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91. 发明申请

US20080293919A1 Fibrous Protein Fusions and Use Thereof in the Formation of Advanced Organic/Inorganic Composite Materials 有权
标题翻译：纤维蛋白融合及其在先进有机/无机复合材料的形成中的应用
公开(公告)号：US20080293919A1
公开(公告)日：2008-11-27
申请号：US11794934
申请日：2006-01-17
申请人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
发明人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
IPC分类号： C07K14/00 , C07H21/04 , C07K1/00
CPC分类号： A61L27/48 , A61L27/446 , A61L27/46 , A61L27/54 , A61L2430/00 , C07K14/43518 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation.
摘要翻译：要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。该融合用于形成有机 - 无机复合材料。这些有机 - 无机复合材料可以根据所使用的纤维蛋白融合结构域的大小从纳米级到大规模构建。在一个实施方案中，根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。这可以在组装材料期间或在矿化步骤期间在材料形成中实现。

92. 发明申请

US20080249965A1 System and Apparatus for Collecting and Distributing Voluntary Environmental Impact Offset Payments on Fuel Purchases at Point of Sale 审中-公开
标题翻译：在销售点收集和分配自愿环境影响抵消支付燃料采购的系统和设备
公开(公告)号：US20080249965A1
公开(公告)日：2008-10-09
申请号：US12049227
申请日：2008-03-14
申请人： Seth B. Pollack , David L. Kaplan , Seth W. Bridges
发明人： Seth B. Pollack , David L. Kaplan , Seth W. Bridges
IPC分类号： G06F17/00
CPC分类号： G06Q30/0603 , G06Q50/06
摘要： Systems and methods are described for collecting and distributing environmental impact offset payments at the point of sale of a fuel. An exemplary method presents a user interface at a point of sale of a purchase of a fuel, receives via the user interface a user-selection indicating an intention of the user to pay an environmental impact offset fee associated with the purchase, presents a choice to the user of making a custom offset payment or of buying a fuel that has the offset fee included in the price of the fuel, and calculates a custom offset payment for the purchase. The custom offset payment can be based on such considerations as an energy equivalency of the fuel purchased, volume or weight of the fuel being purchased, fuel type, fuel grade, e.g., octane level, oxygenation level, temperature of the fuel, fuel composition, climatic data, regional variation in fuel composition, efficiency of a vehicle receiving the fuel, pollution control capability of the vehicle receiving the fuel, and life-cycle environmental impacts of fuels, such as costs for extraction, processing, delivery, and combustion.
摘要翻译：描述了在燃料销售点收集和分配环境影响抵消支付的系统和方法。示例性方法在购买燃料的销售点处呈现用户界面，经由用户界面接收指示用户支付与购买相关的环境影响抵消费用的意图的用户选择，向用户进行自定义的抵消支付或购买燃料价格中包含抵消费用的燃料，并计算购买的定制抵消支付。定制抵消支付可以基于以下考虑：所购买的燃料的能量等价物，所购燃料的体积或重量，燃料类型，燃料等级，例如辛烷值，氧合水平，燃料温度，燃料组成，气候数据，燃料组成的区域变化，接收燃料的车辆的效率，接收燃料的车辆的污染控制能力以及燃料的生命周期环境影响，例如提取，处理，运送和燃烧的成本。

