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1. 发明授权

US07727228B2 Method and apparatus for inflating and deflating balloon catheters 有权
标题翻译：球囊导管充气和放气的方法和装置
公开(公告)号：US07727228B2
公开(公告)日：2010-06-01
申请号：US10806995
申请日：2004-03-23
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Eric Monger
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Eric Monger
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/22051 , A61B2018/0022 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M25/1018 , A61M25/10185
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter is provided. The system includes a balloon catheter, a console having a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system comprises a PID (Proportional Integral Derivative) controller or other pressure-sensing device that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted.
摘要翻译：提供了一种用于控制气囊导管的充气，消融和放气的系统和方法。该系统包括球囊导管，具有加压气体或液体充气源的控制台，以及将加压的冷却剂输送到球囊导管的脐带系统。该系统包括PID（比例积分微分）控制器或其他压力感测装置，其监测气囊导管内的压力和体积的量。在充气期间，气囊内的流体的压力和/或体积保持在目标量，以便提供相对于期望目标区域的足够的机械化压力。该系统会限制通气压力，以便在发生泄漏时释放出安全数量的气体。如果该量低于某一阈值水平，则假设气体或流体出口，并且暂停充气过程。

2. 发明授权

US09027389B2 Fluid control system for a medical device 有权
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US09027389B2
公开(公告)日：2015-05-12
申请号：US13526620
申请日：2012-06-19
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61B18/02 , G01M3/28 , A61B17/00 , A61B18/00
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. A check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. Additionally, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔韧元件之间的接合部。包括止回阀，其与第一柔韧元件和第二柔韧元件之间的接合部流体连通，所述阀还与排气腔流体连通。此外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监测装置。

3. 发明授权

US08206345B2 Fluid control system for a medical device 有权
公开(公告)号：US08206345B2
公开(公告)日：2012-06-26
申请号：US11074293
申请日：2005-03-07
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61M29/00
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.

4. 发明授权

US08491636B2 Method and apparatus for inflating and deflating balloon catheters 有权
标题翻译：球囊导管充气和放气的方法和装置
公开(公告)号：US08491636B2
公开(公告)日：2013-07-23
申请号：US11581592
申请日：2006-10-16
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Gilles Desrochers
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Gilles Desrochers
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M25/10184
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system may include controller that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted.
摘要翻译：用于控制气囊导管的充气，消融和放气的系统和方法。该系统包括球囊导管，控制台，加压气体或液体充气源，以及将加压冷却剂输送到球囊导管的脐带系统。该系统可以包括监控气囊导管内的压力和体积的量的控制器。在充气期间，气囊内的流体的压力和/或体积保持在目标量，以便提供相对于期望目标区域的足够的机械化压力。该系统会限制通气压力，以便在发生泄漏时释放出安全数量的气体。如果该量低于某一阈值水平，则假设气体或流体出口，并且暂停充气过程。

5. 发明申请

US20080221508A1 FLUID CONTROL SYSTEM FOR A MEDICAL DEVICE 有权
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US20080221508A1
公开(公告)日：2008-09-11
申请号：US12125533
申请日：2008-05-22
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61M1/00
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔性元件之间的接合部。此外，包括与第一柔韧元件和第二柔韧元件之间的接合部流体连通的止回阀，阀还与排气腔流体连通。另外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监控装置。

6. 发明授权

US08225643B2 Fluid control system for a medical device 有权
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US08225643B2
公开(公告)日：2012-07-24
申请号：US12125533
申请日：2008-05-22
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： G01M3/26
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔韧元件之间的接合部。此外，包括与第一柔韧元件和第二柔韧元件之间的接合部流体连通的止回阀，阀还与排气腔流体连通。另外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监控装置。

