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1. 发明授权

US09060761B2 Catheter-focused magnetic field induced renal nerve ablation 有权
标题翻译：导管聚焦磁场诱导肾神经消融
公开(公告)号：US09060761B2
公开(公告)日：2015-06-23
申请号：US13292766
申请日：2011-11-09
申请人： Roger Hastings , Scott Smith , Leonard B. Richardson , Mark L. Jenson
发明人： Roger Hastings , Scott Smith , Leonard B. Richardson , Mark L. Jenson
IPC分类号： A61B18/18 , A61B18/04 , A61B18/00
CPC分类号： A61B18/04 , A61B2018/00023 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577
摘要： A flexible catheter includes a magnetically permeable element provided at its distal end. The magnetically permeable element is configured for placement within the renal artery. External coils, positionable on anterior and posterior portions of a patient in proximity to the renal artery, are coupled to a generator which energizes the external coils to create a high-frequency oscillating magnetic field in body tissue between the external coils including the renal artery and perivascular renal nerve tissue. The magnetically permeable element serves to concentrate the magnetic field in a region near the renal artery. The concentrated magnetic field induces high frequency electric current sufficient to ablate the perivascular renal nerve tissue proximate the renal artery. A cooling arrangement can be provided at the catheter's distal end and configured to provide cooling to the renal artery during ablation of the perivascular renal nerve tissue.
摘要翻译：柔性导管包括设置在其远端处的导磁元件。导磁元件构造成放置在肾动脉内。位于靠近肾动脉的患者的前部和后部的外部线圈被耦合到发电机，该发电机激励外部线圈，以在包括肾动脉和外周线圈的外部线圈之间的身体组织中产生高频振荡磁场，血管周围肾神经组织。导磁元件用于将磁场集中在肾动脉附近的区域。集中的磁场诱发高频电流足以消融肾动脉附近的血管周围肾神经组织。可以在导管的远端处提供冷却装置，并且构造成在血管周围肾神经组织的消融期间向肾动脉提供冷却。

2. 发明申请

US20120130362A1 CATHETER-FOCUSED MAGNETIC FIELD INDUCED RENAL NERVE ABLATION 有权
标题翻译：导管聚焦磁场诱导的肾脏神经吸收
公开(公告)号：US20120130362A1
公开(公告)日：2012-05-24
申请号：US13292766
申请日：2011-11-09
申请人： Roger Hastings , Scott Smith , Leonard B. Richardson , Mark L. Jenson
发明人： Roger Hastings , Scott Smith , Leonard B. Richardson , Mark L. Jenson
IPC分类号： A61B18/18
CPC分类号： A61B18/04 , A61B2018/00023 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577
摘要： A flexible catheter includes a magnetically permeable element provided at its distal end. The magnetically permeable element is configured for placement within the renal artery. External coils, positionable on anterior and posterior portions of a patient in proximity to the renal artery, are coupled to a generator which energizes the external coils to create a high-frequency oscillating magnetic field in body tissue between the external coils including the renal artery and perivascular renal nerve tissue. The magnetically permeable element serves to concentrate the magnetic field in a region near the renal artery. The concentrated magnetic field induces high frequency electric current sufficient to ablate the perivascular renal nerve tissue proximate the renal artery. A cooling arrangement can be provided at the catheter's distal end and configured to provide cooling to the renal artery during ablation of the perivascular renal nerve tissue.
摘要翻译：柔性导管包括设置在其远端处的导磁元件。导磁元件构造成放置在肾动脉内。位于靠近肾动脉的患者的前部和后部的外部线圈被耦合到发电机，该发电机激励外部线圈，以在包括肾动脉和外周线圈的外部线圈之间的身体组织中产生高频振荡磁场，血管周围肾神经组织。导磁元件用于将磁场集中在肾动脉附近的区域。集中的磁场诱发高频电流足以消融肾动脉附近的血管周围肾神经组织。可以在导管的远端处提供冷却装置，并且构造成在血管周围肾神经组织的消融期间向肾动脉提供冷却。

