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    • 94. 发明授权
    • Syllable-beat-point synchronized rule-based speech synthesis from coded
utterance-speed-independent phoneme combination parameters
    • 基于编码话音速度独立音素组合参数的音节点同步规则语音合成
    • US5682502A
    • 1997-10-28
    • US490140
    • 1995-06-14
    • Mitsuru OhtsukaYasunori OhoraTakashi AsouTakeshi FujitaToshiaki Fukada
    • Mitsuru OhtsukaYasunori OhoraTakashi AsouTakeshi FujitaToshiaki Fukada
    • G10L13/08G10L13/06G10L21/04G10L5/04
    • G10L13/06G10L21/04
    • In a speech synthesizer, each frame for generating a speech waveform has an expansion degree to which the frame is expanded or compressed in accordance with the production speed of synthetic speech. In accordance with the set speech production speed, the time interval between beat synchronization points is determined on the basis of the speed of the speech to be produced, and the time length of each frame present between the beat synchronization points is determined on the basis of the expansion degree of the frame. Parameters for producing a speech waveform in each frame are properly generated by the time length determined for the frame. In the speech synthesizer for outputting a speech signal by coupling phonemes constituted by one or a plurality of frames having phoneme vowel-consonant combination parameters (VcV, cV, or V) of the speech waveform, the number of frames can be held constant regardless of a change in the speech production speed. This prevents degradation in the tone quality or a variation in the processing quantity resulting from a change in the speech production speed.
    • 在语音合成器中,用于产生语音波形的每个帧具有根据合成语音的生产速度来扩展或压缩帧的扩展度。 根据设定的语音生成速度,基于要产生的语音的速度来确定拍子同步点之间的时间间隔,并且基于在拍子同步点之间存在的每个帧的时间长度 框架的扩展程度。 用于产生每帧中的语音波形的参数通过为帧确定的时间长度适当地产生。 在语音合成器中,通过将由语音波形的音素元音辅音组合参数(VcV,cV或V)组成的一个或多个帧构成的音素耦合到语音信号中,可以将帧数保持不变,而不管 演讲生产速度的变化。 这防止了语音质量的劣化或由语音生成速度的变化导致的处理量的变化。
    • 96. 发明授权
    • Method for analyzing nucleic acid or protein and apparatus therefor
    • 分析核酸或蛋白质的方法及其设备
    • US5458761A
    • 1995-10-17
    • US378973
    • 1995-01-27
    • Masao KamahoriTakeshi FujitaShinichiro UmemuraTakashi Yamada
    • Masao KamahoriTakeshi FujitaShinichiro UmemuraTakashi Yamada
    • G01N27/447G01N27/26
    • G01N27/44704G01N27/44721G01N27/44743
    • Analysis of a nucleic acid samples having thousands of bases is conducted by capillary electrophoresis. The electrophoretic section is provided with a first capillary filled with an agarose gel and a second capillary filled with a polyacrylamide gel. An on-column detector is incorporated with the second capillary for optical detection. To fill a capillary with a gel, a solution is fed under high pressure from a first flow channel through a switching valve into a second flow channel connected to the capillary. To inject a sample in the capillary, a sample injector is connected to a switching valve passage, and a buffer solution is connected to the capillary through a flow channel and the switching valve. After switching the valve, the first passage is incorporated into the flow channel between the buffer solution and the capillary being filled. Then, the sample is electro-kinetically injected into the capillary. When conducting genetic polymorphism by electrophoresis, temperature control elements are provided to maintain the capillary at a predetermined temperature and a DNA sample device is provided to heat the sample to a temperature higher than a disassociation temperature thereof for directly injecting the heated sample into the capillary.
    • 通过毛细管电泳分析具有数千个碱基的核酸样品。 电泳部分设置有填充有琼脂糖凝胶的第一毛细管和填充有聚丙烯酰胺凝胶的第二毛细管。 柱内检测器与第二毛细管并入,用于光学检测。 为了用凝胶填充毛细管,将溶液在高压下从第一流动通道通过切换阀进入连接到毛细管的第二流动通道。 为了在毛细管中注入样品,将样品注射器连接到切换阀通道,并且缓冲溶液通过流动通道和切换阀连接到毛细管。 在切换阀之后,第一通道被并入缓冲溶液和被填充的毛细管之间的流动通道中。 然后,将样品电动注射到毛细管中。 当通过电泳进行遗传多态性时,提供温度控制元件以将毛细管保持在预定温度,并且提供DNA样品装置以将样品加热到高于其解离温度的温度,以将加热的样品直接喷射到毛细管中。
    • 100. 发明授权
    • Fumagillol derivatives and pharmaceutical compositions thereof
    • 烟曲霉醇衍生物及其药物组合物
    • US5166172A
    • 1992-11-24
    • US662120
    • 1991-02-28
    • Shoji KishimotoTakeshi Fujita
    • Shoji KishimotoTakeshi Fujita
    • A61K31/335C07D303/22C07D405/14C07D407/14C07D417/14C07D521/00
    • C07D303/22A61K31/335C07D231/12C07D233/56C07D249/08C07D405/14C07D407/14C07D417/14
    • The present invention is related to a compound of the formula ##STR1## wherein R.sup.1 is a 2-methyl-1-propenyl or isobutyl group which may be substituted and R.sup.2 is (1) a substituted alkanoyl group, (2) a substituted aroyl group having at least one substituent selected from the group consisting of C.sub.2-6 alkyl, amino, halogen, hydroxyl, lower alkoxy, cyano, carbamoyl and carboxyl, (3) an aromatic heterocycle-carbonyl, which may optionally be substituted, (4) a carbamoyl group, which may optionally be substituted, (5) an alkyl group, which may optionally be substituted, (6) a benzenesulfonyl group, which may optionally be substituted, (7) an alkylsulfonyl group, which may optionally be substituted, (8) a sulfamoyl group, which may optionally be substituted, (9) an alkoxycarbonyl group, which may optionally be substituted or (10) a phenoxycarbonyl group, which may optionally be substituted; or a salt thereof.The compound (I) has a strong angiogenesis inhibitory activity.
    • 本发明涉及下式化合物:其中R1是可被取代的2-甲基-1-丙烯基或异丁基,R2是(1)取代的烷酰基,(2)取代的芳酰基 具有至少一个选自C 2-6烷基,氨基,卤素,羟基,低级烷氧基,氰基,氨基甲酰基和羧基的取代基的取代基,(3)可任意取代的芳族杂环羰基,(4) 可任选被取代的(5)可任选被取代的烷基,(6)可任意被取代的苯磺酰基,(7)可任意被取代的烷基磺酰基,(8) )可任选被取代的氨磺酰基,(9)可任选被取代的烷氧基羰基或可任选被取代的(10)苯氧基羰基; 或其盐。 化合物(I)具有强的血管生成抑制活性。