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91. 发明申请

US20130092299A1 HEAT TREATING APPARATUSES HAVING A MAGNETIC DRIVE SYSTEM AND RELATED METHODS 审中-公开
标题翻译：具有磁力驱动系统的热处理装置及相关方法
公开(公告)号：US20130092299A1
公开(公告)日：2013-04-18
申请号：US13271917
申请日：2011-10-12
申请人： Rainer Bregulla , Randolf Von Oepen
发明人： Rainer Bregulla , Randolf Von Oepen
IPC分类号： C22F1/18 , C21D11/00 , C22F1/00 , C21D1/773
CPC分类号： C22C27/02 , C22F1/18
摘要： Embodiments of methods for vacuum heat treating refractory metal articles (e.g., implantable medical devices), and heat treating apparatuses for use in such methods are disclosed. Heat treating refractory metal articles under high vacuum (e.g., 10−6 Torr) may improve strength and ductility and remove material contaminants (e.g., oxygen or hydrogen) that may be absorbed during manufacturing processes. Heat treating methods include disposing a refractory metal article in a heat treating apparatus, drawing a vacuum therein, and moving the article to a heated zone in the furnace using a drive system that permits movement of the article while the vacuum is maintained in the apparatus. A heat treating apparatus may include an elongate furnace tube that may be sealed and placed under vacuum, a heating element disposed around at least a portion of the tube, and a drive system configured for moving articles disposed inside the furnace tube while under vacuum.
摘要翻译：公开了用于真空热处理难熔金属制品（例如，可植入医疗装置）的方法的实施例和用于这种方法的热处理装置。在高真空（例如，10 -6乇）下热处理难熔金属制品可以提高强度和延展性，并去除可能在制造过程中被吸收的材料污染物（例如氧气或氢气）。热处理方法包括将难熔金属制品放置在热处理装置中，在其中抽吸真空，并使用驱动系统将制品移动到炉中的加热区域，该驱动系统允许制品在设备内保持真空的同时运动。热处理装置可以包括可以密封并放置在真空下的细长的炉管，设置在管的至少一部分周围的加热元件，以及构造成用于在真空下移动设置在炉管内部的物品的驱动系统。

92. 发明授权

US08303645B2 Methods and apparatus for a stent having an expandable web structure 有权
标题翻译：具有可扩张腹板结构的支架的方法和装置
公开(公告)号：US08303645B2
公开(公告)日：2012-11-06
申请号：US12875971
申请日：2010-09-03
申请人： Randolf Von Oepen , Gerd Seibold
发明人： Randolf Von Oepen , Gerd Seibold
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558
摘要： The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations.
摘要翻译：本发明提供了一种支架，其包括管状柔性体，其具有壁，所述壁具有可从收缩输送构型扩展到展开构造的腹板结构。网状结构包括多个相邻的网状图案，其中每个网状图案由邻接的网构成，并且网状图案互连。每个邻接的腹板包括插入在两个横向部分之间以形成凹形或凸形构造的中心部分。

93. 发明申请

US20120259400A1 FLEXIBLE INTRALUMINAL SCAFFOLD 审中-公开
标题翻译：灵活的内窥镜SCAFFOLD
公开(公告)号：US20120259400A1
公开(公告)日：2012-10-11
申请号：US13350529
申请日：2012-01-13
申请人： Randolf Von Oepen , Kevin J. Ehrenreich
发明人： Randolf Von Oepen , Kevin J. Ehrenreich
IPC分类号： A61F2/86 , A61F2/84
CPC分类号： A61F2/86 , A61F2/966 , A61F2002/9505 , A61F2002/9665 , A61F2210/0076 , A61F2220/0016 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0058 , A61F2230/0076 , A61F2230/0093
摘要： Expandable intraluminal scaffold defining a longitudinal axis is provided, wherein the scaffold includes at least two filaments extending from a head portion disposed along the longitudinal axis at a first longitudinal end, each of the at least two filaments including a free end portion at a second longitudinal end opposite the head portion. The at least two filaments converge toward each other at a juncture disposed proximate the longitudinal axis between the first longitudinal end and the second longitudinal end. A system including a delivery system and the intraluminal scaffold, as well as a method of delivering the scaffold, is also provided.
摘要翻译：提供了限定纵向轴线的可展开的管腔内支架，其中所述支架包括至少两根从沿所述纵向轴线设置的头部部分延伸的细丝，所述头部沿第一纵向端部延伸，所述至少两根细丝中的每一个包括在第二纵向在头部相对的端部。所述至少两根细丝在第一纵向端和第二纵向端之间的纵向轴线附近的接合部处朝向彼此会聚。还提供了包括递送系统和管腔内支架的系统以及递送支架的方法。

