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91. 发明申请

US20120180884A1 Interconnection of Microfluidic Devices 审中-公开
标题翻译：微流控器件的互连
公开(公告)号：US20120180884A1
公开(公告)日：2012-07-19
申请号：US13499447
申请日：2010-10-07
申请人： Pierre Brunello , Willard Ashton Cutler , Paul Louis Florent Delautre , Sylvain Maxime F. Gremetz , Ionel Lazer , Olivier Lobet
发明人： Pierre Brunello , Willard Ashton Cutler , Paul Louis Florent Delautre , Sylvain Maxime F. Gremetz , Ionel Lazer , Olivier Lobet
IPC分类号： F15B21/00 , B01L3/00
CPC分类号： B01J19/0093 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F15/065 , B01J2219/00783 , B01J2219/00804 , B01J2219/0081 , B01J2219/00822 , B01J2219/00831 , B01J2219/00873 , B01J2219/00889 , B01L3/502715 , B01L3/563 , B01L3/569 , B01L2200/027 , B01L2200/028 , B01L2300/185 , F28D9/0043 , F28F3/083 , F28F9/26 , F28F2260/02 , Y10T137/8593
摘要： A microfluidic device (10) includes at least two glass, ceramic or glass ceramic microfluidic modules (20) fluidicaly interconnected and of substantially plate shape defining generally four relatively thin edges (20a, 20b, 20c, 20d) and two opposite relatively large faces (22, 24), each microfluidic module (20) including at least one microfluidic channel (30) defining at least in part a microchamber (32); at least one fluidic inlet (50) and at least one fluidic outlet (60); and said microfluidic modules being tightly interconnected with a fluid duct (120) through at least one tightly holding connector (90) comprising at least one clamping structure or means (95, 97), and is characterized in that the at least one clamping means (95, 97) comprises a joint (150) comprising a spherical shaped member (160) and a cup shaped member (170).
摘要翻译：微流体装置（10）包括至少两个流体相互连接并且基本上为板状的玻璃，陶瓷或玻璃陶瓷微流体模块（20），其大体上限定了四个相对较薄的边缘（20a，20b，20c，20d）和两个相对较大的面每个微流体模块（20）包括至少部分地限定微室（32）的至少一个微流体通道（30）; 至少一个流体入口（50）和至少一个流体出口（60）; 并且所述微流体模块通过包括至少一个夹持结构或装置（95,97）的至少一个紧密保持连接器（90）与流体管道（120）紧密互连，并且其特征在于，所述至少一个夹紧装置 95，97）包括包括球形构件（160）和杯形构件（170）的接头（150）。

92. 发明申请

US20120171773A1 Temperature Control Of Enrichment And Separation Columns In Chromatography 审中-公开
标题翻译：色谱中富集和分离色谱柱的温度控制
公开(公告)号：US20120171773A1
公开(公告)日：2012-07-05
申请号：US13321666
申请日：2010-05-27
申请人： James P. Murphy , Keith Fadgen , Geoff C. Gerhardt , Angela Doneanu , Martha Degen Stapels
发明人： James P. Murphy , Keith Fadgen , Geoff C. Gerhardt , Angela Doneanu , Martha Degen Stapels
IPC分类号： G01N30/02
CPC分类号： G01N30/6095 , B01D15/22 , B01D15/424 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2300/0816 , B01L2400/0487 , G01N30/461 , G01N30/606 , G01N30/6091 , G01N30/7233 , G01N30/7266 , G01N2030/027 , G01N2030/085 , G01N2030/8881 , Y10T29/49826
摘要： A method of analyzing samples includes loading a sufficient quantity of the sample onto a trap column to overload the trap column; heating an analytical column and the trap column to a greater temperature than the analytical column; and pumping a solvent, to the trap column, having a solvent composition profile that, in cooperation with a temperature differential, causes at least some of the components to elute sequentially from the trap column to the analytical column and focus on the analytical column prior to eluting from the analytical column; or optionally: loading a small-molecule sample onto a cooled portion of an analytical column; heating the analytical column; and pumping a solvent, to the heated analytical column, to elute the components from the analytical column. Chromatographic separation includes: a trap column; a separation column; a trap-column heater; a separation-column heater; a solvent pump unit; and a control unit can be used.
摘要翻译：分析样品的方法包括将足够量的样品加载到陷阱柱上以使捕获柱过载; 将分析柱和捕集柱加热至比分析柱更大的温度; 并将溶剂泵送到捕集塔，其具有溶剂组成分布，其与温差相配合使至少一些组分从捕集塔顺序洗脱至分析柱，并在分离柱之前聚焦在分析柱上从分析柱洗脱; 或任选地：将小分子样品加载到分析柱的冷却部分上; 加热分析柱; 并将溶剂泵入加热的分析柱，以从分析柱中洗脱组分。色谱分离包括：陷阱柱; 分离柱; 一个陷阱加热器; 分离柱加热器; 溶剂泵单元; 并且可以使用控制单元。

