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91. 发明申请

US20090053259A1 VACCINES AND METHODS FOR TREATMENT OR PREVENTION OF GRAM NEGATIVE BACTERIAL INFECTION IN A VERTEBRATE SUBJECT 审中-公开
标题翻译：用于治疗或预防骨质疏松症主要感染细菌感染的疫苗和方法
公开(公告)号：US20090053259A1
公开(公告)日：2009-02-26
申请号：US12178436
申请日：2008-07-23
申请人： Andrew A. Potter , Ursla Fernando
发明人： Andrew A. Potter , Ursla Fernando
IPC分类号： A61K39/106
CPC分类号： A61K39/105 , A61K2039/55 , A61K2039/552 , A61K2039/55566 , Y02A50/47
摘要： Methods for the treatment or prevention of Gram negative bacterial infection in a vertebrate subject are provided. The methods provide administering an antagonist of bacterial flagellar protein biosynthesis to the vertebrate subject in an amount effective to reduce or eliminate the bacterial infection. Methods for the treatment or prevention of Campylobacter jejuni infection in an avian species or a mammalian species are provided.
摘要翻译：提供了在脊椎动物受试者中治疗或预防革兰氏阴性细菌感染的方法。所述方法提供以有效减少或消除细菌感染的量向脊椎动物受试者施用细菌鞭毛蛋白生物合成拮抗剂。提供了用于治疗或预防禽类物种或哺乳动物物种的空肠弯曲杆菌感染的方法。

92. 发明授权

US07368632B2 Plant stress tolerance genes, and uses therefor 失效
标题翻译：植物胁迫耐性基因及其用途
公开(公告)号：US07368632B2
公开(公告)日：2008-05-06
申请号：US10534744
申请日：2003-11-14
申请人： Albert James Robertson , Lawrence Victor Gusta , Guohai Wu
发明人： Albert James Robertson , Lawrence Victor Gusta , Guohai Wu
IPC分类号： A01H5/00 , C12N15/82 , C12N15/87 , C12N5/14 , C07H21/00
CPC分类号： C12N15/8273
摘要： Plant stresses such as pest infestations, disease, drought, flood, and excessive temperatures can lead to significant losses of crops each year. There is a continuing need to develop novel plant varieties that are less susceptible to damage or loss by such stresses. The present invention provides for the isolation, characterization and use of an entirely novel class of plant genes, generally designated ROB5. Transgenic plants expressing ROB5 can show a dramatic improvement in their capacity to tolerate a variety of stress conditions. Moreover, ROB5 expression can further lead to marked increases in plant growth rates and plant vigor. The present invention encompasses all such ROB5 genes and peptides encoded thereby, plants expressing corresponding ROB5 constructs, and plant products thereof.
摘要翻译：病虫害，疾病，干旱，洪水和过度温度等植物胁迫可能导致农作物每年大量损失。继续需要开发不易遭受这种胁迫的损害或损失的新型植物品种。本发明提供了通常称为ROB5的完全新颖的植物基因的分离，表征和使用。表达ROB5的转基因植物可以显着改善耐受各种胁迫条件的能力。此外，ROB5表达可进一步导致植物生长速度和植物活力显着增加。本发明包括所有这样的ROB5基因和由其编码的肽，表达相应的ROB5构建体的植物及其植物产物。

