专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5701460A Intelligent joining system for a relational database 失效
标题翻译：关系数据库的智能加入系统
公开(公告)号：US5701460A
公开(公告)日：1997-12-23
申请号：US652366
申请日：1996-05-23
申请人： David L. Kaplan , Andrew R. Miller
发明人： David L. Kaplan , Andrew R. Miller
IPC分类号： G06F17/30
CPC分类号： G06F17/30392 , G06F17/30436 , Y10S707/99933 , Y10S707/99934
摘要： A system for generating a structured query language query to extract data from a database wherein the database includes a schema defined by a plurality of record sources and a plurality of relationships therebetween. The system includes selecting a field set containing at least one field from among said plurality record sources in said database, and determining a minimal path relationship between each of the plurality of record sources in the database that contain at least one field from the field set. The minimal path relationship includes at least one indirect relationship between two of the plurality of record sources in the database that contain at least one field from the field set. Output from the intelligent joining system is a Structured Query Language (SQL) statement in the syntactical form that a database management system can execute. Additional output can include an edge set containing the minimal paths between record sources that contain at least one field from the field set, and a graph of the sub-schema defined by the field set. The output is generated from the above identified inputs in a manner transparent to the database user.
摘要翻译：一种用于生成结构化查询语言查询以从数据库提取数据的系统，其中所述数据库包括由多个记录源定义的模式及其间的多个关系。所述系统包括从所述数据库中的所述多个记录源中选择包含至少一个字段的字段集，以及确定所述数据库中的所述多个记录源中的每一个包含来自所述字段集的至少一个字段的最小路径关系。所述最小路径关系包括所述数据库中的所述多个记录源中的两个之间的至少一个间接关系，其包含来自所述字段集的至少一个字段。智能加入系统的输出是数据库管理系统可以执行的语法形式的结构化查询语言（SQL）语句。附加输出可以包括一个边缘集合，其中包含记录源之间的最小路径，其中包含来自字段集的至少一个字段，以及由该字段集定义的子模式的图形。输出以对数据库用户透明的方式从上述确定的输入生成。

2. 发明授权

US5737591A Database view generation system 失效
标题翻译：数据库视图生成系统
公开(公告)号：US5737591A
公开(公告)日：1998-04-07
申请号：US653716
申请日：1996-05-23
申请人： David L. Kaplan , Andrew R. Miller , Andrew McRae Warden
发明人： David L. Kaplan , Andrew R. Miller , Andrew McRae Warden
IPC分类号： G06F17/30
CPC分类号： G06F17/30554 , Y10S707/99931 , Y10S707/99932 , Y10S707/99933
摘要： A database view generation system for viewing a result set of data extracted from a database by a query. The database view generation system includes selecting a viewpoint from among at least one field set record source of a database sub-schema and generating a view of the result set in at least one level from a perspective of the viewpoint. Generating a view from a viewpoint includes analyzing the sub-schema for connectedness, identifying the sub-schema type, assigning a level indicator value that is indicative of the hierarchical position of record sources in the sub-schema relative to the viewpoint, and displaying a view of the result set based on the level indicator value assigned to each record source containing data in the result set.
摘要翻译：数据库视图生成系统，用于通过查询查看从数据库提取的数据的结果集。数据库视图生成系统包括从数据库子模式的至少一个字段集记录源中选择视点，并从视点的角度生成至少一个级别中的结果集合的视图。从视点生成视图包括分析用于连接的子模式，识别子模式类型，分配指示相对于视点的子模式中的记录源的分层位置的级别指示符值，以及显示根据分配给包含结果集中数据的每个记录源的级别指示符值，查看结果集。

3. 发明申请

US20090298139A1 Method for Polymer Synthesis Using Microfluidic Enzymatic Cascade 审中-公开
标题翻译：使用微流控酶级联的聚合物合成方法
公开(公告)号：US20090298139A1
公开(公告)日：2009-12-03
申请号：US12224149
申请日：2007-02-27
申请人： Jin Zou , David L. Kaplan , Jin Zou , Peter Y. Wong , David L. Kaplan
发明人： Jin Zou , David L. Kaplan , Jin Zou , Peter Y. Wong , David L. Kaplan
IPC分类号： C12P17/16 , B01J19/00
CPC分类号： C12P17/04
摘要： The present invention discloses a method for producing polymers in a microscale device. The system utilizes a symmetrically branched system of microchannels interconnecting a plurality of loading decks and re-action chambers. The fluid flow is manipulated by the placement of capillary check valves, mixing areas, and microcomb filters. The system provides for cascading enzymatic biosynthesis pathways wherein any variety of enzymes and reactants can be introduced into the system to produce a final product.
摘要翻译：本发明公开了一种在微型装置中制备聚合物的方法。该系统利用互连多个装载甲板和再作用室的对称分支的微通道系统。通过放置毛细管止回阀，混合区域和微孔过滤器来操纵流体流动。该系统提供级联的酶生物合成途径，其中可以将任何多种酶和反应物引入系统以产生最终产物。