93. 发明授权

US08191718B2 Rack modules 有权
标题翻译：机架模块
公开(公告)号：US08191718B2
公开(公告)日：2012-06-05
申请号：US12287529
申请日：2008-10-09
申请人： Kenneth R. Hovatter
发明人： Kenneth R. Hovatter
IPC分类号： A47G29/00
CPC分类号： B01L9/06 , B01L3/5082 , B01L9/523 , B01L2200/023 , B01L2200/028 , B01L2300/0829
摘要： Various aspects include a rack module comprising a side including one or more receptacles. A receptacle may include a contact surface shaped to receive a container. A rack module may include one or more engagement features operable to removably attach the rack module to another rack module having complementary engagement features. The other rack module may also have a side including one or more receptacles, and the attached rack modules may commonly orient their respective receptacles such that the containers received therein may be used.
摘要翻译：各个方面包括一个包括一个包括一个或多个插座的侧面的机架模块。容器可以包括成形为容纳容器的接触表面。机架模块可以包括一个或多个接合特征，可操作以将机架模块可拆卸地附接到具有互补接合特征的另一机架模块。另一个机架模块还可以具有包括一个或多个插座的侧面，并且附接的机架模块可以共同地定向它们各自的插座，使得可以使用容纳在其中的容器。

94. 发明申请

US20120103816A1 MULTI-TASK IMMUNOAFFINITY DEVICE SECURED TO A PERIPHERAL BOX AND INTEGRATED TO A CAPILLARY ELECTROPHORESIS APPARATUS 有权
标题翻译：多用途安全防护装置保护外围盒并集成到毛细管电泳装置
公开(公告)号：US20120103816A1
公开(公告)日：2012-05-03
申请号：US13284087
申请日：2011-10-28
申请人： Norberto A. GUZMAN
发明人： Norberto A. GUZMAN
IPC分类号： G01N27/447 , B82Y30/00 , B82Y99/00
CPC分类号： G01N27/44743 , B01L3/50 , B01L3/502 , B01L3/5025 , B01L9/527 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/0668 , B01L2200/0673 , B01L2200/10 , B01L2300/021 , B01L2300/0627 , B01L2300/0809 , B01L2300/0861 , B01L2400/0415 , B01L2400/06 , B01L2400/082 , G01N30/466 , G01N30/74 , G01N33/53 , G01N33/543 , G01N2030/326
摘要： The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as a modular, multi-task immunoaffinity device secured to a peripheral box and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. In one embodiment, two devices are coupled in-tandem to perform separately and sequentially microreactions and concentrations of proteins. In this embodiment, biological samples containing proteins can be subjected to proteolytic processing in the first device, and the resulting peptides subjected to selective purification and concentration in the second device.
摘要翻译：本发明涉及用于捕获以简单或复杂基质中高或低浓度存在的一种或多种分析物的免疫亲和装置。该设备被设计为固定到外围盒并连接到毛细管电泳或液相色谱的模块化多任务免疫亲和装置，用于分离，富集，分离和鉴定聚合物大分子，主要是蛋白质生物标志物。在一个实施方案中，两个装置串联耦合以执行分开且顺序的微反应和蛋白质浓度。在本实施例中，含有蛋白质的生物样品可以在第一装置中进行蛋白水解处理，所得到的肽在第二装置中进行选择性纯化和浓缩。

