专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明授权

US06649414B1 Microparticles with multiple fluorescent signals and methods of using same 有权
标题翻译：具有多个荧光信号的微粒及其使用方法
公开(公告)号：US06649414B1
公开(公告)日：2003-11-18
申请号：US09639818
申请日：2000-08-17
申请人： Mark B. Chandler , Don J. Chandler
发明人： Mark B. Chandler , Don J. Chandler
IPC分类号： G01N3348
CPC分类号： G01N33/587 , C12Q1/6816 , G01N15/14 , G01N33/582 , Y10S435/81 , Y10S435/975 , Y10S436/805 , Y10S436/808 , Y10S436/823 , Y10S977/707 , Y10S977/773 , Y10S977/904 , Y10S977/92 , Y10T436/10 , Y10T436/109163 , Y10T436/13 , C12Q2563/155 , C12Q2563/107 , C12Q2537/143 , C12Q2565/626
摘要： This invention provides a novel fluorescent particle including a core or carrier particle having on its surface a plurality of smaller polymeric particles or nanoparticles, which are stained with different fluorescent dyes. When excited by a light source they are capable of giving off multiple fluorescent emissions simultaneously, which is useful for multiplexed analysis of a plurality of analytes in a sample. The coupled complex particles carrying on their surface fluorescent nanoparticles, methods of preparing such polymer particles, and various applications and methods of using such particles are claimed.
摘要翻译：本发明提供了一种新颖的荧光颗粒，其包括在其表面上具有多个较小的聚合物颗粒或纳米颗粒的芯或载体颗粒，其被不同的荧光染料染色。当被光源激发时，它们能够同时发出多个荧光发射，这对于样品中多个分析物的多重分析是有用的。涉及其表面上携带有荧光纳米颗粒的偶联复合颗粒，制备这种聚合物颗粒的方法以及使用这种颗粒的各种用途和方法。

92. 发明申请

US20030170893A1 NANOCAPSULE ENCAPSULATION SYSTEM AND METHOD 有权
标题翻译： NANOCAPSULE ENCAPSULATION系统和方法
公开(公告)号：US20030170893A1
公开(公告)日：2003-09-11
申请号：US09796575
申请日：2001-02-28
申请人： Genesegues, Inc.
发明人： Gretchen M. Unger
IPC分类号： A61K048/00 , C12N015/85
CPC分类号： B01J13/08 , A61K9/1075 , A61K9/5138 , A61K9/5161 , A61K9/5192 , B01J13/02 , Y10S977/773 , Y10S977/795 , Y10S977/897 , Y10S977/915 , Y10S977/92
摘要： The present invention generally relates to nanocapsules and methods of preparing these nanocapsules. The present invention includes a method of forming a surfactant micelle and dispersing the surfactant micelle into an aqueous composition having a hydrophilic polymer to form a stabilized dispersion of surfactant micelles. The method further includes mechanically forming droplets of the stabilized dispersion of surfactant micelles, precipitating the hydrophilic polymer to form precipitated nanocapsules, incubating the nanocapsules to reduce a diameter of the nanocapsules, and filtering or centrifuging the nanocapsules.
摘要翻译：本发明一般涉及纳米胶囊和制备这些纳米胶囊的方法。本发明包括形成表面活性剂胶束并将表面活性剂胶束分散到具有亲水性聚合物的水性组合物中以形成稳定的表面活性剂胶束分散体的方法。该方法还包括机械地形成稳定的表面活性剂胶束分散体的液滴，沉淀亲水性聚合物以形成沉淀的纳米胶囊，孵育纳米胶囊以减小纳米胶囊的直径，以及过滤或离心纳米胶囊。

93. 发明授权

US06514685B1 Detection of cancer using antibodies to the alphafeto protein receptor 失效
标题翻译：使用抗体对alphafeto蛋白受体检测癌症
公开(公告)号：US06514685B1
公开(公告)日：2003-02-04
申请号：US08920654
申请日：1997-08-15
申请人： Ricardo J. Moro
发明人： Ricardo J. Moro
IPC分类号： C12Q100
CPC分类号： G01N33/57476 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/30 , Y10S977/92
摘要： A method for detecting cancer in a patient. The method comprises the steps of introducing labeled antibodies or labeled AFP to a biological sample of the patient so the labeled antibodies or labeled AFP will react with the AFP receptor binding sites in the biological sample. Next there is the step of identifying AFP receptor binding sites in the biological material which are reacted with the labeled antibodies or labeled AFP to determine the presence of cancer.
摘要翻译：一种用于检测患者癌症的方法。该方法包括以下步骤：将标记的抗体或标记的AFP引入患者的生物样品中，使得标记的抗体或标记的AFP将与生物样品中的AFP受体结合位点反应。接下来，存在识别生物材料中与标记的抗体或标记的AFP反应以确定癌症存在的AFP受体结合位点的步骤。

