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91. 发明授权

US08701014B1 Account linking 有权
标题翻译：帐户连结
公开(公告)号：US08701014B1
公开(公告)日：2014-04-15
申请号：US10715213
申请日：2003-11-18
申请人： Heather Allison Schlegel , Barry Appelman , Andrew L. Wick , Alan Keister , Chris Chih-Shen Chung , James A. Odell , Barbara McNally , Michael Robert Enloe , Pei-Lin Wu , Russell William Richards , Alexis Inch , David Cox , Xiaopeng Zhang , Gregory Cypes , David McCormick
发明人： Heather Allison Schlegel , Barry Appelman , Andrew L. Wick , Alan Keister , Chris Chih-Shen Chung , James A. Odell , Barbara McNally , Michael Robert Enloe , Pei-Lin Wu , Russell William Richards , Alexis Inch , David Cox , Xiaopeng Zhang , Gregory Cypes , David McCormick
IPC分类号： G06F3/0481
CPC分类号： H04L51/22
摘要： Linking multiple identities from a single service includes for a user of a single service having multiple identities within the single service, authenticating a primary identity having a first buddy list associated with an account, authenticating a secondary identity having a second buddy list associated with the account, and creating an association between the primary identity and the secondary identity, where the primary identity and the secondary identity simultaneously share a common graphical user interface such that the primary identity interacts with the first buddy list and the secondary identity interacts with the second buddy list using the common graphical user interface.
摘要翻译：从单个服务链接多个身份包括对于在单个服务中具有多个身份的单个服务的用户，认证具有与帐户相关联的第一个好友列表的主身份，认证具有与该帐户相关联的第二个好友列表的辅助身份以及在主身份和次身份之间创建关联，其中主身份和辅助身份同时共享公共图形用户界面，使得主身份与第一好友列表交互并且次要身份与第二好友列表交互使用通用的图形用户界面。

92. 发明授权

US07694259B2 Data models for describing an electrical device 有权
标题翻译：用于描述电气设备的数据模型
公开(公告)号：US07694259B2
公开(公告)日：2010-04-06
申请号：US11772486
申请日：2007-07-02
申请人： David Cox , Thomas J Lanoue
发明人： David Cox , Thomas J Lanoue
IPC分类号： G06F9/455 , G06F17/50 , G06F9/44 , G06F9/445
CPC分类号： G06F17/5068
摘要： A method and product are described for creating a model of a physical layout and/or a circuit layout of an electrical device. The layouts are defined in a user interface. A text file having metadata elements in a hierarchical format is produced that can be used by other programs.
摘要翻译：描述了用于创建电气设备的物理布局和/或电路布局的模型的方法和产品。布局在用户界面中定义。产生具有分层格式的元数据元素的文本文件，可由其他程序使用。

93. 发明申请

US20100059133A1 AXIALLY REINFORCED HOSE 有权
标题翻译：轴向增强软管
公开(公告)号：US20100059133A1
公开(公告)日：2010-03-11
申请号：US12312109
申请日：2007-06-29
申请人： Joel Aron Witz , David Cox , Gerard Anthong Hall
发明人： Joel Aron Witz , David Cox , Gerard Anthong Hall
IPC分类号： F16L11/10
CPC分类号： F16L11/115 , F16L11/088 , F16L11/10 , F16L59/141
摘要： A hose comprising a tubular body of flexible material arranged between an inner and an outer helically wound wire, the tubular body serving to transport fluid through the hose and to prevent fluid leakage through the body, the tubular body comprising a reinforcing layer and a sealing layer, wherein the hose further comprises axial strengthening strips extending along the length of the hose.
摘要翻译：一种软管，其包括布置在内螺旋缠绕线和外螺纹缠绕线之间的柔性材料管状体，所述管体用于输送流体通过所述软管并防止流体通过所述主体泄漏，所述管体包括加强层和密封层，其中所述软管还包括沿着所述软管的长度延伸的轴向加强条。

94. 发明申请

US20090239763A1 MARKERS FOR BREAST CANCER 审中-公开
标题翻译：乳腺癌标志物
公开(公告)号：US20090239763A1
公开(公告)日：2009-09-24
申请号：US12370972
申请日：2009-02-13
申请人： David Cox , Dennis Ballinger , Bruce Ponder , Doug Easton
发明人： David Cox , Dennis Ballinger , Bruce Ponder , Doug Easton
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/16
摘要： Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.
摘要翻译：提供多态性与乳腺癌的相关性。提供诊断，预后和治疗乳腺癌的方法。提供用于乳腺癌诊断，预后和治疗的系统和试剂盒。还描述了确定乳腺癌调节剂的方法。