95. 发明申请

US20120088249A1 MICROFLUIDIC DEVICES 有权
标题翻译：微流体装置
公开(公告)号：US20120088249A1
公开(公告)日：2012-04-12
申请号：US13287398
申请日：2011-11-02
申请人： Stevan Bogdan Jovanovich , Iuliu I. Blaga
发明人： Stevan Bogdan Jovanovich , Iuliu I. Blaga
IPC分类号： C12Q1/68 , C12M1/40
CPC分类号： B01L3/50273 , B01F11/0071 , B01F13/0059 , B01J2219/005 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0654 , B01L2300/0803 , B01L2300/0806 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1844 , B01L2400/0409 , B01L2400/0421 , B01L2400/043 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , C12Q2565/629 , G01N1/34 , G01N27/44721 , G01N27/44743 , G01N27/44791 , G01N35/0098
摘要： Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
摘要翻译：公开了用于将微芯片连接到各种类型的模块的方法和装置。所公开的技术可用作各种应用的样品制备和分析系统，如DNA测序和基因分型，蛋白质组学，病原体检测，诊断和生物防治。

96. 发明授权

US08155925B2 Disposable assay device with removables modules and remote data transfer system 失效
标题翻译：一次性测定装置，具有可拆卸模块和远程数据传输系统
公开(公告)号：US08155925B2
公开(公告)日：2012-04-10
申请号：US12305389
申请日：2007-06-20
申请人： Maarten Peter Bodlaender , Wilhelmus Johannes Joseph Stut
发明人： Maarten Peter Bodlaender , Wilhelmus Johannes Joseph Stut
IPC分类号： G06F15/00 , C12M1/34 , G01D11/24 , B01J19/00
CPC分类号： B01L3/502715 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/10 , B01L2300/024 , B01L2300/0816
摘要： Disposable assay device, comprising a carrier having a first carrier part (3) with a respective sample-receiving area (w) for receiving a sample to be tested, and having at least a second carrier part (9), the assay device being configured for transmitting assay data or information to a remote receiving system (20), and the device comprising at least two first carrier parts, said first carrier parts (3, 5) being independently removable from the second carrier part (9).
摘要翻译：一次性测定装置，包括具有第一载体部分（3）的载体，其具有用于接收待测样品的相应样品接收区域（w），并且具有至少第二载体部分（9），所述测定装置被配置用于将测定数据或信息发送到远程接收系统（20），并且所述设备包括至少两个第一载体部分，所述第一载体部分（3,5）可独立地从第二载体部分（9）移除。

97. 发明授权

US08119079B2 Microfluidic apparatus having fluid container 失效
标题翻译：具有流体容器的微流体装置
公开(公告)号：US08119079B2
公开(公告)日：2012-02-21
申请号：US12053656
申请日：2008-03-24
申请人： Yoon-kyoung Cho , Beom-seok Lee , Jeong-gun Lee
发明人： Yoon-kyoung Cho , Beom-seok Lee , Jeong-gun Lee
IPC分类号： B01J19/00
CPC分类号： B01L3/502738 , B01L3/50273 , B01L2200/028 , B01L2300/0803 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , Y10T436/11 , Y10T436/25 , Y10T436/255 , Y10T436/2575
摘要： A microfluidic apparatus having a substrate including a channel through which a fluid is conveyed, a fluid container in which at least one kind of fluid is accommodated and which is disposed on the substrate so as to allow the fluid to flow toward the channel, and a fluid flow controller which controls a flow of the fluid toward the channel from the fluid container.
摘要翻译：一种微流体装置，其具有包括流体被输送的通道的基板，容纳有至少一种流体的流体容器，并且设置在所述基板上以允许流体朝向所述流路流动，流体流量控制器，其控制流体朝向来自流体容器的通道的流动。