93. 发明授权

US07335353B2 Porcine cells comprising an adenovirus E3 gene region 有权
标题翻译：包含腺病毒E3基因区的猪细胞
公开(公告)号：US07335353B2
公开(公告)日：2008-02-26
申请号：US10245603
申请日：2002-09-16
申请人： Police S. Reddy , Suresh K. Tikoo , Lorne A. Babiuk
发明人： Police S. Reddy , Suresh K. Tikoo , Lorne A. Babiuk
IPC分类号： A01N63/00 , A01N65/00 , A61K48/00 , A61K39/23 , A61K39/235 , A61K31/70 , C12N5/00 , C12N5/02 , A01N43/04
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10362
摘要： The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells are provided. Recombinant PAV viruses are obtained by transfection of mammalian cells with recombinant PAV genomes. The PAV-3 genome can be used as a vector for the expression of heterologous nucleotide sequences, for example, for the preparation and administration of subunit vaccines to swine or other mammals. In addition, PAV-3 vectors can be used for gene therapy and expression of heterologous polypeptides. PAV-3 genome sequences can also be used for diagnostic purposes, to detect the presence of PAV-3 DNA in a subject or biological sample.
摘要翻译：提供猪腺病毒3型（PAV-3）基因组的完整核苷酸序列。提供了在原核细胞中通过同源重组构建感染性PAV基因组的方法。通过用重组PAV基因组转染哺乳动物细胞获得重组PAV病毒。 PAV-3基因组可用作异源核苷酸序列的表达载体，例如用于制备和施用猪或其他哺乳动物的亚单位疫苗。此外，PAV-3载体可用于基因治疗和异源多肽的表达。 PAV-3基因组序列也可用于诊断目的，以检测受试者或生物样品中PAV-3 DNA的存在。

94. 发明授权

US06946448B2 In utero oral nucleic acid immunization 有权
标题翻译：在子宫口服核酸免疫
公开(公告)号：US06946448B2
公开(公告)日：2005-09-20
申请号：US10155867
申请日：2002-05-23
申请人： Volker Gerdts , Lorne Babiuk , Sylvia van Drunen Littel-van den Hurk , Philip J. Griebel
发明人： Volker Gerdts , Lorne Babiuk , Sylvia van Drunen Littel-van den Hurk , Philip J. Griebel
IPC分类号： A61K39/00 , A61K39/245 , A01N43/04 , A01N63/00 , A61K39/29 , A61K48/00
CPC分类号： A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/5252 , A61K2039/53 , A61K2039/54 , A61K2039/542 , A61K2039/55505 , A61K2039/57 , C12N2710/16734 , C12N2730/10134
摘要： Methods of nucleic acid immunization comprising the in utero delivery of nucleic acid molecules that encode one or more selected antigens to a vertebrate fetus are disclosed.
摘要翻译：公开了包含将脊椎动物胎儿编码一种或多种选择的抗原的核酸分子的子宫内递送的核酸免疫方法。

95. 发明授权

US06936259B2 CAMP factor of Streptococcus uberis 失效
标题翻译：乳腺链球菌的CAMP因子
公开(公告)号：US06936259B2
公开(公告)日：2005-08-30
申请号：US10134021
申请日：2002-04-26
申请人： Andrew A. Potter , Jose Perez-Casal , Michael Fontaine , Xinming Song
发明人： Andrew A. Potter , Jose Perez-Casal , Michael Fontaine , Xinming Song
IPC分类号： G01N33/569 , A61K39/00 , A61K39/09 , A61P15/14 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12P21/08 , A01N63/00 , A61K39/38 , A61K39/395
CPC分类号： C07K14/315 , A61K39/00 , C07K2319/02
摘要： The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs, including CAMP factor epitopes from more than one bacterial species. The CAMP factors and chimeras including the same can be used in immunogenic compositions for the prevention and treatment of bacterial infections.
摘要翻译：描述了乳房链球菌（乳房链球菌）的CAMP因子基因，以及从其重组产生CAMP因子。还公开了嵌合CAMP因子构建体，包括来自多于一种细菌种的CAMP因子表位。包括其的CAMP因子和嵌合体可用于免疫原性组合物中用于预防和治疗细菌感染。

