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91. 发明授权

US07740627B2 Surgical method and apparatus for treating atrial fibrillation 有权
标题翻译：用于治疗房颤的手术方法和装置
公开(公告)号：US07740627B2
公开(公告)日：2010-06-22
申请号：US11184045
申请日：2006-01-06
申请人： James Gammie , Randy Jordan , Marwan Abboud , Allan Zingeler , Saqib Masroor
发明人： James Gammie , Randy Jordan , Marwan Abboud , Allan Zingeler , Saqib Masroor
IPC分类号： A61B18/02 , A61B18/04
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body, a proximal end and a distal end; a first lumen; a second lumen; and an ablation element expandable from a first diameter to a second diameter, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more deformable balloon and/or flexible elements. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method, a tissue ablation device is provided and tissue in the left atrium is ablated with the device, whereby the ablation is created by freezing tissue.
摘要翻译：本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。在示例性实施例中，冷冻治疗装置包括导管主体，近端和远端; 第一个管腔第二个管腔以及可从第一直径扩展到第二直径的消融元件，所述消融元件具有与心脏组织的不平坦表面形貌一致的表面部分。消融元件可以包括一个或多个可变形的球囊和/或柔性元件。球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。在一种示例性方法中，提供组织消融装置，并且使用该装置消除左心房中的组织，由此通过冷冻组织产生消融。

92. 发明授权

US07727228B2 Method and apparatus for inflating and deflating balloon catheters 有权
标题翻译：球囊导管充气和放气的方法和装置
公开(公告)号：US07727228B2
公开(公告)日：2010-06-01
申请号：US10806995
申请日：2004-03-23
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Eric Monger
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Eric Monger
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/22051 , A61B2018/0022 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M25/1018 , A61M25/10185
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter is provided. The system includes a balloon catheter, a console having a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system comprises a PID (Proportional Integral Derivative) controller or other pressure-sensing device that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted.
摘要翻译：提供了一种用于控制气囊导管的充气，消融和放气的系统和方法。该系统包括球囊导管，具有加压气体或液体充气源的控制台，以及将加压的冷却剂输送到球囊导管的脐带系统。该系统包括PID（比例积分微分）控制器或其他压力感测装置，其监测气囊导管内的压力和体积的量。在充气期间，气囊内的流体的压力和/或体积保持在目标量，以便提供相对于期望目标区域的足够的机械化压力。该系统会限制通气压力，以便在发生泄漏时释放出安全数量的气体。如果该量低于某一阈值水平，则假设气体或流体出口，并且暂停充气过程。

93. 发明授权

US07591814B2 Extended treatment zone catheter 有权
标题翻译：扩展治疗区导管
公开(公告)号：US07591814B2
公开(公告)日：2009-09-22
申请号：US11093179
申请日：2005-03-29
申请人： Domenic Santoianni , Marwan Abboud , Sean Carroll
发明人： Domenic Santoianni , Marwan Abboud , Sean Carroll
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00053 , A61B2017/00243 , A61B2017/00973 , A61B2018/00095 , A61B2018/0212 , A61B2018/0262
摘要： A catheter having an extended treatment zone for cooling tissue is provided. The catheter includes an elongate catheter body having a distal tip, and a fluid injection conduit disposed inside the catheter body defining a return lumen therein. The fluid injection conduit further defines two or more injection orifices including a first distal orifice near the distal tip, and a second orifice longitudinally offset along the fluid injection conduit to be less proximate the distal tip than the first orifice. Fluid cryogen flowing through the orifices creates an extended tissue cooling contour about the distal end portion of the catheter. At least one ECG ring electrode is provided about the catheter body near the second orifice. The catheter may thus provide for electrocardiographic mapping of tissue nodes lying transversely between the distal tip and the ECG ring electrode.
摘要翻译：提供了一种具有用于冷却组织的延伸处理区的导管。导管包括具有远侧末端的细长导管主体和设置在导管主体内部的流体注入导管，其在其中限定回流腔。流体注射导管还限定两个或更多个注射孔，其包括靠近远侧末端的第一远端孔，以及沿着流体注射导管纵向偏移的第二孔，以比第一孔更靠近远端。流经孔的流体冷冻剂围绕导管的远端部分产生延长的组织冷却轮廓。在第二孔周围的导管本体周围设置至少一个ECG环形电极。因此，导管可以提供横向位于远端尖端和ECG环形电极之间的组织结节的心电图。