4. 发明授权

US09517357B2 Plasmonic nanoparticle-doped silk materials 有权
标题翻译：掺杂等离子体纳米粒子的丝材料
公开(公告)号：US09517357B2
公开(公告)日：2016-12-13
申请号：US13819419
申请日：2011-09-03
申请人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
发明人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
IPC分类号： A61N5/00 , A61N5/06 , A61F7/03 , A61L31/00 , A61L31/12 , A61L31/14 , H01L35/30
CPC分类号： A61N5/0625 , A61F7/03 , A61L31/005 , A61L31/125 , A61L31/14 , A61L2400/12 , A61N5/062 , H01L35/30 , Y10T428/268 , Y10T428/2927
摘要： Provided herein are silk fibroin-based photothermal elements and uses thereof. The silk fibroin-based photothermal elements comprise a plurality of plasmonic nanoparticle distributed in a silk fibroin matrix, and can generate heat when the plasmonic nanoparticles are exposed to electromagnetic radiation. The silk fibroin-based photothermal elements can be adapted to be conformable and biodegradable, and can further be integrated with various electronic components, such as a thermo-electric device for conversion of heat into electricity. The invention is useful for various in vivo applications, such as photothermal therapy, controlled drug-delivery devices or wireless powering of implanted micro-devices.
摘要翻译：本文提供的是丝素蛋白基光热元件及其用途。基于丝素蛋白的光热元件包括分布在丝素蛋白基质中的多个等离子体激元纳米颗粒，当等离子体激元纳米粒子暴露于电磁辐射时可产生热量。丝素蛋白的光热元件可以适应和可生物降解，并且可以进一步与各种电子部件集成，例如用于将热量转换成电的热电装置。本发明可用于各种体内应用，例如光热治疗，受控药物递送装置或植入的微器件的无线供电。

5. 发明授权

US08986380B2 Multilayered silk scaffolds for meniscus tissue engineering 有权
标题翻译：用于半月板组织工程的多层丝绸支架
公开(公告)号：US08986380B2
公开(公告)日：2015-03-24
申请号：US13702606
申请日：2011-06-09
申请人： David L. Kaplan , Biman B. Mandal
发明人： David L. Kaplan , Biman B. Mandal
IPC分类号： A61F2/30 , A61L27/36 , A61L27/38 , A61L27/54 , A61L27/56 , C12N5/00 , C12N5/077
CPC分类号： A61F2/30756 , A61L27/3604 , A61L27/3654 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/30 , A61L2300/414 , C12N5/0068 , C12N5/0655 , C12N2533/50 , C12N2533/90
摘要： Provided herein is a biocompatible implant for meniscus tissue engineering. Particularly, the biocompatible implant comprises a multi-layered crescent-shaped silk fibroin scaffold, in which each layer comprises distinct pore size and/or pore orientation, e.g., to mimic native meniscus complex architecture. Accordingly, the biocompatible implant can be used for repairing any meniscal defect or promoting meniscal regeneration in a subject.
摘要翻译：本文提供了用于弯液面组织工程的生物相容性植入物。特别地，生物相容性植入物包括多层新月形丝素蛋白支架，其中每个层包含不同的孔径和/或孔取向，例如模拟天然半月板复合体系结构。因此，生物相容性植入物可用于修复受试者中的任何半月板缺损或促进半月板再生。

6. 发明授权

US08906444B2 Diazonium salt modification of silk polymer 有权
标题翻译：丝绸聚合物的重氮盐改性
公开(公告)号：US08906444B2
公开(公告)日：2014-12-09
申请号：US13479709
申请日：2012-05-24
申请人： David L. Kaplan , Amanda Murphy
发明人： David L. Kaplan , Amanda Murphy
IPC分类号： B05D3/00 , C12N5/02 , A61K38/17 , C08L89/00 , C08H1/00
CPC分类号： C09D189/00 , C08H1/00 , C08L89/00
摘要： A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk protein. Thus, silk proteins with desired physical properties can be produced by the methods described herein. These methods are particularly useful when the introduction of cells to a mammal is desired, since modifications to the silk protein affect the physical properties and thus the adhesion, metabolic activity and cell morphology of the desired cells. The silk protein can be modified to produce, or modify, a structure that provides an optimal environment for the desired cells.
摘要翻译：本文描述了通过将化学部分偶联到丝聚合物的酪氨酸残基来修饰丝聚合物的方法，用于改变丝蛋白的物理性质。因此，可以通过本文所述的方法制备具有所需物理性质的丝蛋白。当需要向哺乳动物引入细胞时，这些方法特别有用，因为对丝蛋白的修饰会影响所需细胞的物理性质，因此影响粘附，代谢活性和细胞形态。可以修饰丝蛋白以产生或修饰为所需细胞提供最佳环境的结构。

