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1. 发明申请

US20060000982A1 Non-linear signal amplifiers and uses thereof in a mass spectrometer device 失效
标题翻译：非线性信号放大器及其在质谱仪装置中的应用
公开(公告)号：US20060000982A1
公开(公告)日：2006-01-05
申请号：US11173236
申请日：2005-06-30
申请人： Craig Keller , Steve Waltman , Steve Miller , Michael Youngquist
发明人： Craig Keller , Steve Waltman , Steve Miller , Michael Youngquist
IPC分类号： G01T3/00
CPC分类号： H01J49/025 , H03F3/08 , H03F3/45475 , H03F2200/261 , H03F2203/45138
摘要： Signal amplifiers having a non-linear transfer function. A high speed (high bandwidth) circuit with a non-linear transfer function over a limited range of input signal is provided. By appropriate choice of components, the non-linear transfer function can be used to accurately approximate any monotonic function such as a square root transfer function. In another aspect, a piecewise non-linear circuit arrangement using a set of non-linear sub-circuits is provided to accurately generate a desired non-linear transfer function over an extended dynamic range of input signal. In one implementation of such a circuit, each of the sub-circuits approximates the desired non-linear function over a portion of the input range.
摘要翻译：具有非线性传递函数的信号放大器。提供了在有限输入信号范围内具有非线性传递函数的高速（高带宽）电路。通过适当选择组件，可以使用非线性传递函数来精确地近似任何单调函数，如平方根传递函数。在另一方面，提供使用一组非线性子电路的分段非线性电路装置，以在输入信号的扩展动态范围上精确地产生期望的非线性传递函数。在这种电路的一个实现中，每个子电路在输入范围的一部分上接近期望的非线性函数。

2. 发明申请

US20080024190A1 NON-LINEAR SIGNAL AMPLIFIERS AND USES THEREOF IN A MASS SPECTROMETER DEVICE 审中-公开
标题翻译：非线性信号放大器及其在大型光谱仪器中的应用
公开(公告)号：US20080024190A1
公开(公告)日：2008-01-31
申请号：US11773310
申请日：2007-07-03
申请人： Craig Keller , Steve Waltman , Steve Miller , Michael Youngquist
发明人： Craig Keller , Steve Waltman , Steve Miller , Michael Youngquist
IPC分类号： G06F7/556
CPC分类号： H01J49/025 , H03F3/08 , H03F3/45475 , H03F2200/261 , H03F2203/45138
摘要： Signal amplifiers having a non-linear transfer function. A high speed (high bandwidth) circuit with a non-linear transfer function over a limited range of input signal is provided. By appropriate choice of components, the non-linear transfer function can be used to accurately approximate any monotonic function such as a square root transfer function. In another aspect, a piecewise non-linear circuit arrangement using a set of non-linear sub-circuits is provided to accurately generate a desired non-linear transfer function over an extended dynamic range of input signal. In one implementation of such a circuit, each of the sub-circuits approximates the desired non-linear function over a portion of the input range.
摘要翻译：具有非线性传递函数的信号放大器。提供了在有限输入信号范围内具有非线性传递函数的高速（高带宽）电路。通过适当选择组件，可以使用非线性传递函数来精确地近似任何单调函数，如平方根传递函数。在另一方面，提供使用一组非线性子电路的分段非线性电路装置，以在输入信号的扩展动态范围上精确地产生期望的非线性传递函数。在这种电路的一个实现中，每个子电路在输入范围的一部分上接近期望的非线性函数。

