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91. 发明申请

US20090177104A1 System and Method for Distinguishing Among Cardiac Ischemia, Hypoglycemia and Hyperglycemia Using an Implantable Medical Device 有权
标题翻译：使用植入式医疗器械区分心脏缺血，低血糖和高血糖的系统和方法
公开(公告)号：US20090177104A1
公开(公告)日：2009-07-09
申请号：US12360822
申请日：2009-01-27
申请人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
IPC分类号： A61B5/0472
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/0468 , A61B5/14532 , A61N1/3621 , A61N1/3627 , A61N1/36557 , A61N1/3925
摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.
摘要翻译：描述了基于心内电描记图（IEGM）信号检测缺血，低血糖或高血糖的技术。基于QRS复合体与T波结束（QTmax）之间的间隔的缩短单独或与ST段抬高的变化相结合来检测局部缺血。或者，基于ST段抬高的变化结合QRS复合体与T波结束（QTend）之间的间隔的最小变化来检测局部缺血。基于ST段抬高的变化以及QTmax或QTend的延长来检测低血糖。基于ST段抬高的变化以及QTmax和QTend中的最小变化来检测高血糖。通过利用QTmax和QTend与ST段抬高相结合，可以将由低/高血糖引起的ST段抬高的变化与缺血引起的变化进行适当区分。

92. 发明授权

US07502644B2 System and method for distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device 有权
标题翻译：使用可植入医疗器械区分心脏缺血，低血糖和高血糖的系统和方法
公开(公告)号：US07502644B2
公开(公告)日：2009-03-10
申请号：US11043612
申请日：2005-01-25
申请人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael Benser , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael Benser , Gene A. Bornzin
IPC分类号： A61B5/0468
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/0468 , A61B5/14532 , A61N1/3621 , A61N1/3627 , A61N1/36557 , A61N1/3925
摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.
摘要翻译：描述了基于心内电描记图（IEGM）信号检测缺血，低血糖或高血糖的技术。基于QRS复合体与T波结束（QTmax）之间的间隔的缩短单独或与ST段抬高的变化相结合来检测局部缺血。或者，基于ST段抬高的变化结合QRS复合体与T波结束（QTend）之间的间隔的最小变化来检测局部缺血。基于ST段抬高的变化以及QTmax或QTend的延长来检测低血糖。基于ST段抬高的变化以及QTmax和QTend中的最小变化来检测高血糖。通过利用QTmax和QTend与ST段抬高相结合，可以将由低/高血糖引起的ST段抬高的变化与缺血引起的变化进行适当区分。

93. 发明授权

US07297114B2 System and method for distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device 有权
标题翻译：使用可植入医疗器械区分心脏缺血，低血糖和高血糖的系统和方法
公开(公告)号：US07297114B2
公开(公告)日：2007-11-20
申请号：US11043804
申请日：2005-01-25
申请人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael Benser , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael Benser , Gene A. Bornzin
IPC分类号： A61B5/0452
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/0468 , A61B5/14532 , A61N1/3621 , A61N1/3627 , A61N1/36557 , A61N1/3925
摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.
摘要翻译：描述了基于心内电描记图（IEGM）信号检测缺血，低血糖或高血糖的技术。基于QRS复合体与T波结束（QTmax）之间的间隔的缩短单独或与ST段抬高的变化相结合来检测局部缺血。或者，基于ST段抬高的变化结合QRS复合体与T波结束（QTend）之间的间隔的最小变化来检测局部缺血。基于ST段抬高的变化以及QTmax或QTend的延长来检测低血糖。基于ST段抬高的变化以及QTmax和QTend中的最小变化来检测高血糖。通过利用QTmax和QTend与ST段抬高相结合，可以将由低/高血糖引起的ST段抬高的变化与缺血引起的变化进行适当区分。