96. 发明申请

US20050159393A1 Aliphatic amino carboxylic and amino phosphonic acids, amino nitriles and amino tetrazoles as cellular rescue agents 审中-公开
标题翻译：脂肪族氨基羧酸和氨基膦酸，氨基腈和氨基四唑作为细胞拯救剂
公开(公告)号：US20050159393A1
公开(公告)日：2005-07-21
申请号：US11077124
申请日：2005-03-11
申请人： Lillian Dyck , Bruce Davis , Ya-Dong Liu , David Durden , Alan Boulton , I. Paterson , Brenda Kennedy , Kevin Rogers
发明人： Lillian Dyck , Bruce Davis , Ya-Dong Liu , David Durden , Alan Boulton , I. Paterson , Brenda Kennedy , Kevin Rogers
IPC分类号： C07C229/12 , C07C255/24 , C07C255/25 , C07F9/38 , C07F9/40 , C07F9/28 , A61K31/195 , A61K31/275 , A61K31/41 , A61K31/66
CPC分类号： C07F9/3808 , C07C229/12 , C07C255/24 , C07C255/25 , C07F9/4006
摘要： Novel compounds of the formula I are described: wherein: R1=(CH2)mCH3 where m is 0 or an integer in the range from 1 to 16, or an alkenyl, alkynyl, alkoxy, alkylthio, or alkyl sulfinyl group having from 2 to 17 carbon atoms, R2=H, CH3 or CH2CH3 R3=H or CH3 R4=H or CH3 R5=lower alkyl having from 1 to 5 carbon atoms n is an integer in the range from 1 to 3, and X is carboxyl (COOH) or carbalkoxy (COOR5), cyano (C≡N), phosphonic acid (PO3H2), phosphonate ester (PO3[R5]2) or 5-tetrazole, and pharmaceutically acceptable salts thereof. Preferably, the compounds are optically pure enantiomers of the R- or S-configuration in which R3=R4=R5=H, R2=CH3 and R1 is a saturated aliphatic chain of one to five carbon atoms. The compounds are useful as cellular rescue agents.
摘要翻译：描述了新的式I化合物：其中：R 1 =（CH 2 CH 2）m CH 3其中 m为0或1至16的整数，或具有2至17个碳原子的烯基，炔基，烷氧基，烷硫基或烷基亚磺酰基，R 2 = H，CH 2， 3> 3或CH 2 CH 3 3 R 3 = H或CH 3 R＆lt; SUB＆lt; 3＆gt; > 4 = H或CH 3 R 5 =具有1至5个碳原子的低级烷基n是1至3的整数，并且 X是羧基（COOH）或烷氧基（COOR 5），氰基（C≡N），膦酸（PO 3 H 2 H 2）膦酸酯（PO 3/3 [R 5/2] 2）或5-四唑及其药学上可接受的盐。优选地，化合物是其中R 3 = R 4 = R 5 = H的R-或S-构型的光学纯对映异构体， R 2 = CH 3和R 1是1至5个碳原子的饱和脂族链。这些化合物可用作细胞拯救剂。

97. 发明申请

US20050142615A1 Immunization of dairy cattle with chimeric GapC protein against Streptococcus infection 有权
标题翻译：用针对链球菌感染的嵌合GapC蛋白免疫奶牛
公开(公告)号：US20050142615A1
公开(公告)日：2005-06-30
申请号：US11066594
申请日：2005-02-25
申请人： Andrew Potter , Jose Perez-Casal , Michael Fontaine
发明人： Andrew Potter , Jose Perez-Casal , Michael Fontaine
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , A61P31/04 , C07K14/315 , G01N33/53 , A61K39/09
CPC分类号： G01N33/56944 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/315 , C07K2319/00 , G01N2469/20
摘要： The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.
摘要翻译：描述了除了来自婴儿链球菌和无乳链球菌GapC蛋白质的唯一氨基酸序列之外，重组产生包含除了乳酸链球菌GapC蛋白的全部氨基酸序列的嵌合GapC纤溶酶结合蛋白的Gap4。还描述了Gap4嵌合GapC蛋白在疫苗组合物中的用途，特别是预防或治疗一般的链球菌感染和乳腺炎。

