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1. 发明授权

US5858318A Methods of synthesizing hydroxyapatite powders and bulk materials 失效
标题翻译：羟基磷灰石粉末和散装材料的合成方法
公开(公告)号：US5858318A
公开(公告)日：1999-01-12
申请号：US757849
申请日：1996-11-27
申请人： Ping Luo
发明人： Ping Luo
IPC分类号： C01B25/32 , C04B35/447 , C04B35/622
CPC分类号： C01B25/325 , C04B35/447 , C04B35/622
摘要： Methods are provided for producing non-porous controlled morphology hydroxyapatite granules of less than 8 .mu.m by a spray-drying process. Solid or hollow spheres or doughnuts can be formed by controlling the volume fraction and viscosity of the slurry as well as the spray-drying conditions. Methods of providing for homogenous cellular structure hydroxyapatite granules are also provided. Pores or channels or varying size and number can be formed by varying the temperature at which a hydroxyapatite slurry formed in basic, saturated ammonium hydroxide is spray-dried. Methods of providing non-porous controlled morphology hydroxyapatite granules in ammonium hydroxide are also provided. The hydroxyapatite granules and bulk materials formed by these methods are also provided.
摘要翻译：提供了通过喷雾干燥方法生产小于8μm的无孔受控形态的羟基磷灰石颗粒的方法。可以通过控制浆料的体积分数和粘度以及喷雾干燥条件来形成固体或中空球体或甜甜圈。还提供了提供均质细胞结构羟基磷灰石颗粒的方法。可以通过改变在碱性饱和氢氧化铵中形成的羟基磷灰石浆料喷雾干燥的温度来形成孔或通道或变化的尺寸和数量。还提供了在氢氧化铵中提供无孔受控形态的羟基磷灰石颗粒的方法。还提供了通过这些方法形成的羟基磷灰石颗粒和散装材料。

2. 发明授权

US5676976A Synthesis of reactive amorphous calcium phosphates 失效
标题翻译：反应性无定形磷酸钙的合成
公开(公告)号：US5676976A
公开(公告)日：1997-10-14
申请号：US446182
申请日：1995-05-19
申请人： Dosuk D. Lee , Christian Rey , Maria Aiolova
发明人： Dosuk D. Lee , Christian Rey , Maria Aiolova
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/46 , A61K9/20 , A61L24/02 , A61L27/12 , A61L27/38 , A61L27/42 , C01B25/16 , C01B25/32 , A61K33/42
CPC分类号： C04B28/344 , A61F2/28 , A61F2/30756 , A61K9/2009 , A61L24/02 , A61L27/12 , A61L27/38 , A61L27/425 , C01B25/16 , C01B25/32 , C01B25/321 , C01B25/325 , A61F2002/30062 , A61F2002/30762 , A61F2002/4648 , A61F2210/0004 , A61F2310/00293 , A61L2400/06 , A61L2430/02 , C04B2111/00836 , Y10S977/70 , Y10S977/775 , Y10S977/776 , Y10S977/779 , Y10S977/833 , Y10S977/896 , Y10S977/90 , Y10S977/915 , Y10S977/926
摘要： The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-crystalline synthetic hydroxyapatite that provides both bioactivity and structural integrity. This novel amorphous material can be reacted with other calcium phosphates at or below 37.degree. C. to form a bone-like material consisting of poorly crystalline hydroxyapatite.
摘要翻译：本发明提供了将标准惰性无定形磷酸钙沉淀物转化为高反应性无定形固体的新方法。无定形固体可用于与其他磷酸钙固体反应以形成提供生物活性和结构完整性的不良结晶合成羟基磷灰石。这种新型无定形材料可以在等于或低于37℃与其它磷酸钙反应形成由不完全结晶的羟基磷灰石组成的骨状材料。

3. 发明授权

US5486365A Calcium hydrogen phosphate, a method for preparing it, and an excipient utilizing it 失效
标题翻译：磷酸氢钙，其制备方法和利用它的赋形剂
公开(公告)号：US5486365A
公开(公告)日：1996-01-23
申请号：US272043
申请日：1994-07-08
申请人： Kanemasa Takado , Tatsuo Murakami
发明人： Kanemasa Takado , Tatsuo Murakami
IPC分类号： A23L29/00 , A61K8/19 , A61K8/24 , A61K8/36 , A61K8/362 , A61K47/04 , C01B25/32 , A61K33/42
CPC分类号： C01B25/325 , C01B25/322
摘要： The object of the present invention is to prepare a calcium hydrogen phosphate that has excellent binding properties, a large oil adsorption capacity and a specific surface area, and is therefore suitable as an excipient.A scale-like calcium hydrogen phosphate is prepared by reacting phosphoric acid with an alkaline calcium compound such as quick lime, in the presence of a multivalent organic acid with coordinating ability, such as citric acid, to obtain a columnar calcium hydrogen phosphate, and then hydrothermally treating the obtained columnar calcium hydrogen phosphate at a temperature of 60.degree. C. or higher.
摘要翻译：本发明的目的是制备具有优异的结合性，大的吸油量和比表面积的磷酸氢钙，因此适合作为赋形剂。在具有配位能力的多价有机酸如柠檬酸的存在下，使磷酸与碱性钙化合物如生石灰反应制备鳞状磷酸氢钙，得到柱状磷酸氢钙，然后在60℃以上的温度下水解处理得到的柱状磷酸氢钙。

