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1. 发明申请

US20160270709A1 METHODS, SYSTEMS, AND DEVICES FOR DETERMINING AND VISUALLY INDICATING DEMYELINATED PATHWAYS 审中-公开
标题翻译：方法，系统和装置，用于确定和可视化地指示脱乙酰化途径
公开(公告)号：US20160270709A1
公开(公告)日：2016-09-22
申请号：US15034062
申请日：2014-11-04
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： Paul Jacob Maccabee , Lawrence Philip Eberle
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0488
CPC分类号： A61B5/4041 , A61B5/04012 , A61B5/0488 , A61B5/0492 , A61B5/1107 , A61B5/162 , A61B5/4052 , A61B5/6877 , A61B5/742
摘要： A method includes receiving multiple compound muscle action potential values (CMAPs), wherein each CMAP is an onset latency, a peak latency, a conduction velocity, or a response amplitude measured from a baseline; for each of the CMAPs and for each of a number parameters calculated from the CMAPs, determining a corresponding demyelinating boundary value using a normal value from a preselected population; determining whether each of the CMAPs and each of the parameters exceeds the corresponding demyelinating boundary value; determining one or more demyelinated nerve pathways based on which of the CMAPs and the parameters exceeds the corresponding demyelinating boundary value; indicating on a display which of the CMAPs and the parameters exceed the corresponding demyelinating boundary value; and displaying, in pictorial form, an anatomical diagram indicating the demyelinated nerve pathways.
摘要翻译：一种方法包括接收多个复合肌肉动作电位值（CMAP），其中每个CMAP是从基线测量的起始潜伏期，峰值潜伏期，传导速度或响应幅度; 对于每个CMAP和针对从CMAP计算的每个参数，使用来自预选群体的正常值确定相应的脱髓鞘边界值; 确定每个CMAP和每个参数是否超过相应的脱髓鞘边界值; 基于哪个CMAP和参数超过相应的脱髓鞘边界值来确定一个或多个脱髓鞘神经通路; 在显示器上指示哪个CMAP和参数超过相应的脱髓鞘边界值; 并以图示形式显示指示脱髓鞘神经通路的解剖图。

2. 发明授权

US08992444B2 Devices, systems, and methods for determining isometric and isotonic activity of luminal organs 有权
标题翻译：用于确定腔内器官的等长和等渗活性的装置，系统和方法
公开(公告)号：US08992444B2
公开(公告)日：2015-03-31
申请号：US12727909
申请日：2010-03-19
申请人： Ghassan S. Kassab , Xiao Lu
发明人： Ghassan S. Kassab , Xiao Lu
IPC分类号： A61B5/103 , A61B5/0488 , A61B5/02 , A61B5/03 , A61B5/00
CPC分类号： G01N33/5088 , A61B5/02007 , A61B5/036 , A61B5/04882 , A61B5/4047 , A61B5/4052 , A61B5/418 , A61B2503/40 , G01N3/12 , G01N33/4833
摘要： Devices, systems, and methods for determining isometric and isotonic activity of luminal organs. In an exemplary method for detecting a luminal organ response to mechanical stimulation of the present disclosure, the method comprises the steps of maintaining a luminal organ at a first internal pressure, increasing the first internal pressure of the luminal organ, and measuring a first organ parameter change in response to the increase in internal pressure. In an exemplary system for detecting a luminal organ response to mechanical stimulation of the present disclosure, the system comprises a first conduit having a proximal end, a distal end, and a lumen therethrough, the distal end sized and shaped to fit within a luminal organ, a pressure transducer, and at least one pressurized vessel capable of introducing a fluid into the lumen of the first conduit, wherein the first conduit, the pressure transducer, and the at least one pressurized vessel are either directly or indirectly coupled to one another so that a pressure of a fluid present within the first conduit can be measured using the pressure transducer.
摘要翻译：用于确定腔内器官的等长和等渗活性的装置，系统和方法。在用于检测对本公开的机械刺激的管腔器官反应的示例性方法中，所述方法包括以下步骤：将腔内器官保持在第一内部压力，增加腔内器官的第一内部压力，以及测量第一器官参数随着内部压力的增加而改变。在用于检测对本公开的机械刺激的管腔器官反应的示例性系统中，该系统包括具有近端，远端和穿过其中的腔的第一导管，该远端尺寸和形状适合于内腔器官压力传感器和能够将流体引入第一导管的内腔中的至少一个加压容器，其中第一导管，压力换能器和至少一个加压容器彼此直接或间接耦合，因此可以使用压力传感器测量存在于第一导管内的流体的压力。

