日：2005-07-13
申请人： Mitsuaki Ogihara , Hidetaka Nakayama
发明人： Mitsuaki Ogihara , Hidetaka Nakayama
IPC分类号： B01D53/22 , A61M1/16
CPC分类号： A61M1/1698 , A61M1/3627 , A61M2205/7527 , Y10S128/03 , Y10S261/28
摘要： An artificial lung includes a housing, a tubular hollow fiber membrane bundle contained in the housing and providing a multiplicity of hollow fiber membranes having a gas exchange function, a gas inflow port and a gas outflow port communicating with each other through hollow portions of the hollow fiber membranes, and a blood inflow port and a blood outflow port through which blood is distributed. The tubular hollow fiber membrane bundle has a cylindrical overall shape, and a filter member having a bubble-trapping function is provided on an outer peripheral portion of the tubular hollow fiber membrane bundle.
摘要翻译：人造肺包括壳体，容纳在壳体中的管状中空纤维膜束，并且提供多个具有气体交换功能的中空纤维膜，气体流入口和气体流出口，其通过中空部分的中空部分彼此连通纤维膜，血液流入口和血液流出口。管状中空纤维膜束具有圆筒形的整体形状，并且在管状中空纤维膜束的外周部设置有具有气泡捕获功能的过滤器部件。

106. 发明申请

US20080234623A1 Device For Enriching And/Or Depleting Materials In A Liquid 有权
标题翻译：在液体中丰富和/或消耗材料的装置
公开(公告)号：US20080234623A1
公开(公告)日：2008-09-25
申请号：US12064030
申请日：2006-08-18
申请人： Andreas Strauss , Mustafa Akdis
发明人： Andreas Strauss , Mustafa Akdis
IPC分类号： A61M1/00 , B01D69/00
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1013 , A61M1/1017 , A61M1/1022 , A61M1/1031 , A61M1/262 , A61M1/267 , B01D63/02 , B01D2313/04 , B01D2313/20 , F04D7/04 , F04D29/047
摘要： A device and method for enriching and/or depleting substances in a liquid is disclosed. An exemplary device comprises a membrane module that consists essentially of concentric elements and that has a separation element in which the substance to be enriched and/or depleted is carried, and whereby the liquid is carried outside of the separation element. The exemplary device also comprises a drive module that encompasses a drive unit for driving a conveying element that conveys the liquid, the drive unit having a radial magnetic coupling for a central impeller located on the inside. The exemplary device further comprises a conveying module for conveying the liquid through the device, housing the conveying element, whereby the drive module is adapted to be inserted into and removed from the membrane module with a liquid-tight closure. The exemplary device further an oxygenator having an outside fiber bundle and an inside fiber bundle. Finally, the exemplary device comprises an electromagnetic drive unit disposed between the outside fiber bundle and the inside fiber bundle.
摘要翻译：公开了一种用于富集和/或消耗液体中的物质的装置和方法。示例性装置包括膜组件，该膜组件基本上由同心元件组成，并且具有分离元件，在该分离元件中携带要富集和/或耗尽的物质，并且由此将液体携带在分离元件的外部。示例性装置还包括驱动模块，该驱动模块包围用于驱动输送液体的输送元件的驱动单元，该驱动单元具有位于内侧的中央叶轮的径向磁耦合。示例性装置还包括用于将液体输送通过装置的输送模块，容纳输送元件，由此驱动模块适于用液密封闭件将其插入和移出膜组件。该示例性装置还包括具有外部纤维束和内部纤维束的充氧器。最后，该示例性装置包括设置在外部纤维束和内部纤维束之间的电磁驱动单元。

107. 发明申请

US20080138434A1 Methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood 有权
标题翻译：降低血液中促炎症或抗炎刺激物或介质的水平的方法
公开(公告)号：US20080138434A1
公开(公告)日：2008-06-12
申请号：US12002634
申请日：2007-12-18
申请人： James A. Brady , James F. Winchester , Vadim Davankov , Maria Tsyurupa , Ludmila Pavlova , Frank M. Norris , Peter J. Quartararo , Jamie A. Salsberg
发明人： James A. Brady , James F. Winchester , Vadim Davankov , Maria Tsyurupa , Ludmila Pavlova , Frank M. Norris , Peter J. Quartararo , Jamie A. Salsberg
IPC分类号： A01N1/02 , A61K35/14
CPC分类号： A61M1/3679 , A01N1/0215 , A61M1/16 , A61M1/1698 , A61M1/28 , A61M1/34 , A61M1/3403 , A61M1/3496 , A61M1/38 , A61M2202/0421 , A61M2205/3331 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/267 , B01J20/28078 , B01J20/3064 , B01J20/321 , B01J20/327 , B01J20/3276 , B01J20/3293 , B01J2220/445 , B01J2220/603 , C07K14/745 , A61M2202/0057
摘要： Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of pro-inflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators.
摘要翻译：装置，系统和方法通过选择性吸附降低血液中促炎症或抗炎刺激物或介质的水平。器官，系统和方法适用于在促炎症或抗炎刺激物或介质发生异常水平或不协调或过度相互作用的情况下，或在诱导或有可能引起异常生产促炎症炎性或抗炎刺激物或介质。装置，系统和方法用于预防，控制，减少或减轻与促炎症或抗炎刺激剂或介体的异常水平或不协调或过度相互作用相关的炎症反应和疾病状态的严重性。