4. 发明授权

US4836994A Calcium-phosphorus-apatite having novel properties and process for preparing the same 失效
标题翻译：具有新颖性质的磷酸钙磷灰石及其制备方法
公开(公告)号：US4836994A
公开(公告)日：1989-06-06
申请号：US95222
申请日：1987-09-11
申请人： Senya Inoue , Akira Ono
发明人： Senya Inoue , Akira Ono
IPC分类号： B01J20/04 , C01B25/32 , C01B25/455
CPC分类号： B01J20/048 , B01J20/282 , C01B25/32 , C01B25/322 , C01B25/325 , C01B25/455 , B01J2220/54
摘要： The present invention relates to a process for preparing a calcium-phosphorus-apatite, essentially characterized by admixing a single solvent of water or an organic solvent compatible with water or a mixed solvent of water with an organic solvent compatible with water with calcium and phosphorus compounds soluble in said single or mixed solvent to prepare a raw material solution, and atomizing the raw material solution into a flame or a heating zone for effecting a thermal decomposition reaction thereof to form a calcium-phosphorus-apatite; a calcium-phosphorus-apatite obtained by the process and having novel characteristics; and the use of the calcium-phosphorus-apatite as a chromatographic packing material.

5. 发明授权

US4044105A Process for preparation of calcium hydrogen phosphate anhydride 失效
标题翻译：磷酸氢钙无机酸的制备方法
公开(公告)号：US4044105A
公开(公告)日：1977-08-23
申请号：US653036
申请日：1976-01-28
申请人： Takamitsu Enomoto , Motoshige Ogura , Tetsuhiro Ono
发明人： Takamitsu Enomoto , Motoshige Ogura , Tetsuhiro Ono
IPC分类号： C01B25/32 , C09K11/71 , C01B15/16 , C01B25/26
CPC分类号： C01B25/327 , C01B25/325 , C09K11/71
摘要： An aqueous slurry of CaHPO.sub.4.2H.sub.2 O in a 5-20 Wt% concentration is prepared by the use of the phosphate dihydrate obtained by reaction of NaNH.sub.4 HPO.sub.4.4H.sub.2 O with CaCl.sub.2 in water. After adjustment of the pH of the slurry to 4.5-5.5, the slurry is rapidly heated to 85.degree.-97.degree. C by contact with steam to convert the dihydrate to the anhydride, which is suitable for use in the preparation of fluorescent materials due to its high purity, platy and square crystal shape and uniform particle size.
摘要翻译：通过使用通过NaNH 4 HPO 4·4H 2 O与CaCl 2在水中反应获得的磷酸盐二水合物制备5-20重量％浓度的CaHPO 4·2H 2 O的含水浆料。在将浆料的pH调节至4.5-5.5之后，通过与蒸汽接触将浆料快速加热至85℃-97℃，以将二水合物转化为酸酐，其适用于制备荧光材料，因为其纯度高，板状和方晶晶粒尺寸均匀。

6. 发明授权

US3505012A Process for making brushite form of calcium hydrogen phosphate 失效
标题翻译：制备磷酸氢钙的形式的方法
公开(公告)号：US3505012A
公开(公告)日：1970-04-07
申请号：US3505012D
申请日：1968-04-11
申请人： SYLVANIA ELECTRIC PROD
发明人： DALE ERNEST A , BUTLER KEITH H , THOMAS MARTHA J B
IPC分类号： C01B25/32 , C01C1/16
CPC分类号： C01B25/325

7. 发明授权

US3110560A Preparation of alkaline earth metal phosphates 失效
标题翻译：碱土金属磷酸盐的制备
公开(公告)号：US3110560A
公开(公告)日：1963-11-12
申请号：US4223460
申请日：1960-07-12
申请人： THORN ELECTRICAL IND LTD
发明人： WHITTEN RANBY PETER , LEONARD BURRUS HENRY
IPC分类号： C01B25/32 , C09K11/70
CPC分类号： C01B25/325 , C09K11/705