3. 发明申请

US20050236564A1 Laser desorption mass spectrometer with uniform illumination of the sample 审中-公开
标题翻译：激光解吸质谱仪具有均匀照明的样品
公开(公告)号：US20050236564A1
公开(公告)日：2005-10-27
申请号：US10832822
申请日：2004-04-26
申请人： Craig Keller , Curtis Lomax , Edward Wallerstein , Timothy Montagne , Michael Youngquist
发明人： Craig Keller , Curtis Lomax , Edward Wallerstein , Timothy Montagne , Michael Youngquist
IPC分类号： H01J49/04 , H01J49/16
CPC分类号： H01J49/164 , H01J49/0413 , H01J49/0418
摘要： Systems and methods for rastering a series of illumination pulses across the surface of a sample under investigation in a mass spectrometer system so as to create a two dimensional illumination pattern (raster pattern) on the sample. A probe interface that engages a probe is configured to translate the probe along a first direction, and a pulse deflection mechanism is configured to vary the pulse-probe intersect position along a second direction. A control system, implementing a rastering algorithm, provides control signals to the pulse deflection mechanism to adjust the pulse path and the probe translation mechanism to adjust the probe position so that each illumination pulse impinges on one of a plurality of addressable locations on the sample. The resulting raster pattern may cover the entire sample or one or more portions of the sample, depending on the spot size and the displacement distances for each pulse along the first and second directions. Ions desorbed from the sample by each pulse are detected, and a corresponding series of spectra are generated for each of the series of pulses. The spectrum resulting from each pulse may be combined with others to form a combined spectrum for the portion of the sample illuminated by the raster pattern.
摘要翻译：用于在质谱仪系统中对正在研究的样品的表面上的一系列照明脉冲进行扫描以在样品上产生二维照明图案（光栅图案）的系统和方法。接合探针的探针接口被配置为沿着第一方向平移探针，并且脉冲偏转机构被配置为沿着第二方向改变脉冲 - 探针相交位置。控制系统实现了一种复原算法，向脉冲偏转机构提供控制信号，以调整脉冲路径和探头平移机构，以调整探头位置，使得每个照明脉冲射入样本上的多个可寻址位置之一。取决于沿着第一和第二方向的每个脉冲的光斑尺寸和位移距离，所得到的光栅图案可以覆盖样品的整个样品或一个或多个部分。检测每个脉冲从样品中脱离的离子，并为每个脉冲序列产生相应的一系列光谱。每个脉冲产生的光谱可以与其他脉冲组合，以形成由光栅图案照射的样本部分的组合光谱。

4. 发明申请

US20050279929A1 Laser desorption and ionization mass spectrometer with quantitative reproducibility 有权
标题翻译：激光解吸和电离质谱仪具有定量重现性
公开(公告)号：US20050279929A1
公开(公告)日：2005-12-22
申请号：US11155302
申请日：2005-06-17
申请人： Michael Youngquist , Craig Keller
发明人： Michael Youngquist , Craig Keller
IPC分类号： B01D59/44 , H01J49/16
CPC分类号： H01J49/164
摘要： Laser desorption/ionization time-of-flight mass spectrometer (“LDI-TOF-MS”) devices, and methods, that accurately measure the mass of analytes contained in a sample and which also measure the quantities of analytes present in a sample in a consistent manner from instrument-to-instrument and over time on a single instrument. In particular, the invention provides LDI-TOF-MS devices and methods in which: 1) the energy of the laser pulse and the area of the sample illuminated (fluence) is consistent and controlled so as to produce consistent conditions for analyte desorption and ionization; 2) the mass analyzer behaves in a reproducible manner; and 3) the detection system produces a signal that consistently represents the arrival of ions of different masses.
摘要翻译：激光解吸/离子化飞行时间质谱仪（“LDI-TOF-MS”）装置和方法，可精确测量样品中所含分析物的质量，并测量样品中存在的分析物的量从仪器到仪器的一致方式，以及随着时间的推移在单个仪器上。特别地，本发明提供了LDI-TOF-MS装置和方法，其中：1）激光脉冲的能量和照射的样品的面积（注量）一致和控制，以便产生用于分析物解吸和电离的一致条件 ; 2）质量分析仪以可重复的方式进行操作; 和3）检测系统产生一致地表示不同质量的离子的到达的信号。

5. 发明申请

US20060139621A1 Automated microdissection instrument 有权
标题翻译：自动显微切割仪
公开(公告)号：US20060139621A1
公开(公告)日：2006-06-29
申请号：US11236045
申请日：2005-09-26
申请人： Thomas Baer , Michael Youngquist , Brian Donovan , Alan Wessel , Norbert Leclerc , Michael Smith , George Dawson , Craig Barker
发明人： Thomas Baer , Michael Youngquist , Brian Donovan , Alan Wessel , Norbert Leclerc , Michael Smith , George Dawson , Craig Barker
IPC分类号： G01N1/00
CPC分类号： G01N1/2813 , G01B11/002 , G01N2001/282 , G01N2001/284 , Y10T156/10 , Y10T156/1054
摘要： Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
摘要翻译：公开了用于自动激光显微切割的系统和方法，包括自动滑动检测，切割和捕获激光器的位置检测，用于切割和捕获激光器的聚焦优化，用于切割和捕获激光器的能量和持续时间优化，检查和第二相捕获和/或消融质量控制站和用于将衬底载体或输出显微切割区域与输入样品或载片连接的跟踪信息。

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