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91. 发明授权

US4217354A Ketazocine anesthetic method of use 失效
标题翻译：卡替舒麻醉方法使用
公开(公告)号：US4217354A
公开(公告)日：1980-08-12
申请号：US11107
申请日：1979-02-12
申请人： Alfred E. Farah
发明人： Alfred E. Farah
IPC分类号： C07D221/26 , A61K31/435 , A61K31/445 , A61P23/00
CPC分类号： A61K31/445
摘要： The method of producing anesthesia in a mammal comprising administering intravenously to the mammal an anesthetically effective amount of a pharmaceutically acceptable salt of racemic ketazocine or levo-ketazocine with or without diazepam premedication and the method of producing analgesia in a human which comprises administering intramuscularly to the human an anesthetically effective amount of at least 1 mg. of a pharmaceutically acceptable salt of racemic ketazocine or levo-ketazocine are disclosed.
摘要翻译：在哺乳动物中产生麻醉的方法，包括向哺乳动物施用麻醉有效量的具有或不具有地西泮预处理的外消旋的酮替卡因或左旋酮佐昔康的药学上可接受的盐以及在人中产生止痛的方法，所述方法包括以下步骤施用：肌内注射人麻醉有效量至少1mg。的外消旋的酮替卡因或左旋酮扎昔康的药学上可接受的盐。

92. 发明授权

US4209526A Antiviral arylenedioxyalkyl substituted pyrazoles 失效
标题翻译：抗病毒亚芳基二氧基烷基取代的吡唑
公开(公告)号：US4209526A
公开(公告)日：1980-06-24
申请号：US8412
申请日：1979-02-01
申请人： Guy D. Diana , Philip M. Carabateas
发明人： Guy D. Diana , Philip M. Carabateas
IPC分类号： C07C41/16 , C07C43/225 , C07D231/12 , A61K31/415
CPC分类号： C07D231/12 , C07C317/00 , C07C41/16 , C07C41/22 , C07C45/68
摘要： 4-(Aryloxyalkyl)pyrazoles of the formula ##STR1## useful as antiviral agents, are prepared by reacting the corresponding diketones of the formula Ar-O-Alk-CH(COR')COR" with hydrazine or a substituted hydrazine H.sub.2 NNHR. Mono- or bis-pyrazoles are similarly obtained from bis-diketones of the formula ##STR2##
摘要翻译：通过使式Ar-O-Alk-CH（COR'）COR“的相应二酮与肼或取代肼H2NNHR反应制备用作抗病毒剂的式（IMAGE）的4-（芳氧基烷基）吡唑。单 - 或双 - 吡唑类似地由式（IMAGE）的双 - 二酮得到

93. 发明授权

US4207982A Flip top container 失效
标题翻译：翻盖顶部容器
公开(公告)号：US4207982A
公开(公告)日：1980-06-17
申请号：US35902
申请日：1979-05-03
申请人： Donald J. Maxwell , David J. Crisp
发明人： Donald J. Maxwell , David J. Crisp
IPC分类号： B65D85/58 , A61J7/04 , B65D47/06 , B65D45/00 , B65D83/04 , B65D85/56
CPC分类号： B65D47/068
摘要： This invention relates to a pivotal closure for a container. The closure structure includes a collar defining an opening, and associated with the opening is a lid mounted for rotation about an axis generally coaxial with this opening. This lid is further mounted for pivoting about an axis normal to the axis of rotation between a closed position in which the lid closes the opening and an open position in which an aperture defined by the lid and/or the collar allows access through the opening. The rotation of the lid is governed by a cam mechanism operable by pivoting movement of the lid. The can mechanism is, generally, a saw-tooth cam surface associated with either the collar or the lid and a cam follower associated with either the collar or the lid, so that pivoting the lid from a closed position through an open position and back to a closed position causes the lid to rotate about the axis of the opening by an amount determined by the cam surface.
摘要翻译：本发明涉及容器的枢转闭合件。闭合结构包括限定开口的套环，并且与开口相关联的是安装成围绕与该开口大致同轴的轴线旋转的盖。该盖进一步安装成用于在盖关闭开口的关闭位置和由盖和/或套环限定的孔允许通过开口进入的打开位置之间绕垂直于旋转轴线的轴线转动。盖的旋转由通过盖的枢转运动可操作的凸轮机构来控制。罐机构通常是与套环或盖子相关联的锯齿凸轮表面和与套环或盖子相关联的凸轮从动件，使得盖子从关闭位置枢转通过打开位置并且回到关闭位置使盖子围绕开口的轴线旋转由凸轮表面确定的量。

