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101. 发明申请

US20120209378A1 Venous Valve With Sinus 有权
标题翻译：静脉瓣与窦
公开(公告)号：US20120209378A1
公开(公告)日：2012-08-16
申请号：US13454778
申请日：2012-04-24
申请人： William J. Drasler , Mark L. Jenson , Jason P. Hill , David J. Sogard , Patrick A. Haverkost , Susan M. Shoemaker
发明人： William J. Drasler , Mark L. Jenson , Jason P. Hill , David J. Sogard , Patrick A. Haverkost , Susan M. Shoemaker
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/06 , A61F2/2418 , A61F2/2436 , A61F2210/0014 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2230/0013 , A61F2250/0098 , Y10T29/49405
摘要： A venous valve-with a structural member and valve leaflets that provide a sinus.
摘要翻译：静脉瓣 - 具有结构构件和提供窦的瓣叶。

102. 发明申请

US20120184952A1 LOW-PROFILE OFF-WALL ELECTRODE DEVICE FOR RENAL NERVE ABLATION 审中-公开
标题翻译：用于肾神经退缩的低剖面离墙电极装置
公开(公告)号：US20120184952A1
公开(公告)日：2012-07-19
申请号：US13243729
申请日：2011-09-23
申请人： Mark L. Jenson , Scott Smith
发明人： Mark L. Jenson , Scott Smith
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00867 , A61B2018/00005 , A61B2018/00029 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00345 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/1472 , A61B2090/3784 , A61N7/022 , A61N2007/003
摘要： A catheter includes at least one electrode provided at its distal end. A spacing structure, provided at the catheter's distal end and encompassing the electrode, is transformable between a low-profile introduction configuration and a larger-profile deployed configuration, and maintains space between the electrode and a wall of a renal artery when electrical energy sufficient to ablate perivascular renal nerve tissue adjacent the renal artery is delivered by the electrode. The spacing structure may comprise perforations allowing for passage of arterial blood therethrough and transport of high frequency alternating current from the electrode to the perivascular renal nerve tissue via the blood, with no or negligible thermal injury to the artery wall. An ablation catheter with an electrode encompassed spacing structure can be deployed in each renal artery to deliver bipolar RF energy for ablating perivascular renal nerve tissue and ganglia near the aortorenal junctions.
摘要翻译：导管包括设置在其远端处的至少一个电极。设置在导管的远端并且包围电极的间隔结构可在低轮廓引入构型和较大轮廓的部署构型之间变换，并且当电能足以满足以下条件时，可保持电极与肾动脉壁之间的空间通过电极输送邻近肾动脉的消融血管周围肾神经组织。间隔结构可以包括允许动脉血通过的穿孔，并且通过血液将高频交流电从电极传送到血管周围肾神经组织，对动脉壁没有或可忽略的热损伤。可以在每个肾动脉中部署具有包围间隔结构的电极的消融导管，以输送双极射频能量，以消除靠近主动脉导管处接近的血管周围肾神经组织和神经节。

103. 发明申请

US20120130368A1 RENAL DENERVATION CATHETER WITH COOLED RF ELECTRODE 有权
标题翻译：具有冷却RF电极的RENAL DENERVATION CATHETER
公开(公告)号：US20120130368A1
公开(公告)日：2012-05-24
申请号：US13302651
申请日：2011-11-22
申请人： Mark L. Jenson
发明人： Mark L. Jenson
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00214 , A61B2018/00279 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61B2018/00648 , A61B2018/00654 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875 , A61B2018/1497
摘要： A catheter has a flexible shaft with a proximal end, a distal end, a lumen arrangement, and a length sufficient to access a patient's renal artery. A conductor arrangement extends between the proximal and distal ends of the shaft. An actuatable helical tip region is provided at the distal end of the shaft, and a bend region is located proximal of the actuatable helical tip region. An electrode arrangement is provided at the actuatable helical tip region and dimensioned for deployment within the target vessel, such as the renal artery. The electrode arrangement is coupled to the conductor arrangement and includes a multiplicity of electrodes positioned on the distal end of the shaft in a spaced relationship. The electrodes have a protruding portion that extends out a distance beyond an outer surface of the distal end of the shaft.
摘要翻译：导管具有柔性轴，其具有近端，远端，管腔布置以及足以进入患者肾动脉的长度。导体布置在轴的近端和远端之间延伸。可致动的螺旋尖端区域设置在轴的远端处，并且弯曲区域位于可致动的螺旋尖端区域的近侧。在可致动的螺旋尖端区域处提供电极布置，并且将其设计成用于展开在目标血管（例如肾动脉）内。电极布置被耦合到导体布置并且包括以间隔开的关系定位在轴的远端上的多个电极。电极具有伸出远离轴的远端的外表面的距离的突出部分。

