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91. 发明申请

US20060269289A1 Communications system 失效
公开(公告)号：US20060269289A1
公开(公告)日：2006-11-30
申请号：US10559635
申请日：2003-06-04
申请人： William Stewart
发明人： William Stewart
IPC分类号： H04B10/00
CPC分类号： H04J14/02 , H04J14/08
摘要： In a telecommunication system, channels of information are modulated onto respective carriers that are swept repeatedly across a frequency range in a time-staggered fashion so that, at any one time each carrier is at a different frequency. The carriers are multiplexed onto a single communications link and separated, on reception, by filters swept in synchronism so as to de-multiplex the signals.

92. 发明申请

US20060252159A1 Photocrosslinked hydrogel blend surface coatings 审中-公开
公开(公告)号：US20060252159A1
公开(公告)日：2006-11-09
申请号：US11407347
申请日：2006-04-20
申请人： Wenxi Huang , Pil-Je Um
发明人： Wenxi Huang , Pil-Je Um
IPC分类号： G01N33/543 , C08G59/68
CPC分类号： C08L101/14 , B01D15/1807 , B01J20/286 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/22 , C40B40/10 , G01N33/6848
摘要： Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.

93. 发明申请

US20060223127A1 Serum biomarkers in lung cancer 失效
标题翻译：肺癌血清生物标志物
公开(公告)号：US20060223127A1
公开(公告)日：2006-10-05
申请号：US10539291
申请日：2003-12-16
申请人： Timothy Tak Yip , Chi Cho , Siu Au , Tai-Tung Yip , Christine Yip , Victor Yip
发明人： Timothy Tak Yip , Chi Cho , Siu Au , Tai-Tung Yip , Christine Yip , Victor Yip
IPC分类号： G01N33/574 , G06F19/00 , G01N33/00
CPC分类号： G01N33/6851 , G01N33/57423 , G06F19/18
摘要： Certain biomarkers and biomarker combinations are useful in a qualifying lung cancer status in a subject. A diagnostic methodology employing these biomarkers and combinations can detect whether a subject has lung cancer.
摘要翻译：某些生物标志物和生物标志物组合在受试者的合格肺癌状态中是有用的。使用这些生物标志物和组合的诊断方法可以检测受试者是否患有肺癌。

94. 发明授权

US07046357B2 Apparatus for microfluidic processing and reading of biochip arrays 失效
标题翻译：用于微流体处理和读取生物芯片阵列的装置
公开(公告)号：US07046357B2
公开(公告)日：2006-05-16
申请号：US10769293
申请日：2004-01-29
申请人： Scot R. Weinberger , Louis Hlousek
发明人： Scot R. Weinberger , Louis Hlousek
IPC分类号： G01N21/00 , G01N33/00
CPC分类号： G01N33/54366 , B01L3/502715 , B01L9/527 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2400/0415 , B01L2400/0487 , B01L2400/0605 , G01N21/553 , G01N27/44782 , G01N30/6095 , G01N33/54386 , Y10T436/24
摘要： A method and a device for detecting an analyte, including a substrate having a chemically selective surface; and a fluidic system disposed on the substrate, the manifold having at least one fluid path in communication with at least a discrete region of the surface, wherein the one fluid path and the discrete region together define a contained sample region on the surface. The fluidic system has a removable portion, wherein the removal of the removable portion of the fluidic system renders the discrete region directly interrogatable by a surface-based analytical tool.
摘要翻译：一种用于检测分析物的方法和装置，包括具有化学选择性表面的基底; 以及设置在所述基底上的流体系统，所述歧管具有与所述表面的至少一个离散区域连通的至少一个流体路径，其中所述一个流体路径和所述离散区域一起限定所述表面上包含的样品区域。流体系统具有可移除部分，其中流体系统的可移除部分的移除使离散的区域通过基于表面的分析工具可直接询问。