94. 发明授权

US4207418A 1,2-Ethanediamine salts of nalidixic acid 失效
标题翻译：萘啶酸的1,2-乙二胺盐
公开(公告)号：US4207418A
公开(公告)日：1980-06-10
申请号：US948956
申请日：1978-10-05
申请人： Denis M. Bailey
发明人： Denis M. Bailey
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： 1:1 and 1:2 molar salts of 1,2-ethanediamine and nalidixic acid are prepared by reacting 1,2-ethanediamine with one or two molar equivalents of nalidixic acid. Also shown are aqueous solutions of the 1:1 equimolar salt and their preparation from the corresponding 1:2 molar salt.
摘要翻译：通过1,2-乙二胺与1或2摩尔当量的萘啶酸反应制备1,2-乙二胺和萘啶酸的1：1和1：2摩尔盐。还显示了1:1等摩尔盐的水溶液及其相应的1:2摩尔盐的制备。

95. 发明授权

US4207306A Process for producing polycrystalline ceramic oxides 失效
标题翻译：生产多晶陶瓷氧化物的方法
公开(公告)号：US4207306A
公开(公告)日：1980-06-10
申请号：US862784
申请日：1977-12-21
申请人： Michael Jarcho
发明人： Michael Jarcho
IPC分类号： A61F2/00 , A61L27/10 , A61L27/12 , C01B25/32 , C04B35/447 , C01G49/06
CPC分类号： C04B35/447 , A61K6/021 , A61K6/0215 , A61K6/023 , A61K6/0235 , A61K6/033 , A61L27/10 , A61L27/12 , C01B25/325 , A61F2310/00179 , A61F2310/00203 , A61F2310/00293
摘要： A novel ceramic form of hydroxylapatite and a novel ceramic product comprising a mixture of the latter and whitlockite, the preparation of these ceramics and dental restorative compositions and dental and surgical prosthetic materials containing the same are disclosed. Also described is a novel and improved process for producing polycrystalline ceramic oxides.
摘要翻译：公开了一种羟基磷灰石的新型陶瓷形式和包含后者和白铁矿的混合物的新型陶瓷产品，这些陶瓷和牙科修复组合物的制备以及含有它们的牙科和外科手术修复材料。还描述了一种用于生产多晶陶瓷氧化物的新颖和改进的方法。

96. 发明授权

US4204875A Cementitious compositions 失效
标题翻译：水泥组合物
公开(公告)号：US4204875A
公开(公告)日：1980-05-27
申请号：US809057
申请日：1977-06-22
申请人： Miklos Szalavitz
发明人： Miklos Szalavitz
IPC分类号： C04B22/00 , C04B22/06 , C04B22/14 , C04B24/12 , C04B28/02 , C04B7/02
CPC分类号： C04B22/14 , C04B22/0013 , C04B22/068 , C04B24/12 , C04B28/02
摘要： A method for preventing shrinkage of alkaline aqueous hydraulic cementitious mixtures during setting and hardening which comprises incorporating in the mixtures a monopersulfate salt, or a monopersulfate salt together with at least one peroxygen compound other than the monopersulfate salt; and hydraulic cement compositions for preparing such alkaline aqueous hydraulic cementitious mixtures. The monopersulfate salt, or monopersulfate salt together with at least one peroxygen compound other than monopersulfate salt, generates sufficient oxygen gas during setting and hardening of the alkaline aqueous hydraulic cementitious mixture to provide controlled expansion of the mixture.
摘要翻译：一种在凝固和硬化过程中防止碱性水性水硬性混合物收缩的方法，其包括在混合物中加入单过硫酸盐或单过硫酸盐以及除了单过硫酸盐以外的至少一种过氧化合物; 和用于制备这种碱性水性水硬性水泥混合物的水硬性水泥组合物。单过硫酸盐或单过硫酸盐以及除了单过硫酸盐以外的至少一种过氧化合物在碱性水性水硬性水泥混合物的固化和硬化期间产生足够的氧气，以提供混合物的受控膨胀。