3. 发明授权

US08755904B2 Circuit arrangements for generating currents and the application thereof 有权
标题翻译：用于产生电流的电路布置及其应用
公开(公告)号：US08755904B2
公开(公告)日：2014-06-17
申请号：US13934418
申请日：2013-07-03
申请人： inomed Medizintechnik GmbH
发明人： Matthias Baag
IPC分类号： A61N1/00
CPC分类号： A61B5/04001 , A61B5/04004 , A61B5/0492 , A61B5/4047 , A61B5/4052 , A61N1/36125 , A61N1/3912 , H02J4/00 , Y10T307/50
摘要： Electronic circuit arrangements for generating at least two different constant currents at a load resistor, including a bridge circuit (especially an H bridge=H bridge circuit) having at least (in the case of an H bridge, precisely) four legs, and switching elements and a bridge branch between the legs, in which the load resistor is inserted, and at least two current sources which are connected to the legs of the bridge circuit in such a manner that it provides for current via one of the legs through the bridge branch and through a leg, connected to the other end of the bridge branch, with a corresponding switch position, the at least two current sources being adjustable if desired. The use of the circuit arrangement for generating such stimulation currents and corresponding procedures currents and methods.
摘要翻译：用于在负载电阻器处产生至少两个不同恒定电流的电子电路装置，包括具有至少（在H桥的情况下，精确地）四个支腿的桥接电路（尤其是H桥= H桥电路）和开关元件以及插入负载电阻器的支腿之间的桥接支路以及连接到桥接电路的支腿的至少两个电流源，使得其经由一个支腿通过桥接支路提供电流并且通过连接到所述桥接支路的另一端的支腿具有相应的开关位置，如果需要，所述至少两个电流源是可调节的。使用电路装置产生这种刺激电流和相应的程序电流和方法。

4. 发明申请

US20140081347A1 ASSESSING COGNITIVE DISORDERS BASED ON NON-MOTOR EPILEPTIFORM BIOELECTRICAL BRAIN ACTIVITY 有权
标题翻译：基于非电动机电生理大脑活动评估认知障碍
公开(公告)号：US20140081347A1
公开(公告)日：2014-03-20
申请号：US13777091
申请日：2013-02-26
申请人： Medtronic, Inc.
发明人： Dwight E. Nelson , Jonathon E. Giftakis
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/4052 , A61B5/4088 , A61B5/4094 , A61B5/4842 , A61N1/36025 , A61N1/36064 , A61N1/36082
摘要： Various embodiments concern assessing a degenerative cognitive disorder of a patient based on a plurality of episodes of non-motor epileptiform bioelectrical activity. The non-motor epileptiform bioelectrical activity can be detected from one or more bioelectrical brain signals. A worsening cognitive disorder may be indicated by an increase in one or more of intensity, duration, and frequency of occurrence of the episodes of non-motor epileptiform bioelectrical activity. A therapy can be delivered to reduce one or more of intensity, duration, and frequency of occurrence of the episodes of non-motor epileptiform bioelectrical activity. The delivery of the therapy can be controlled based on the plurality of episodes of non-motor epileptiform bioelectrical activity.
摘要翻译：各种实施方案涉及基于多次发作的非运动性癫痫样生物电活性来评估患者的退行性认知障碍。可以从一个或多个生物电脑信号检测非运动性癫痫样生物电活动。恶化的认知障碍可以通过非运动性癫痫样生物电活动发作的强度，持续时间和发生频率中的一种或多种的增加来表示。可以递送治疗以减少非运动性癫痫样生物电活动发作的强度，持续时间和发生频率中的一种或多种。可以基于多次非运动性癫痫样生物电活动来控制治疗的递送。

5. 发明申请

US20140058284A1 NERVE MONITORING SYSTEM 审中-公开
标题翻译：神经监测系统
公开(公告)号：US20140058284A1
公开(公告)日：2014-02-27
申请号：US13591280
申请日：2012-08-22
申请人： Stephen Bartol , Christopher Wybo
发明人： Stephen Bartol , Christopher Wybo
IPC分类号： A61B5/11
CPC分类号： A61B5/1104 , A61B5/1107 , A61B5/205 , A61B5/4047 , A61B5/4052 , A61B5/4222
摘要： A neural monitoring system includes a stimulator configured to provide an electrical stimulus within an intracorporeal treatment area of a subject, an elongate sphincter contraction sensor, and a receiver in communication with the sphincter contraction sensor. The elongate sphincter contraction sensor includes an elongate device body configured to be inserted within a sphincter of the subject and a force sensor in mechanical communication with the elongate device body. The force sensor is configured to provide a mechanomyography output signal in response to a contact force applied against the elongate device body by the sphincter. The receiver is configured to receive the mechanomyography output signal from the elongate sphincter contraction sensor and provide an indicator to a user based on at least a portion of the output of the sphincter contraction sensor.
摘要翻译：神经监测系统包括被配置为在受试者的体内治疗区域内提供电刺激的刺激器，细长括约肌收缩传感器和与括约肌收缩传感器连通的接收器。细长括约肌收缩传感器包括被配置为插入到受检者的括约肌内的细长装置主体和与细长装置主体机械连通的力传感器。力传感器被配置为响应于由括约肌施加到细长装置主体的接触力而提供机械通道输出信号。接收器被配置为从细长括约肌收缩传感器接收机械通道输出信号，并且基于括约肌收缩传感器的输出的至少一部分向用户提供指示器。