95. 发明申请

US20060063161A1 Detecting RNAi using SELDI mass spectrometry 审中-公开
标题翻译：使用SELDI质谱法检测RNAi
公开(公告)号：US20060063161A1
公开(公告)日：2006-03-23
申请号：US10948028
申请日：2004-09-22
申请人： Gurucharan Reddy , William Rich
发明人： Gurucharan Reddy , William Rich
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： G01N33/6848
摘要： The present invention relates to the fields of protein expression and molecular biology. In particular, the present invention includes methods for monitoring the levels of polypeptide inhibition caused by inhibitory nucleic acids.
摘要翻译：本发明涉及蛋白质表达和分子生物学领域。特别地，本发明包括监测由抑制性核酸引起的多肽抑制水平的方法。

96. 发明申请

US20050279929A1 Laser desorption and ionization mass spectrometer with quantitative reproducibility 有权
标题翻译：激光解吸和电离质谱仪具有定量重现性
公开(公告)号：US20050279929A1
公开(公告)日：2005-12-22
申请号：US11155302
申请日：2005-06-17
申请人： Michael Youngquist , Craig Keller
发明人： Michael Youngquist , Craig Keller
IPC分类号： B01D59/44 , H01J49/16
CPC分类号： H01J49/164
摘要： Laser desorption/ionization time-of-flight mass spectrometer (“LDI-TOF-MS”) devices, and methods, that accurately measure the mass of analytes contained in a sample and which also measure the quantities of analytes present in a sample in a consistent manner from instrument-to-instrument and over time on a single instrument. In particular, the invention provides LDI-TOF-MS devices and methods in which: 1) the energy of the laser pulse and the area of the sample illuminated (fluence) is consistent and controlled so as to produce consistent conditions for analyte desorption and ionization; 2) the mass analyzer behaves in a reproducible manner; and 3) the detection system produces a signal that consistently represents the arrival of ions of different masses.
摘要翻译：激光解吸/离子化飞行时间质谱仪（“LDI-TOF-MS”）装置和方法，可精确测量样品中所含分析物的质量，并测量样品中存在的分析物的量从仪器到仪器的一致方式，以及随着时间的推移在单个仪器上。特别地，本发明提供了LDI-TOF-MS装置和方法，其中：1）激光脉冲的能量和照射的样品的面积（注量）一致和控制，以便产生用于分析物解吸和电离的一致条件 ; 2）质量分析仪以可重复的方式进行操作; 和3）检测系统产生一致地表示不同质量的离子的到达的信号。

97. 发明申请

US20050224708A1 Electric sector time-of-flight mass spectrometer with adjustable ion optical elements 失效
标题翻译：具有可调式离子光学元件的电扇飞行时间质谱仪
公开(公告)号：US20050224708A1
公开(公告)日：2005-10-13
申请号：US11148865
申请日：2005-06-08
申请人： Sidney Buttrill
发明人： Sidney Buttrill
IPC分类号： H01J49/28 , H01J49/40
CPC分类号： H01J49/282 , H01J49/408
摘要： The invention provides apparatus and methods for performing time-of-flight (TOF) mass spectrometry. A TOF mass spectrometer of the present invention comprises one or more ion focusing electric sectors. At least one of the S electric sectors is associated with an ion optical element. The ion optical elements comprise at least one adjustable electrode, such that the adjustable electrode is able to modify the potential experienced by an ion entering or exiting the electric sector with which it is associated.
摘要翻译：本发明提供了用于执行飞行时间（TOF）质谱的装置和方法。本发明的TOF质谱仪包括一个或多个离子聚焦电扇区。 S电扇区中的至少一个与离子光学元件相关联。离子光学元件包括至少一个可调电极，使得可调节电极能够改变进入或离开与其相关联的电扇区的离子所经历的电位。