93. 发明授权

US06330689B1 Server architecture with detection and recovery of failed out-of-process application 失效
标题翻译：具有检测和恢复失败的进程外应用程序的服务器架构
公开(公告)号：US06330689B1
公开(公告)日：2001-12-11
申请号：US09066504
申请日：1998-04-23
申请人： Lei Jin , David L. Kaplan , Murali R. Krishnan
发明人： Lei Jin , David L. Kaplan , Murali R. Krishnan
IPC分类号： G06F1100
CPC分类号： G06F11/1415 , G06F11/1471
摘要： A server architecture has a server program to receive client requests and multiple applications to process the requests. Each application comprises a collection of agents that can be invoked to process the requests and an application manager that manages the collection of agents. The agents within the associated collection are independent from, but dynamically accessible by, the application manager. Depending on the request, the application manager selects one or more agents to generate content to be returned to the client. An application manager director manages the application managers and facilitates delivery of the client requests from the server program to the suitable application. The application managers are independent from, but dynamically accessible by, the application manager director. For a given request, the director selects the appropriate application manager to handle the request. The application manager, in turn, selects the appropriate agent to process the request. The applications, including the agents and associated application managers, can be run either in-process or out-of-process with the server program. The server architecture has a detection and recovery subsystem that detects when an out-of-process application crashes and then recovers the application from that crash. The subsystem logs requests when they are passed to the out-of-process application, and remove the requests from the log when responses to the requests are returned from the application. If the out-of-process application crashes while one or more requests are outstanding, those requests remain listed on the log and thus readily identifiable. During recovery, the subsystem cleans up the outstanding requests until the log is cleared. Thereafter, the subsystem restarts the failed application to restore the service.
摘要翻译：服务器架构具有服务器程序来接收客户端请求和多个应用程序来处理请求。每个应用程序包括可以调用以处理请求的代理的集合以及管理代理程序集合的应用程序管理器。相关集合中的代理独立于应用程序管理器，但可由其进行动态访问。根据请求，应用程序管理器选择一个或多个代理来生成要返回给客户端的内容。应用程序管理器主管管理应用程序管理器，并有助于将客户端请求从服务器程序传递到合适的应用程序。应用程序经理独立于应用程序经理主任，但可由其进行动态访问。对于给定的请求，导演选择适当的应用程序管理器来处理请求。反过来，应用程序管理器选择适当的代理来处理请求。应用程序（包括代理程序和关联的应用程序管理器）可以通过服务器程序在进程内或进程内运行。服务器体系结构具有一个检测和恢复子系统，用于检测进程外应用程序何时崩溃，然后从崩溃中恢复应用程序。子系统在将请求传递到进程外应用程序时记录请求，并从应用程序返回对请求的响应时从日志中删除请求。如果进程外应用程序在一个或多个请求未完成时崩溃，那么这些请求仍然列在日志中，因此可以很容易地识别。在恢复期间，子系统清理未完成的请求，直到日志被清除。此后，子系统重新启动失败的应用程序以恢复服务。

94. 发明授权

US6096859A Process to control the molecular weight and polydispersity of substituted polyphenols and polyaromatic amines by enzymatic synthesis in organic solvents, microemulsions, and biphasic systems 失效
公开(公告)号：US6096859A
公开(公告)日：2000-08-01
申请号：US598737
申请日：1996-01-16
申请人： Joseph A. Akkara , David L. Kaplan , Madhu Ayyagari
发明人： Joseph A. Akkara , David L. Kaplan , Madhu Ayyagari
IPC分类号： C08G61/10 , C08F6/12 , C08J3/14
CPC分类号： C08G61/10
摘要： A process of controlling the molecular weight and dispersity of poly(p-ethylphenol) and poly(m-cresol) synthesized enzymatically by varying the composition of the reaction medium. Polymers with low dispersities and molecular weights from 1000 to 3000 are synthesized in reversed micelles and biphasic systems. In comparison, reactions in bulk solvents resulted in a narrow range of molecular weights (281 to 675 with poly(p-ethylphenol) in a DMF/water system and 1,400 to 25,000 with poly(m-cresol) in an ethanol/water system). Poly(p-ethylphenol) was functionalized at hydroxyl positions with palmitoyl, cinnamoyl, and biotin groups.

95. 发明授权

US6067559A Server architecture for segregation of dynamic content generation applications into separate process spaces 失效
标题翻译：将动态内容生成应用程序隔离到单独的进程空间中的服务器体系结构
公开(公告)号：US6067559A
公开(公告)日：2000-05-23
申请号：US66742
申请日：1998-04-23
申请人： James E. Allard , Mark T. Anders , Lei Jin , David L. Kaplan , Murali R. Krishnan , Seth B. Pollack , Andrew Sigal
发明人： James E. Allard , Mark T. Anders , Lei Jin , David L. Kaplan , Murali R. Krishnan , Seth B. Pollack , Andrew Sigal
IPC分类号： G06F9/50 , G06F13/00
CPC分类号： G06F9/5055
摘要： A server architecture has a server program to receive client requests and multiple applications to process the requests. Each application comprises a collection of agents that can be invoked to process the requests and an application manager that manages the collection of agents. The agents within the associated collection are independent from, but dynamically accessible by, the application manager. Depending on the request, the application manager selects one or more agents to generate content to be returned to the client. An application manager director manages the application managers and facilitates delivery of the client requests from the server program to the suitable application. The application managers are independent from, but dynamically accessible by, the application manager director. For a given request, the director selects the appropriate application manager to handle the request. The application manager, in turn, selects the appropriate agent to process the request. The director can be implemented as part of the server program. The applications, including the agents and associated application managers, can be run either in-process or out-of-process with the server program.
摘要翻译：服务器架构具有服务器程序来接收客户端请求和多个应用程序来处理请求。每个应用程序包括可以调用以处理请求的代理的集合以及管理代理程序集合的应用程序管理器。相关集合中的代理独立于应用程序管理器，但可由其进行动态访问。根据请求，应用程序管理器选择一个或多个代理来生成要返回给客户端的内容。应用程序管理器主管管理应用程序管理器，并有助于将客户端请求从服务器程序传递到合适的应用程序。应用程序经理独立于应用程序经理主任，但可由其进行动态访问。对于给定的请求，导演选择适当的应用程序管理器来处理请求。反过来，应用程序管理器选择适当的代理来处理请求。导演可以作为服务器程序的一部分实现。应用程序（包括代理程序和关联的应用程序管理器）可以在服务器程序中进行进程或进程内运行。