8. 发明授权

US08333996B2 Calcium phosphate delivery vehicle and adjuvant 失效
标题翻译：磷酸钙输送载体和佐剂
公开(公告)号：US08333996B2
公开(公告)日：2012-12-18
申请号：US09153133
申请日：1998-09-15
申请人： D. Duke Lee , Maria Aiolova
发明人： D. Duke Lee , Maria Aiolova
IPC分类号： A01N59/26 , A61K33/42 , A61K51/00 , A61M36/14
CPC分类号： A61K39/39 , A61F2/28 , A61F2/30756 , A61F2002/30062 , A61F2002/30762 , A61F2002/4648 , A61F2210/0004 , A61F2310/00293 , A61K9/143 , A61K9/2009 , A61K47/02 , A61L24/02 , A61L27/12 , A61L27/425 , A61L27/54 , A61L27/58 , A61L2300/426 , A61L2300/438 , A61L2400/06 , A61L2430/02 , C01B25/16 , C01B25/32 , C01B25/321 , C01B25/325
摘要： An improved calcium phosphate delivery vehicle or adjuvant with incorporated adjuvanticity enhancing means and methods of producing same are disclosed. The adjuvant can be fabricated to desired formulations as appropriate and based on the intended purpose. Particle sizes can be adjusted to enhance adjuvant activity. Other supplemental materials may be added as desired and in appropriate proportions to selectively elicit preferred components of the immune system and to enhance the adjuvant's effect on the host response.
摘要翻译：公开了一种改进的磷酸钙递送载体或具有引入佐剂性增强方法的佐剂及其制备方法。佐剂可以根据预期的目的适当地制备成所需的制剂。可以调整粒径以增强佐剂活性。可以根据需要和适当的比例添加其它补充材料以选择性地引发免疫系统的优选组分并增强佐剂对宿主反应的影响。

9. 发明授权

US06541037B1 Delivery vehicle 失效
标题翻译：送货车
公开(公告)号：US06541037B1
公开(公告)日：2003-04-01
申请号：US08729342
申请日：1996-10-16
申请人： Dosuk D. Lee , Christian Rey , Maria Aiolova
发明人： Dosuk D. Lee , Christian Rey , Maria Aiolova
IPC分类号： A61K3342
CPC分类号： A61F2/28 , A61F2/30756 , A61F2002/30062 , A61F2002/30762 , A61F2002/4648 , A61F2210/0004 , A61F2310/00293 , A61K9/2009 , A61L24/02 , A61L27/12 , A61L27/38 , A61L27/425 , A61L27/54 , A61L27/58 , A61L2300/426 , A61L2300/438 , A61L2400/06 , A61L2430/02 , C01B25/16 , C01B25/32 , C01B25/321 , C01B25/325 , C04B28/344 , C04B2111/00836 , Y10S977/906
摘要： The present invention provides delivery vehicles comprising a synthetic, poorly crystalline apatite (PCA) calcium phosphate and a biologically active agent. The PCA calcium phosphate offers many advantages over known delivery materials and is particularly useful for delivery of agents to bone sites, the central nervous system, intramuscular sites, subcutaneous sites, interperitoneal sites, and occular sites. The invention also provides methods of preparing delivery vehicles, of altering delivery vehicle characteristics, and of delivering biologically active agents to a site. The invention is useful for both medical and veterinary applications.
摘要翻译：本发明提供了包含合成的，结晶不良的磷灰石（PCA）磷酸钙和生物活性剂的递送载体。 PCA磷酸钙提供了超过已知递送材料的许多优点，并且特别可用于将药物递送到骨部位，中枢神经系统，肌内部位，皮下部位，腹膜内部位和眼部位置。本发明还提供了制备递送载体，改变递送载体特性以及将生物活性剂递送至部位的方法。本发明对于医学和兽医应用都是有用的。

10. 发明申请

US20020155137A1 Methods and products related to the physical conversion of reactive amorphous calcium phosphate 审中-公开
标题翻译：与反应性无定形磷酸钙的物理转化相关的方法和产品
公开(公告)号：US20020155137A1
公开(公告)日：2002-10-24
申请号：US10117764
申请日：2002-04-05
申请人： Etex Corporation
发明人： Dosuk D. Lee , Christian Rey , Maria Aiolova , Aliassghar Tofighi
IPC分类号： A61K009/00 , A61F002/00 , A61K033/42
CPC分类号： A61F2/28 , A61F2/30756 , A61F2002/30062 , A61F2002/30762 , A61F2002/4648 , A61F2210/0004 , A61F2310/00293 , A61K9/2009 , A61L24/02 , A61L27/12 , A61L27/38 , A61L27/425 , A61L27/54 , A61L27/58 , A61L2300/22 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2300/452 , A61L2400/06 , A61L2430/02 , C01B25/16 , C01B25/32 , C01B25/321 , C01B25/325 , C04B28/344 , C04B2111/00836 , Y10S977/70 , Y10S977/775 , Y10S977/91 , Y10S977/915 , Y10S977/926
摘要： The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature an is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing.
摘要翻译：本发明提供了一种用于生产与吸热反应相关的以温度依赖的方式硬化的磷酸钙水泥或填料的新方法。在反应中，将有限量的水与干燥的磷酸钙前体混合以产生水合前体浆料。糊状物的硬化在体温下迅速发生，伴随着一种或多种反应物转化为结晶不良的磷灰石磷酸钙。本发明的硬化水泥，填料，生长基质，矫形和递送装置可快速吸收并刺激硬组织的生长和愈合。

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