3. 发明申请

US20120029513A1 PRECISION ELECTRODE MOVEMENT CONTROL FOR RENAL NERVE ABLATION 有权
标题翻译：精神电极运动控制用于神经退行性疾病
公开(公告)号：US20120029513A1
公开(公告)日：2012-02-02
申请号：US13194920
申请日：2011-07-30
申请人： Scott Smith , Leonard B. Richardson , Mark L. Jenson
发明人： Scott Smith , Leonard B. Richardson , Mark L. Jenson
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/1815 , A61B18/20 , A61B90/39 , A61B2018/00011 , A61B2018/00434 , A61B2018/00577 , A61B2018/00589 , A61B2018/00791 , A61B2018/00875 , A61M25/0054 , A61M25/0113 , A61M25/0127 , A61M25/0138 , A61M25/0147
摘要： A catheter is configured to access a renal artery. A lumen of the catheter's shaft is dimensioned to receive a flexible actuation member which extends between the shaft's proximal and distal ends. The actuation member is moveable within the lumen and subject to elastic deformation, friction, and/or whip along its length. A flexible support member is coupled to a distal end of the actuation member and extendible beyond a distal tip of the shaft. An RF ablation electrode at a distal end of the support member is configured to ablated perivascular renal nerve tissue. A position converter at the distal end of the shaft is configured to convert movement of the actuation member into one or both of controlled rotational and axial movement of the support member and electrode to one of a multiplicity of stable circumferential positions substantially free of elastic deformation, friction, and/or whip impacting actuation member movement.
摘要翻译：导管配置成进入肾动脉。导管轴的内腔的尺寸被设计成容纳在轴的近端和远端之间延伸的柔性致动构件。致动构件可在内腔内移动并且沿其长度受到弹性变形，摩擦和/或鞭状。柔性支撑构件联接到致动构件的远端并且可延伸超过轴的远侧末端。在支撑构件的远端处的RF消融电极被配置为消融血管周围肾神经组织。在轴的远端处的位置转换器被配置为将致动构件的运动转换成支撑构件和电极的受控旋转和轴向运动到基本上没有弹性变形的多个稳定的圆周位置中的一个或两个，摩擦和/或搅动撞击致动构件运动。

4. 发明授权

US09358365B2 Precision electrode movement control for renal nerve ablation 有权
标题翻译：精神电极移动控制肾神经消融
公开(公告)号：US09358365B2
公开(公告)日：2016-06-07
申请号：US13194920
申请日：2011-07-30
申请人： Scott Smith , Leonard B. Richardson , Mark L. Jenson
发明人： Scott Smith , Leonard B. Richardson , Mark L. Jenson
IPC分类号： A61B18/14 , A61M25/01 , A61B18/18 , A61B18/20 , A61B19/00 , A61B18/00 , A61M25/00
CPC分类号： A61B18/1492 , A61B18/1815 , A61B18/20 , A61B90/39 , A61B2018/00011 , A61B2018/00434 , A61B2018/00577 , A61B2018/00589 , A61B2018/00791 , A61B2018/00875 , A61M25/0054 , A61M25/0113 , A61M25/0127 , A61M25/0138 , A61M25/0147
摘要： A catheter is configured to access a renal artery. A lumen of the catheter's shaft is dimensioned to receive a flexible actuation member which extends between the shaft's proximal and distal ends. The actuation member is moveable within the lumen and subject to elastic deformation, friction, and/or whip along its length. A flexible support member is coupled to a distal end of the actuation member and extendible beyond a distal tip of the shaft. An RF ablation electrode at a distal end of the support member is configured to ablated perivascular renal nerve tissue. A position converter at the distal end of the shaft is configured to convert movement of the actuation member into one or both of controlled rotational and axial movement of the support member and electrode to one of a multiplicity of stable circumferential positions substantially free of elastic deformation, friction, and/or whip impacting actuation member movement.
摘要翻译：导管配置成进入肾动脉。导管轴的内腔的尺寸被设计成容纳在轴的近端和远端之间延伸的柔性致动构件。致动构件可在内腔内移动并且沿其长度受到弹性变形，摩擦和/或鞭状。柔性支撑构件联接到致动构件的远端并且可延伸超过轴的远侧末端。在支撑构件的远端处的RF消融电极被配置为消融血管周围肾神经组织。在轴的远端处的位置转换器被配置为将致动构件的运动转换成支撑构件和电极的受控旋转和轴向运动到基本上没有弹性变形的多个稳定的圆周位置中的一个或两个，摩擦和/或搅动撞击致动构件运动。