7. 发明申请

US20050215989A1 Method and apparatus for inflating and deflating balloon catheters 有权
标题翻译：球囊导管充气和放气的方法和装置
公开(公告)号：US20050215989A1
公开(公告)日：2005-09-29
申请号：US10806995
申请日：2004-03-23
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Eric Monger
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Eric Monger
IPC分类号： A61F2/958 , A61B17/22 , A61B18/02 , A61B18/04 , A61B18/14 , A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/22051 , A61B2018/0022 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M25/1018 , A61M25/10185
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, having a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system comprises a PID (Proportional Integral Derivative) controller or other pressure-sensing device that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted. In one embodiment, an intermediate console is placed between the console and the balloon catheter and coupled thereto. If a leak is detected, a shut off valve in the intermediate station is activated and the flow of pressurized coolant is interrupted. The balloon catheter can be re-inflated by a separate coolant source in the intermediate station or by a syringe. A further embodiment provides a second balloon to envelope the first balloon and in order to provide a safety vacuum between the two balloons.
摘要翻译：用于控制气囊导管的充气，消融和放气的系统和方法。该系统包括气囊导管，具有加压气体或液体充气源的控制台，以及将加压冷却剂输送到球囊导管的脐带系统。该系统包括PID（比例积分微分）控制器或其他压力感测装置，其监测气囊导管内的压力和体积的量。在充气期间，气囊内的流体的压力和/或体积保持在目标量，以便提供相对于期望目标区域的足够的机械化压力。该系统会限制通气压力，以便在发生泄漏时释放出安全数量的气体。如果该量低于某一阈值水平，则假设气体或流体出口，并且暂停充气过程。在一个实施例中，将中间控制台放置在控制台和气囊导管之间并与其连接。如果检测到泄漏，则中间站中的截止阀被激活，并且加压冷却剂的流动被中断。气囊导管可以通过中间站中的单独的冷却剂源或注射器重新充气。另一实施例提供第二气囊以包围第一气囊并且为了在两个气球之间提供安全真空。

8. 发明授权

US08545491B2 Method and apparatus for inflating and deflating balloon catheters 有权
标题翻译：球囊导管充气和放气的方法和装置
公开(公告)号：US08545491B2
公开(公告)日：2013-10-01
申请号：US11301768
申请日：2005-12-13
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Eric Monger
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Eric Monger
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/22051 , A61B2018/0022 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M25/1018 , A61M25/10185
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, having a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system comprises a PID (Proportional Integral Derivative) controller or other pressure-sensing device that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted. In one embodiment, an intermediate console is placed between the console and the balloon catheter and coupled thereto. If a leak is detected, a shut off valve in the intermediate station is activated and the flow of pressurized coolant is interrupted. The balloon catheter can be re-inflated by a separate coolant source in the intermediate station or by a syringe. A further embodiment provides a second balloon to envelope the first balloon and in order to provide a safety vacuum between the two balloons.
摘要翻译：用于控制气囊导管的充气，消融和放气的系统和方法。该系统包括气囊导管，具有加压气体或液体充气源的控制台，以及将加压冷却剂输送到球囊导管的脐带系统。该系统包括PID（比例积分微分）控制器或其他压力感测装置，其监测气囊导管内的压力和体积的量。在充气期间，气囊内的流体的压力和/或体积保持在目标量，以便提供相对于期望目标区域的足够的机械化压力。该系统会限制通气压力，以便在发生泄漏时释放出安全数量的气体。如果该量低于某一阈值水平，则假设气体或流体出口，并且暂停充气过程。在一个实施例中，将中间控制台放置在控制台和气囊导管之间并与其连接。如果检测到泄漏，则中间站中的截止阀被激活，并且加压冷却剂的流动被中断。气囊导管可以通过中间站中的单独的冷却剂源或注射器重新充气。另一实施例提供第二气囊以包围第一气囊并且为了在两个气球之间提供安全真空。

9. 发明申请

US20060122589A1 Method and apparatus for inflating and deflating balloon catheters 有权
公开(公告)号：US20060122589A1
公开(公告)日：2006-06-08
申请号：US11301768
申请日：2005-12-13
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Eric Monger
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Eric Monger
IPC分类号： A61B18/02 , A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/22051 , A61B2018/0022 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M25/1018 , A61M25/10185
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, having a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system comprises a PID (Proportional Integral Derivative) controller or other pressure-sensing device that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted. In one embodiment, an intermediate console is placed between the console and the balloon catheter and coupled thereto. If a leak is detected, a shut off valve in the intermediate station is activated and the flow of pressurized coolant is interrupted. The balloon catheter can be re-inflated by a separate coolant source in the intermediate station or by a syringe. A further embodiment provides a second balloon to envelope the first balloon and in order to provide a safety vacuum between the two balloons.

10. 发明授权

US08298217B2 Endovascular cryotreatment catheter 有权
标题翻译：血管内冷冻治疗导管
公开(公告)号：US08298217B2
公开(公告)日：2012-10-30
申请号：US12410835
申请日：2009-03-25
申请人： Miriam Lane , Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik
发明人： Miriam Lane , Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. One or more sensors may be disposed between the balloons or the vacuum return lumen, to detect leaks and control the flow of fluid through the device. Examples of sensors include pressure and temperature sensors, optical sensors, magnetic flow switches and flow meters.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。一个或多个传感器可以设置在气球或真空返回腔之间，以检测泄漏并控制通过装置的流体的流动。传感器的示例包括压力和温度传感器，光学传感器，磁流量开关和流量计。

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