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91. 发明申请

US20080262558A1 PATIENT CHARACTERISTIC BASED ADAPTIVE ANTI-TACHY PACING PROGRAMMING 有权
标题翻译：基于特征特征的自适应防篡改编程
公开(公告)号：US20080262558A1
公开(公告)日：2008-10-23
申请号：US11736286
申请日：2007-04-17
申请人： Yanting Dong , Quan Ni , Xuan Wei , Dan Li , Qian Zhong
发明人： Yanting Dong , Quan Ni , Xuan Wei , Dan Li , Qian Zhong
IPC分类号： A61N1/365
CPC分类号： A61N1/3621
摘要： A system including at least one implantable sensor circuit adapted to produce an electrical sensor signal related to one or more physiologic cardiovascular events of a subject, a therapy circuit configured to provide anti-tachycardia pacing (ATP) therapy, and a controller. The controller includes a tachyarrhythmia detection circuit and an efficacy circuit. The tachyarrhythmia detection circuit is configured to detect a tachyarrhythmia episode in the subject using the electrical sensor signal, and to determine whether the tachyarrhythmia episode is of a type that is treatable with ATP. The efficacy circuit is configured to estimate an efficacy of a currently configured ATP therapy for the subject, and the controller is configured to alter a delivery regimen of the currently configured ATP therapy when the estimated ATP therapy efficacy is deemed insufficient. Other systems and methods are described.
摘要翻译：一种系统，包括适于产生与受试者的一个或多个生理性心血管事件相关的电传感器信号的至少一个可植入传感器电路，被配置为提供抗心动过速起搏（ATP）治疗的治疗电路和控制器。控制器包括快速性心律失常检测电路和功效电路。快速心律失常检测电路被配置为使用电传感器信号检测受试者的快速性心律失常发作，并且确定快速性心律失常发作是否是可用ATP治疗的类型。功效电路被配置为估计当前配置的ATP治疗对受试者的功效，并且当估计的ATP治疗功效被认为不足时，控制器被配置为改变当前配置的ATP治疗的递送方案。描述了其他系统和方法。

92. 发明申请

US20070049976A1 Pacing management during cardiopulmonary resuscitation 有权
标题翻译：心肺复苏期间的起搏管理
公开(公告)号：US20070049976A1
公开(公告)日：2007-03-01
申请号：US11209975
申请日：2005-08-23
申请人： Quan Ni , Yanting Dong
发明人： Quan Ni , Yanting Dong
IPC分类号： A61N1/00
CPC分类号： A61N1/3962 , A61N1/36514 , A61N1/37 , G09B23/288
摘要： Systems and methods provide for coordinated cardiac pacing with delivery of cardiopulmonary resuscitation (CPR) to a patient. Managing cardiac pacing in a patient during a cardiac arrhythmia involves detecting a cardiac arrhythmia using a patient implantable medical device, prompting a cardiopulmonary resuscitation compression, and delivering, using the patient implantable medical device, a pacing pulse to a heart chamber in coordination with the compression prompt.
摘要翻译：系统和方法提供协调的心脏起搏和向患者输送心肺复苏（CPR）。在心律失常期间管理患者的心脏起搏包括使用患者可植入医疗装置检测心律失常，促使心肺复苏压缩，以及使用患者可植入医疗装置，与压缩器协调地向心室输送起搏脉冲提示。

93. 发明申请

US20060247695A1 Methods and systems for managing fusion and noise in cardiac pacing response classification 有权
标题翻译：用于管理心脏起搏反应分类中的融合和噪声的方法和系统
公开(公告)号：US20060247695A1
公开(公告)日：2006-11-02
申请号：US11116565
申请日：2005-04-28
申请人： Kevin Stalsberg , Yanting Dong , Scott Meyer , John Voegele , Derek Bohn , Eric Enrooth , Clayton Foster , David Yost
发明人： Kevin Stalsberg , Yanting Dong , Scott Meyer , John Voegele , Derek Bohn , Eric Enrooth , Clayton Foster , David Yost
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61B5/0452 , A61B5/7203 , A61B5/7217 , A61B5/7264
摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.
摘要翻译：用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。融合/噪声管理过程包括在相对较高的能量级别进行起搏，直到在融合之后检测到捕获，进行不确定或可能错误的起搏响应分类。可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

