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91. 发明申请

US20110008798A1 Lipid insertion for antigen capture and presentation and use as a sensor platform 审中-公开
标题翻译：脂质插入用于抗原捕获和呈递和用作传感器平台
公开(公告)号：US20110008798A1
公开(公告)日：2011-01-13
申请号：US12658298
申请日：2010-02-08
申请人： Harshini Mukundan , Anu Chaudhary , Basil I. Swanson
发明人： Harshini Mukundan , Anu Chaudhary , Basil I. Swanson
IPC分类号： G01N33/569
CPC分类号： G01N33/5432 , G01N33/54373 , G01N2333/35 , G01N2400/50
摘要： It has been found that moieties containing a lipophilic domain, e.g., lipophilic pathogen activated molecular patterns (PAMPs), insert into the lipid bilayer on a cell membrane to facilitate antigen recognition by the innate immune response receptors. This changes the basic understanding of antigen recognition by the innate immune system. A sensor platform for the ultra-sensitive and specific detection of moieties containing such a lipophilic domain, e.g., PAMPs, that are associated with a disease, has now been developed. To date, this approach has been validated with Lipoarabinomannan (LAM) from Mycobacterium tuberculosis and lipopolysacharide (LPS), associated with gram-negative bacteria. This approach may be extendable to all lipophilic targets associated with pathogens and thus, is the basis of a very simple and specific sensing platform. In addition, novel applications for this technology in the selection of recognition ligands by mass spectroscopy have been identified.
摘要翻译：已经发现，含有亲脂性结构域的部分，例如亲脂性病原体激活的分子模式（PAMP）插入到细胞膜上的脂质双层中以促进先天性免疫应答受体的抗原识别。这改变了先天免疫系统对抗原识别的基本了解。已经开发了用于超敏感和特异性检测含有与疾病相关的亲脂性结构域（例如PAMP）的部分的传感器平台。迄今为止，这种方法已经与结核分枝杆菌的脂褐素甘露聚糖（LAM）和与革兰氏阴性细菌相关的脂多糖（LPS）验证。这种方法可以扩展到与病原体相关的所有亲脂性靶标，因此是非常简单和特异性感测平台的基础。此外，已经鉴定了通过质谱法选择识别配体的该技术的新型应用。

92. 发明授权

US07585641B2 Immunoassay and method of use 失效
标题翻译：免疫测定和使用方法
公开(公告)号：US07585641B2
公开(公告)日：2009-09-08
申请号：US10348078
申请日：2003-01-21
申请人： Murali D. Bandla , Matthew R. Chambers , Chester L. Sutula
发明人： Murali D. Bandla , Matthew R. Chambers , Chester L. Sutula
IPC分类号： C12N7/00 , C12N7/01 , C12N11/14 , C12N13/00 , C12Q1/06 , C12Q1/70 , G01N33/53
CPC分类号： G01N33/558 , G01N33/56911 , G01N2400/50
摘要： A method for performing an immunoassay is described. The method is particularly useful for detecting extracellular polysaccharide (EPS) and/or lipopolysaccharide (LPS) producing microorganisms. The method is particularly useful for detecting microorganisms which produce extracellular polysaccharides (EPS) also known as exocellular polysaccharides, capsule, and/or lipopolysaccharides (LPS). In a preferred method for detecting microorganisms which produce EPS, LPS, or both, the EPS and/or LPS is extracted from a sample with cetyltrimethylammonium bromide (CTAB) to produce molecular aggregates which are then preferentially bound to colored polystyrene latex particles over other components in the sample, and the bound EPS and/or LPS detected using a lateral flow immunoassay apparatus which has immobilized thereon antibodies specific for the EPS and/or LPS. The method can also be used to detect particular viruses, for example viruses of the potyviridae or tobamoviridae group.
摘要翻译：描述了进行免疫测定的方法。该方法特别适用于检测产生细胞外多糖（EPS）和/或脂多糖（LPS）的微生物。该方法特别可用于检测产生也被称为外细胞多糖，胶囊和/或脂多糖（LPS）的细胞外多糖（EPS）的微生物。在用于检测产生EPS，LPS或两者的微生物的优选方法中，用十六烷基三甲基溴化铵（CTAB）从样品中提取EPS和/或LPS以产生分子聚集体，然后优选与着色聚苯乙烯胶乳颗粒结合到其它组分上并且使用已经固定有EPS和/或LPS特异性抗体的侧流免疫测定装置检测结合的EPS和/或LPS。该方法还可以用于检测特定病毒，例如病毒科或鸟病毒科的病毒。