94. 发明授权

US07295873B1 Anti-tachycardia pacing method and apparatus for multi-chamber pacing 有权
标题翻译：用于多室起搏的抗心动过速起搏方法和装置
公开(公告)号：US07295873B1
公开(公告)日：2007-11-13
申请号：US10893710
申请日：2004-07-15
申请人： Xiaoyi Min , Gene A. Bornzin , Mark W. Kroll
发明人： Xiaoyi Min , Gene A. Bornzin , Mark W. Kroll
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： Improved methods and devices perform tachycardia detection and anti-tachycardia pacing (ATP) to convert a tachycardia (e.g., VT or AT) to normal sinus rhythm. According to one embodiment, an anti-tachycardia pacing method includes sensing, during sinus rhythm, first and second cardiac signals at first and second sites, respectively, in a patient's heart. The first and second sites include left and right ventricles or left and right atria, for example. The method further includes sensing third and fourth cardiac signals at the first and second sites, respectively, during a tachycardia (e.g., ventricular tachycardia or atrial tachycardia). The cardiac signals are processed to provide respective values. One or more anti-tachycardia pacing pulses are delivered at the site closest to the reentrant circuit based on a comparison of a first ratio of the first and third values and a second ratio of the second and fourth values. Unipolar sensing of the cardiac signals may be employed by, for example, shorting together pairs of electrodes implanted at each site.
摘要翻译：改进的方法和装置执行心动过速检测和抗心动过速起搏（ATP）以将心动过速（例如VT或AT）转换为正常窦性心律。根据一个实施例，抗心动过速起搏方法包括在病人心脏中分别在窦性心律期间感测第一和第二部位的第一和第二心脏信号。第一和第二个地点包括左心室和右心室，例如左心房和右心房。该方法还包括在心动过速（例如，室性心动过速或心房心动过速）期间分别在第一和第二位置处感测第三和第四心脏信号。处理心脏信号以提供相应的值。基于第一值和第三值的第一比率以及第二和第四值的第二比率的比较，在最靠近可重入电路的位置处递送一个或多个抗心动过速起搏脉冲。可以通过例如将植入在每个部位的电极对短路来采用心脏信号的单极性感测。

95. 发明授权

US07272436B2 System and method for distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device 有权
公开(公告)号：US07272436B2
公开(公告)日：2007-09-18
申请号：US11043780
申请日：2005-01-25
申请人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael Benser , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael Benser , Gene A. Bornzin
IPC分类号： A61B5/0452
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/0468 , A61B5/14532 , A61N1/3621 , A61N1/3627 , A61N1/36557 , A61N1/3925
摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

96. 发明授权

US07218960B1 System and method for detecting cardiac ischemia based on T-waves using an implantable medical device 有权
标题翻译：使用可植入医疗装置检测基于T波的心脏缺血的系统和方法
公开(公告)号：US07218960B1
公开(公告)日：2007-05-15
申请号：US10606299
申请日：2003-06-24
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/7242 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.
摘要翻译：提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发病的方法。简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

97. 发明申请

US20130116741A1 DUAL-CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE WITH INTRA-CARDIAC EXTENSION 有权
标题翻译：双室无胸腔内科医疗器械与心脏扩张
公开(公告)号：US20130116741A1
公开(公告)日：2013-05-09
申请号：US13352136
申请日：2012-01-17
申请人： Gene A. Bornzin , Gabriel A. Mouchawar , Xiaoyi Min , John W. Poore , Edward Karst , Richard Samade , Zoltan Somogyi , Didier Theret
发明人： Gene A. Bornzin , Gabriel A. Mouchawar , Xiaoyi Min , John W. Poore , Edward Karst , Richard Samade , Zoltan Somogyi , Didier Theret
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/057 , A61N1/0573 , A61N1/3622 , A61N1/368 , A61N1/3684 , A61N1/3688 , A61N1/3756
摘要： A leadless intra-cardiac medical device includes a housing that is configured to be implanted entirely within a single local chamber of the heart. A first electrode is provided on the housing at a first position such that when the housing is implanted in the local chamber, the first electrode engages the local wall tissue at a local activation site within the conduction network of the local chamber. An intra-cardiac extension is coupled to the housing and configured to extend from the local chamber into an adjacent chamber of the heart. A stabilization arm of the intra-cardiac extension engages the adjacent chamber. A second electrode on the intra-cardiac extension engages distal wall tissue at a distal activation site within the conduction network of the adjacent chamber.
摘要翻译：无引线心脏内心脏医疗设备包括被配置为完全植入心脏的单个局部腔室内的壳体。第一电极在第一位置处设置在壳体上，使得当壳体被植入局部腔室时，第一电极在局部腔室的传导网络内的局部激活位置接合局部壁组织。心脏内延伸部分耦合到壳体并且构造成从局部腔室延伸到心脏的相邻室中。心脏内延伸部的稳定臂与相邻的腔室相接合。心脏延伸部分上的第二个电极与相邻腔室的传导网络内的远端活化位点处的远端壁组织接合。