104. 发明申请

US20120130362A1 CATHETER-FOCUSED MAGNETIC FIELD INDUCED RENAL NERVE ABLATION 有权
标题翻译：导管聚焦磁场诱导的肾脏神经吸收
公开(公告)号：US20120130362A1
公开(公告)日：2012-05-24
申请号：US13292766
申请日：2011-11-09
申请人： Roger Hastings , Scott Smith , Leonard B. Richardson , Mark L. Jenson
发明人： Roger Hastings , Scott Smith , Leonard B. Richardson , Mark L. Jenson
IPC分类号： A61B18/18
CPC分类号： A61B18/04 , A61B2018/00023 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577
摘要： A flexible catheter includes a magnetically permeable element provided at its distal end. The magnetically permeable element is configured for placement within the renal artery. External coils, positionable on anterior and posterior portions of a patient in proximity to the renal artery, are coupled to a generator which energizes the external coils to create a high-frequency oscillating magnetic field in body tissue between the external coils including the renal artery and perivascular renal nerve tissue. The magnetically permeable element serves to concentrate the magnetic field in a region near the renal artery. The concentrated magnetic field induces high frequency electric current sufficient to ablate the perivascular renal nerve tissue proximate the renal artery. A cooling arrangement can be provided at the catheter's distal end and configured to provide cooling to the renal artery during ablation of the perivascular renal nerve tissue.
摘要翻译：柔性导管包括设置在其远端处的导磁元件。导磁元件构造成放置在肾动脉内。位于靠近肾动脉的患者的前部和后部的外部线圈被耦合到发电机，该发电机激励外部线圈，以在包括肾动脉和外周线圈的外部线圈之间的身体组织中产生高频振荡磁场，血管周围肾神经组织。导磁元件用于将磁场集中在肾动脉附近的区域。集中的磁场诱发高频电流足以消融肾动脉附近的血管周围肾神经组织。可以在导管的远端处提供冷却装置，并且构造成在血管周围肾神经组织的消融期间向肾动脉提供冷却。

105. 发明申请

US20120123261A1 Renal Nerve Ablation Using Mild Freezing and Vibration 审中-公开
标题翻译：使用轻度冷冻和振动的肾神经消融
公开(公告)号：US20120123261A1
公开(公告)日：2012-05-17
申请号：US13243114
申请日：2011-09-23
申请人： Mark L. Jenson , Scott Smith
发明人： Mark L. Jenson , Scott Smith
IPC分类号： A61N7/00 , A61B8/12 , A61H1/00
CPC分类号： A61B8/0841 , A61B8/12 , A61B8/4488 , A61B17/22004 , A61B17/2202 , A61B18/02 , A61B18/0206 , A61B2017/22008 , A61B2017/22024 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61N7/022
摘要： A catheter includes a thermal unit provided at its distal end and configured to receive a thermal transfer fluid. The thermal unit is configured to cause formation of ice particles in perivascular renal nerve tissue adjacent the thermal unit and warm tissue of the renal artery adjacent the thermal unit to a temperature above freezing while ice particles remain formed in the perivascular renal nerve tissue. A vibration source is configured to generate vibration of the ice particles sufficient to disrupt perivascular renal nerve tissue and terminate sympathetic renal nerve activity with no or negligible damage to thawed renal artery tissue. The vibration source may be configured to generate vibration sufficient to nucleate ice formation within at least the perivascular renal nerve tissue so that ice particles form throughout the perivascular renal nerve tissue adjacent the thermal unit.
摘要翻译：导管包括设置在其远端处并构造成接收热传递流体的热单元。热单元被配置成在邻近热单元的热单元和肾动脉附近的血管周围肾神经组织中形成冰颗粒至高于冰点的温度，同时在血管周围肾神经组织中保持形成冰颗粒。振动源被配置为产生足以破坏血管周围肾神经组织的冰粒的振动，并终止对解冻的肾动脉组织没有或可忽略的损伤的交感神经肾神经活动。振动源可以被配置为产生足以使至少血管周围肾神经组织内的冰形成成核的振动，使得冰颗粒在与热单元相邻的血管周围肾神经组织中形成。