93. 发明申请

US20090081649A1 Diagnostic method for detecting cancer by measuring amount of cytokine like il -6 有权
标题翻译：通过测量细胞因子的量来检测癌症的诊断方法，如il -6
公开(公告)号：US20090081649A1
公开(公告)日：2009-03-26
申请号：US11918488
申请日：2006-04-12
申请人： Leif Hakansson , Birgitta Clinchy , Rune Sjodahl
发明人： Leif Hakansson , Birgitta Clinchy , Rune Sjodahl
IPC分类号： C12Q1/68 , G01N33/574 , C40B30/04 , G01N33/53 , C12Q1/02
CPC分类号： G01N33/6863 , C07K14/52 , C07K14/5412 , G01N33/5047 , G01N33/5091 , G01N33/57488 , G01N2333/5412 , G01N2400/50
摘要： The present invention relates to a diagnostic method for predicting the possible recurrence of tumours in cancer patients. The method comprises culturing blood cells from a patient suffering from cancer in the presence of a cytokine stimulating factor, where after the amount of induced cytokine thereby produced is determined giving an indication of the risk of recurrence of the cancer.
摘要翻译：本发明涉及用于预测癌症患者肿瘤可能复发的诊断方法。该方法包括在细胞因子刺激因子存在下培养来自患有癌症的患者的血细胞，其中确定了由此产生的诱导的细胞因子的量，其给出了癌症复发风险的指征。

94. 发明申请

US20090081192A1 METHODS OF SCREENING FOR COMPOUNDS HAVING ANTI-INFLAMMATORY ACTIVITY 审中-公开
标题翻译：筛选具有抗炎活性的化合物的方法
公开(公告)号：US20090081192A1
公开(公告)日：2009-03-26
申请号：US11860488
申请日：2007-09-24
申请人： Peter PETZELBAUER , Rainer HENNING , Sonja REINGRUBER , Waltraud PASTEINER , Marion GROGER
发明人： Peter PETZELBAUER , Rainer HENNING , Sonja REINGRUBER , Waltraud PASTEINER , Marion GROGER
IPC分类号： C12Q1/34 , A61K39/395 , A61K38/02 , C12Q1/48 , C12Q1/00 , A61P9/00
CPC分类号： G01N33/5064 , G01N33/5088 , G01N2400/50 , G01N2800/328
摘要： A method screens compounds out of the group consisting of proteins, peptides, peptidomimetics, antibodies and small organic molecules that increase the activity of the protein Rac1 by virtue of their binding to the extracellular portion of this protein. The method includes the steps of: contacting a confluent layer of cultured endothelial cells with at least one of test compounds, lysing the endothelial cells with a lysation buffer, and measuring the amount of Rac1 activity.
摘要翻译：一种方法筛选由蛋白质，肽，肽模拟物，抗体和小有机分子组成的组，其通过与蛋白质的细胞外部分结合而增加蛋白Rac1的活性。所述方法包括以下步骤：使培养的内皮细胞的汇合层与至少一种测试化合物，裂解内皮细胞与裂解缓冲液和测量Rac1活性的量接触。