94. 发明申请

US20060247694A1 Capture detection for multi-chamber pacing 有权
标题翻译：捕获检测多腔起搏
公开(公告)号：US20060247694A1
公开(公告)日：2006-11-02
申请号：US11116563
申请日：2005-04-28
申请人： Yanting Dong , Scott Meyer , Kevin Stalsberg
发明人： Yanting Dong , Scott Meyer , Kevin Stalsberg
IPC分类号： A61N1/362
CPC分类号： A61N1/3712 , A61N1/3684
摘要： Multi-chamber pacing may result in capture of one chamber, capture of multiple chambers, fusion, or non-capture. Approaches for detecting various capture conditions during multi-chamber pacing are described. Pacing pulses are delivered to left and right heart chambers during a cardiac cycle. A cardiac electrogram signal is sensed following the delivery of the pacing pulses. Left chamber capture only, right chamber capture only, and bi-chamber capture may be distinguished based on characteristics of the cardiac electrogram signal. Multi-chamber capture detection may be implemented using detection windows having dimensions of time and amplitude. The detection windows are associated with expected features, such as expected signal peaks, under a particular capture condition. The cardiac electrogram signal features are compared to detection windows to determine the capture condition.
摘要翻译：多腔起搏可能导致一个腔室的捕获，多个腔室的捕获，融合或非捕获。描述了在多室起搏期间检测各种捕获条件的方法。在心动周期期间，起搏脉冲被传送到左心室和右心室。在起搏脉冲输送之后感测心电图信号。仅左室捕获，右室捕获，双室捕获可以基于心电图信号的特征来区分。可以使用具有时间和幅度尺寸的检测窗来实现多室捕获检测。检测窗口与特定捕获条件下的预期特征（例如期望的信号峰值）相关联。将心电图信号特征与检测窗口进行比较以确定捕获条件。

95. 发明申请

US20060247693A1 Non-captured intrinsic discrimination in cardiac pacing response classification 审中-公开
公开(公告)号：US20060247693A1
公开(公告)日：2006-11-02
申请号：US11116558
申请日：2005-04-28
申请人： Yanting Dong , Scott Meyer , Kevin Stalsberg
发明人： Yanting Dong , Scott Meyer , Kevin Stalsberg
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61B5/04525
摘要： Cardiac devices and methods discriminate non-captured intrinsic beats during evoked response detection and classification by comparing the features of a post-pace cardiac signal with expected features associated with a non-captured response with intrinsic activation. Detection of a non-captured response with intrinsic activation may be based on the peak amplitude and timing of the cardiac signal. The methods may be used to discriminate between a fusion or capture beat and a non-captured intrinsic beat. Discriminating between possible cardiac responses to the pacing pulse may be useful, for example, during automatic capture verification and/or a capture threshold test.

96. 发明申请

US20050131477A1 Cardiac response classification using retriggerable classification windows 有权
标题翻译：使用可重新触发分类窗口的心脏反应分类
公开(公告)号：US20050131477A1
公开(公告)日：2005-06-16
申请号：US10734599
申请日：2003-12-12
申请人： Scott Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
发明人： Scott Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
IPC分类号： A61B5/04 , A61B5/0452 , A61N1/37
CPC分类号： A61B5/7264 , A61B5/04525 , A61B5/7217 , A61N1/371
摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a retriggerable cardiac response classification window. A first cardiac response classification window is established subsequent to delivery of a pacing pulse. A cardiac signal following the pacing stimulation is sensed in the first classification window. A second cardiac response classification may be triggered if a trigger characteristic is detected in the first classification window. The cardiac signal is sensed in the second classification window if the second classification window is established. The cardiac response to the pacing stimulation is determined based on characteristics of the cardiac signal. The cardiac response may be determined to be one of a captured response, a non-captured response; a non-captured response added to an intrinsic beat, and a fusion/pseudofusion beat, for example.
摘要翻译：用于分类心脏起搏应答的方法和装置包括建立可再触发的心脏反应分类窗口。在递送起搏脉冲之后建立第一心脏响应分类窗口。起搏刺激后的心脏信号在第一分类窗口中被感测。如果在第一分类窗口中检测到触发特性，则可以触发第二心跳响应分类。如果建立第二分类窗口，则在第二分类窗口中感测到心脏信号。基于心脏信号的特征确定对起搏刺激的心脏反应。心脏反应可以被确定为捕获的应答，非捕获的响应之一; 例如，添加到固有节拍的非捕获响应以及融合/假融合节拍。