94. 发明授权

US06485985B1 Processes and compounds for magnetorelaxometric detection of analytes and their use 失效
标题翻译：用于分析物的磁共振检测及其用途的方法和化合物
公开(公告)号：US06485985B1
公开(公告)日：2002-11-26
申请号：US09389223
申请日：1999-09-03
申请人： Werner Weitschies , Roman Kottiz , Lucz Trahms , Thomas Bunte
发明人： Werner Weitschies , Roman Kottiz , Lucz Trahms , Thomas Bunte
IPC分类号： G01N33553
CPC分类号： G01R33/12 , A61B5/05 , A61B5/411 , A61B5/415 , A61K49/1863 , A61K49/1875 , G01N27/745 , G01N33/532 , G01N33/54333 , G01N33/54373 , G01N2333/78 , Y10S436/806 , Y10S977/916 , Y10S977/92 , Y10S977/924 , Y10S977/927 , Y10S977/96 , Y10T436/24
摘要： A process for magnetorelaxometric quantitative detection of analytes in the liquid and solid phases, compounds for magnetorelaxometric detection, and their use in analysis and immunomagnetography is described.
摘要翻译：描述了液相和固相中分析物的磁致谱定量检测方法，用于磁共振检测的化合物及其在分析和免疫磁性技术中的应用。

95. 发明授权

US06462255B1 Viral amplification of recombinant messenger RNA in transgenic plants 失效
公开(公告)号：US06462255B1
公开(公告)日：2002-10-08
申请号：US09414916
申请日：1999-10-08
申请人： Thomas H. Turpen
发明人： Thomas H. Turpen
IPC分类号： C12N1583
CPC分类号： C07K14/005 , C12N15/8203 , C12N15/8216 , C12N2770/00022 , Y10S47/01 , Y10S977/804 , Y10S977/916 , Y10S977/92
摘要： A novel method of over expressing genes in plants is provided. This method is based on the RNA amplification properties of plus strand RNA viruses of plants. A chimeric multicistronic gene is constructed containing a plant promoter, viral replication origins, a viral movement protein gene, and one or more foreign genes under control of viral subgenomic promoters. Plants containing one or more of these recombinant RNA transcripts are inoculated with helper virus. In the presence of helper virus recombinant transcripts are replicated producing high levels of foreign gene RNA. Sequences are provided for the high level expression of the enzyme chloramphenicol acetyltransferase in tobacco plants by replicon RNA amplification with helper viruses and movement protein genes derived from the tobamovirus group.

96. 发明申请

US20020144308A1 Viral amplification of recombinant messenger RNA in transgenic plants 审中-公开
公开(公告)号：US20020144308A1
公开(公告)日：2002-10-03
申请号：US09930342
申请日：2001-08-14
发明人： Thomas H. Turpen
IPC分类号： A01H001/00 , C12N007/00 , C12N015/86
CPC分类号： C07K14/005 , C12N15/8203 , C12N15/8216 , C12N2770/00022 , Y10S47/01 , Y10S977/804 , Y10S977/916 , Y10S977/92
摘要： A novel method of over expressing genes in plants is provided. This method is based on the RNA amplification properties of plus strand RNA viruses of plants. A chimeric multicistronic gene is constructed containing a plant promoter, viral replication origins, a viral movement protein gene, and one or more foreign genes under control of viral subgenomic promoters. Plants containing one or more of these recombinant RNA transcripts are inoculated with helper virus. In the presence of helper virus recombinant transcripts are replicated producing high levels of foreign gene RNA. Sequences are provided for the high level expression of the enzyme chloramphenicol acetyltransferase in tobacco plants by replicon RNA amplification with helper viruses and movement protein genes derived from the tobamovirus group.

97. 发明授权

US06410517B1 Targeted gene delivery system 有权
标题翻译：靶向基因传递系统
公开(公告)号：US06410517B1
公开(公告)日：2002-06-25
申请号：US09315033
申请日：1999-05-20
申请人： Vu L. Truong , Thomas August , Kam W. Leong
发明人： Vu L. Truong , Thomas August , Kam W. Leong
IPC分类号： A61K4800
CPC分类号： B82Y5/00 , A61K9/167 , A61K47/6927 , A61K48/00 , C12N15/87 , C12N15/88 , Y10S977/906 , Y10S977/907 , Y10S977/916 , Y10S977/92
摘要： A target-specific gene delivery system is made of enzymatically degradable gelatin and nucleic acids (DNA or RNA) microparticles with a linking moiety or a targeting ligand attached to the surface. The delivery system can be made by a simple method. Targeting ligands can be attached to the microparticle directly or via a linking moiety. The linkage design allows the attachment of any molecule onto the microparticle surface including antibodies, cell adhesion molecules, hormones and other cell-specific ligands.
摘要翻译：目标特异性基因递送系统由可酶降解的明胶和具有连接部分的连接部分或连接于表面的靶向配体的核酸（DNA或RNA）微粒制成。输送系统可以通过简单的方法进行。靶向配体可以直接或通过连接部分连接到微粒上。连接设计允许将任何分子附着在微粒表面上，包括抗体，细胞粘附分子，激素和其他细胞特异性配体。