95. 发明申请

US20070224088A1 Fluid processing device including output interface with analyzer 审中-公开
标题翻译：流体处理装置包括与分析仪的输出接口
公开(公告)号：US20070224088A1
公开(公告)日：2007-09-27
申请号：US11388655
申请日：2006-03-24
申请人： David Cox , Abizar Lakdawalla
发明人： David Cox , Abizar Lakdawalla
IPC分类号： G01N33/00
CPC分类号： G01N27/44782 , B01L3/5025 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L2200/027 , B01L2300/0816 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , G01N35/1074 , Y10T436/25 , Y10T436/2575
摘要： A fluid processing device, system, and method, are provided, for processing one or more samples. The device can comprise two or more sets of substantially parallel fluid processing pathways, each set comprising one or more fluid processing pathways. Each fluid processing pathway can comprise a reaction region, one or more inlet chambers, and one or more outlet chambers. The one or more outlet chambers of each set of fluid processing pathways can be arranged in an array configured to interface with an analyzer comprising a plurality of injectors, for example, injectors for capillaries of a multi-capillary electrophoresis instrument. The one or more inlet chambers of each set of fluid processing pathways can be arranged in an array configured to interface with a loading device comprising a plurality of injectors, for example, the loading tips of a multi-pipette robotic filling device.
摘要翻译：提供流体处理装置，系统和方法，用于处理一个或多个样品。该装置可以包括两组或多组基本上平行的流体处理通道，每组包括一个或多个流体处理通路。每个流体处理途径可以包括反应区域，一个或多个入口室和一个或多个出口室。每组流体处理通道中的一个或多个出口室可以布置成与包括多个注射器的分析器（例如，多毛细管电泳仪的毛细管的注射器）相接口的阵列。每组流体处理通道中的一个或多个入口室可以布置成阵列，其配置成与包括多个注射器的加载装置（例如多吸管机器人填充装置的装载尖端）相接合。

96. 发明申请

US20070068573A1 Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible 审中-公开
标题翻译：用于与第二流体接触的第一流体的微流控制的装置和方法，其中第一和第二流体是不混溶的
公开(公告)号：US20070068573A1
公开(公告)日：2007-03-29
申请号：US11508756
申请日：2006-08-22
申请人： David Cox , Sam Woo , Steven Boege , Mark Oldham , Richard Reel , Eric Nordman , Linda Lee , Willy Wiyatno , Dmitry Sagatelyan
发明人： David Cox , Sam Woo , Steven Boege , Mark Oldham , Richard Reel , Eric Nordman , Linda Lee , Willy Wiyatno , Dmitry Sagatelyan
IPC分类号： F17D1/00
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , C12Q2535/101 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575
摘要： Various embodiments described in the application relate to an apparatus, system, and method for fluidically controlling, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise combinations of detectors, controllers, valves, and fluid supply units to control the spatial size, location and/or fluidic composition of discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.
摘要翻译：在本申请中描述的各种实施例涉及用于在管道内流体控制与第二流体不混溶的一种或多种流体的离散体积的装置，系统和方法。离散体积可用于涉及小体积的生物化学或分子生物学过程，例如微升体积，纳升级体积或更小体积。该系统可以包括检测器，控制器，阀和流体供应单元的组合，以控制通过与离散的流体不混溶的流体彼此分离的离散体积的空间尺寸，位置和/或流体组成体积，例如由油分离的含水不混溶流体离散体积。

97. 发明申请

US20070059214A1 Closing blade for deformable valve in a microfluidic device and method 有权
标题翻译：微流体装置和方法中的可变形阀的关闭叶片
公开(公告)号：US20070059214A1
公开(公告)日：2007-03-15
申请号：US11598480
申请日：2006-11-13
申请人： David Cox , Zbigniew Bryning
发明人： David Cox , Zbigniew Bryning
IPC分类号： B01L3/00
CPC分类号： F16K99/0026 , B01L3/502715 , B01L3/502738 , B01L2200/0689 , B01L2300/0816 , B01L2400/0655 , F16K99/0001 , F16K99/003 , F16K99/0034 , F16K2099/008 , Y10T436/2575
摘要： A microfluidic manipulation system is provided that includes a blade for manipulating deformable material and at least one movable support that is capable of moving the blade into contact with a microfluidic device including a deformable feature. When the microfluidic device is operatively held by a holder, a movable support can position the distal end of the blade relative to the microfluidic device and move the contact tip surface of the blade such that it deforms the deformable feature.
摘要翻译：提供了一种微流体操纵系统，其包括用于操纵可变形材料的刀片和能够使刀片与包括可变形特征的微流体装置接触的至少一个可移动支撑件。当微流体装置由保持器可操作地保持时，可移动支撑件可以相对于微流体装置定位叶片的远端并移动叶片的接触尖端表面，使得其使可变形特征变形。