96. 发明授权

US5846753A Chemiluminescence-based method for rapid and sensitive in-situ detection of organophosphorus compounds and metal ions 失效
标题翻译：基于化学发光的方法，用于快速和灵敏地原位检测有机磷化合物和金属离子
公开(公告)号：US5846753A
公开(公告)日：1998-12-08
申请号：US445565
申请日：1995-05-30
申请人： Joseph A. Akkara , David L. Kaplan , Madhu S. R. Ayyagari , Kenneth A. Marx , Sanjay Kamtekar , Rajiv Pande , Sukant K. Tripathy , Jayant Kumar
发明人： Joseph A. Akkara , David L. Kaplan , Madhu S. R. Ayyagari , Kenneth A. Marx , Sanjay Kamtekar , Rajiv Pande , Sukant K. Tripathy , Jayant Kumar
IPC分类号： C12Q1/42 , C07D305/14 , C12Q1/44
CPC分类号： C12Q1/42 , C12Q2334/00
摘要： A method of detecting the presence of a substance being monitored in a medium, selected from the group of substances including organophosphorus compounds and the metal ions Zn, Be and Bi, including the steps of: providing a 1,2-dioxetane phenyl phosphate compound; providing a phosphatase that catalytically degrades the 1,2-dioxetane phenyl phosphate compound to produce light, the catalytic activity of the phosphatase toward 1,2-dioxetane phenyl phosphate compound being altered by the substance being monitored; exposing the 1,2-dioxetane phenyl phosphate compound and the phosphatase together to a medium which may contain the substance being monitored; detecting light produced after the exposing step; and determining, from the detected light, the presence and concentration in the medium of the substance being monitored.
摘要翻译：一种检测在包括有机磷化合物和金属离子Zn，Be和Bi的物质组中的介质中被监测物质的存在的方法，包括以下步骤：提供1,2-二氧环乙烷苯基磷酸酯化合物; 提供催化降解1,2-二氧杂环丁烷苯基磷酸酯化合物以产生光的磷酸酶，磷酸酯对正在监测的物质的1,2-二氧环乙烷苯基磷酸酯化合物的催化活性改变; 将1,2-二氧环乙烷苯基磷酸酯化合物和磷酸酶一起暴露于可能含有被监测物质的介质中; 检测曝光步骤后产生的光; 并且从检测到的光中确定被监测物质的介质中的存在和浓度。

97. 发明授权

US5701460A Intelligent joining system for a relational database 失效
标题翻译：关系数据库的智能加入系统
公开(公告)号：US5701460A
公开(公告)日：1997-12-23
申请号：US652366
申请日：1996-05-23
申请人： David L. Kaplan , Andrew R. Miller
发明人： David L. Kaplan , Andrew R. Miller
IPC分类号： G06F17/30
CPC分类号： G06F17/30392 , G06F17/30436 , Y10S707/99933 , Y10S707/99934
摘要： A system for generating a structured query language query to extract data from a database wherein the database includes a schema defined by a plurality of record sources and a plurality of relationships therebetween. The system includes selecting a field set containing at least one field from among said plurality record sources in said database, and determining a minimal path relationship between each of the plurality of record sources in the database that contain at least one field from the field set. The minimal path relationship includes at least one indirect relationship between two of the plurality of record sources in the database that contain at least one field from the field set. Output from the intelligent joining system is a Structured Query Language (SQL) statement in the syntactical form that a database management system can execute. Additional output can include an edge set containing the minimal paths between record sources that contain at least one field from the field set, and a graph of the sub-schema defined by the field set. The output is generated from the above identified inputs in a manner transparent to the database user.
摘要翻译：一种用于生成结构化查询语言查询以从数据库提取数据的系统，其中所述数据库包括由多个记录源定义的模式及其间的多个关系。所述系统包括从所述数据库中的所述多个记录源中选择包含至少一个字段的字段集，以及确定所述数据库中的所述多个记录源中的每一个包含来自所述字段集的至少一个字段的最小路径关系。所述最小路径关系包括所述数据库中的所述多个记录源中的两个之间的至少一个间接关系，其包含来自所述字段集的至少一个字段。智能加入系统的输出是数据库管理系统可以执行的语法形式的结构化查询语言（SQL）语句。附加输出可以包括一个边缘集合，其中包含记录源之间的最小路径，其中包含来自字段集的至少一个字段，以及由该字段集定义的子模式的图形。输出以对数据库用户透明的方式从上述确定的输入生成。