98. 发明授权

US06359159B1 MOCVD precursors based on organometalloid ligands 有权
标题翻译：基于有机金属配体的MOCVD前体
公开(公告)号：US06359159B1
公开(公告)日：2002-03-19
申请号：US09729115
申请日：2000-12-04
申请人： John T. Welch , Paul J. Toscano , Rolf Claessen , Andrei Kornilov , Kulbinder Kumar Banger
发明人： John T. Welch , Paul J. Toscano , Rolf Claessen , Andrei Kornilov , Kulbinder Kumar Banger
IPC分类号： C07F702
CPC分类号： C07F15/065 , C07F7/0803 , C07F7/081 , C07F13/005 , Y10S977/84 , Y10S977/89 , Y10S977/891 , Y10S977/92
摘要： Chemical vapor deposition processes utilize as precursors volatile metal complexes with ligands containing metalloid elements silicon, germanium, tin or lead.
摘要翻译：化学气相沉积工艺利用与含金属元素硅，锗，锡或铅的配体的前体挥发性金属配合物。

99. 发明授权

US06328972B1 Compositions and methods for inducing cytotoxic T lymphocyte responses by immunization with protein antigens 失效
标题翻译：用蛋白质抗原免疫诱导细胞毒性T淋巴细胞反应的组合物和方法
公开(公告)号：US06328972B1
公开(公告)日：2001-12-11
申请号：US08425679
申请日：1995-04-18
申请人： Kenneth L. Rock
发明人： Kenneth L. Rock
IPC分类号： A61K39385
CPC分类号： A61K9/167 , A61K39/00 , A61K2039/60 , Y02A50/466 , Y10S977/802 , Y10S977/803 , Y10S977/915 , Y10S977/917 , Y10S977/918 , Y10S977/92
摘要： The invention provides compositions and methods for inducing MHC class I-restricted cytotoxic T lymphocyte responses in a mammalian host by immunization with non-replicating protein antigens. The compositions of the invention comprise a two-component complex including a particle component, which is not a prokaryotic or eukaryotic cell, or a micellar, multimicellar, or liposome vesicle composed of detergents and/or lipids, ranging in size from about 10 nm to about 50 &mgr;m, and a non-replicating protein antigen. The non-replicating protein antigen is attached to the particle component through a covalent or non-covalent association to form particulate protein antigen complexes and the complexes are administered to a mammalian host in conjunction with a pharmaceutically acceptable excipient, in a CTL-stimulatory amount. The invention also provides non-replicating vaccines and methods of vaccinating a mammalian host for CTL immunity.
摘要翻译：本发明提供了通过用非复制蛋白抗原免疫在哺乳动物宿主中诱导MHC I类限制性细胞毒性T淋巴细胞应答的组合物和方法。本发明的组合物包含双组分复合物，其包括不是原核或真核细胞的颗粒组分，或由洗涤剂和/或脂质组成的胶束，多片或脂质体囊泡，其尺寸范围为约10nm至约50微克，以及非复制蛋白质抗原。非复制蛋白质抗原通过共价或非共价缔合连接到颗粒组分上以形成颗粒蛋白抗原复合物，并且将复合物以CTL刺激量与药学上可接受的赋形剂联合施用于哺乳动物宿主。本发明还提供了非复制疫苗和用于CTL免疫接种哺乳动物宿主的方法。

100. 发明授权

US06291227B1 Nucleic acids containing modified human immunodeficiency virus genomes devoid of long terminal repeats encoding non-infectious, replication-deficient, immunogenic retrovirus-like particles 失效
标题翻译：含有修饰的人类免疫缺陷病毒基因组的核酸缺乏编码非感染性，复制缺陷型，免疫原性逆转录病毒样颗粒的长末端重复序列
公开(公告)号：US06291227B1
公开(公告)日：2001-09-18
申请号：US08401355
申请日：1995-03-09
申请人： Joel Haynes , Michel Henri Klein , Benjamin Rovinski , Shi Xian Cao
发明人： Joel Haynes , Michel Henri Klein , Benjamin Rovinski , Shi Xian Cao
IPC分类号： C12N704
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/15023 , C12N2740/16023 , C12N2740/16122 , Y10S435/974 , Y10S530/826 , Y10S977/802 , Y10S977/804 , Y10S977/917 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： An immunogenic retrovirus-like particle which is non-infectious and non-replicating and which is useful as a candidate vaccine component against retroviral infections, including AIDS and ATLL, is produced by genetic engineering. A DNA molecule comprising a retroviral genome devoid of long terminal repeats is incorporated into an expression vector, which is introduced into mammalian cells for expression of the retrovirus-like particle.
摘要翻译：通过遗传工程生产非传染性和非复制型的免疫原性逆转录病毒样颗粒，其可用作抗逆转录病毒感染的候选疫苗组分，包括AIDS和ATLL。将包含不具有长末端重复序列的逆转录病毒基因组成的DNA分子并入表达载体中，其被导入到哺乳动物细胞中用于表达逆转录病毒样颗粒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式