98. 发明申请

US20070037198A1 Methods for genetic analysis 审中-公开
标题翻译：遗传分析方法
公开(公告)号：US20070037198A1
公开(公告)日：2007-02-15
申请号：US11510261
申请日：2006-08-25
申请人： David Cox , Mark McCamish
发明人： David Cox , Mark McCamish
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G06Q50/24 , G16B20/00 , G16B40/00
摘要： Methods are described for assessing an individual's likelihood of developing or exhibiting a multifactorial trait, and for predicting the effectiveness of a drug treatment regimen in an individual. The methods include determining a plurality of genotypes for the individual at a plurality of biallelic polymorphic loci, using the genotypes to compute a score for the individual, and comparing the score to at least one threshold value. Genetic tests are also described for assessing an individual's likelihood of developing or exhibiting a multifactorial trait.
摘要翻译：描述了评估个体发展或展现多因素性状的可能性以及用于预测个体药物治疗方案的有效性的方法。所述方法包括使用基因型来计算个体的分数，并将评分与至少一个阈值进行比较来确定个体在多个双重多态性基因座上的多种基因型。还描述了遗传测试来评估个体发展或表现多因素性状的可能性。

99. 发明申请

US20070025955A1 TISSUE ADHESIVE SEALANT 审中-公开
标题翻译：组织胶粘剂
公开(公告)号：US20070025955A1
公开(公告)日：2007-02-01
申请号：US11535111
申请日：2006-09-26
申请人： Johan Lowinger , Bruno Lowinger , Frank DeLustro , David Cox , David Browdie
发明人： Johan Lowinger , Bruno Lowinger , Frank DeLustro , David Cox , David Browdie
IPC分类号： A61K39/395 , A61K31/785
CPC分类号： A61L24/102 , A61L24/108
摘要： A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.
摘要翻译：组织粘合剂密封剂包括在与包含醛和氨基酸的交联剂溶液组合的溶液中的可交联蛋白质，所述交联剂溶液含有与醛交联反应的物质以形成密封。密封剂非常适合单独粘合组织或与贴片组合。醛和含氨基酸的物质之间的比例在醛部分上为20:1和1:1之间：氨基酸或肽亚基摩尔数。当蛋白质和交联剂以15:1至1:1的摩尔比存在时，形成特别强的密封。

100. 发明申请

US20060110486A1 Potting method 有权
标题翻译：灌封法
公开(公告)号：US20060110486A1
公开(公告)日：2006-05-25
申请号：US11197969
申请日：2005-08-05
申请人： David Cox , Georg Schnieder , Fufang Zha , Joachim Muller , Cinzia Lea
发明人： David Cox , Georg Schnieder , Fufang Zha , Joachim Muller , Cinzia Lea
IPC分类号： B29C31/00
CPC分类号： B01D63/022
摘要： A method of forming a pot for an array of hollow fibre membranes (7) is provided, including the steps of placing the ends (6) of the fibre membranes (7) in a mould (5); forming a first layer (20) of curable resin material in a non-cured state around the fibre membrane ends (6), applying a second layer (21) of a polyurethane resin material to the first layer (20) prior to full curing of the first layer, the polyurethane resin material layer being chemically reactive with the first layer material to form an adhesive bond therebetween; at least partially curing both layers and removing the pot formed from the mould (5), wherein the second layer material is of higher flexibility than the first layer material when each layer is fully cured. Apparatus for performing the method is also disclosed.
摘要翻译：提供一种形成中空纤维膜阵列（7）的罐的方法，包括将纤维膜（7）的端部（6）放置在模具（5）中的步骤; 在所述纤维膜端部（6）的周围形成处于非固化状态的可固化树脂材料的第一层（20），在完全固化所述第一层（20）之前，向所述第一层（20）施加聚氨酯树脂材料的第二层（21）所述第一层，所述聚氨酯树脂材料层与所述第一层材料发生化学反应，以在其间形成粘结剂; 至少部分地固化两层并移除由模具（5）形成的罐，其中当每层完全固化时，第二层材料比第一层材料具有更高的柔韧性。还公开了用于执行该方法的装置。

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