106. 发明申请

US20120109021A1 RENAL DENERVATION CATHETER EMPLOYING ACOUSTIC WAVE GENERATOR ARRANGEMENT 审中-公开
标题翻译：使用声波发生器装置的RENAL DENERVATION CATHETER
公开(公告)号：US20120109021A1
公开(公告)日：2012-05-03
申请号：US13283203
申请日：2011-10-27
申请人： Roger Hastings , Mark L. Jenson
发明人： Roger Hastings , Mark L. Jenson
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B2017/22021 , A61B2017/22024 , A61N2007/003 , A61N2007/0073
摘要： A transducer supported by a positioning arrangement is placed within a renal artery at a desired location that is a predetermined distance from a reflector equal to an odd number of quarter wavelengths of acoustic energy emitted by the transducer. The positioning arrangement is actuated to transition from a low-profile introduction configuration to a deployed configuration within the renal artery thereby stabilizing the transducer at a desired location. Acoustic energy is emitted by the transducer so that it propagates axially along an outer surface of the target vessel to impinge the reflector, which can be biological or artificial. The emitted energy builds up to resonance at a point of reflection defined by a location of the reflector, and the amount of energy build up is sufficient to ablate perivascular renal nerves in the vicinity of the reflector.
摘要翻译：由定位装置支撑的换能器放置在与反射器相距预定距离的期望位置处的肾动脉内，所述反射器等于由换能器发射的声能的奇数个四分之一波长。定位装置被致动以从低轮廓引入配置转变到肾动脉内的部署配置，从而将换能器稳定在期望的位置。传声器发出声能，使其沿目标容器的外表面轴向传播，以撞击可能是生物或人造的反射器。发射的能量在由反射器的位置限定的反射点处形成共振，并且积聚的能量足以消除反射器附近的血管周围肾神经。

107. 发明申请

US20120101525A1 FIBROUS CONTAINMENT FOR HEMOSTASIS PLUG 审中-公开
标题翻译：用于HEMOSTASIS PLUG的FIBROUS容纳
公开(公告)号：US20120101525A1
公开(公告)日：2012-04-26
申请号：US13278910
申请日：2011-10-21
申请人： Mark L. Jenson , Jason P. Hill , James Q. Feng , David J. Sogard , Robert W. Warner , Patrick A. Haverkost
发明人： Mark L. Jenson , Jason P. Hill , James Q. Feng , David J. Sogard , Robert W. Warner , Patrick A. Haverkost
IPC分类号： A61B17/04
CPC分类号： A61B17/0057 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/0404 , A61B2017/0417 , A61B2017/06185
摘要： A device for sealing an opening in a vessel includes an anchor attached to a suture. The anchor is inserted through the opening into the vessel, and the suture pulls the anchor against the vessel wall, forming a seal. A plug is inserted over the suture and is axially compressed toward the anchor, locking the elements in place. The suture is braided or woven outside of the anchor so that it may be stored and handled easily, and is unbraided, unwoven and/or untangled at its distal end inside the anchor, so that individual filaments within the suture may extend laterally within the anchor. The laterally extending filaments subtend a larger footprint within the anchor than a comparable footprint if the suture were to remain braided or tied into a knot within the anchor, which may more effectively distribute the retaining forces within the anchor.
摘要翻译：用于密封容器中的开口的装置包括附接到缝合线的锚固件。锚固件通过开口插入容器中，并且缝合线将锚固件拉靠在血管壁上，形成密封。将塞子插入缝合线上并朝向锚固件轴向压缩，将元件锁定就位。该缝合线被编织或编织在锚定体之外，使得其可以容易地储存和处理，并且在其锚固体内部的远端处是未被覆盖的，无纺的和/或解开的，使得缝合线内的单个细丝可以在锚定件内横向延伸。横向延伸的长丝在锚固体内对着较大的覆盖区域，而不是如果缝合线保持编织或连接到锚固体内的结，这可以更有效地将锚定力分配在锚固体内。

