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91. 发明授权

US07163797B2 50 human secreted proteins 失效
标题翻译： 50种人体分泌的蛋白质
公开(公告)号：US07163797B2
公开(公告)日：2007-01-16
申请号：US10970493
申请日：2004-10-22
申请人： Steven M. Ruben , Craig A. Rosen , Reinhard Ebner
发明人： Steven M. Ruben , Craig A. Rosen , Reinhard Ebner
IPC分类号： G01N33/53 , C12N5/00 , C12N5/02 , C12N1/20 , C12N5/06 , C12N5/16 , C12N5/12 , C12N5/22 , C07K16/00 , C07K16/18 , C12P21/08
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

92. 发明授权

US07064189B2 Antibodies that immunospecifically bind to trail receptors 有权
公开(公告)号：US07064189B2
公开(公告)日：2006-06-20
申请号：US10139785
申请日：2002-05-07
申请人： Theodora Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
发明人： Theodora Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , A61K31/00 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/2878 , C07K2317/565 , C07K2317/622 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

93. 发明授权

US06844170B1 Cytokine receptor common gamma chain like 有权
标题翻译：细胞因子受体常见γ链
公开(公告)号：US06844170B1
公开(公告)日：2005-01-18
申请号：US09263626
申请日：1999-03-05
申请人： Paul A. Moore , Craig A. Rosen , Steven M. Ruben
发明人： Paul A. Moore , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K14/715 , C07K1/00 , C07H21/04 , C12N1/20 , C12P21/06
CPC分类号： C07K14/715
摘要： The present invention relates to a novel human protein called Cytokine Receptor Common Gamma Chain Like, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译：本发明涉及称为细胞因子受体通用γ链的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

94. 发明授权

US06824993B2 Antibodies that bind human prostate specific G-protein receptor HPRAJ70 失效
标题翻译：结合人前列腺特异性G蛋白受体HPRAJ70的抗体
公开(公告)号：US06824993B2
公开(公告)日：2004-11-30
申请号：US09968033
申请日：2001-10-02
申请人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K1618
CPC分类号： C07K16/28 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/705 , C07K2317/622
摘要： The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.
摘要翻译：本发明涉及PSGR，一种与在前列腺癌中过表达的G蛋白偶联受体具有同源性的新型前列腺特异性基因。更具体地，本发明涉及PSGR多核苷酸和由这些多核苷酸编码的多肽，以及使用PSGR多核苷酸和多肽来检测生殖系统疾病，包括前列腺疾病，特别是癌症的存在。本发明涉及PSGR多核苷酸和多肽以及载体，宿主细胞，针对PSGR多核苷酸和多肽的抗体以及用于制备它的重组和合成方法。还提供了用于诊断，治疗，预防和/或预后与前列腺相关的疾病（包括癌症）的方法。本发明还涉及用于鉴定本发明的PSGR多核苷酸和多肽的激动剂和拮抗剂的筛选方法以及用于抑制或增强本发明的PSGR多肽的产生和/或功能的方法和/或组合物。

95. 发明授权

US06569992B1 Protein HLQDR48 失效
标题翻译：蛋白HLQDR48
公开(公告)号：US06569992B1
公开(公告)日：2003-05-27
申请号：US09369247
申请日：1999-08-05
申请人： David W. LaFleur , Steven M. Ruben , Craig A. Rosen , Paul A. Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
发明人： David W. LaFleur , Steven M. Ruben , Craig A. Rosen , Paul A. Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
IPC分类号： A61K3800
CPC分类号： C12Q1/6883 , A61K35/13 , A61K38/00 , C07K14/47 , G01N33/6893 , Y02A50/465
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

96. 发明授权

US06486301B1 Interleukin-20 失效
标题翻译：白细胞介素20
公开(公告)号：US06486301B1
公开(公告)日：2002-11-26
申请号：US09231788
申请日：1999-01-15
申请人： Reinhard Ebner , Marianne Murphy , Steven M. Ruben , Jing-Shan Hu , D. Roxanne Duan , Kimberly A. Florence , Craig A. Rosen
发明人： Reinhard Ebner , Marianne Murphy , Steven M. Ruben , Jing-Shan Hu , D. Roxanne Duan , Kimberly A. Florence , Craig A. Rosen
IPC分类号： C07K14475
CPC分类号： C07K14/47 , A61K38/00 , C07K14/54 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel IL-20 protein which is a member of the cytokine polypeptide family. In particular, isolated nucleic acid molecules are provided encoding the human IL-20 protein. IL-20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL-20 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及作为细胞因子多肽家族成员的新型IL-20蛋白。特别地，提供编码人IL-20蛋白的分离的核酸分子。还提供了IL-20多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定IL-20活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

97. 发明授权

US06416984B1 Human DNA mismatch repair proteins 失效
标题翻译：人类DNA错配修复蛋白
公开(公告)号：US06416984B1
公开(公告)日：2002-07-09
申请号：US08468024
申请日：1995-06-06
申请人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
发明人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
IPC分类号： C12N900
CPC分类号： C07K14/47 , Y10T436/143333
摘要： The invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
摘要翻译：本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA），以及通过重组技术生产此类蛋白质的方法。人类DNA修复蛋白hMLH1已被映射到染色体3，而hMLH2已被映射到染色体2，并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可用于治疗和诊断治疗遗传易感性癌症。

98. 发明授权

US06372456B1 Polynucleotides encoding chemokine &agr;-6 失效
标题翻译：编码趋化因子α-6的多核苷酸
公开(公告)号：US06372456B1
公开(公告)日：2002-04-16
申请号：US09177304
申请日：1998-10-23
申请人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
发明人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
IPC分类号： C12N1519
CPC分类号： C07K16/24 , A61K38/00 , C07K14/522
摘要： The present invention relates to a novel CK(&agr;-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK&agr;-6 protein. CK&agr;-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK&agr;-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.
摘要翻译：本发明涉及一种新的CK（α-6蛋白，其是α趋化因子家族的成员，特别是编码人CKalpha-6蛋白的分离的核酸分子，也提供了CKalpha-6多肽本发明还涉及用于鉴定CKalpha-6活性的激动剂和拮抗剂的筛选方法，还提供了用于检测CNS和免疫系统相关疾病的诊断方法以及用于治疗CNS和免疫系统相关疾病。

99. 发明授权

US06338951B1 G-protein parathyroid hormone receptor HLTDG74 失效
公开(公告)号：US06338951B1
公开(公告)日：2002-01-15
申请号：US09236468
申请日：1999-01-25
申请人： Daniel Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人： Daniel Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K1472
CPC分类号： C07K14/723 , A61K48/00 , C12N2799/026
摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

100. 发明授权

US5948890A Human G-protein receptor HPRAJ70 失效
公开(公告)号：US5948890A
公开(公告)日：1999-09-07
申请号：US53303
申请日：1998-04-01
申请人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K14/705 , C07K16/28
CPC分类号： C07K16/28 , A61K2039/505
摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

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