98. 发明申请

US20040062774A1 Immunization of dairy cattle with chimeric GapC protein against streptococcus infection 有权
标题翻译：用针对链球菌感染的嵌合GapC蛋白免疫奶牛
公开(公告)号：US20040062774A1
公开(公告)日：2004-04-01
申请号：US10650369
申请日：2003-08-27
申请人： University of Saskatchewan
发明人： Andrew A. Potter , Jose Perez-Casal , Michael Fontaine
IPC分类号： A61K039/00 , C07K014/705
CPC分类号： G01N33/56944 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/315 , C07K2319/00 , G01N2469/20
摘要： The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.
摘要翻译：描述了除了来自婴儿链球菌和无乳链球菌GapC蛋白质的唯一氨基酸序列之外，重组产生包含除了乳酸链球菌GapC蛋白的全部氨基酸序列的嵌合GapC纤溶酶结合蛋白的Gap4。还描述了Gap4嵌合GapC蛋白在疫苗组合物中的用途，特别是预防或治疗一般的链球菌感染和乳腺炎。

99. 发明申请

US20020106639A1 Postweaning multisystemic wasting syndrome virus from pigs 审中-公开
标题翻译：断奶多系统消耗综合征病毒从猪
公开(公告)号：US20020106639A1
公开(公告)日：2002-08-08
申请号：US09935428
申请日：2001-08-20
申请人： University of Saskatchewan
发明人： Li Wang , Lorne A. Babiuk , Andrew A. Potter , Philip Willson
IPC分类号： C12Q001/70 , C07H021/04 , C12N015/09 , C12N007/00 , C12N015/00 , C12N015/70 , C12N005/06 , C07K001/00 , C07K017/00 , C12P021/08 , C12Q001/68 , C12P021/04 , C12N015/63 , C12N005/16 , C07K016/00 , C12P021/06 , C12N007/01 , C12N015/74 , C07K014/00 , G01N033/53
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/12 , A61K2039/552 , C12N7/00 , C12N15/86 , C12N2750/10022 , C12N2750/10043 , C12Q1/701
摘要： The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.
摘要翻译：新型PCVII病毒基因组的克隆描述为源自PCVII基因组的蛋白质的表达。这些蛋白质可用于预防和治疗PCVII感染的疫苗组合物中，以及用于确定脊椎动物受试者中PCVII感染存在的诊断方法。衍生自病毒基因组的多核苷酸可用作诊断引物和探针。

100. 发明授权

US6096320A Vaccines with chimeric protein comprising gamma-interferon and leukotoxin derived from pasteurella haemolytica 失效
标题翻译：含有衍生自溶血性巴斯德氏菌的γ-干扰素和白细胞毒素的嵌合蛋白的疫苗
公开(公告)号：US6096320A
公开(公告)日：2000-08-01
申请号：US954418
申请日：1997-10-20
申请人： Andrew Potter , Manuel Campos , Huw P. A. Hughes
发明人： Andrew Potter , Manuel Campos , Huw P. A. Hughes
IPC分类号： A61K39/00 , A61P11/00 , C07K14/285 , C07K14/55 , C07K14/57 , C12N15/23 , A61K39/102
CPC分类号： C07K14/285 , C07K14/55 , C07K14/57 , A61K39/00 , C07K2319/00 , C07K2319/55 , C07K2319/61 , C07K2319/75 , Y10S530/825
摘要： New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of an RTX cytotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.
摘要翻译：公开了新的嵌合蛋白质，编码相同的DNA，以及这些蛋白质在刺激抗呼吸系统疾病如肺炎的免疫力（包括运送发热性肺炎）中的用途。嵌合蛋白包括与细胞因子的活性片段融合的RTX细胞毒素的至少一个表位。嵌合蛋白可用于疫苗组合物。还公开了接种疫苗的方法以及制备疫苗中使用的蛋白质的方法。

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