5. 发明授权

US09463062B2 Cooled conductive balloon RF catheter for renal nerve ablation 有权
标题翻译：冷气导电气球射频导管用于肾神经消融
公开(公告)号：US09463062B2
公开(公告)日：2016-10-11
申请号：US13188677
申请日：2011-07-22
申请人： Scott Smith , Joe Koblish , Mark L. Jenson , Roger Hastings
发明人： Scott Smith , Joe Koblish , Mark L. Jenson , Roger Hastings
IPC分类号： A61B18/18 , A61B18/14 , A61B18/00
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00035 , A61B2018/00065 , A61B2018/0016 , A61B2018/0022 , A61B2018/00238 , A61B2018/00285 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00821 , A61B2018/1472
摘要： A catheter includes a flexible shaft having a lumen arrangement and a length sufficient to access a target vessel of a patient. A balloon at the distal end of the shaft is fluidly coupled to the lumen arrangement. The balloon body comprises a first material and a second material different from the first material. The second material comprises a hydrophilic polymer that becomes electrically conductive in response to absorption of the conductive fluid. The fluid conductive regions facilitate perfusion of the conductive fluid through the balloon body to an inner wall of the target vessel during ablation of perivascular tissues. A cooling arrangement is configured for one of receiving a thermal transfer fluid from the lumen arrangement or facilitating perfusion of blood passing through the target vessel to cool the balloon body during ablation of the perivascular tissues.
摘要翻译：导管包括柔性轴，其具有管腔布置和足以进入患者的目标血管的长度。在轴的远端处的气囊流体地联接到管腔装置。球囊体包括第一材料和与第一材料不同的第二材料。第二种材料包括响应于导电流体的吸收变得导电的亲水性聚合物。流体导电区域便于在血管周围组织消融期间将导电流体通过球囊体灌注到目标血管的内壁。冷却装置构造成用于接收来自管腔装置的热转移流体，或者促进血液通过靶血管的灌注，以在血管周围组织消融期间冷却球囊体。

6. 发明申请

US20120029511A1 Cooled Conductive Balloon RF Catheter for Renal Nerve Ablation 有权
标题翻译：冷气导气球射频导管用于肾神经消融
公开(公告)号：US20120029511A1
公开(公告)日：2012-02-02
申请号：US13188677
申请日：2011-07-22
申请人： Scott Smith , Joe Koblish , Mark L. Jenson , Roger Hastings
发明人： Scott Smith , Joe Koblish , Mark L. Jenson , Roger Hastings
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00035 , A61B2018/00065 , A61B2018/0016 , A61B2018/0022 , A61B2018/00238 , A61B2018/00285 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00821 , A61B2018/1472
摘要： A catheter includes a flexible shaft having a lumen arrangement and a length sufficient to access a target vessel of a patient. A balloon at the distal end of the shaft is fluidly coupled to the lumen arrangement. The balloon body comprises a first material and a second material different from the first material. The second material comprises a hydrophilic polymer that becomes electrically conductive in response to absorption of the conductive fluid. The fluid conductive regions facilitate perfusion of the conductive fluid through the balloon body to an inner wall of the target vessel during ablation of perivascular tissues. A cooling arrangement is configured for one of receiving a thermal transfer fluid from the lumen arrangement or facilitating perfusion of blood passing through the target vessel to cool the balloon body during ablation of the perivascular tissues.
摘要翻译：导管包括柔性轴，其具有管腔布置和足以进入患者的目标血管的长度。在轴的远端处的气囊流体地联接到管腔装置。球囊体包括第一材料和与第一材料不同的第二材料。第二种材料包括响应于导电流体的吸收变得导电的亲水性聚合物。流体导电区域便于在血管周围组织消融期间将导电流体通过球囊体灌注到目标血管的内壁。冷却装置构造成用于接收来自管腔装置的热转移流体，或者促进血液通过靶血管的灌注，以在血管周围组织消融期间冷却球囊体。

7. 发明申请

US20120265198A1 RENAL NERVE DETECTION AND ABLATION APPARATUS AND METHOD 审中-公开
标题翻译：肾脏神经检测和消融装置及方法
公开(公告)号：US20120265198A1
公开(公告)日：2012-10-18
申请号：US13299932
申请日：2011-11-18
申请人： Loren M. Crow , Mark L. Jenson , Scott Smith
发明人： Loren M. Crow , Mark L. Jenson , Scott Smith
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61N1/36007 , A61N7/022
摘要： Stimulation energy is delivered to one or more renal artery sites in accordance with a predetermined energy delivery protocol. The stimulation energy is sufficient to elicit a physiologic response from the patient but insufficient to ablate renal nerves. Target renal artery sites that elicit a physiologic response are identified, and renal nerve tissue at or proximate the target sites is ablated.
摘要翻译：根据预定的能量递送方案，将刺激能量递送至一个或多个肾动脉部位。刺激能量足以引起患者的生理反应，但不足以消融肾神经。确定引起生理反应的目标肾动脉部位，消除靶点位置或其附近的肾神经组织。