108. 发明申请

US20120101519A1 POROUS VASCULAR CLOSURE PLUG WITH STARCH POWDER 审中-公开
标题翻译：多孔血管闭塞插管
公开(公告)号：US20120101519A1
公开(公告)日：2012-04-26
申请号：US13278853
申请日：2011-10-21
申请人： Jason P. Hill , Mark L. Jenson , Haitao Zhang , Kai Wang , Pu Zhou
发明人： Jason P. Hill , Mark L. Jenson , Haitao Zhang , Kai Wang , Pu Zhou
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B2017/00601 , A61B2017/00654 , A61B2017/00898 , A61L24/0036 , A61L24/0042 , A61L24/0094 , A61L2400/04 , C08L3/00
摘要： The disclosure provides a composite plug for vascular closure including a hemostatic material, and a method of manufacturing the composite plug including a hemostatic material. The composite plug may comprise one or more materials having varying porosity, density, or composition, and may include a powdered hemostatic material.
摘要翻译：本公开提供了一种用于血管闭合的复合塞，包括止血材料，以及制造包括止血材料的复合塞的方法。复合塞子可以包括具有不同孔隙率，密度或组成的一种或多种材料，并且可以包括粉末状止血材料。

109. 发明申请

US20120029511A1 Cooled Conductive Balloon RF Catheter for Renal Nerve Ablation 有权
标题翻译：冷气导气球射频导管用于肾神经消融
公开(公告)号：US20120029511A1
公开(公告)日：2012-02-02
申请号：US13188677
申请日：2011-07-22
申请人： Scott Smith , Joe Koblish , Mark L. Jenson , Roger Hastings
发明人： Scott Smith , Joe Koblish , Mark L. Jenson , Roger Hastings
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00035 , A61B2018/00065 , A61B2018/0016 , A61B2018/0022 , A61B2018/00238 , A61B2018/00285 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00821 , A61B2018/1472
摘要： A catheter includes a flexible shaft having a lumen arrangement and a length sufficient to access a target vessel of a patient. A balloon at the distal end of the shaft is fluidly coupled to the lumen arrangement. The balloon body comprises a first material and a second material different from the first material. The second material comprises a hydrophilic polymer that becomes electrically conductive in response to absorption of the conductive fluid. The fluid conductive regions facilitate perfusion of the conductive fluid through the balloon body to an inner wall of the target vessel during ablation of perivascular tissues. A cooling arrangement is configured for one of receiving a thermal transfer fluid from the lumen arrangement or facilitating perfusion of blood passing through the target vessel to cool the balloon body during ablation of the perivascular tissues.
摘要翻译：导管包括柔性轴，其具有管腔布置和足以进入患者的目标血管的长度。在轴的远端处的气囊流体地联接到管腔装置。球囊体包括第一材料和与第一材料不同的第二材料。第二种材料包括响应于导电流体的吸收变得导电的亲水性聚合物。流体导电区域便于在血管周围组织消融期间将导电流体通过球囊体灌注到目标血管的内壁。冷却装置构造成用于接收来自管腔装置的热转移流体，或者促进血液通过靶血管的灌注，以在血管周围组织消融期间冷却球囊体。

110. 发明申请

US20120029505A1 Self-Leveling Electrode Sets for Renal Nerve Ablation 审中-公开
标题翻译：用于肾神经消融的自流平电极组
公开(公告)号：US20120029505A1
公开(公告)日：2012-02-02
申请号：US13188687
申请日：2011-07-22
申请人： Mark L. Jenson
发明人： Mark L. Jenson
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2017/00867 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/143 , A61B2018/1432 , A61B2018/1475 , C08L2201/12
摘要： A catheter comprises a flexible shaft having a length for accessing the renal artery and a multiplicity of electrode sets each supported a support member. Each electrode set extends beyond the catheter's distal end and includes several elongated resilient members comprising a pre-formed curve and supporting an electrode. The resilient members are constrained to a low profile when encompassed by a wall of a removable sheath or a lumen wall of the catheter's shaft, and expand outwardly to assume a shape of their pre-formed curve when removed from the removable sheath or shaft lumen. The resilient members have a stiffness sufficient to maintain contact between the electrodes and an inner wall of the renal artery including irregularities of the inner wall of the renal artery. One or more temperature sensors can be situated at or proximate the plurality of electrode sets.
摘要翻译：导管包括具有用于进入肾动脉的长度的柔性轴和多个各自支撑支撑构件的电极组。每个电极组延伸超过导管的远端并且包括几个细长的弹性构件，其包括预形成的曲线并支撑电极。当被可移除的护套的壁或导管的轴的管腔壁包围时，弹性构件被限制为低轮廓，并且当从可移除的护套或轴腔内移除时，向外扩张以呈现其预形成曲线的形状。弹性构件具有足以维持电极与肾动脉内壁之间的接触的刚度，其包括肾动脉内壁的不规则性。一个或多个温度传感器可以位于或接近多个电极组。

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