97. 发明授权

US4202984A .beta.-(Hexahydro-2,6-methano-3-benzazocin-11-yl)propionic acids, esters and amides 失效
标题翻译： β-（（六氢-2,6-亚甲基-3-苯并佐辛-11-基）丙酸，酯和酰胺
公开(公告)号：US4202984A
公开(公告)日：1980-05-13
申请号：US35937
申请日：1979-05-04
申请人： Thomas R. Lewis , William F. Michne
发明人： Thomas R. Lewis , William F. Michne
IPC分类号： C07D221/26
CPC分类号： C07D221/26 , Y10S514/823
摘要： .beta.-[3-R.sub.1 -6(eq)-R.sub.4 -7-R.sub.2 "-8-R.sub.2 -9-R.sub.2 '-10-R.sub.2 '"-11(ax)-R.sub.3 -1,2,3,4,5,6,-hexahydro-2,6-methano-3-benzazocin-11(eq)-yl]propionic acids, esters and amides, useful as analgesics and narcotic antagonists, are prepared by heating, with formic acid in an organic solvent or with certain ammonium formates, certain di-lower-alkyl 1-R.sub.1 -4a.alpha.-R.sub.3 -5.alpha.-R.sub.4 -6-R.sub.2 "-7-R.sub.2 -8-R.sub.2 '-9-R.sub.2 "'-1,2,3,4,4a,5,10,10a-octahydro-2,5-methanobenzo[g]quinoline-3,3-dicarboxylates, to prepare the esters, hydrolysis of the latter to prepare the acids and conversion of the acids to a mixed anhydride and reaction of the latter with ammonia or an appropriate amine to form the amides.
摘要翻译： β - [3-R1-6（eq）-R4-7-R2“-8-R2-9-R2'-10-R2”'-11（ax）-R3-1,2,3,4 ，5,6,6-六氢-2,6-亚甲基-3-苯并佐辛-11（eq） - 基]丙酸，酯和酰胺，可用作止痛剂和麻醉拮抗剂，通过加热甲酸制备，有机溶剂或某些甲酸铵，某些二低级烷基1-R1-4aα-R3-5αR4-6-R2“-7-R2-8-R2'-9-R2” - 1,2,3,4,4a，5,10,10a-八氢-2,5-甲氧基苯并[g]喹啉-3,3-二羧酸酯，制备酯，后者的水解制备酸和转化的酸与混合酸酐反应，后者与氨或适当的胺反应形成酰胺。

98. 发明授权

US4199586A Di-(lower-alkyl) N-[1,2-dihydro-2-oxo-5-(pyridinyl)-3-pyridinyl]amino-methylanemalonates 失效
标题翻译：二 - （低级烷基）N- [1,2-二氢-2-氧代-5-（吡啶基）-3-吡啶基]氨基 - 甲基丙二酸酯
公开(公告)号：US4199586A
公开(公告)日：1980-04-22
申请号：US937120
申请日：1978-08-28
申请人： George Y. Lesher , Chester J. Opalka, Jr.
发明人： George Y. Lesher , Chester J. Opalka, Jr.
IPC分类号： A61K31/44 , C07D213/38 , C07D213/48 , C07D213/53 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D213/85
CPC分类号： C07D213/53 , C07D213/38 , C07D213/48 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D213/85
摘要： Compounds useful as cardiotonic agents are 1-R-3-Q-5-PY-2(1H)-pyridinones (I) where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, Q is amino (preferred), lower-alkylamino, di-(lower-alkyl)amino or NHAc, Ac is lower-alkanoyl or lower-carbalkoxy, and PY is 4- or 3- or 2-pyridinyl or 4- or 3- or 2-pyridinyl having one or two lower-alkyl substituents. The corresponding compounds where Q is nitro, carbamyl, cyano, halo or hydrogen are useful as intermediates and those where Q is hydrogen or cyano also are useful as cardiotonic agents. Said compounds are prepared: by reacting .alpha.-PY-.beta.-(R.sub.1 R.sub.2 N)acrolein (II) with malonamide to produce 1,2-dihydro-2-oxo-5-PY-nicotinamide (Ia) and reacting Ia with a reagent capable of converting carbamyl to amino to produce 3-amino-5-PY-2(1H)-pyridinone (Ib); by reacting II or .alpha.-PY-malonaldehye (II') with .alpha.-cyanoacetamide to produce 1,2-dihydro-2-oxo-5-PY-nicotinonitrile (III) and partially hydrolyzing III to produce Ia; and, by heating 1,2-dihydro-2-oxo-5-PY-nicotininc acid (IV) with a mixture of concentrated sulfuric acid and concentrated nitric acid to produce 3-nitro-5-PY-2(1H)-pyridinone (Ic) and then either reducing Ic to produce Ib or first reacting Ic with an alkylating agent to produce 1-R'-3-nitro-5-PY-2(1H)-pyridinone (Id) and reducing Ic to produce 1-R'-3-amino-5-PY-2(1H)-pyridinone (Ib) where R' is lower-alkyl or lower-hydroxyalkyl. Other derivatives of I where Q is amino are shown.
摘要翻译：可用作强心剂的化合物是1-R-3-Q-5-PY-2（1H） - 吡啶酮（I），其中R是氢，低级烷基或低级羟基烷基，Q是氨基（优选），低级烷基氨基，二 - （低级烷基）氨基或NHAc，Ac是低级烷酰基或低级 - 烷酰氧基，PY是4-或3-或2-吡啶基或具有一个或两个低级烷酰氧基的4-或3-或2-吡啶基，烷基取代基。其中Q为硝基，氨基甲酰基，氰基，卤素或氢的相应化合物可用作中间体，Q为氢或氰基的化合物也可用作强心剂。制备所述化合物：通过使α-P-β - （R 1 R 2 N）丙烯醛（II）与丙二酰胺反应以产生1,2-二氢-2-氧代-5-PY-烟酰胺（Ia），并使Ia与能够将氨基甲酰转化为氨基，得到3-氨基-5-PY-2（1H） - 吡啶酮（Ib）; 通过使II或α-P-马来酸酐（II'）与α-氰基乙酰胺反应，生成1,2-二氢-2-氧代-5-PY-烟腈（III）并部分水解III产生Ia; 并通过用浓硫酸和浓硝酸的混合物加热1,2-二氢-2-氧代-5-PY-烟酸（IV）以产生3-硝基-5- PY-2（1H） - 吡啶酮（Ic），然后还原Ic以产生Ib或首先使Ic与烷基化剂反应以产生1-R'-3-硝基-5-PY-2（1H） - 吡啶酮（Id）并还原Ic以产生1- R'-3-氨基-5-PY-2（1H） - 吡啶酮（Ib）其中R'是低级烷基或低级 - 羟基烷基。其中Q为氨基的I的其它衍生物被显示。