98. 发明授权

US5679533A Biotin-binding containment systems 失效
公开(公告)号：US5679533A
公开(公告)日：1997-10-21
申请号：US479390
申请日：1995-06-07
申请人： Przemyslaw Szafranski , Charlene M. Mello , Takeshi Sano , Kenneth A. Marx , Charles R. Cantor , David L. Kaplan , Cassandra L. Smith
发明人： Przemyslaw Szafranski , Charlene M. Mello , Takeshi Sano , Kenneth A. Marx , Charles R. Cantor , David L. Kaplan , Cassandra L. Smith
IPC分类号： C07K14/36 , C07K14/465 , C12N1/21 , C12N15/12 , C12N15/70 , G01N33/53
CPC分类号： C12N15/70 , C07K14/36 , C07K14/465
摘要： The present invention relates to genetic containment systems which express a biotin-binding component that can be used for selectively destroying recombinant cells such as genetically engineered microorganisms. These systems may comprise a streptavidin or an avidin gene whose expression is controlled by a regulatable promoter. The regulatory agent such as a transcriptional effector is expressed from another gene which may also be expressed and its expression controlled by the containment system. Expression of the agent can be designed to respond to physiological changes in the environment. The invention also relates to containment systems and methods for the selective detection or tracking of recombinant cells and to eukaryotic and prokaryotic cells which contain these genetic containment systems.

99. 发明授权

US5143828A Method for synthesizing an enzyme-catalyzed polymerized monolayer 失效
标题翻译：合成酶催化聚合单层的方法
公开(公告)号：US5143828A
公开(公告)日：1992-09-01
申请号：US815213
申请日：1991-12-31
申请人： Joseph A. Akkara , David L. Kaplan , Lynne A. Samuelson , Braja K. Mandal , Sukant K. Tripathy , Ferdinando F. Bruno , Kenneth A. Marx
发明人： Joseph A. Akkara , David L. Kaplan , Lynne A. Samuelson , Braja K. Mandal , Sukant K. Tripathy , Ferdinando F. Bruno , Kenneth A. Marx
IPC分类号： B05D1/20 , C08G61/10 , C08G73/02 , C12P7/22 , C12P13/00
CPC分类号： B82Y30/00 , B05D1/204 , B82Y40/00 , C08G61/10 , C08G73/0266 , C12P13/001 , C12P7/22
摘要： A method for synthesizing enzyme-catalyzed polymers using the Langmuir-Blodgett technique. In one embodiment, the process comprises spreading one or more enzyme-polymerizable monomers on a water-miscible solvent. The monomers are sufficiently surface active that they align themselves on the air-solvent interface. Next, pressure is applied to the interface to form a monolayer made up of the monomers. An enzyme is then introduced into the solvent, causing polymerization of the monomers in the monolayer. The polymeric monolayers produced by the present method are easier to process and have reduced cross-linking and branching as compared to similar polymers produced in bulk by enzyme-catalyzed reactions.
摘要翻译：使用Langmuir-Blodgett技术合成酶催化聚合物的方法。在一个实施方案中，该方法包括将一种或多种可酶聚合的单体铺在水混溶性溶剂上。单体具有足够的表面活性，使得它们自己在空气 - 溶剂界面上对准。接下来，向界面施加压力以形成由单体组成的单层。然后将酶引入溶剂中，引起单体在单层中的聚合。通过本发明方法制备的聚合物单层与通过酶催化反应在本体产生的类似聚合物相比更容易加工并且具有减少的交联和支化。

100. 发明授权

US10933173B2 Silk fibroin-based microneedles and methods of making the same 有权
公开(公告)号：US10933173B2
公开(公告)日：2021-03-02
申请号：US13880592
申请日：2011-10-19
申请人： David L. Kaplan , Konstantinos Tsioris , Fiorenzo G. Omenetto , Eleanor M. Pritchard
发明人： David L. Kaplan , Konstantinos Tsioris , Fiorenzo G. Omenetto , Eleanor M. Pritchard
IPC分类号： A61L31/12 , A61B17/20 , A61K9/00 , A61L31/04 , A61L31/16 , A61M5/158 , A61M37/00
摘要： A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include one or more microneedles mounted to a substrate. The silk fibroin can include active agents to be transported into or across biological barriers such as skin, tissue and cell membranes. The silk fibroin microneedles can be fully or partially biodegradable and/or bioerodible. The silk fibroin is highly stable, affords room temperature storage and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery.

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