98. 发明申请

US20120020837A1 Portable Apparatus for Improved Sample Analysis 有权
标题翻译：便携式设备，用于改进样品分析
公开(公告)号：US20120020837A1
公开(公告)日：2012-01-26
申请号：US13248307
申请日：2011-09-29
申请人： Edward W. Withrow, III , Jorn Gorlach
发明人： Edward W. Withrow, III , Jorn Gorlach
IPC分类号： G01N33/53
CPC分类号： G01N33/54366 , A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/411 , A61B5/415 , A61B5/416 , A61B5/418 , B01L3/5023 , B01L2200/028 , B01L2300/023 , B01L2300/024 , B01L2300/0636 , B01L2300/0663 , B01L2400/0478 , G01N35/00871 , G06F19/00 , G16H40/63 , Y02A90/26 , Y10S435/809
摘要： The present invention is an improved apparatus for sample analysis. The apparatus employs an assay component containing a membrane having one or a plurality of analyte-specific binding agents attached thereto, a means for absorbing liquid, and a piston means for drawing analytes through said membrane into said means for absorbing liquid. The apparatus is configured to be portable and provide a detector for detecting binding of an analyte to an analyte-specific binding agent, a plurality of data acquisition components, and a computer for integrating, analyzing and storing the detected analyte specific binding and acquired data.
摘要翻译：本发明是用于样品分析的改进装置。该装置采用包含附着有一种或多种分析物特异性结合剂的膜的测定组分，用于吸收液体的装置，以及用于将分析物通过所述膜吸入所述用于吸收液体的装置的活塞装置。该装置被配置为便携式并且提供用于检测分析物与分析物特异性结合剂的结合的检测器，多个数据采集组件和用于整合，分析和存储检测到的分析物特异性结合和获取的数据的计算机。

99. 发明申请

US20110294201A1 Test device for liquids of the human or animal body 审中-公开
标题翻译：用于人体或动物体液体的测试装置
公开(公告)号：US20110294201A1
公开(公告)日：2011-12-01
申请号：US13138315
申请日：2010-02-03
申请人： Walter Franz
发明人： Walter Franz
IPC分类号： C12M1/34
CPC分类号： B01L3/502 , B01L3/5082 , B01L2200/025 , B01L2200/028 , B01L2300/0832 , B01L2400/0683
摘要： A test device for liquids of the human or animal body, comprises a tube-shaped housing, in which are disposed: an in-feed area for feeding in a prescribed quantity of a bodily fluid, a reaction area connected downstream of the in-feed area and separated from the same by at least one closed separating wall, and in which the bodily fluid is brought to a chemical reaction with at least one reagent, and an indication area connected downstream of the reaction area and separated from the same by a separating element having a defined through-hole, and in which an indication element is disposed, the bodily fluid being passed through the through-hole after reacting with the reagent. A cutting device is thereby provided by means of which the separating wall can be opened or destroyed.
摘要翻译：用于人体或动物体液体的试验装置包括管状壳体，其中设置有用于供给规定量的体液的进食区域，连接在进料口下游的反应区域并且通过至少一个封闭分离壁与其分离，并且其中体液与至少一种试剂进行化学反应，以及连接在反应区域下游的指示区域，并通过分离具有限定的通孔的元件，并且其中设置有指示元件，所述体液在与所述试剂反应之后通过所述通孔。由此提供切割装置，通过该切割装置可以打开或破坏分隔壁。

100. 发明申请

US20110275160A1 MICROFLUIDIC SYSTEMS AND CONTROL METHODS 有权
标题翻译：微流体系统和控制方法
公开(公告)号：US20110275160A1
公开(公告)日：2011-11-10
申请号：US13152881
申请日：2011-06-03
申请人： Peng Zhou , Lincoln C. Young
发明人： Peng Zhou , Lincoln C. Young
IPC分类号： G01N35/08
CPC分类号： G01N1/28 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/1827 , B01L2400/0481 , B01L2400/0622 , B01L2400/0633 , B01L2400/0655 , B01L2400/0666 , B01L2400/084 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0084 , F16K2099/0094 , Y10T137/0324 , Y10T436/117497 , Y10T436/2575
摘要： The systems and methods disclosed herein include a microfluidic system, comprising a pneumatic manifold having a plurality of apertures, and a chip manifold having channels disposed therein for routing pneumatic signals from respective ones of the apertures to a plurality of valves in a microfluidic chip, wherein the channels route the pneumatic signals in accordance with a configuration of the plurality of valves in the microfluidic chip.
摘要翻译：本文公开的系统和方法包括微流体系统，其包括具有多个孔的气动歧管和具有设置在其中的通道的芯片歧管，用于将来自相应孔的气动信号路由到微流体芯片中的多个阀，其中通道根据微流体芯片中的多个阀的结构来传送气动信号。

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