95. 发明授权

US07498028B2 Preparation of spheres for diagnostic tests 失效
标题翻译：准备用于诊断测试的球体
公开(公告)号：US07498028B2
公开(公告)日：2009-03-03
申请号：US11818712
申请日：2007-06-14
申请人： Susan Goertz , Paul Hemmes
发明人： Susan Goertz , Paul Hemmes
IPC分类号： G01N33/533
CPC分类号： G01N33/5432 , G01N33/54313 , G01N33/554 , G01N33/566 , G01N33/569 , G01N33/6893 , G01N2400/50
摘要： The invention relates to surfactant-free reagent spheres useful for biological tests particularly those involving antigen/antibody reactions.
摘要翻译：本发明涉及用于生物试验的无表面活性剂的试剂球，特别是涉及抗原/抗体反应的试剂球。

96. 发明申请

US20050208614A1 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia 失效
标题翻译：在呼出呼气浓缩物中利用脂多糖来诊断革兰氏阴性肺炎
公开(公告)号：US20050208614A1
公开(公告)日：2005-09-22
申请号：US11135265
申请日：2005-05-23
申请人： Jeffrey Kline , Jackeline Hernandez , John Watts
发明人： Jeffrey Kline , Jackeline Hernandez , John Watts
IPC分类号： A61B5/097 , C12Q1/04 , G01N33/579
CPC分类号： C12Q1/14 , A61B5/0813 , A61B5/083 , A61B5/097 , A61B5/412 , C12Q1/04 , G01N33/579 , G01N33/92 , G01N2400/50
摘要： A method for determining whether a subject has Gram negative bacterial pneumonia based on the presence of lipopolysaccharide in exhaled breath condensate collected from the subject. The collection devices utilized to collect exhaled breath condensate from both spontaneously breathing and mechanically ventilated subjects and the devices utilized to determine whether lipopolysaccharide is present in the collected exhaled breath condensate.
摘要翻译：基于从受试者收集的呼出呼气浓缩物中存在脂多糖来确定受试者是否具有革兰氏阴性细菌性肺炎的方法。用于从自发呼吸和机械通气的受试者收集呼出的呼吸冷凝物的收集装置和用于确定脂多糖是否存在于收集的呼出气体冷凝物中的装置。

97. 发明申请

US20040142398A1 Immunoassay and method of use 失效
标题翻译：免疫测定和使用方法
公开(公告)号：US20040142398A1
公开(公告)日：2004-07-22
申请号：US10348078
申请日：2003-01-21
申请人： Agdia, Inc.
发明人： Murali D. Bandla , Matthew R. Chambers , Chester L. Sutula
IPC分类号： G01N033/554 , G01N033/569
CPC分类号： G01N33/558 , G01N33/56911 , G01N2400/50
摘要： A method for performing an immunoassay is described. The method is particularly useful for detecting extracellular polysaccharide (EPS) and/or lipopolysaccharide (LPS) producing microorganisms. The method is particularly useful for detecting microorganisms which produce extracellular polysaccharides (EPS) also known as exocellular polysaccharides, capsule, and/or lipopolysaccharides (LPS). In a preferred method for detecting microorganisms which produce EPS, LPS, or both, the EPS and/or LPS is extracted from a sample with cetyltrimethylammonium bromide (CTAB) to produce molecular aggregates which are then preferentially bound to colored polystyrene latex particles over other components in the sample, and the bound EPS and/or LPS detected using a lateral flow immunoassay apparatus which has immobilized thereon antibodies specific for the EPS and/or LPS. The method can also be used to detect particular viruses, for example viruses of the potyviridae or tobamoviridae group.
摘要翻译：描述了进行免疫测定的方法。该方法特别适用于检测产生细胞外多糖（EPS）和/或脂多糖（LPS）的微生物。该方法特别可用于检测产生也被称为外细胞多糖，胶囊和/或脂多糖（LPS）的细胞外多糖（EPS）的微生物。在用于检测产生EPS，LPS或两者的微生物的优选方法中，用十六烷基三甲基溴化铵（CTAB）从样品中提取EPS和/或LPS以产生分子聚集体，然后优选与着色聚苯乙烯胶乳颗粒结合到其它组分上并且使用已经固定有EPS和/或LPS特异性抗体的侧流免疫测定装置检测结合的EPS和/或LPS。该方法还可以用于检测特定病毒，例如病毒科或鸟病毒科的病毒。