98. 发明申请

US20050214815A1 Bi-functional polymer chip 有权
标题翻译：双功能聚合物芯片
公开(公告)号：US20050214815A1
公开(公告)日：2005-09-29
申请号：US11014225
申请日：2004-12-17
申请人： Egisto Boschetti , Luc Bourgeois
发明人： Egisto Boschetti , Luc Bourgeois
IPC分类号： B01D15/36 , B01J20/32 , B01J39/26 , B01J41/20 , B01J47/00 , C12Q1/68
CPC分类号： B01J39/26 , B01D15/361 , B01J20/3204 , B01J20/3208 , B01J20/3217 , B01J20/3219 , B01J20/3221 , B01J20/3257 , B01J20/3272 , B01J20/3274 , B01J20/3289 , B01J41/20 , B01J47/016 , B01J2220/54 , G01N33/54393 , G01N33/6851
摘要： In relation to a chromatographic chip, for protein separation, a polymer surface is provided that has a first polymer layer, attached to a support surface, which can be anionic or cationic. To the first layer is attached a second polymer layer, characterized by an opposite charge.
摘要翻译：关于色谱芯片，对于蛋白质分离，提供聚合物表面，其具有连接到支撑表面的第一聚合物层，其可以是阴离子或阳离子的。第一层附着有第二聚合物层，其特征在于相反的电荷。

99. 发明申请

US20050206363A1 Method for clustering signals in spectra 有权
标题翻译：光谱信号聚类方法
公开(公告)号：US20050206363A1
公开(公告)日：2005-09-22
申请号：US11040493
申请日：2005-01-20
申请人： Patrick Ho , Edward Gavin
发明人： Patrick Ho , Edward Gavin
IPC分类号： C12P17/18 , G06F15/00 , H01J49/04
CPC分类号： H01J49/0036
摘要： Methods for processing spectra are disclosed. The method includes obtaining a plurality of spectra, each spectrum in the plurality of spectra comprising a signal including a signal strength as a function of time-of-flight, mass-to-charge ratio, or a value derived from time-of-flight or mass-to-charge ratio. Then, a signal cluster is formed by clustering signals from the plurality of spectra with time-of-flights, mass-to-charge ratios, or values derived from time-of-flights or mass-to-charge ratios that are within a window that is defined using an expected signal width value.
摘要翻译：公开了处理光谱的方法。该方法包括获得多个光谱，多个光谱中的每个光谱包括包括作为飞行时间的函数的信号强度，质荷比或从飞行时间导出的值的信号或质荷比。然后，通过使来自多个频谱的信号聚集来自飞行中的时间，质荷比或从窗口内的飞行时间或质量 - 荷载比导出的值来形成信号簇这是使用期望的信号宽度值定义的。

100. 发明授权

US06946653B2 Methods and apparatus for improved laser desorption ionization tandem mass spectrometry 有权
标题翻译：改进激光解吸电离串联质谱法的方法和装置
公开(公告)号：US06946653B2
公开(公告)日：2005-09-20
申请号：US10184450
申请日：2002-06-26
申请人： Scot R. Weinberger , Pete Tornatore
发明人： Scot R. Weinberger , Pete Tornatore
IPC分类号： G01N27/62 , G01N27/64 , H01J49/10 , H01J49/16 , H01J49/40 , H01J49/42
CPC分类号： H01J49/004 , H01J49/0481 , H01J49/164
摘要： Laser desorption/ionization tandem mass spectrometer instruments that include immediate post source collisional cooling are presented, as are analytical methods that employ such instruments to achieve increased sensitivity and ion yield. Also presented are laser desorption/ionization mass spectrometry methods that improve sensitivity and relative ion yield by combining affinity capture probes with matrices having low melting point energy absorbing molecules combined with alkali metal scavengers.
摘要翻译：提出了包括立即源源碰撞冷却的激光解吸/电离串联质谱仪器，以及采用这些仪器来实现增加的灵敏度和离子产率的分析方法。还提出了通过将亲和捕获探针与具有与碱金属清除剂结合的低熔点能量吸收分子的基质结合来提高灵敏度和相对离子产率的激光解吸/电离质谱法。

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