8. 发明申请

US20120123303A1 Minimally Invasive Access for Renal Nerve Ablation 有权
标题翻译：微创获取肾神经消融
公开(公告)号：US20120123303A1
公开(公告)日：2012-05-17
申请号：US13243134
申请日：2011-09-23
申请人： David Sogard , Scott Smith , Mark L. Jenson
发明人： David Sogard , Scott Smith , Mark L. Jenson
IPC分类号： A61B18/18 , A61B18/04 , A61N7/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B90/37 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00791 , A61B2018/00875 , A61B2018/0212 , A61N5/062 , A61N7/022 , A61N2005/067 , A61N2007/003
摘要： An elongated flexible medical device is inserted into a patient's body via a natural orifice, and advanced through the natural orifice to a location proximate innervated tissue that influences renal sympathetic nerve activity. The medical device can be advanced into a body organ and to a location within the organ proximate the innervated tissue. The organ may comprise an organ of the gastrointestinal tract or urinary tract. The medical device may be advanced through and beyond an access hole in a wall of the organ, and situated at a location proximate the innervated tissue. One or both of imaging and ablation energy is delivered from a distal end of the medical device to the innervated tissue. Innervated renal tissue can be ablated using various forms of energy, including RF energy, ultrasound energy, optical energy, and thermal energy.
摘要翻译：细长的柔性医疗装置通过自然孔插入患者体内，并通过自然孔推进到影响肾交感神经活动的靠近神经组织的位置。医疗装置可以进入身体器官和靠近神经组织的器官内的位置。器官可以包括胃肠道或泌尿道的器官。医疗装置可以前进穿过器官壁中的进入孔并且位于邻近神经组织的位置处。成像和消融能量中的一个或两个从医疗装置的远端传送到神经组织。可以使用各种形式的能量消融内源性肾组织，包括射频能量，超声能量，光能和热能。

9. 发明授权

US09668811B2 Minimally invasive access for renal nerve ablation 有权
公开(公告)号：US09668811B2
公开(公告)日：2017-06-06
申请号：US13243134
申请日：2011-09-23
申请人： David J. Sogard , Scott Smith , Mark L. Jenson
发明人： David J. Sogard , Scott Smith , Mark L. Jenson
IPC分类号： A61H1/00 , A61B18/14 , A61N5/06 , A61B18/00 , A61B18/02 , A61N7/02 , A61N7/00 , A61N5/067 , A61B90/00
CPC分类号： A61B18/1492 , A61B90/37 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00791 , A61B2018/00875 , A61B2018/0212 , A61N5/062 , A61N7/022 , A61N2005/067 , A61N2007/003
摘要： An elongated flexible medical device is inserted into a patient's body via a natural orifice, and advanced through the natural orifice to a location proximate innervated tissue that influences renal sympathetic nerve activity. The medical device can be advanced into a body organ and to a location within the organ proximate the innervated tissue. The organ may comprise an organ of the gastrointestinal tract or urinary tract. The medical device may be advanced through and beyond an access hole in a wall of the organ, and situated at a location proximate the innervated tissue. One or both of imaging and ablation energy is delivered from a distal end of the medical device to the innervated tissue. Innervated renal tissue can be ablated using various forms of energy, including RF energy, ultrasound energy, optical energy, and thermal energy.

10. 发明申请

US20120157992A1 OFF-WALL ELECTRODE DEVICE FOR RENAL NERVE ABLATION 审中-公开
标题翻译：用于肾神经消融的非球形电极装置
公开(公告)号：US20120157992A1
公开(公告)日：2012-06-21
申请号：US13243724
申请日：2011-09-23
申请人： Scott Smith , Mark L. Jenson
发明人： Scott Smith , Mark L. Jenson
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B90/39 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00821 , A61B2018/00875
摘要： An ablation apparatus includes a catheter, a conductor arrangement provided along the catheter, and one or more electrodes provided at a distal end of the catheter. A flexible structure maintains the one or more electrode elements in a spaced relationship relative to an inner wall of the renal artery when in a deployed configuration. Each electrode is coupled to the conductor arrangement and configured to deliver energy sufficient to ablate perivascular renal nerve tissue. The flexible structure may comprise a basket structure and at least one electrode is situated within the basket structure. The flexible structure may comprise a tube structure having spaced-apart electrically non-conductive segments, and at least one electrode is situated between adjacent electrically non-conductive segments.
摘要翻译：消融装置包括导管，沿导管设置的导体装置和设置在导管远端的一个或多个电极。当处于展开构型时，柔性结构将一个或多个电极元件相对于肾动脉的内壁保持间隔开的关系。每个电极耦合到导体装置并且被配置成输送足以消除血管周围肾神经组织的能量。柔性结构可以包括篮状结构，并且至少一个电极位于篮状结构内。柔性结构可以包括具有间隔开的非导电段的管结构，并且至少一个电极位于相邻的非导电段之间。

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