108. 发明申请

US20080014115A1 Blood/Air Mass Exchange Apparatus 审中-公开
标题翻译：血液/空气质量交换装置
公开(公告)号：US20080014115A1
公开(公告)日：2008-01-17
申请号：US11628312
申请日：2005-05-27
申请人： William Johns
发明人： William Johns
IPC分类号： A61M1/16
CPC分类号： A61M1/1678 , A61M1/1003 , A61M1/1006 , A61M1/1039 , A61M1/1698 , A61M2205/07
摘要： There is provided a mass exchange apparatus for use in blood/air mass exchange comprising plural blood flow conduits for defining blood flow; and plural air flow conduits for defining air flow. The plural air flow conduits and the plural blood flow conduits at least partially comprise gas-permeate membrane material, and the conduits are arranged relative to each other such as to enable transfer of oxygen from the air to the blood and transfer of carbon dioxide from the blood to the air. The blood and air do not directly come into contact (i.e. the mass exchange is indirect). There is also provided a prosthetic lung comprising an elastic bellows and the at least one mass exchange apparatus herein. There is further provided an external respiratory aid to augment patient lung function comprising the at least one mass exchange apparatus herein and means to pump air and blood through the apparatus. There is further provided an intermediate respiratory aid apparatus for internal connection to a patient comprising at least one mass exchange apparatus herein and an air pump.
摘要翻译：提供一种用于血液/空气质量交换的质量交换装置，包括用于限定血液流动的多个血流管道; 以及用于限定气流的多个气流导管。多个空气流动管道和多个血流管道至少部分地包括气体渗透膜材料，并且导管相对于彼此布置，以便能够将氧气从空气传递到血液并将二氧化碳从血到空气血液和空气不直接接触（即大量交换是间接的）。还提供了一种假体肺，其包括弹性波纹管和本文中的至少一个质量交换装置。还提供了一种用于增加患者肺功能的外部呼吸辅助装置，其包括本文中的至少一个质量交换装置以及将空气和血液泵送通过该装置的装置。还提供了一种用于内部连接到患者的中间呼吸辅助装置，包括至少一个此处的质量交换装置和空气泵。

109. 发明申请

US20070258983A1 DEVICES, SYSTEMS, AND METHODS FOR REDUCING LEVELS OF PRO-INFLAMMATORY OR ANTI-INFLAMMATORY STIMULATORS OR MEDIATORS IN THE BLOOD, GENERATED AS A RESULT OF EXTRACORPOREAL BLOOD PROCESSING 有权
标题翻译：用于降低血液中的炎症反应或抗炎剂刺激物或者血液中的剂量的装置，系统和方法，作为血液外加工的结果产生
公开(公告)号：US20070258983A1
公开(公告)日：2007-11-08
申请号：US10980510
申请日：2004-11-03
申请人： James Brady , James Winchester , Vadim Davankov , Maria Tsyurupa , Ludmila Pavlova , Frank Norris , Peter Quartararo , Jamie Salsberg
发明人： James Brady , James Winchester , Vadim Davankov , Maria Tsyurupa , Ludmila Pavlova , Frank Norris , Peter Quartararo , Jamie Salsberg
IPC分类号： A61K39/00 , C12N5/08
CPC分类号： A61M1/3679 , A01N1/0215 , A61M1/16 , A61M1/1698 , A61M1/28 , A61M1/34 , A61M1/3403 , A61M1/3496 , A61M1/38 , A61M2202/0421 , A61M2205/3331 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/267 , B01J20/28078 , B01J20/3064 , B01J20/321 , B01J20/327 , B01J20/3276 , B01J20/3293 , B01J2220/445 , B01J2220/603 , C07K14/745 , A61M2202/0057
摘要： Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of pro-inflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators.
摘要翻译：装置，系统和方法通过选择性吸附降低血液中促炎症或抗炎刺激物或介质的水平。器官，系统和方法适用于在促炎症或抗炎刺激物或介质发生异常水平或不协调或过度相互作用的情况下，或在诱导或有可能引起异常生产促炎症炎性或抗炎刺激物或介质。装置，系统和方法用于预防，控制，减少或减轻与促炎症或抗炎刺激剂或介体的异常水平或不协调或过度相互作用相关的炎症反应和疾病状态的严重性。

110. 发明申请

US20070258856A1 Active air removal from an extracorporeal blood circuit 有权
标题翻译：从体外血液回路主动去除空气
公开(公告)号：US20070258856A1
公开(公告)日：2007-11-08
申请号：US11818134
申请日：2007-06-13
申请人： Robert Olsen , Walter Carpenter , John Dickey , Mark Stringham
发明人： Robert Olsen , Walter Carpenter , John Dickey , Mark Stringham
IPC分类号： A61M1/32
CPC分类号： A61M1/3627 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1086 , A61M1/1089 , A61M1/1698 , A61M1/32 , A61M1/3621 , A61M1/3626 , A61M1/3666 , A61M1/3667 , A61M2205/3379 , A61M2205/50 , A61M2205/502 , A61M2205/505 , A61M2205/8206 , A61M2209/08 , A61M2209/082 , Y10S261/28
摘要： A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way as to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components.
摘要翻译：在体外循环手术中使用的一次性，一体化的体外血液回路以节省体积，减少安装和更换时间，消除静脉血液储存器的方式进行气体交换，热传递和微栓塞过滤功能，并显着减少血液空气界面。来自患者或主溶液的血液通过装备有用于检测空气的空气传感器的空气去除装置。主动除气控制器从空气去除装置中的血液中除去检测到的空气。一次性电路支持模块用于将一次性的，集成的体外血液回路的部件安装在非常接近的位置并且具有期望的空间关系，以优化一次性的，集成的体外血液回路的灌注和使用。一个可重复使用的电路支架支持一次性电路支撑模块相对于主要解决方案源，主动排气控制器和其他部件。

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