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    • 94. 发明申请
    • Implantable biosensor
    • 植入式生物传感器
    • US20050107677A1
    • 2005-05-19
    • US10948954
    • 2004-09-24
    • W. Kenneth WardMichael Wood
    • W. Kenneth WardMichael Wood
    • A61B5/00C12Q1/00A61B5/05
    • A61B5/14865A61B5/14532C12Q1/005
    • The invention consists of a sensor with multiple indicating (sensing) electrodes covered with a selectively permeable membrane for monitoring fluid concentrations in a biological environment. The indicating electrodes respond to changes in certain analytes, such as glucose, through an enzyme-mediated reaction. The currents generated from the enzyme-mediated reactions are transmitted through radio signals to an external receiver where the information is processed and recorded. Through the use of various biomaterials and biochemicals associated with the sensor, the monitoring accuracy is improved and the overall viability is prolonged. The process of foreign body fibrosis (formation of a scar capsule around the implanted sensor) eventually limits the functional life of the device. We teach methods of delivery of certain biochemicals that can increase the functional life of the sensor by inhibiting the formation of the foreign body capsule or by stimulating the growth of capillaries into the capsule.
    • 本发明包括具有多个指示(感测)电极的传感器,该电极覆盖有用于监测生物环境中的流体浓度的选择性渗透膜。 指示电极通过酶介导的反应响应某些分析物(例如葡萄糖)的变化。 从酶介导的反应产生的电流通过无线电信号传输到信息被处理和记录的外部接收器。 通过使用与传感器相关的各种生物材料和生物化学品,提高了监测精度,延长了整体的生存能力。 异物纤维化(植入传感器周围形成疤痕胶囊)的过程最终限制了器械的功能寿命。 我们教导了递送某些生物化学物质的方法,这些化学物质可以通过抑制异物胶囊的形成或通过刺激毛细血管进入胶囊来增加传感器的功能寿命。