94. 发明申请

US20060259023A1 Contact assessment of balloon catheters 有权
标题翻译：球囊导管接触评估
公开(公告)号：US20060259023A1
公开(公告)日：2006-11-16
申请号：US11129205
申请日：2005-05-13
申请人： Marwan Abboud , Teresa Mihalik , Johnny Asmar , Chadi Harmouche
发明人： Marwan Abboud , Teresa Mihalik , Johnny Asmar , Chadi Harmouche
IPC分类号： A61B18/02
CPC分类号： A61B5/6885 , A61B5/053 , A61B5/0538 , A61B5/6886 , A61B18/02 , A61B2017/00026 , A61B2017/00039 , A61B2017/00084 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2090/065
摘要： A method and system for determining contact assessment includes the steps of positioning a catheter at a tissue treatment site, where the catheter has a proximal end portion and a distal end portion, the proximal end portion defining at least one fluid inlet port and at least one fluid outlet port, an expandable membrane defining a cooling chamber a coolant injection lumen in fluid communication with the at least one fluid inlet port and the cooling chamber, a coolant return lumen in fluid communication with the at least one fluid outlet port and the cooling chamber, the coolant injection tube, the cooling chamber, and the primary coolant return lumen defining a fluid pathway and a temperature sensor located near the coolant return lumen; measuring an internal temperature of the chamber, and modifying the position of the catheter in response to the measured temperature. The method and system can also use a measured impedance to determine contact assessment.
摘要翻译：用于确定接触评估的方法和系统包括将导管定位在组织治疗部位的步骤，其中所述导管具有近端部分和远端部分，所述近端部分限定至少一个流体入口端口和至少一个流体出口端口，限定冷却室的可膨胀膜，与所述至少一个流体入口和所述冷却室流体连通的冷却剂注入腔，与所述至少一个流体出口和所述冷却室流体连通的冷却剂返回内腔冷却剂注入管，冷却室和第一冷却剂回流腔限定流体通路和位于冷却剂回流腔附近的温度传感器; 测量腔室的内部温度，以及响应于测量的温度改变导管的位置。该方法和系统还可以使用测量的阻抗来确定接触评估。

95. 发明授权

US07118565B2 Cryoblation catheter handle 有权
公开(公告)号：US07118565B2
公开(公告)日：2006-10-10
申请号：US10706525
申请日：2003-11-12
申请人： Marwan Abboud , Domenic Santoianni , Philippe Marchand
发明人： Marwan Abboud , Domenic Santoianni , Philippe Marchand
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61M25/0136 , A61M25/0147 , A61M39/1011 , A61M39/105
摘要： A cryocatheter system includes a first handle portion having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path; a second handle portion having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path; and a catheter having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path. The distal end of the first handle portion is matable with the proximal end of the second handle portion to place the respective first and second fluid flow paths of each handle portion in fluid communication; and the distal end of the second handle portion is matable with the proximal end of the catheter to place the respective first and second fluid flow paths of the second handle portion and the catheter in fluid communication.

96. 发明申请

US20060122589A1 Method and apparatus for inflating and deflating balloon catheters 有权
公开(公告)号：US20060122589A1
公开(公告)日：2006-06-08
申请号：US11301768
申请日：2005-12-13
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Eric Monger
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Eric Monger
IPC分类号： A61B18/02 , A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/22051 , A61B2018/0022 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M25/1018 , A61M25/10185
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, having a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system comprises a PID (Proportional Integral Derivative) controller or other pressure-sensing device that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted. In one embodiment, an intermediate console is placed between the console and the balloon catheter and coupled thereto. If a leak is detected, a shut off valve in the intermediate station is activated and the flow of pressurized coolant is interrupted. The balloon catheter can be re-inflated by a separate coolant source in the intermediate station or by a syringe. A further embodiment provides a second balloon to envelope the first balloon and in order to provide a safety vacuum between the two balloons.

97. 发明申请

US20050228367A1 Leak detection system for catheter based medical device 审中-公开
标题翻译：基于导管的医疗器械泄漏检测系统
公开(公告)号：US20050228367A1
公开(公告)日：2005-10-13
申请号：US11129021
申请日：2005-05-13
申请人： Marwan Abboud , Johnny Asmar , John Lehmann
发明人： Marwan Abboud , Johnny Asmar , John Lehmann
IPC分类号： A61B18/02 , A61B18/18
CPC分类号： A61B18/02 , A61B2018/00214 , A61B2018/0212 , A61B2018/0262
摘要： The present invention provides a medical device having an elongate body, which includes an injection lumen, an exhaust lumen, and a guidewire lumen. The medical device further includes a first pliable element defining a cooling chamber, and a second pliable element at least partially enclosing the first pliable element, defining a junction between the first and second pliable element. Moreover, a first leak detector is provided in fluid communication with the cooling chamber, while a second leak detector is in fluid communication with the junction. In addition, the medical device may be in communication with a control console, a fluid supply, or a vacuum source.
摘要翻译：本发明提供一种具有细长主体的医疗装置，其包括注射腔，排气腔和导丝腔。医疗装置还包括限定冷却室的第一柔韧元件和至少部分地包围第一柔韧元件的第二柔韧元件，其限定第一和第二柔韧元件之间的接合部。此外，第一泄漏检测器设置成与冷却室流体连通，而第二泄漏检测器与结点流体连通。此外，医疗装置可以与控制台，流体供应或真空源连通。