97. 发明授权

US08942791B2 Off-line sensing method and its applications in detecting undersensing, oversensing, and noise 有权
标题翻译：离线感测方法及其在检测不足，过流和噪声方面的应用
公开(公告)号：US08942791B2
公开(公告)日：2015-01-27
申请号：US13483387
申请日：2012-05-30
申请人： Yanting Dong , Shijie Zhang , Deepa Mahajan , Chenguang Liu , Dan Li , Yayun Lin , Derek D. Bohn
发明人： Yanting Dong , Shijie Zhang , Deepa Mahajan , Chenguang Liu , Dan Li , Yayun Lin , Derek D. Bohn
IPC分类号： A61B5/04 , A61N1/39
CPC分类号： A61B5/04012 , A61B5/0245 , A61B5/042 , A61B5/0452 , A61B5/7217 , A61N1/3704 , A61N1/3937
摘要： A system and method for performing independent, off-line evaluation of event sensing for collected electrograms, comprising: sensing an electrogram using an implantable medical device (IMD); determining locations of heart beats on at least one channel of the electrogram using a multi-pass process, resulting in a group of multi-pass beat locations; storing the electrogram and device-identified beat locations in a memory location; and retrieving the electrogram and device-identified beat locations from the memory location. The multi-pass process determines locations of heart beats on at least a first channel of the electrogram. The device-identified group of beat locations are then compared to the multi-pass group of beat locations identified using the multi-pass method. Based on the comparing step, oversensing of beats, undersensing of beats, or noise from the device can be detected.
摘要翻译：一种用于对收集的电描记图执行事件感测的独立离线评估的系统和方法，包括：使用可植入医疗装置（IMD）感测电描记图; 使用多遍处理确定心电图的至少一个通道上的心跳位置，从而产生一组多通拍位置; 将电描记图和设备识别的节拍位置存储在存储器位置中; 以及从存储器位置检索电描记图和设备标识的拍摄位置。多遍处理确定心电图的至少第一个通道的位置。然后将设备识别的拍摄位置组与使用多遍方法识别的拍摄位置的多通道组进行比较。基于比较步骤，可以检测节拍过度，节拍不足或来自装置的噪音。

98. 发明申请

US20130261476A1 PHRENIC NERVE STIMULATION DETECTION 有权
标题翻译：腓肠神经刺激检测
公开(公告)号：US20130261476A1
公开(公告)日：2013-10-03
申请号：US13781177
申请日：2013-02-28
申请人： Holly Rockweiler , Sunipa Saha , Yanting Dong
发明人： Holly Rockweiler , Sunipa Saha , Yanting Dong
IPC分类号： A61B5/04
CPC分类号： A61B5/04001 , A61B5/1107 , A61B5/4052 , A61B5/686 , A61B5/7217 , A61B5/7221 , A61B5/7246 , A61B2562/0219
摘要： In an example, a system includes a cardiac pulse generator configured to generate cardiac paces to pace the heart, a sensor configured to sense a physiological signal for use in detecting pace-induced phrenic nerve stimulation where the pace-induced phrenic nerve stimulation is phrenic nerve stimulation induced by electrical cardiac pace signals, and a phrenic nerve stimulation detector configured to analyze the sensed physiological signal to detect PS beats where the PS beats are cardiac paces that induce phrenic nerve stimulation. The detector may be configured to correlate signal data for sensed beat signals to a PS template to detect PS beats, or may be configured to analyze morphological features of sensed beat signals to detect PS beats, or may be configured to detect PS beats using a combination that both correlates signal data for sensed beat signals to a PS template and analyzes morphological features of sensed beat signals.
摘要翻译：在一个示例中，系统包括心脏脉冲发生器，其被配置为产生心脏步调以心跳，传感器被配置为感测生理信号，以用于检测步速诱发的膈神经刺激，其中步速诱发的膈神经刺激是膈神经由心脏心电图信号引起的刺激，以及膈神经刺激检测器，其被配置成分析感测到的生理信号以检测PS节拍，其中PS节拍是诱导膈神经刺激的心脏步。检测器可以被配置为将用于感测的拍频信号的信号数据与PS模板相关联以检测PS拍子，或者可以被配置为分析感测的拍子信号的形态特征以检测PS拍子，或者可以被配置为使用组合来检测PS拍子两者将感测到的拍频信号的信号数据相关联到PS模板并且分析感测到的拍频信号的形态特征。