99. 发明授权

US4198436A Dialkylamino- and dialkylaminoalkoxy-substituted aryloxyalkyl diketones 失效
标题翻译：二烷基氨基 - 和二烷基氨基烷氧基取代的芳氧基烷基二酮
公开(公告)号：US4198436A
公开(公告)日：1980-04-15
申请号：US913363
申请日：1978-06-07
申请人： Joseph C. Collins , Guy D. Diana
发明人： Joseph C. Collins , Guy D. Diana
IPC分类号： C07C45/67 , C07C45/68 , C07C45/70 , C07C49/16 , C07C49/255 , C07C205/57 , A01N9/20 , A01N9/24 , C07C91/42 , C07C93/06
CPC分类号： C07C217/84 , C07C217/20
摘要： Dialkylamino- and dialkylaminoalkoxy-substituted aryloxyalkyl diketones, useful as anti-viral agents, are prepared by reacting a dialkylamino-substituted phenoxyalkyl halide with an alkali metal enolate salt of a diketone; or by reacting the corresponding hydroxy-substituted phenoxyalkyl diketone with a dialkylaminoalkyl halide.
摘要翻译：可用作抗病毒剂的二烷基氨基 - 和二烷基氨基烷氧基取代的芳氧基烷基二酮通过二烷基氨基取代的苯氧烷基卤化物与二酮的碱金属烯醇盐反应制备; 或通过使相应的羟基取代的苯氧基烷基二酮与二烷基氨基烷基卤化物反应。

100. 发明授权

US4182895A 1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles 失效
标题翻译： 1-氨基 - 低级烷基-3,4-二苯基-1H-吡唑
公开(公告)号：US4182895A
公开(公告)日：1980-01-08
申请号：US924677
申请日：1978-07-14
申请人： Denis M. Bailey
发明人： Denis M. Bailey
IPC分类号： C07D231/12
CPC分类号： C07D231/12
摘要： 1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles, useful as anti-depressants and analgesics, are prepared by reduction with an alkali metal aluminum hydride of an .omega.[1-(3,4-diphenyl-1H-pyrazolyl)]-lower alkanamide; reduction with hydrogen in the presence of ammonia, methylamine, dimethylamine or diethylamine over a catalyst of a 1-(cyano-lower-alkyl)-3,4-diphenyl-1-H-pyrazole; reaction of a 1-(tosyloxy-lower-alkyl)-3,4-diphenyl-1H-pyrazole with a lower-alkylamine; reaction of 3,4-diphenylpyrazole with a halo-lower-alkylamine in the presence of an acid acceptor; or reductive alkylation with formaldehyde of a 1-(3-aminopropyl)-3,4-diphenyl-1H-pyrazole.
摘要翻译：可用作抗抑郁剂和止痛剂的1-氨基 - 低级烷基-3,4-二苯基-1H-吡唑通过用ω-[1-（3,4-二苯基-1H- - 吡唑基）] - 低级烷酰胺; 在氨，甲胺，二甲胺或二乙胺的存在下，用1-（氰基 - 低级 - 烷基）-3,4-二苯基-1H-吡唑的催化剂还原氢; 1-（甲苯磺酰氧基 - 低级 - 烷基）-3,4-二苯基-1H-吡唑与低级烷基胺的反应; 在酸受体存在下，3,4-二苯基吡唑与卤代低级烷基胺的反应; 或用1-（3-氨基丙基）-3,4-二苯基-1H-吡唑的甲醛还原烷基化。

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