98. 发明申请

US20110152990A1 MRI COMPATIBLE LEAD EMPLOYING MULTIPLE MINIATURE INDUCTORS 审中-公开
标题翻译： MRI兼容多用途微电极的铅
公开(公告)号：US20110152990A1
公开(公告)日：2011-06-23
申请号：US12645252
申请日：2009-12-22
申请人： Ramez Shehada , Xiaoyi Min , Jin Zhang , Benjamin Coppola , Dave Anderson , Gene A. Bornzin , Phong D. Doan
发明人： Ramez Shehada , Xiaoyi Min , Jin Zhang , Benjamin Coppola , Dave Anderson , Gene A. Bornzin , Phong D. Doan
IPC分类号： A61N1/05 , H03H7/01
CPC分类号： A61N1/05 , A61N1/086 , H03H7/0115 , H03H2007/013
摘要： An implantable medical lead is disclosed herein. The lead includes a first electrode and a first electrical circuit. The first electrode is near a distal portion of the lead. The first electrical circuit extends through the lead to the first electrode and includes at least one conductor and a first band stop filter coupled between the distal end of the conductor and the electrode. The first band stop filter includes a first group of inductors in parallel and a second group of inductors in parallel. The first group is in series with the second group. The first group of inductors may include a self resonant L. The first group of inductors may include a self resonant tank LC. The first group of inductors may include a miniature self resonant L or miniature self resonant tank LC. The first group of inductors may include an integrated circuit of L and C components.
摘要翻译：本文公开了可植入医疗引线。引线包括第一电极和第一电路。第一电极靠近导线的远端部分。第一电路通过引线延伸到第一电极并且包括耦合在导体的远端和电极之间的至少一个导体和第一带阻滤波器。第一带阻滤波器包括并联的第一组电感器和并联的第二组电感器。第一组与第二组合作。第一组电感器可以包括自谐振L。第一组电感器可以包括自谐振槽LC。第一组电感器可以包括微型自谐振L或微型自谐振箱LC。第一组电感器可以包括L和C组件的集成电路。

99. 发明授权

US07917216B1 Multi-site pacing for atrial tachyarrhythmias 有权
标题翻译：多节段起搏用于房性快速性心律失常
公开(公告)号：US07917216B1
公开(公告)日：2011-03-29
申请号：US11458649
申请日：2006-07-19
申请人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
IPC分类号： A61N1/18
CPC分类号： A61N1/3622 , A61N1/0587 , A61N1/3686
摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.
摘要翻译：通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

100. 发明授权

US07850616B1 Determination of diastolic heart failure 有权
标题翻译：舒张性心力衰竭的测定
公开(公告)号：US07850616B1
公开(公告)日：2010-12-14
申请号：US11154064
申请日：2005-06-15
申请人： Jong Gill , Xiaoyi Min , Gene A. Bornzin , Falkenberg Eric
发明人： Jong Gill , Xiaoyi Min , Gene A. Bornzin , Falkenberg Eric
IPC分类号： A61B5/021 , A61B5/0225
CPC分类号： A61B5/0215 , A61B5/042 , A61B5/0464 , A61B5/053 , A61B7/00 , A61N1/36578
摘要： An exemplary method includes detecting a change in state of a cardiac valve, detecting elongation of the left ventricle substantially along its major axis, determining a time difference between the change in state of the cardiac valve and the elongation of the left ventricle and, based at least in part on the time difference, deciding whether a diastolic abnormality exists. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括检测心脏瓣膜的状态变化，检测左心室基本上沿其长轴的伸长，确定心脏瓣膜状态变化与左心室伸长之间的时间差，并基于至少部分地基于时间差，决定是否存在舒张异常。还公开了其它示例性方法，装置，系统等。

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