98. 发明申请

US20030125235A1 Treatment of diseases associated with cytokine production with inhibitors of the tec family of protein tyrosine kinases 审中-公开
标题翻译：用蛋白酪氨酸激酶的tec家族抑制剂治疗与细胞因子产生相关的疾病
公开(公告)号：US20030125235A1
公开(公告)日：2003-07-03
申请号：US10220801
申请日：2002-11-14
发明人： Brian Maurice John Foxwell
IPC分类号： A61K038/00 , G01N033/53 , G01N033/567
CPC分类号： C12Q1/485 , A61K31/00 , A61K31/275 , A61K31/277 , A61K48/00 , A61K2039/505 , C07K16/40 , G01N33/5047 , G01N2400/50 , G01N2500/10 , Y02A50/57
摘要： The present invention relates to a method of treating a condition comprising administering a pharmaceutically effective amount of an inhibitor of the Tec family of protein tyrosine kinases (PTKs). The condition is typically associated with cytokine production. Conditions addressed by the invention include sepsis, septic shock, inflammation, rheumatoid arthritis and Crohn's disease. In one embodiment, the condition is induced by zymosan. The invention also provides the use of an inhibitor of a member or members of the Tec family of PTKs in the manufacture of a medicament for use in the treatment of a condition associated with cytokine production and methods for identifying an inhibitor of a member or members of the Tec family of PTKs which is also suitable for use in the treatment of a condition associated with stimulus-induced cytokine production.
摘要翻译：本发明涉及一种治疗病症的方法，包括施用药学有效量的蛋白酪氨酸激酶（PTK）的Tec家族的抑制剂。该病症通常与细胞因子产生相关。本发明解决的病症包括败血症，败血性休克，炎症，类风湿性关节炎和克罗恩氏病。在一个实施方案中，酵母聚糖诱导该病症。本发明还提供PTK的Tec家族成员或成员的抑制剂在制备用于治疗与细胞因子产生相关的病症的药物中的用途以及用于鉴定成员的成员或成员的抑制剂的方法也适用于治疗与刺激诱导的细胞因子产生相关的病症的PTK的Tec家族。

99. 发明申请

US20030059766A1 Preparation of spheres for diagnostic tests 有权
公开(公告)号：US20030059766A1
公开(公告)日：2003-03-27
申请号：US10190213
申请日：2002-07-05
发明人： Susan Goertz , Paul Hemmes
IPC分类号： C12Q001/70 , G01N033/567 , G01N033/554 , G01N033/569 , C12M001/34
CPC分类号： G01N33/5432 , G01N33/54313 , G01N33/554 , G01N33/566 , G01N33/569 , G01N33/6893 , G01N2400/50
摘要： The invention relates to surfactant-free reagent spheres useful for biological tests particularly those involving antigen/antibody reactions.

100. 发明申请

US20030054432A1 Methods and reagents for detecting endotoxin 有权
标题翻译：检测内毒素的方法和试剂
公开(公告)号：US20030054432A1
公开(公告)日：2003-03-20
申请号：US10183992
申请日：2002-06-28
申请人： BioWhittaker, Inc.
发明人： Lin Chen , Michael Pepe
IPC分类号： C12Q001/26 , C12Q001/04
CPC分类号： G01N33/579 , C12Q1/04 , G01N2400/50
摘要： A reagent containing a purified horseshoe crab Factor C, particularly a recombinantly produced Factor C, and a surfactant can be used in a sensitive, rapid, and reproducible assay to detect endotoxin.
摘要翻译：含有纯化的马蹄蟹因子C，特别是重组产生的因子C和表面活性剂的试剂可用于灵敏，快速和可再现的测定中以检测内毒素。

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