98. 发明授权

US07905879B2 Cryoablation catheter handle 有权
标题翻译：冷冻消融导管手柄
公开(公告)号：US07905879B2
公开(公告)日：2011-03-15
申请号：US11499213
申请日：2006-08-04
申请人： Marwan Abboud , Domenic Santoianni , Philippe Marchand
发明人： Marwan Abboud , Domenic Santoianni , Philippe Marchand
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61M39/1011
摘要： A cryocatheter system includes a first handle portion having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path; a second handle portion having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path; and a catheter having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path. The distal end of the first handle portion is matable with the proximal end of the second handle portion to place the respective first and second fluid flow paths of each handle portion in fluid communication; and the distal end of the second handle portion is matable with the proximal end of the catheter to place the respective first and second fluid flow paths of the second handle portion and the catheter in fluid communication.
摘要翻译：一种低温切管系统包括具有近端，远端，第一流体流动路径和第二流体流路的第一手柄部分; 具有近端，远端，第一流体流动路径和第二流体流路的第二手柄部分; 以及具有近端，远端，第一流体流动路径和第二流体流动路径的导管。第一手柄部分的远端可与第二手柄部分的近端配合，以使每个手柄部分的相应的第一和第二流体流动路径流体连通; 并且第二手柄部分的远端可与导管的近端配合，以使第二手柄部分和导管的相应的第一和第二流体流动路径流体连通。

99. 发明授权

US07842031B2 Bioimpedance measurement system and method 有权
标题翻译：生物阻抗测量系统和方法
公开(公告)号：US07842031B2
公开(公告)日：2010-11-30
申请号：US11283057
申请日：2005-11-18
申请人： Marwan Abboud , Johnny Al Asmar , Chadi Harmouche
发明人： Marwan Abboud , Johnny Al Asmar , Chadi Harmouche
IPC分类号： A61B18/18 , A61B5/05
CPC分类号： A61B5/0537 , A61B18/02 , A61B2017/00026 , A61B2018/0022 , A61B2018/0212
摘要： Methods and systems for detecting fluid egress, assessing lesion quality, determining tissue composition or structure, determining ice coverage of catheter tip and providing tissue contact assessment, by providing a catheter having a shaft with a proximal end portion and a distal end portion, the proximal end portion and the distal end portion define at least one fluid pathway therebetween with the shaft having a plurality of electrodes, positioning the catheter at a tissue treatment site, applying an electrical current between at least two of the plurality of electrodes, measuring impedance voltage between the at least two of the plurality of electrodes and, processing the measured impedance voltage caused by the applied electrical current to determine if fluid egress is present, to assess lesion quality, to determine tissue composition, ice cover of catheter tip, and to provide contact assessment. The system may have a control unit, a microprocessor, an impedance measuring device or the like to perform processing of impedance data.
摘要翻译：用于检测流体出口的方法和系统，评估病变质量，确定组织组成或结构，通过提供具有近端部分和远端部分的轴的导管，确定导管尖端的冰覆盖和提供组织接触评估，末端部分和远端部分限定其间的至少一个流体通路，其中轴具有多个电极，将导管定位在组织治疗部位，在多个电极中的至少两个之间施加电流，测量多个电极之间的阻抗电压所述多个电极中的至少两个，并且处理由施加的电流引起的测量的阻抗电压以确定是否存在流体出口，以评估病变质量，确定组织组成，导管尖端的冰盖，并提供接触评定。系统可以具有控制单元，微处理器，阻抗测量装置等，以执行阻抗数据的处理。

100. 发明申请

US20080243111A1 Surgical method and apparatus for treating atrial fibrillation 有权
标题翻译：用于治疗房颤的手术方法和装置
公开(公告)号：US20080243111A1
公开(公告)日：2008-10-02
申请号：US11184045
申请日：2006-01-06
申请人： James Gammie , Randy Jordan , Marwan Abboud , Allan Zingeler , Saqib Masroor
发明人： James Gammie , Randy Jordan , Marwan Abboud , Allan Zingeler , Saqib Masroor
IPC分类号： A61B17/32 , A61B18/02
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body, a proximal end and a distal end; a first lumen; a second lumen; and an ablation element expandable from a first diameter to a second diameter, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more deformable balloon and/or flexible elements. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method, a tissue ablation device is provided and tissue in the left atrium is ablated with the device, whereby the ablation is created by freezing tissue.
摘要翻译：本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。在示例性实施例中，冷冻治疗装置包括导管主体，近端和远端; 第一个管腔第二个管腔以及可从第一直径扩展到第二直径的消融元件，所述消融元件具有与心脏组织的不平坦表面形貌一致的表面部分。消融元件可以包括一个或多个可变形的球囊和/或柔性元件。球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。在一种示例性方法中，提供组织消融装置，并且使用该装置消除左心房中的组织，由此通过冷冻组织产生消融。

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