6. 发明授权

US08512262B2 Energetic modulation of nerves 有权
标题翻译：神经的能量调节
公开(公告)号：US08512262B2
公开(公告)日：2013-08-20
申请号：US13535070
申请日：2012-06-27
申请人： Michael Gertner
发明人： Michael Gertner
IPC分类号： A61B5/05
CPC分类号： A61N2/006 , A61B5/0225 , A61B5/055 , A61B5/4035 , A61B5/4041 , A61B5/4047 , A61B5/4052 , A61B5/412 , A61B5/4528 , A61B5/4839 , A61B5/489 , A61B5/4893 , A61B6/03 , A61B6/032 , A61B6/037 , A61B6/506 , A61B8/00 , A61B8/06 , A61B8/08 , A61B8/4245 , A61B8/485 , A61B17/320068 , A61B18/14 , A61B18/18 , A61B90/37 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2090/374 , A61B2090/3762 , A61B2090/378 , A61N1/0551 , A61N5/00 , A61N5/0601 , A61N5/062 , A61N5/0622 , A61N7/00 , A61N7/02 , A61N2005/063 , A61N2007/0026 , A61N2007/003 , A61N2007/0078
摘要： A system to modulate an autonomic nerve in a patient utilizing transcutaneous ultrasound energy delivery includes a processor comprising an input for receiving information regarding energy and power to be delivered to a treatment region containing the nerve, and an output for outputting a signal, wherein the processor is configured to determine a position of a reference target from outside the patient to localize the nerve relative to the reference target, a therapeutic energy device comprising a transducer for delivering ultrasound energy from outside the patient, a controller to control an aiming of the transducer based at least in part on the signal from the processor, and an imaging system coupled to the processor or the therapeutic energy device.
摘要翻译：利用经皮超声能量递送来调节患者的自主神经的系统包括处理器，该处理器包括用于接收关于要传递到包含神经的治疗区域的能量和功率的信息的输入端和用于输出信号的输出端，其中处理器被配置为从患者外部确定参考目标的位置以相对于参考目标定位神经，包括用于从患者外部递送超声能量的换能器的治疗能量装置，用于控制基于传感器的瞄准的控制器至少部分地来自处理器的信号，以及耦合到处理器或治疗能量装置的成像系统。

7. 发明授权

US08346354B2 Determining a neuromodulation treatment regimen in response to contactlessly acquired information 有权
标题翻译：根据无接触获取的信息确定神经调节治疗方案
公开(公告)号：US08346354B2
公开(公告)日：2013-01-01
申请号：US12462123
申请日：2009-07-28
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： A61N1/00
CPC分类号： A61B5/04001 , A61B5/4052 , A61B5/6846 , A61N1/3601 , A61N1/36014 , A61N1/36078 , A61N1/3611 , A61N1/36139 , A61N1/37211
摘要： Described embodiments include a system, an apparatus, and a method. A described system includes a sensor device configured to sense a property of a mammal without physically contacting the mammal. The system also includes a signal generator configured to generate a signal indicative of the sensed property of the mammal. The system further includes a treatment decision device configured to determine in response to the signal indicative of the sensed property of the mammal a neuromodulation treatment regimen for administration to a nervous system component of the mammal. The system also includes a computer-readable medium configured to maintain and to provide access to information corresponding to the determined neuromodulation treatment regimen.
摘要翻译：所描述的实施例包括系统，装置和方法。所描述的系统包括被配置为感测哺乳动物的性质而不与哺乳动物物理接触的传感器装置。该系统还包括被配置为产生指示哺乳动物感测到的特性的信号的信号发生器。该系统还包括治疗决定装置，其被配置为响应于指示哺乳动物感测到的属性的信号确定用于给予哺乳动物的神经系统组分的神经调节治疗方案。该系统还包括计算机可读介质，其配置为维持并提供对与确定的神经调节治疗方案相对应的信息的访问。