94. 发明授权

US08261420B2 Method and apparatus for reducing stress during stent manufacture 有权
标题翻译：用于减少支架制造过程中的压力的方法和装置
公开(公告)号：US08261420B2
公开(公告)日：2012-09-11
申请号：US12119945
申请日：2008-05-13
申请人： Randolf Von Oepen , Travis Richard Yribarren , Richard Roy Newhauser , Rainer Bregulla
发明人： Randolf Von Oepen , Travis Richard Yribarren , Richard Roy Newhauser , Rainer Bregulla
IPC分类号： B23P17/00 , A61F2/06
CPC分类号： A61F2/91 , A61F2210/0014 , A61F2230/0013 , A61F2230/0054 , A61F2240/001 , Y10T29/49863 , Y10T29/49865 , Y10T29/53657 , Y10T29/53909 , Y10T29/53987 , Y10T29/53996 , Y10T29/54
摘要： The invention relates to a method and apparatus of reducing stress during stent manufacture. Particularly, the invention is directed to a method and apparatus for expanding a stent using primarily radial loads thereby reducing the stresses that are generated due to the axial loads applied during loading of the stent onto a mandrel or other expansion device. The method of the invention provides for the stepwise expansion of shape memory stents, while reducing the overall stresses that the stent encounters, and thereby improving manufacturing yields due to fractured struts during expansion.
摘要翻译：本发明涉及减少支架制造过程中的压力的方法和装置。特别地，本发明涉及一种用于使用主要径向载荷来扩张支架的方法和装置，从而减少由于在将支架装载到心轴或其它扩张装置上时施加的轴向载荷而产生的应力。本发明的方法提供了形状记忆支架的逐步扩张，同时降低了支架遭受的总体应力，从而提高了在扩张期间由于断裂的支柱引起的制造产量。

95. 发明申请

US20120209368A1 SYSTEM AND METHOD FOR DELIVERING A STENT TO A BIFURCATED VESSEL 审中-公开
标题翻译：用于将固体输送到分散的容器的系统和方法
公开(公告)号：US20120209368A1
公开(公告)日：2012-08-16
申请号：US13458768
申请日：2012-04-27
申请人： Randolf Von Oepen , Thomas Michael Rieth , Lorcan James Coffey , Richard Roy Newhauser , Travis Richard Yribarren
发明人： Randolf Von Oepen , Thomas Michael Rieth , Lorcan James Coffey , Richard Roy Newhauser , Travis Richard Yribarren
IPC分类号： A61F2/84
CPC分类号： A61F2/954 , A61F2/91 , A61F2/958 , A61F2002/821 , A61F2250/0098 , A61M25/1002
摘要： A stent delivery catheter system for accurately positioning a stent in a bifurcated vessel is disclosed. The system includes a catheter having a terminal portion and distal tip that is placed in a main branch of the vessel proximate the bifurcation. A fixed guidewire is attached to distal tip. A port is defined in the terminal portion of the catheter. The port is aligned with an ostium of a side branch of the bifurcated vessel to allow the passage of a stent delivery device, such as a balloon catheter having a stent crimped thereon, into the side branch. Radiopaque bands are positioned on opposite ends of the port. A positioning balloon is included on a surface of the catheter opposite the port and is selectively inflatable to position the radiopaque bands adjacent the side branch ostium. The radiopaque bands are referenced to place the stent proximate the side branch ostium.
摘要翻译：公开了一种用于将支架精确定位在分叉血管中的支架输送导管系统。该系统包括具有末端部分和远侧末端的导管，其被放置在靠近分叉处的血管的主分支中。固定的导丝连接到远端。端口被限定在导管的末端部分。端口与分叉血管的侧分支的口对准，以允许支架输送装置（例如具有卷曲在其上的支架的球囊导管）通入侧支。无线电波段位于端口的相对端。定位球囊包括在导管的与端口相对的表面上，并且选择性地可充气以将不透射线的带定位在侧分支口附近。参考不透射线带将支架置于侧分支口附近。