99. 发明申请

US20130158615A1 RHYTHM DISCRIMINATION ENHANCEMENT - AV DRIVE 有权
标题翻译： RHYTHM歧视增强 - AV驱动
公开(公告)号：US20130158615A1
公开(公告)日：2013-06-20
申请号：US13765186
申请日：2013-02-12
申请人： Deepa Mahajan , Yanting Dong , David L. Perschbacher
发明人： Deepa Mahajan , Yanting Dong , David L. Perschbacher
IPC分类号： A61N1/362
CPC分类号： A61N1/3621 , A61B5/0464 , A61N1/3622 , A61N1/3624 , A61N1/3704 , A61N1/3962
摘要： An apparatus comprises an implantable cardiac signal sensing circuit and a controller circuit. The implantable cardiac signal sensing circuit provides a sensed depolarization signal from a ventricle and a sensed depolarization signal from an atrium. The controller circuit includes a one-to-one detector circuit and a tachyarrhythmia discrimination circuit. The one-to-one detector circuit measures cardiac depolarization intervals of the atrium and the ventricle and determines whether a relationship of atrial depolarizations to ventricular depolarizations is substantially one-to-one. The tachyarrhythmia discrimination circuit classifies the episode as VT when detecting a shortening or prolonging of a V-V interval that immediately precedes the same shortening or prolonging of an A-A interval.
摘要翻译：一种装置包括可植入心脏信号感测电路和控制器电路。可植入心脏信号感测电路提供来自心室的感测去极化信号和来自心房的感测去极化信号。控制器电路包括一对一检测器电路和快速心律失常鉴别电路。一对一检测器电路测量心房和心室的心脏去极化间隔，并确定心房去极化与心室去极化的关系是否基本上是一对一的。快速性心律失常辨别电路在检测到紧急或延长A-A间隔之前的V-V间隔的缩短或延长时，将该发作分类为VT。

100. 发明授权

US08452405B2 Methods and systems for mitigating the occurrence of arrhythmia during atrial pacing 有权
标题翻译：减轻心房起搏心律失常发生的方法和系统
公开(公告)号：US08452405B2
公开(公告)日：2013-05-28
申请号：US12772725
申请日：2010-05-03
申请人： Eric Enrooth , Yanting Dong , Kenneth N. Hayes , Gary T. Seim , Kevin John Stalsberg , Aaron McCabe
发明人： Eric Enrooth , Yanting Dong , Kenneth N. Hayes , Gary T. Seim , Kevin John Stalsberg , Aaron McCabe
IPC分类号： A61N1/362
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： Noncaptured atrial paces can result in long-short cardiac cycles which are proarrhythmic for ventricular tachyarrhythmia. Approaches are described which are directed to avoiding proarrhythmic long-short cycles. For cardiac cycles in which the atrial pace captures the atrium, a first post ventricular refractory period (PVARP) and a first A-A interval are used. For cardiac cycles in which the atrial pace does not capture the atrium, both an extended PVARP and an extended A-A interval are used. The A-A interval following a noncaptured atrial pace is extended from an atrial depolarization sensed during the extended PVARP.
摘要翻译：非心房颤动可导致心律失常的心律失常的长时间心脏周期。描述了旨在避免心律失常长时间短周期的方法。对于心房搏动捕获心房的心脏周期，使用第一个心室后不应期（PVARP）和第一个A-A间隔。对于其中心房速度不捕获心房的心脏周期，使用延长的PVARP和延长的A-A间隔。在非扩张性PVARP期间感觉到的心房去极化之后，A-A间隔未被捕获。

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