8. 发明申请

US20120245494A1 METHODS FOR TREATMENT USING ULTRASONIC ENERGY 审中-公开
标题翻译：使用超声能量治疗的方法
公开(公告)号：US20120245494A1
公开(公告)日：2012-09-27
申请号：US13487118
申请日：2012-06-01
申请人： Michael Gertner
发明人： Michael Gertner
IPC分类号： A61N7/00
CPC分类号： A61N2/006 , A61B5/0225 , A61B5/055 , A61B5/4035 , A61B5/4041 , A61B5/4047 , A61B5/4052 , A61B5/412 , A61B5/4528 , A61B5/4839 , A61B5/489 , A61B5/4893 , A61B6/03 , A61B6/032 , A61B6/037 , A61B6/506 , A61B8/00 , A61B8/06 , A61B8/08 , A61B8/4245 , A61B8/485 , A61B17/320068 , A61B18/14 , A61B18/18 , A61B90/37 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2090/374 , A61B2090/3762 , A61B2090/378 , A61N1/0551 , A61N5/00 , A61N5/0601 , A61N5/062 , A61N5/0622 , A61N7/00 , A61N7/02 , A61N2005/063 , A61N2007/0026 , A61N2007/003 , A61N2007/0078
摘要： In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.
摘要翻译：在一些实例中，围绕动脉或通向器官的神经以能量来靶向以校正或调节生理过程。在一些示例中，不同类型的能量源单独使用或彼此组合使用。在一些实例中，由能量源激活的生物活性剂或装置被输送到感兴趣的区域，并且能量被这种试剂增强，或者这些试剂被能量源增强。

9. 发明申请

US20120238918A1 METHODS FOR DELIVERING ENERGY TO MODULATE NEURAL STRUCTURES 审中-公开
标题翻译：提供能量来调节神经结构的方法
公开(公告)号：US20120238918A1
公开(公告)日：2012-09-20
申请号：US13487121
申请日：2012-06-01
申请人： Michael Gertner
发明人： Michael Gertner
IPC分类号： A61N7/00
CPC分类号： A61N2/006 , A61B5/0225 , A61B5/055 , A61B5/4035 , A61B5/4041 , A61B5/4047 , A61B5/4052 , A61B5/412 , A61B5/4528 , A61B5/4839 , A61B5/489 , A61B5/4893 , A61B6/03 , A61B6/032 , A61B6/037 , A61B6/506 , A61B8/00 , A61B8/06 , A61B8/08 , A61B8/4245 , A61B8/485 , A61B17/320068 , A61B18/14 , A61B18/18 , A61B90/37 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2090/374 , A61B2090/3762 , A61B2090/378 , A61N1/0551 , A61N5/00 , A61N5/0601 , A61N5/062 , A61N5/0622 , A61N7/00 , A61N7/02 , A61N2005/063 , A61N2007/0026 , A61N2007/003 , A61N2007/0078
摘要： In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.
摘要翻译：在一些实例中，围绕动脉或通向器官的神经以能量来靶向以校正或调节生理过程。在一些示例中，不同类型的能量源单独使用或彼此组合使用。在一些实例中，由能量源激活的生物活性剂或装置被输送到感兴趣的区域，并且能量被这种试剂增强，或者这些试剂被能量源增强。

10. 发明申请

US20120172723A1 INTRAVASCULAR CATHETER TO DELIVER UNFOCUSED ENERGY TO NERVES SURROUNDING A BLOOD VESSEL 审中-公开
标题翻译：输血管导管将不可聚光的能量输送到血管周围的血管
公开(公告)号：US20120172723A1
公开(公告)日：2012-07-05
申请号：US13417194
申请日：2012-03-09
申请人： Michael Gertner
发明人： Michael Gertner
IPC分类号： A61N7/02 , A61H1/00 , A61B18/00 , A61N7/00 , A61B8/00
CPC分类号： A61N2/006 , A61B5/0225 , A61B5/055 , A61B5/4035 , A61B5/4041 , A61B5/4047 , A61B5/4052 , A61B5/412 , A61B5/4528 , A61B5/4839 , A61B5/489 , A61B5/4893 , A61B6/03 , A61B6/032 , A61B6/037 , A61B6/506 , A61B8/00 , A61B8/06 , A61B8/08 , A61B8/4245 , A61B8/485 , A61B17/320068 , A61B18/14 , A61B18/18 , A61B90/37 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2090/374 , A61B2090/3762 , A61B2090/378 , A61N1/0551 , A61N5/00 , A61N5/0601 , A61N5/062 , A61N5/0622 , A61N7/00 , A61N7/02 , A61N2005/063 , A61N2007/0026 , A61N2007/003 , A61N2007/0078
摘要： In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.
摘要翻译：在一些实例中，围绕动脉或通向器官的神经以能量来靶向以校正或调节生理过程。在一些示例中，不同类型的能量源单独使用或彼此组合使用。在一些实例中，由能量源激活的生物活性剂或装置被输送到感兴趣的区域，并且能量被这种试剂增强，或者这些试剂被能量源增强。

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