96. 发明申请

US20120065719A1 MEDICAL DEVICE SHIELD AND METHODS FOR DELIVERING A MEDICAL DEVICE 审中-公开
标题翻译：医疗装置护罩及用于输送医疗装置的方法
公开(公告)号：US20120065719A1
公开(公告)日：2012-03-15
申请号：US13220123
申请日：2011-08-29
申请人： Randolf Von Oepen , Travis R. Yribarren , Alex D. Alviar , Barbara E. Stamberg
发明人： Randolf Von Oepen , Travis R. Yribarren , Alex D. Alviar , Barbara E. Stamberg
IPC分类号： A61F2/06 , A61M25/00
CPC分类号： A61F2/0095 , A61F2002/9505 , A61F2002/9583 , A61F2002/9665
摘要： Device shields for packaging and protecting medical devices during storage and deployment. A device shield includes a body or housing configured to maintain a medical device and at least a portion of a medical device delivery apparatus within the body or housing, and a limit element having a first constraining position and a second open position.
摘要翻译：在存储和部署期间用于包装和保护医疗设备的设备屏蔽。设备屏蔽包括被配置为将医疗设备和医疗设备传送设备的至少一部分保持在主体或外壳内的主体或外壳以及具有第一约束位置和第二打开位置的限制元件。

97. 发明申请

US20110184509A1 DUAL SHEATH ASSEMBLY AND METHOD OF USE 审中-公开
标题翻译：双层组件及其使用方法
公开(公告)号：US20110184509A1
公开(公告)日：2011-07-28
申请号：US12694821
申请日：2010-01-27
申请人： Randolf Von Oepen , Travis R. Yribarren
发明人： Randolf Von Oepen , Travis R. Yribarren
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/958 , A61F2/97 , A61F2002/9583 , A61F2250/0018
摘要： A sheath assembly is provided for protecting a stent mounted on a catheter. An inner tubular member is positioned over the stent without longitudinal movement of the inner tubular member along the stent surface thereby eliminating the possibility of scraping or scratching a drug coating or polymer coating on the stent surface or balloon surface. An outer tubular member slides over the inner tubular member to firmly compress it onto the stent for further protection. In use, the outer tubular member is removed from over the inner tubular member so that the two half-cylindrical portions of the inner tubular member can fall away from the stent without longitudinal movement along the stent surface.
摘要翻译：提供护套组件用于保护安装在导管上的支架。内部管状构件被定位在支架上方，而不沿着支架表面的内部管状构件的纵向移动，从而消除刮擦或刮擦支架表面或气囊表面上的药物涂层或聚合物涂层的可能性。外部管状构件在内部管状构件上滑动以将其牢固地压缩到支架上用于进一步保护。在使用中，外部管状构件从内部管状构件上方移除，使得内部管状构件的两个半圆柱形部分可以从支架脱落而不沿着支架表面纵向移动。

98. 发明授权

US07927364B2 Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation 有权
公开(公告)号：US07927364B2
公开(公告)日：2011-04-19
申请号：US10859636
申请日：2004-06-03
申请人： Joost J. Fierens , Silvio R. Schaffner , Marc Gianotti , Gerd Seibold , Randolf Von Oepen
发明人： Joost J. Fierens , Silvio R. Schaffner , Marc Gianotti , Gerd Seibold , Randolf Von Oepen
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.

99. 发明申请

US20110004289A1 METHODS AND APPARATUS FOR A STENT HAVING AN EXPANDABLE WEB STRUCTURE 有权
标题翻译：具有可扩展网络结构的方法和装置
公开(公告)号：US20110004289A1
公开(公告)日：2011-01-06
申请号：US12875971
申请日：2010-09-03
申请人： Randolf Von Oepen , Gerd Seibold
发明人： Randolf Von Oepen , Gerd Seibold
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558
摘要： The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations.
摘要翻译：本发明提供了一种支架，其包括管状柔性体，其具有壁，所述壁具有可从收缩输送构型扩展到展开构造的腹板结构。网状结构包括多个相邻的网状图案，其中每个网状图案由邻接的网构成，并且网状图案互连。每个邻接的腹板包括插入在两个横向部分之间以形成凹形或凸形构造的中心部分。

100. 发明申请

US20100030183A1 Method of treating vascular disease at a bifurcated vessel using a coated balloon 审中-公开
标题翻译：使用涂覆气球在分叉血管处理血管疾病的方法
公开(公告)号：US20100030183A1
公开(公告)日：2010-02-04
申请号：US12371426
申请日：2009-02-13
申请人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf Von Oepen
发明人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf Von Oepen
IPC分类号： A61M31/00 , A61M29/00
CPC分类号： A61M25/104 , A61F2/958 , A61F2250/0067 , A61F2310/0097 , A61K31/4745 , A61K45/06 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61M25/10 , A61M2025/105 , A61M2025/1088
摘要： Disclosed is a method for delivery of at least one therapeutic agent from an angioplasty balloon for treating vascular disease at a bifurcated vessel. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to a method of loading multiple beneficial agents onto the balloon surfaces
摘要翻译：公开了一种用于从血管成形术球囊递送至少一种治疗剂以在分叉血管处理血管疾病的方法。本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。本发明还涉及一种将多种有益剂装载到球囊表面上的方法

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