7. 发明申请

US20140154788A1 ELECTRONIC COMPONENTS ON PAPER-BASED SUBSTRATES 审中-公开
标题翻译：基于纸张基板的电子元件
公开(公告)号：US20140154788A1
公开(公告)日：2014-06-05
申请号：US13977233
申请日：2012-01-04
申请人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
发明人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
IPC分类号： B01L3/00 , C12Q1/54 , G01N22/00 , G01J1/02 , G01J5/02
CPC分类号： B01L3/502707 , C12Q1/54 , G01J1/02 , G01J5/02 , G01N21/3563 , G01N21/3581 , G01N22/00
摘要： The present disclosure relates to paper-based substrates and apparatus comprising such substrates. The apparatus may include a patterned conductive structure coupled to the paper-based substrate, wherein the patterned conductive structure responds to electromagnetic radiation.
摘要翻译：本公开涉及基于纸的基板和包括这种基板的装置。该装置可以包括耦合到纸基基板的图案化导电结构，其中图案化导电结构响应于电磁辐射。

8. 发明授权

US08722067B2 Method for silk fibroin gelation using sonication 有权
标题翻译：使用超声处理丝素蛋白凝胶化方法
公开(公告)号：US08722067B2
公开(公告)日：2014-05-13
申请号：US13457705
申请日：2012-04-27
申请人： Xiaoqin Wang , Jon Kluge , Gary G. Leisk , David L. Kaplan
发明人： Xiaoqin Wang , Jon Kluge , Gary G. Leisk , David L. Kaplan
IPC分类号： A61K9/00 , A61K38/17
CPC分类号： A61K47/42 , A61K9/06 , A61K9/5052 , A61K9/5063 , A61K9/5089 , A61K35/28 , A61K2035/124 , C07K14/43586
摘要： This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
摘要翻译：本发明提供了通过超声波快速形成丝素蛋白凝胶化的方法。在适当的条件下，超声波处理后两小时即可控制凝胶化。包括活细胞或治疗剂在内的生物材料可以包封在由该方法形成的水凝胶中并用作输送载体。

9. 发明授权

US08715740B2 Silk nanospheres and microspheres and methods of making same 有权
标题翻译：丝纳米球和微球及其制备方法
公开(公告)号：US08715740B2
公开(公告)日：2014-05-06
申请号：US13496227
申请日：2010-09-29
申请人： Xiaoqin Wang , David L. Kaplan
发明人： Xiaoqin Wang , David L. Kaplan
IPC分类号： A61K9/50 , A61K9/127 , B01J13/02
CPC分类号： A61K9/5169 , A61K9/14 , A61K9/1605 , A61K9/1647 , A61K9/5052 , A61K9/5089 , A61K9/5192 , A61K31/352 , Y10T428/2982
摘要： The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles.
摘要翻译：本发明提供了制备丝纳米颗粒和微粒的方法，将活性剂包封在丝纳米和微粒中的方法和包含这些丝颗粒的组合物。

10. 发明授权

US08614293B2 Concentrated aqueous silk fibroin solution and use thereof 有权
公开(公告)号：US08614293B2
公开(公告)日：2013-12-24
申请号：US12611256
申请日：2009-11-03
申请人： David L. Kaplan , Ung-Jin Kim , Jaehyung Park , Hyoung-Joon Jin
发明人： David L. Kaplan , Ung-Jin Kim , Jaehyung Park , Hyoung-Joon Jin
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： A61L27/227 , A61L27/3604 , A61L27/38 , A61L27/52 , A61L27/56 , A61L2430/02 , B29C39/003 , B29C39/203 , B29C55/005 , B29D7/01 , B29K2089/00 , B29L2007/00 , B29L2009/00 , C07K14/43536 , C07K14/43586 , C08J3/07 , C08J3/075 , C08J5/18 , C08J9/0061 , C08J9/26 , C08J9/28 , C08J2201/0444 , C08J2201/0504 , C08J2205/022 , C08J2389/00 , C08L89/00 , D01D5/0007 , D01F4/02 , Y10T428/249921 , Y10T442/10 , Y10T442/60
摘要： The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式